Search Results - "ROBERTSON, Alan D"

Insulin-induced palmitoylation regulates the Cardiac Na+/Ca2+ exchanger NCX1 by Gök, Caglar, Robertson, Alan D., Fuller, William

“…•Insulin induces NCX1 palmitoylation.•Unpalmitoylatable NCX1 is not activated by insulin.•Insulin promotes palmitoylation of zDHHC5 by activating fatty acyl…”
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Antiviral agents 3. Discovery of a novel small molecule non-nucleoside inhibitor of Hepatitis B Virus (HBV) by Crosby, Ian T., Bourke, David G., Jones, Eric D., Jeynes, Tyrone P., Cox, Susan, Coates, Jonathan A.V., Robertson, Alan D.

“…The discovery of a small molecule non-nucleoside inhibitor of Hepatitis B Virus is described. During our work on conocurvone derived naphthoquinone ‘trimers’…”
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Dynamic Palmitoylation of the Sodium-Calcium Exchanger Modulates Its Structure, Affinity for Lipid-Ordered Domains, and Inhibition by XIP by Gök, Caglar, Plain, Fiona, Robertson, Alan D., Howie, Jacqueline, Baillie, George S., Fraser, Niall J., Fuller, William

“…The transmembrane sodium-calcium (Na-Ca) exchanger 1 (NCX1) regulates cytoplasmic Ca levels by facilitating electrogenic exchange of Ca for Na. Palmitoylation,…”
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Combining monoamine oxidase B and semicarbazide-sensitive amine oxidase enzyme inhibition to address inflammatory disease by Foot, Jonathan S., Buson, Alberto, Deodhar, Mandar, Findlay, Alison D., Robertson, Alan D., Turner, Craig I., Yow, Tin, Zhou, Wenbin, Jarolimek, Wolfgang

“…The discovery of a dual MAO-B/SSAO inhibitor PXS-5131 is reported. The compound offers a compact and rigid three-dimensional structure with superior…”
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Insights into the molecular basis of the palmitoylation and depalmitoylation of NCX1 by Gök, Caglar, Main, Alice, Gao, Xing, Kerekes, Zsombor, Plain, Fiona, Kuo, Chien-Wen, Robertson, Alan D., Fraser, Niall J., Fuller, William

“…[Display omitted] •The structural element that directs NCX1 palmitoylation interacts with zDHHC-PATs.•NCX2 and NCX3 are dually palmitoylated.•Arresting NCX1…”
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Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives : Novel agonists for the CB1 receptor by MOLONEY, Gerard P, ANGUS, James A, ROBERTSON, Alan D, STOERMER, Martin J, ROBINSON, Michael, WRIGHT, Christine E, MCRAE, Ken, CHRISTOPOULOS, Arthur

“…An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB(1) agonists. It is hoped that compounds of this type…”
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Paspalum lepton - a valuable adjunct to the suite of grasses used in grazing systems in the subtropics or a potential weed by Cook, Bruce G., Lloyd, David L., Scattini, Walter J., Robertson, Alan D.

“…Native and exotic C4 grasses currently used in grazing systems in the subtropics have specific limitations with management, decline in feed quality as they…”
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PI 3-kinase p110β: a new target for antithrombotic therapy by Jackson, Shaun P, Schoenwaelder, Simone M, Goncalves, Isaac, Nesbitt, Warwick S, Yap, Cindy L, Wright, Christine E, Kenche, Vijaya, Anderson, Karen E, Dopheide, Sacha M, Yuan, Yuping, Sturgeon, Sharelle A, Prabaharan, Hishani, Thompson, Philip E, Smith, Gregg D, Shepherd, Peter R, Daniele, Nathalie, Kulkarni, Suhasini, Abbott, Belinda, Saylik, Dilek, Jones, Catherine, Lu, Lucy, Giuliano, Simon, Hughan, Sascha C, Angus, James A, Robertson, Alan D, Salem, Hatem H

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Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6-tetrahydropyridines as 5-HT2C agonists by Conway, Richard J., Valant, Celine, Christopoulos, Arthur, Robertson, Alan D., Capuano, Ben, Crosby, Ian T.

“…A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the…”
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Antiviral agents 2. Synthesis of trimeric naphthoquinone analogues of conocurvone and their antiviral evaluation against HIV by Crosby, Ian T., Bourke, David G., Jones, Eric D., de Bruyn, Paula J., Rhodes, David, Vandegraaff, Nick, Cox, Susan, Coates, Jonathan A.V., Robertson, Alan D.

