Search Results - "ROBERTSON, Kevin A"

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response by Blanc, Mathieu, Hsieh, Wei Yuan, Robertson, Kevin A., Kropp, Kai A., Forster, Thorsten, Shui, Guanghou, Lacaze, Paul, Watterson, Steven, Griffiths, Samantha J., Spann, Nathanael J., Meljon, Anna, Talbot, Simon, Krishnan, Kathiresan, Covey, Douglas F., Wenk, Markus R., Craigon, Marie, Ruzsics, Zsolts, Haas, Jürgen, Angulo, Ana, Griffiths, William J., Glass, Christopher K., Wang, Yuqin, Ghazal, Peter

“…Recent studies suggest that the sterol metabolic network participates in the interferon (IFN) antiviral response. However, the molecular mechanisms linking IFN…”
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The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells by Perucha, Esperanza, Melchiotti, Rossella, Bibby, Jack A, Wu, Wing, Frederiksen, Klaus Stensgaard, Roberts, Ceri A., Hall, Zoe, LeFriec, Gaelle, Robertson, Kevin A., Lavender, Paul, Gerwien, Jens Gammeltoft, Taams, Leonie S., Griffin, Julian L., de Rinaldis, Emanuele, van Baarsen, Lisa G. M., Kemper, Claudia, Ghazal, Peter, Cope, Andrew P.

“…The mechanisms controlling CD4 + T cell switching from an effector to an anti-inflammatory (IL-10 + ) phenotype play an important role in the persistence of…”
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Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis by Blanc, Mathieu, Hsieh, Wei Yuan, Robertson, Kevin A, Watterson, Steven, Shui, Guanghou, Lacaze, Paul, Khondoker, Mizanur, Dickinson, Paul, Sing, Garwin, Rodríguez-Martín, Sara, Phelan, Peter, Forster, Thorsten, Strobl, Birgit, Müller, Matthias, Riemersma, Rudolph, Osborne, Timothy, Wenk, Markus R, Angulo, Ana, Ghazal, Peter

“…Little is known about the protective role of inflammatory processes in modulating lipid metabolism in infection. Here we report an intimate link between the…”
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Embedding Assessment Literacy Can Enhance Graduate Attribute Development in a Biomedical Sciences Curriculum by Robertson, Kevin A, Hughes, Kirsty J, Rhind, Susan M

“…This paper describes the successful implementation of an assessment literacy strategy within a Biomedical Sciences degree. Teaching was aligned with an…”
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Metabolic Regulators Nampt and Sirt6 Serially Participate in the Macrophage Interferon Antiviral Cascade by Dantoft, Widad, Robertson, Kevin A, Watkins, W John, Strobl, Birgit, Ghazal, Peter

“…Molecular determinants underlying interferon (IFN)-macrophage biology can help delineate enzyme systems, pathways and mechanisms for enabling host-directed…”
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An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway by Robertson, Kevin A, Hsieh, Wei Yuan, Forster, Thorsten, Blanc, Mathieu, Lu, Hongjin, Crick, Peter J, Yutuc, Eylan, Watterson, Steven, Martin, Kimberly, Griffiths, Samantha J, Enright, Anton J, Yamamoto, Mami, Pradeepa, Madapura M, Lennox, Kimberly A, Behlke, Mark A, Talbot, Simon, Haas, Jürgen, Dölken, Lars, Griffiths, William J, Wang, Yuqin, Angulo, Ana, Ghazal, Peter

“…In invertebrates, small interfering RNAs are at the vanguard of cell-autonomous antiviral immunity. In contrast, antiviral mechanisms initiated by interferon…”
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Discrete Clusters of Virus-Encoded MicroRNAs Are Associated with Complementary Strands of the Genome and the 7.2-Kilobase Stable Intron in Murine Cytomegalovirus by BUCK, Amy H, SANTOYO-LOPEZ, Javier, ROBERTSON, Kevin A, KUMAR, Diwakar S, RECZKO, Martin, GHAZAL, Peter

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN-γ) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State by KROPP, Kai A, ROBERTSON, Kevin A, FORSTER, Thorsten, STROBL, Birgit, MUELLER, Mathias, JONJIC, Stipan, ANGULO, Ana, GHAZAL, Peter, SING, Garwin, RODRIGUEZ-MARTIN, Sara, BLANC, Mathieu, LACAZE, Paul, NOOR HASSIM, Muhamad F. B, KHONDOKER, Mizanur R, BUSCHE, Andreas, DICKINSON, Paul

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Differential Proteomics Analysis of Synaptic Proteins Identifies Potential Cellular Targets and Protein Mediators of Synaptic Neuroprotection Conferred by the Slow Wallerian Degeneration (Wlds) Gene by Wishart, Thomas M., Paterson, Janet M., Short, Duncan M., Meredith, Sara, Robertson, Kevin A., Sutherland, Calum, Cousin, Michael A., Dutia, Mayank B., Gillingwater, Thomas H.

