Search Results - "ROBINSON, Brian D"

N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer by Dardenne, Etienne, Beltran, Himisha, Benelli, Matteo, Gayvert, Kaitlyn, Berger, Adeline, Puca, Loredana, Cyrta, Joanna, Sboner, Andrea, Noorzad, Zohal, MacDonald, Theresa, Cheung, Cynthia, Yuen, Ka Shing, Gao, Dong, Chen, Yu, Eilers, Martin, Mosquera, Juan-Miguel, Robinson, Brian D., Elemento, Olivier, Rubin, Mark A., Demichelis, Francesca, Rickman, David S.

“…The transition from castration-resistant prostate adenocarcinoma (CRPC) to neuroendocrine prostate cancer (NEPC) has emerged as an important mechanism of…”
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Intraductal carcinoma of the prostate without invasive carcinoma on needle biopsy: emphasis on radical prostatectomy findings by Robinson, Brian D, Epstein, Jonathan I

“…Limited information is available on radical prostatectomy findings in men with intraductal carcinoma of the prostate on needle core biopsy in the absence of…”
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Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling by Robinson, Brian D., Vlachostergios, Panagiotis J., Bhinder, Bhavneet, Liu, Weisi, Li, Kailyn, Moss, Tyler J., Bareja, Rohan, Park, Kyung, Tavassoli, Peyman, Cyrta, Joanna, Tagawa, Scott T., Nanus, David M., Beltran, Himisha, Molina, Ana M., Khani, Francesca, Miguel Mosquera, Juan, Xylinas, Evanguelos, Shariat, Shahrokh F., Scherr, Douglas S., Rubin, Mark A., Lerner, Seth P., Matin, Surena F., Elemento, Olivier, Faltas, Bishoy M.

“…Upper tract urothelial carcinoma (UTUC) is characterized by a distinctly aggressive clinical phenotype. To define the biological features driving this…”
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SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling by Blattner, Mirjam, Liu, Deli, Robinson, Brian D., Huang, Dennis, Poliakov, Anton, Gao, Dong, Nataraj, Srilakshmi, Deonarine, Lesa D., Augello, Michael A., Sailer, Verena, Ponnala, Lalit, Ittmann, Michael, Chinnaiyan, Arul M., Sboner, Andrea, Chen, Yu, Rubin, Mark A., Barbieri, Christopher E.

“…Recurrent point mutations in SPOP define a distinct molecular subclass of prostate cancer. Here, we describe a mouse model showing that mutant SPOP drives…”
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A Deep Learning Approach to Diagnostic Classification of Prostate Cancer Using Pathology–Radiology Fusion by Khosravi, Pegah, Lysandrou, Maria, Eljalby, Mahmoud, Li, Qianzi, Kazemi, Ehsan, Zisimopoulos, Pantelis, Sigaras, Alexandros, Brendel, Matthew, Barnes, Josue, Ricketts, Camir, Meleshko, Dmitry, Yat, Andy, McClure, Timothy D., Robinson, Brian D., Sboner, Andrea, Elemento, Olivier, Chughtai, Bilal, Hajirasouliha, Iman

“…Background A definitive diagnosis of prostate cancer requires a biopsy to obtain tissue for pathologic analysis, but this is an invasive procedure and is…”
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A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors by Crowley, Laura, Cambuli, Francesco, Aparicio, Luis, Shibata, Maho, Robinson, Brian D, Xuan, Shouhong, Li, Weiping, Hibshoosh, Hanina, Loda, Massimo, Rabadan, Raul, Shen, Michael M

“…Understanding the cellular constituents of the prostate is essential for identifying the cell of origin for prostate adenocarcinoma. Here, we describe a…”
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Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee by ITTMANN, Michael, JIAOTI HUANG, LODA, Massimo, THOMAS, George, BOROWSKY, Alexander, CARDIFF, Robert D, RADAELLI, Enrico, MARTIN, Philip, SIGNORETTI, Sabina, SULLIVAN, Ruth, SIMONS, Brian W, WARD, Jerrold M, ROBINSON, Brian D, CHU, Gerald C

“…Animal models, particularly mouse models, play a central role in the study of the etiology, prevention, and treatment of human prostate cancer. While tissue…”
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CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis by Augello, Michael A., Liu, Deli, Deonarine, Lesa D., Robinson, Brian D., Huang, Dennis, Stelloo, Suzan, Blattner, Mirjam, Doane, Ashley S., Wong, Elissa W.P., Chen, Yu, Rubin, Mark A., Beltran, Himisha, Elemento, Olivier, Bergman, Andries M., Zwart, Wilbert, Sboner, Andrea, Dephoure, Noah, Barbieri, Christopher E.