“…The synthesis of a new series of conocurvone analogues is presented that explores the importance of the pyran rings of conocurvone, their degree of…”
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The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices by Smith, Maree T, Cabot, Peter J, Ross, Fraser B, Robertson, Alan D, Lewis, Richard J

“…N-type calcium channels modulate the release of key pro-nociceptive neurotransmitters such as glutamate and substance P (SP) in the central nervous system…”
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Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid by Coghlan, Daniel R., Bremner, John B., Keller, Paul A., Pyne, Stephen G., David, Dorothy M., Somphol, Kittiya, Baylis, Dean, Coates, Jonathan, Deadman, John, Rhodes, David I., Robertson, Alan D.

“…Twelve macrocyclic derivatives with anti-bacterial activity against Staphylococcus aureus are reported. As part of a programme investigating antibacterial…”
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Recovery of experimental Parkinson's disease with the melatonin analogues ML-23 and S-20928 in a chronic, bilateral 6-OHDA model: a new mechanism involving antagonism of the melatonin receptor by Willis, Gregory L., Robertson, Alan D.

“…Over the past 10 years, there has been a resurgence of interest in examining the role of melatonin in health and disease. While the brunt of research in this…”
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Recovery from experimental Parkinson's disease in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride treated marmoset with the melatonin analogue ML-23 by Willis, Gregory L., Robertson, Alan D.

“…A new mechanism has been recently proposed, whereby melatonin may participate in the ongoing process of neuronal degeneration in models of neurodegenerative…”
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Insulin-induced palmitoylation regulates the Cardiac Na + /Ca 2+ exchanger NCX1 by Gök, Caglar, Robertson, Alan D, Fuller, William

“…The cardiac Na+/Ca2+ Exchanger (NCX1) controls Ca2+ extrusion from the cytosol by mediating bidirectional exchange of Na+ for Ca2+, and therefore controls…”
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Computer-Aided Design and Synthesis of 5-Substituted Tryptamines and Their Pharmacology at the 5-HT1D Receptor: Discovery of Compounds with Potential Anti-Migraine Properties by Buckingham, Janet, Glen, Robert C, Hill, Alan P, Hyde, Richard M, Martin, Graeme R, Robertson, Alan D, Salmon, John A, Woollard, Patrick M

“…The design and synthesis of a series of novel 5-substituted tryptamines with pharmacological activity at 5-HT1D and other monoamine receptors is described…”
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Synthesis of hexahydrocyclopentimidazol-2-(1 H)-one derivatives displaying selective DP-receptor agonist properties by Barraclough, Paul, Bolofo, Mary L., Giles, Heather, Gillam, Janet, John Harris, C., Kelly, Michael G., Leff, Paul, McNeill, Alan, Robertson, Alan D., Stepney, Ray J., Whittle, Brendan J.R.

“…The rationale for investigating conformationally restricted analogues of BW245C as DP-receptor ligands and the syntheses of three such racemic bicyclic…”
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A Novel Series of 2,5-Substituted Tryptamine Derivatives as Vascular 5HT1B/1D Receptor Antagonists by Moloney, Gerard P, Robertson, Alan D, Martin, Graeme R, MacLennan, Steven, Mathews, Neil, Dodsworth, Susan, Sang, Pang Yih, Knight, Cameron, Glen, Robert

“…The design, synthesis, and activity of a novel series of 2,5-substituted tryptamine derivatives at vascular 5HT1B-like receptors is described. Several…”
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Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: Novel agonists for the CB 1 receptor by Moloney, Gerard P., Angus, James A., Robertson, Alan D., Stoermer, Martin J., Robinson, Michael, Wright, Christine E., McRae, Ken, Christopoulos, Arthur

“…An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB 1 agonists. It is hoped that compounds of this type…”
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Cardiovascular and autonomic effects of ω‐conotoxins MVIIA and CVID in conscious rabbits and isolated tissue assays by Wright, Christine E, Robertson, Alan D, Whorlow, Sarah L, Angus, James A

“…The effects of a novel N‐type voltage‐operated calcium channel antagonist, ω‐conotoxin CVID, were compared with ω‐conotoxin MVIIA on sympathetic‐evoked…”
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