Search Results - "ROBINS, R. A"

Systemic cytokine levels and the effects of etanercept in TNF receptor-associated periodic syndrome (TRAPS) involving a C33Y mutation in TNFRSF1A by Nowlan, M. L., Drewe, E., Bulsara, H., Esposito, N., Robins, R. A., Tighe, P. J., Powell, R. J., Todd, I.

“…Objective. To investigate the levels of the pro-inflammatory cytokines IL-6, TNF-α, IL-1β, IL-8, IL-10 and IL-12p70 in the plasma of patients with TNF…”
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Enhanced expression of the complement regulatory protein CD55 predicts a poor prognosis in colorectal cancer patients by DURRANT, L. G, CHAPMAN, M. A, BUCKLEY, D. J, SPENDLOVE, I, ROBINS, R. A, ARMITAGE, N. C

“…This study prospectively correlated the level of expression of CD55 on tumours with 7-year survival in 136 colorectal cancer patients. Patients with tumours…”
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Monocytes Are Highly Sensitive to Clostridium difficile Toxin A-Induced Apoptotic and Nonapoptotic Cell Death by Solomon, K, Webb, J, Ali, N, Robins, R. A, Mahida, Y. R

“…In this study we investigated the in vitro responses of peripheral blood mononuclear preparations and purified monocytes to Clostridium difficile toxin A. In…”
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Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells by Jean-Gilles, L., Braitch, M., Latif, M. L., Aram, J., Fahey, A. J., Edwards, L. J., Robins, R. A., Tanasescu, R., Tighe, P. J., Gran, B., Showe, L. C., Alexander, S. P., Chapman, V., Kendall, D. A., Constantinescu, C. S.

“…Aims To investigate the regulation of cannabinoid receptors CB1 and CB2 on immune cells by pro‐inflammatory cytokines and its potential relevance to the…”
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Kinetics of immune cell migration at the human ocular surface by Chan, J H, Amankwah, R, Robins, R A, Gray, T, Dua, H S

“…The conjunctiva has a resident population of intraepithelial and stromal immune cells. These cells play an active part in ocular surface defence and disease…”
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Endothelial monocyte-activating polypeptide-II (EMAP-II): a novel inducer of lymphocyte apoptosis by Murray, J. C., Heng, Y. M., Symonds, P., Rice, K., Ward, W., Huggins, M., Todd, I., Robins, R. A.

“…The novel, proinflammatory cytokine endothelial monocyte‐activating polypeptide‐II (EMAP‐II) was first found in tumor cell supernatants. EMAP‐II is closely…”
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Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients by Damanhouri, L. H., Dromey, J. A., Christie, M. R., Nasrat, H. A., Ardawi, M. S. M., Robins, R. A., Todd, I.

“…Aims  To determine the prevalence of autoantibodies in sera of Saudi diabetic patients including Type 1 and Type 2 diabetes mellitus (DM) and gestational…”
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Decreased interferon‐β induced STAT‐4 activation in immune cells and clinical outcome in multiple sclerosis by Tanasescu, R., Midgley, A., Robins, R. A., Constantinescu, C. S.

“…Objectives Interferon‐β (IFN‐β) is used in the treatment of multiple sclerosis (MS). IFN‐β activation of signal transduction and activation of transcription…”
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Randomized double-blind phase II survival study comparing immunization with the anti-idiotypic monoclonal antibody 105AD7 against placebo in advanced colorectal cancer by MAXWELL-ARMSTRONG, C. A, DURRANT, L. G, HARDCASTLE, J. D, BUCKLEY, T. J. D, SCHOLEFIELD, J. H, ROBINS, R. A, FIELDING, K, MONSON, J. R. T, GUILLOU, P, CALVERT, H, CARMICHAEL, J

“…The cancer vaccine 105AD7 is an anti-idiotypic monoclonal antibody that mimics the tumour-associated antigen 791T/gp72 (CD55, Decay Accelerating Factor) on…”
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Glucocorticoids increase CD4+CD25high cell percentage and Foxp3 expression in patients with multiple sclerosis by Braitch, M., Harikrishnan, S., Robins, R. A., Nichols, C., Fahey, A. J., Showe, L., Constantinescu, C. S.

