Search Results - "ROBINSON, Edward D"

Fructose-1,6-bisphosphatase Inhibitors. 1. Purine Phosphonic Acids as Novel AMP Mimics by Dang, Qun, Brown, Brian S, Liu, Yan, Rydzewski, Robert M, Robinson, Edward D, Poelje, Paul D. van, Reddy, M. Rami, Erion, Mark D

“…Inhibition of FBPase is considered a promising way to reduce hepatic gluconeogenesis and therefore could be a potential approach to treat type 2 diabetes…”
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A mild method for the synthesis of furans. Application to 2,5-bridged furano macrocyclic compounds by Marshall, James A, Robinson, Edward D

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Structure–activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads by Ullman, Brett R., Aja, Teresa, Chen, Ning, Diaz, Jose-Luis, Gu, Xin, Herrmann, Julia, Kalish, Vincent J., Karanewsky, Donald S., Kodandapani, Lalitha, Krebs, Joseph J., Linton, Steven D., Meduna, Steven P., Nalley, Kip, Robinson, Edward D., Roggo, Silvio P., Sayers, Robert O., Schmitz, Albert, Ternansky, Robert J., Tomaselli, Kevin J., Wu, Joe C.

“…Various heterocyclic hetero-methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A study of their structure–activity relationship…”
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First-in-Class Pan Caspase Inhibitor Developed for the Treatment of Liver Disease by Linton, Steven D, Aja, Teresa, Armstrong, Robert A, Bai, Xu, Chen, Long-Shiuh, Chen, Ning, Ching, Brett, Contreras, Patricia, Diaz, Jose-Luis, Fisher, Craig D, Fritz, Lawrence C, Gladstone, Patricia, Groessl, Todd, Gu, Xin, Herrmann, Julia, Hirakawa, Brad P, Hoglen, Niel C, Jahangiri, Kathy G, Kalish, Vincent J, Karanewsky, Donald S, Kodandapani, Lalitha, Krebs, Joseph, McQuiston, Jeff, Meduna, Steven P, Nalley, Kip, Robinson, Edward D, Sayers, Robert O, Sebring, Kristen, Spada, Alfred P, Ternansky, Robert J, Tomaselli, Kevin J, Ullman, Brett R, Valentino, Karen L, Weeks, Suzanne, Winn, David, Wu, Joe C, Yeo, Pauline, Zhang, Cheng-zhi

“…A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure−activity…”
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Furans in synthesis. 11. Total syntheses of (.+-.)- and (-)-fastigilin C by Tanis, Steven P, Robinson, Edward D, McMills, Mark C, Watt, William

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[2,3] Wittig rearrangement of nonracemic propargyl ethers leading to allenes of high stereochemical integrity by Marshall, James A, Robinson, Edward D, Zapata, Antonio

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Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke by Linton, Steven D., Aja, Teresa, Allegrini, Peter R., Deckwerth, Thomas L., Diaz, Jose-Luis, Hengerer, Bastian, Herrmann, Julia, Jahangiri, Kathy G., Kallen, Joerg, Karanewsky, Donald S., Meduna, Steven P., Nalley, Kip, Robinson, Edward D., Roggo, Silvio, Rovelli, Giorgio, Sauter, Andre, Sayers, Robert O., Schmitz, Albert, Smidt, Robert, Ternansky, Robert J., Tomaselli, Kevin J., Ullman, Brett R., Wiessner, Christoph, Wu, Joe C.

“…Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies…”
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Structure-activity relationships within a series of caspase inhibitors: Effect of leaving group modifications by ULLMAN, Brett R, AJA, Teresa, ROGGO, Silvio P, SAYERS, Robert O, SCHMITZ, Albert, TERNANSKY, Robert J, TOMASELLI, Kevin J, WU, Joe C, DECKWERTH, Thomas L, DIAZ, Jose-Luis, HERRMANN, Julia, KALISH, Vincent J, KARANEWSKY, Donald S, MEDUNA, Steven P, NALLEY, Kip, ROBINSON, Edward D

“…Various aryloxy methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A systematic study of their structure-activity relationship…”
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Acyl dipeptides as reversible caspase inhibitors. Part 2: Further optimization by LINTON, Steven D, KARANEWSKY, Donald S, WU, Joe C, PHAM, Brian, KODANDAPANI, Lalitha, SMIDT, Robert, DIAZ, Jose-Luis, FRITZ, Lawrence C, VON KROSIGK, U, ROGGO, Silvio, SCHMITZ, Albert, TOMASELLI, Kevin J, TERNANSKY, Robert J, NING CHEN, GUO, Xian, JAHANGIRI, Kathy G, KALISH, Vincent J, MEDUNA, Steven P, ROBINSON, Edward D, ULLMAN, Brett R

“…A new structural class of broad spectrum caspase inhibitors was optimized for its activity against caspases 1, 3, 6, 7, and 8. The most potent compound had low…”
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Cyclopentane construction with control of side-chain configuration: enantioselective synthesis of (+)-brefeldin A by Taber, Douglass F, Silverberg, Lee J, Robinson, Edward D

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Synthesis of the tumor-inhibitory tobacco constituents .alpha.- and .beta.-2,7,11-cembratriene-4,6-diol by diastereoselective [2,3] Wittig ring contraction by Marshall, James A, Robinson, Edward D, Lebreton, Jacques

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Hepatitis B Reverse Seroconversion and Transmission in a Hemodialysis Center: A Public Health Investigation and Case Report by Rhea, Sarah, DVM, PhD, Moorman, Anne, MPH, Pace, Robert, BS, Mobley, Victoria, MD, MPH, MacFarquhar, Jennifer, MPH, Robinson, Edward, MD, Hayden, Tonya, PhD, Thai, Hong, PhD, Drobeniuc, Jan, MD, PhD, Brooks, John T., MD, Moore, Zack, MD, MPH, Patel, Priti R., MD, MPH

“…In March 2013, public health authorities were notified of a new hepatitis B virus (HBV) infection in a patient receiving hemodialysis. We investigated to…”
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