“…Deletion of the gene encoding the chromatin remodeler CHD1 is among the most common alterations in prostate cancer (PCa); however, the tumor-suppressive…”
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Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination by ROBINSON, Brian D, SICA, Gabriel L, LIU, Yi-Fang, ROHAN, Thomas E, GERTLER, Frank B, CONDEELIS, John S, JONES, Joan G

“…Purpose: Multiphoton-based intravital imaging has shown that invasive carcinoma cells in mouse and rat mammary tumors intravasate when associated with…”
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Erythropoietin‐secreting metanephric adenoma presenting as erythrocytosis by Liu, Angela, Kremyanskaya, Marina, Mehrazin, Reza, Si, Qiusheng, Robinson, Brian D., Cushing, Melissa M., Hoffman, Ronald, Ginzburg, Yelena Z.

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Concurrent AURKA and MYCN Gene Amplifications Are Harbingers of Lethal TreatmentRelated Neuroendocrine Prostate Cancer by Mosquera, Juan Miguel, Beltran, Himisha, Park, Kyung, MacDonald, Theresa Y, Robinson, Brian D, Tagawa, Scott T, Perner, Sven, Bismar, Tarek A, Erbersdobler, Andreas, Dhir, Rajiv, Nelson, Joel B, Nanus, David M, Rubin, Mark A

“…Abstract Neuroendocrine prostate cancer (NEPC), also referred to as anaplastic prostate cancer, is a lethal tumor that most commonly arises in late stages of…”
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Cytoplasmic PTEN protein loss distinguishes intraductal carcinoma of the prostate from high-grade prostatic intraepithelial neoplasia by Lotan, Tamara L, Gumuskaya, Berrak, Rahimi, Hameed, Hicks, Jessica L, Iwata, Tsuyoshi, Robinson, Brian D, Epstein, Jonathan I, De Marzo, Angelo M

“…Intraductal carcinoma of the prostate is a marker of aggressive disease. However, intraductal carcinoma exists on a morphologic continuum with high-grade…”
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Somatic Mutations in Renal Cyst Epithelium in Autosomal Dominant Polycystic Kidney Disease by Tan, Adrian Y, Zhang, Tuo, Michaeel, Alber, Blumenfeld, Jon, Liu, Genyan, Zhang, Wanying, Zhang, Zhengmao, Zhu, Yi, Rennert, Lior, Martin, Che, Xiang, Jenny, Salvatore, Steven P, Robinson, Brian D, Kapur, Sandip, Donahue, Stephanie, Bobb, Warren O, Rennert, Hanna

“…Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy caused by mutations in and that is characterized by renal tubular epithelial cell…”
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Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer by Kauffman, Eric C., Robinson, Brian D., Downes, Martin J., Powell, Leagh G., Lee, Ming Ming, Scherr, Douglas S., Gudas, Lorraine J., Mongan, Nigel P.

“…Bladder cancer is approximately three times more common in men as compared to women. We and others have previously investigated the contribution of androgens…”
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SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts by Blattner, Mirjam, Lee, Daniel J, O'Reilly, Catherine, Park, Kyung, MacDonald, Theresa Y, Khani, Francesca, Turner, Kevin R, Chiu, Ya-Lin, Wild, Peter J, Dolgalev, Igor, Heguy, Adriana, Sboner, Andrea, Ramazangolu, Sinan, Hieronymus, Haley, Sawyers, Charles, Tewari, Ashutosh K, Moch, Holger, Yoon, Ghil Suk, Known, Yong Chul, Andrén, Ove, Fall, Katja, Demichelis, Francecsa, Mosquera, Juan Miguel, Robinson, Brian D, Barbieri, Christopher E, Rubin, Mark A