“…Objectives –  To determine whether percentages of CD4+CD25high T cells (a group of regulatory T cells, Treg) differ in patients with multiple sclerosis (MS) in…”
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Th17/Th1 phenotype in demyelinating disease by Edwards, L.J., Robins, R.A., Constantinescu, C.S.

“…Background: Th17 cells are thought to contribute to the immunopathology of allergic and autoimmune conditions. Their role in multiple sclerosis (MS) pathology…”
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Immunological aspects of head and neck cancer: Biology, pathophysiology and therapeutic mechanisms by McKechnie, A., Robins, R.A., Eremin, O.

“…Advanced cancer and head and neck cancer, in particular, remains a major clinical challenge with its associated morbidity and inevitable mortality. Local…”
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Vaccination and malignant disease: Promising therapeutic approach by McKechnie, A., Robins, R.A., Eremin, O.

“…Immunotherapy of cancer is now entering its second century. Much of our understanding of the complex interaction between tumours and the host immune system has…”
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A Neoadjuvant Clinical Trial in Colorectal Cancer Patients of the Human Anti-Idiotypic Antibody 105AD7, Which Mimics CD55 by Durrant, L G, Maxwell-Armstrong, C, Buckley, D, Amin, S, Robins, R A, Carmichael, J, Scholefield, J H

“…Thirty-five patients received 105AD7 human anti-idiotype vaccination prior to surgery for colorectal carcinoma. Patients were immunized before and also…”
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Preclinical evaluation of whole cell vaccines for prophylaxis and therapy using a disabled infectious single cycle-herpes simplex virus vector to transduce cytokine genes by ALI, S. A, MCLEAN, C. S, VILE, R, ROBINS, R. A, REES, R. C, BOURSNELL, M. E. G, MARTIN, G, HOLMES, C. L, REEDER, S, ENTWISLE, C, BLAKELEY, D. M, SHIELDS, J. G, TODRYK, S

“…The development of genetically modified "whole" tumor cell vaccines for cancer therapy relies on the efficient transduction and expression of genes by vectors…”
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Vaccination therapy in malignant disease by Aloysius, M.M., Robins, R.A., Eremin, J.M., Eremin, O.

“…Improvement in survival among patients with early malignancy is well established in various cancers. However, long-term survival in those with advanced…”
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Loss of cytomegalovirus‐specific immunological memory in a patient with thymoma by HUISSOON, A. P., DAVIES, G., COX, R. A., SLOPER, C. M. L., THOMSON, B. J., ROBINS, R. A.

“…SUMMARY Cytomegalovirus (CMV) retinitis is a re‐activation infection associated with severely impaired T cell‐mediated immunity. We describe a patient with…”
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Increased activation of lymphocytes infiltrating primary colorectal cancers following immunisation with the anti-idiotypic monoclonal antibody 105AD7 by Maxwell-Armstrong, C A, Durrant, L G, Robins, R A, Galvin, A M, Scholefield, J H, Hardcastle, J D

“…BACKGROUND The anti-idiotypic monoclonal antibody 105AD7 mimics the tumour associated antigen 791Tgp72, expressed on 70–80% of colorectal cancers. Phase I…”
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S antigen specific effector T cell activation detected by cytokine flow cytometry by Morgan, J P, Robins, R A, Dua, H S, Tighe, P J

“…Background/aims: Effector T cell activation is particularly important in the initiation of autoimmune uveitis. This pilot study seeks to demonstrate activation…”
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105Ad7 cancer vaccine stimulates anti‐tumour helper and cytotoxic T‐cell responses in colorectal cancer patients but repeated immunisations are required to maintain these responses by Durrant, Lindy G., Buckley, Declan J., Robins, R. Adrian, Spendlove, Ian

“…105AD7 is a human anti‐idiotypic antibody that recognises the binding site of the anti‐tumour antibody 791T/36 and can thereby mimic the CD55 antigen. The…”
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