Search Results - "ROBERTS, Noel A"

Neuraminidase Is Important for the Initiation of Influenza Virus Infection in Human Airway Epithelium by Matrosovich, Mikhail N, Matrosovich, Tatyana Y, Gray, Thomas, Roberts, Noel A, Klenk, Hans-Dieter

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Human and Avian Influenza Viruses Target Different Cell Types in Cultures of Human Airway Epithelium by Matrosovich, Mikhail N., Matrosovich, Tatyana Y., Gray, Thomas, Roberts, Noel A., Klenk, Hans-Dieter, Palese, Peter

“…The recent human infections caused by H5N1, H9N2, and H7N7 avian influenza viruses highlighted the continuous threat of new pathogenic influenza viruses…”
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Influenza Viruses Resistant to the Antiviral Drug Oseltamivir: Transmission Studies in Ferrets by Herlocher, M. Louise, Truscon, Rachel, Elias, Stephanie, Yen, Hui-Ling, Roberts, Noel A., Ohmit, Suzanne E., Monto, Arnold S.

“…Three type A influenza viruses, each of which has a distinct neuraminidase-gene mutation and is resistant to the neuraminidase inhibitor oseltamivir, have been…”
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Overexpression of the α-2,6-Sialyltransferase in MDCK Cells Increases Influenza Virus Sensitivity to Neuraminidase Inhibitors by Matrosovich, Mikhail, Matrosovich, Tatyana, Carr, Jackie, Roberts, Noel A, Klenk, Hans-Dieter

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Solubility behaviour, crystallisation kinetics and pour point: A comparison of linear alkane and triacyl glyceride solute/solvent mixtures by Fletcher, Paul D.I., Roberts, Noel A., Urquhart, Choephel

“…We compare solubility, crystallisation and pour point of n-tetracosane in n-heptane solution (left) and tristearin in tricaprylin (right). Mixtures of either a…”
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Rate of Emergence of Cytomegalovirus (CMV) Mutations in Leukocytes of Patients with Acquired Immunodeficiency Syndrome Who Are Receiving Valganciclovir as Induction and Maintenance Therapy for CMV Retinitis by Boivin, Guy, Gilbert, Christian, Gaudreau, Annie, Greenfield, Isobel, Sudlow, Rebecca, Roberts, Noel A.

“…The emergence of mutations conferring ganciclovir resistance was evaluated in an open-label randomized clinical trial that compared oral valganciclovir with…”
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Metal Ion Catalysis of RNA Cleavage by the Influenza Virus Endonuclease by Doan, Linh, Handa, Balraj, Roberts, Noel A, Klumpp, Klaus

“…The influenza virus RNA-dependent RNA polymerase protein complex contains an associated RNA endonuclease activity, which cleaves host mRNA precursors in the…”
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Rational Design of Peptide-Based HIV Proteinase Inhibitors by Roberts, Noel A., Martin, Joseph A., Kinchington, Derek, Broadhurst, Anne V., Craig, J. Charles, Duncan, Ian B., Galpin, Sarah A., Handa, Balraj K., Kay, John, Kröhn, Antonin, Lambert, Robert W., Merrett, John H., Mills, John S., Kevin E. B. Parkes, Redshaw, Sally, Ritchie, Alison J., Taylor, Debra L., Thomas, Gareth J., Machin, Peter J.

“…A series of peptide derivatives based on the transition-state mimetic concept has been designed that inhibit the proteinase from the human immunodeficiency…”
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Synthesis and antiviral activity of monofluoro and difluoro analogs of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1) by Martin, Joseph A, Bushnell, David J, Duncan, Ian B, Dunsdon, Stephen J, Hall, Michael J, Machin, Peter J, Merrett, John H, Parkes, Kevin E. B, Roberts, Noel A

“…A range of 2'-fluoro and 2',3'-difluoro analogues of pyrimidine deoxyribonucleosides have been synthesized and evaluated against human immunodeficiency virus…”
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Anti-influenza drugs and neuraminidase inhibitors by Roberts, N A

“…Each year, influenza viruses are responsible for considerable illness, complications and mortality. An effective treatment will have a major impact on the…”
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RNA and DNA Hydrolysis Are Catalyzed by the Influenza Virus Endonuclease by Klumpp, Klaus, Doan, Linh, Roberts, Noel A., Handa, Balraj

“…The influenza virus polymerase complex contains a metal ion-dependent endonuclease activity, which generates short capped RNA primer molecules from capped RNA…”
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In-vitro and in-vivo efficacy of influenza neuraminidase inhibitors by Mendel, Dirk B, Roberts, Noel A

“…Influenza continues to be a major health concern and there is always the threat of a pandemic due to the emergence of a viral strain new to the human…”
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Non-specific antiviral activity of antisense molecules targeted to the E1 region of human papillomavirus by Lewis, E.Jonathan, Agrawal, Sudhir, Bishop, Jill, Chadwick, Jenny, Cristensen, Neil D, Cuthill, Scott, Dunford, Paul, Field, A.Kirk, Francis, John, Gibson, Vivien, Greenham, Anna K, Kelly, Fiona, Kilkushie, Robert, Kreider, John W, Mills, John S, Mulqueen, Michael, Roberts, Noel A, Roberts, Peter, Szymkowski, David E

“…Antisense phosphorothioate oligonucleotides (ODN1 0x5 OMe) directed against the E1 start region of human papillomavirus 11 (HPV11) can inhibit papillomavirus…”
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The role of endogenous interleukin-12 in resistance to murine cytomegalovirus (MCMV) infection and a novel action for endogenous IL-12 p40 by Carr, J A, Rogerson, J A, Mulqueen, M J, Roberts, N A, Nash, A A

“…Biologically active interleukin-12 (IL-12), comprising a 40 kDa subunit (p40) covalently linked to a 35 kDa subunit (p35), is produced in response to a range…”
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Treatment of influenza with neuraminidase inhibitors: virological implications by Roberts, Noel A.

“…studies if pre–clinical data are to have predictive value. Haemagglutinin mutations generated…”
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Resistance and cross-resistance with saquinavir and other HIV protease inhibitors: theory and practice by Roberts, N A, Craig, J C, Sheldon, J

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Anti-influenza drugs and neuraminidase inhibitors by Roberts, N A

“…Each year, influenza viruses are responsible for considerable illness, complications and mortality. An effective treatment will have a major impact on the…”
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Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium by MATROSOVICH, Mikhail N, MATROSOVICH, Tatyana Y, GRAY, Thomas, ROBERTS, Noel A, KLENK, Hans-Dieter

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Cloning, expression and characterization of the proteinase from human herpesvirus 6 by Tigue, N J, Matharu, P J, Roberts, N A, Mills, J S, Kay, J, Jupp, R

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HIV proteinase inhibitors by Roberts, N A, Craig, J C, Duncan, I B

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