“…Non-somatic synaptic and axonal compartments of neurons are primary pathological targets in many neurodegenerative conditions, ranging from Alzheimer disease…”
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Interferon Control of the Sterol Metabolic Network: Bidirectional Molecular Circuitry-Mediating Host Protection by Robertson, Kevin A, Ghazal, Peter

“…The sterol metabolic network is emerging center stage in inflammation and immunity. Historically, observational clinical studies show that hypocholesterolemia…”
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Chronic Mild Hypoxia Protects Heart-derived H9c2 Cells against Acute Hypoxia/Reoxygenation by Regulating Expression of the SUR2A Subunit of the ATP-sensitive K+ Channel by Crawford, Russell M., Jovanović, Sofija, Budas, Grant R., Davies, Anthony M., Lad, Harish, Wenger, Roland H., Robertson, Kevin A., Roy, Douglas J., Ranki, Harri J., Jovanović, Aleksandar

“…Chronic exposure to lower oxygen tension may increase cellular resistance to different types of acute metabolic stress. Here, we show that 24-h-long exposure…”
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Expression Profiling Reveals Novel Innate and Inflammatory Responses in the Jejunal Epithelial Compartment during Infection with Trichinella spiralis by KNIGHT, Pamela A, PEMBERTON, Alan D, ROBERTSON, Kevin A, ROY, Douglas J, WRIGHT, Steven H, MILLER, Hugh R. P

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis by Lu, Hongjin, Talbot, Simon, Robertson, Kevin A., Watterson, Steven, Forster, Thorsten, Roy, Douglas, Ghazal, Peter

“…•IFN-γ leads to the proteasomal degradation of HMGCR.•IFN-γ and 25-HC can transcriptionally and post-translationally alter levels of HMGCR.•The reduction of…”
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GPX-Macrophage Expression Atlas: a database for expression profiles of macrophages challenged with a variety of pro-inflammatory, anti-inflammatory, benign and pathogen insults by Grimes, Graeme R, Moodie, Stuart, Beattie, John S, Craigon, Marie, Dickinson, Paul, Forster, Thorsten, Livingston, Andrew D, Mewissen, Muriel, Robertson, Kevin A, Ross, Alan J, Sing, Garwin, Ghazal, Peter

“…Macrophages play an integral role in the host immune system, bridging innate and adaptive immunity. As such, they are finely attuned to extracellular and…”
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A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction by Watterson, Steven, Guerriero, Maria Luisa, Blanc, Mathieu, Mazein, Alexander, Loewe, Laurence, Robertson, Kevin A., Gibbs, Holly, Shui, Guanghou, Wenk, Markus R., Hillston, Jane, Ghazal, Peter

“…The cholesterol biosynthesis pathway has recently been shown to play an important role in the innate immune response to viral infection with host protection…”
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A logic-based diagram of signalling pathways central to macrophage activation by Raza, Sobia, Robertson, Kevin A, Lacaze, Paul A, Page, David, Enright, Anton J, Ghazal, Peter, Freeman, Tom C

“…The complex yet flexible cellular response to pathogens is orchestrated by the interaction of multiple signalling and metabolic pathways. The molecular…”
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Extending signaling pathways with protein-interaction networks. Application to apoptosis by Planas-Iglesias, Joan, Guney, Emre, García-García, Javier, Robertson, Kevin A, Raza, Sobia, Freeman, Tom C, Ghazal, Peter, Oliva, Baldo

“…Cells exploit signaling pathways during responses to environmental changes, and these processes are often modulated during disease. Particularly, relevant…”
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Gene expression profiling of mid to late secretory phase endometrial biopsies from women with menstrual complaint by Critchley, Hilary O.D., Robertson, Kevin A., Forster, Thorsten, Henderson, Teresa A., Williams, Alistair R.W., Ghazal, Peter

“…The purpose of this study was to test whether a quantitative high-throughput molecular screen can be used to probe human endometrium and initiate the…”
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Training Multidisciplinary Biomedical Informatics Students: Three Years of Experience by van Mulligen, Erik M., Cases, Montserrat, Hettne, Kristina, Molero, Eva, Weeber, Marc, Robertson, Kevin A., Oliva, Baldomero, de la Calle, Guillermo, Maojo, Victor

“…The European INFOBIOMED Network of Excellence1 recognized that a successful education program in biomedical informatics should include not only traditional…”
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Vaccination with inactivated murine gammaherpesvirus 68 strongly limits viral replication and latency and protects type I IFN receptor knockout mice from a lethal infection by Aricò, Eleonora, Robertson, Kevin A., Belardelli, Filippo, Ferrantini, Maria, Nash, Anthony A.

“…Human gammaherpesviruses such as Epstein-Barr virus (EBV) cause lifelong infections and associated diseases, including malignancies, and the development of an…”
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