“…Abstract BACKGROUND: Recurrent mutations in the Speckle-Type POZ Protein ( SPOP ) gene occur in up to 15% of prostate cancers. However, the frequency and…”
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Impact of Smoking and Smoking Cessation on Oncologic Outcomes in Primary Non–muscle-invasive Bladder Cancer by Rink, Michael, Furberg, Helena, Zabor, Emily C, Xylinas, Evanguelos, Babjuk, Marko, Pycha, Armin, Lotan, Yair, Karakiewicz, Pierre I, Novara, Giacomo, Robinson, Brian D, Montorsi, Francesco, Chun, Felix K, Scherr, Douglas S, Shariat, Shahrokh F

“…Abstract Background Cigarette smoking is the best-established risk factor for urothelial carcinoma (UC) development, but the impact on oncologic outcomes…”
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Common germline-somatic variant interactions in advanced urothelial cancer by Vosoughi, Aram, Zhang, Tuo, Shohdy, Kyrillus S., Vlachostergios, Panagiotis J., Wilkes, David C., Bhinder, Bhavneet, Tagawa, Scott T., Nanus, David M., Molina, Ana M., Beltran, Himisha, Sternberg, Cora N., Motanagh, Samaneh, Robinson, Brian D., Xiang, Jenny, Fan, Xiao, Chung, Wendy K., Rubin, Mark A., Elemento, Olivier, Sboner, Andrea, Mosquera, Juan Miguel, Faltas, Bishoy M.

“…The prevalence and biological consequences of deleterious germline variants in urothelial cancer (UC) are not fully characterized. We performed whole-exome…”
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The evolution of metastatic upper tract urothelial carcinoma through genomic-transcriptomic and single-cell protein markers analysis by Ohara, Kentaro, Rendeiro, André Figueiredo, Bhinder, Bhavneet, Eng, Kenneth Wha, Ravichandran, Hiranmayi, Nguyen, Duy, Pisapia, David, Vosoughi, Aram, Fernandez, Evan, Shohdy, Kyrillus S., Manohar, Jyothi, Beg, Shaham, Wilkes, David, Robinson, Brian D., Khani, Francesca, Bareja, Rohan, Tagawa, Scott T., Ouseph, Madhu M., Sboner, Andrea, Elemento, Olivier, Faltas, Bishoy M., Mosquera, Juan Miguel

“…The molecular characteristics of metastatic upper tract urothelial carcinoma (UTUC) are not well understood, and there is a lack of knowledge regarding the…”
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Epitranscriptomic mechanisms of androgen signalling and prostate cancer by Patke, Rodhan, Harris, Anna E., Woodcock, Corinne L., Thompson, Rachel, Santos, Rute, Kumari, Amber, Allegrucci, Cinzia, Archer, Nathan, Gudas, Lorraine J., Robinson, Brian D., Persson, Jenny L., Fray, Rupert, Jeyapalan, Jennie, Rutland, Catrin S., Rakha, Emad, Madhusudan, Srinivasan, Emes, Richard D., Muyangwa-Semenova, Musalwa, Alsaleem, Mansour, de Brot, Simone, Green, William, Ratan, Hari, Mongan, Nigel P., Lothion-Roy, Jennifer

“…Prostate cancer (PCa) is the second most common cancer diagnosed in men. While radical prostatectomy and radiotherapy are often successful in treating…”
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Anatomical grades of nerve sparing: a risk‐stratified approach to neural‐hammock sparing during robot‐assisted radical prostatectomy (RARP) by Tewari, Ashutosh K., Srivastava, Abhishek, Huang, Michael W., Robinson, Brian D., Shevchuk, Maria M., Durand, Matthieu, Sooriakumaran, Prasanna, Grover, Sonal, Yadav, Rajiv, Mishra, Nishant, Mohan, Sanjay, Brooks, Danielle C., Shaikh, Nusrat, Khanna, Abhinav, Leung, Robert

“…What's known on the subject? and What does the study add? During radical prostatectomy, urological surgeons have tried to identify the “cord‐like NVB” at the…”
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