Search Results - "ROBERTS, DAVID W"

Extension of the Dermal Sensitisation Threshold (DST) approach to incorporate chemicals classified as reactive by Safford, Robert J., Api, Anne Marie, Roberts, David W., Lalko, Jon F.

“…•The Dermal Sensitisation Threshold applies TTC principals to skin sensitisation.•The DST is useful for both non-reactive and protein reactive chemicals.•The…”
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Variation partitioning involving orthogonal spatial eigenfunction submodels by Legendre, Pierre, Borcard, Daniel, Roberts, David W

“…When partitioning the variation of univariate or multivariate ecological data with respect to several submodels of spatial eigenfunctions (e.g., Moran's…”
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Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery by Valdés, Pablo A, Jacobs, Valerie, Harris, Brent T, Wilson, Brian C, Leblond, Frederic, Paulsen, Keith D, Roberts, David W

“…Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used…”
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5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery by Valdes, Pablo A., Millesi, Matthias, Widhalm, Georg, Roberts, David W.

“…Introduction 5-aminolevulinic acid induced protoporphyrin IX (5-ALA-PpIX) fluorescence guidance has emerged as a valuable surgical adjunct for resection of…”
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Vegetation classification by two new iterative reallocation optimization algorithms by Roberts, David W.

“…This paper presents two new non-hierarchical iterative reallocation optimization algorithms for vegetation classification. The OPTimal PARTitioning algorithm…”
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Hippocampal interictal epileptiform activity disrupts cognition in humans by Kleen, Jonathan K, Scott, Rod C, Holmes, Gregory L, Roberts, David W, Rundle, Melissa M, Testorf, Markus, Lenck-Santini, Pierre-Pascal, Jobst, Barbara C

“…OBJECTIVE:We investigated whether interictal epileptiform discharges (IED) in the human hippocampus are related to impairment of specific memory processes, and…”
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Optical technologies for intraoperative neurosurgical guidance by Valdés, Pablo A, Roberts, David W, Lu, Fa-Ke, Golby, Alexandra

“…Biomedical optics is a broadly interdisciplinary field at the interface of optical engineering, biophysics, computer science, medicine, biology, and chemistry,…”
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Measuring Understory Fire Effects from Space: Canopy Change in Response to Tropical Understory Fire and What This Means for Applications of GEDI to Tropical Forest Fire by East, Alyson, Hansen, Andrew, Armenteras, Dolors, Jantz, Patrick, Roberts, David W.

“…The ability to measure the ecological effects of understory fire in the Amazon on a landscape scale remains a frontier in remote sensing. The Global Ecosystem…”
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Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker by Valdés, Pablo A, Leblond, Frederic, Kim, Anthony, Harris, Brent T, Wilson, Brian C, Fan, Xiaoyao, Tosteson, Tor D, Hartov, Alex, Ji, Songbai, Erkmen, Kadir, Simmons, Nathan E, Paulsen, Keith D, Roberts, David W

“…Accurate discrimination between tumor and normal tissue is crucial for optimal tumor resection. Qualitative fluorescence of protoporphyrin IX (PpIX),…”
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Mechanistic Applicability Domain Classification of a Local Lymph Node Assay Dataset for Skin Sensitization by Roberts, David W, Patlewicz, Grace, Kern, Petra S, Gerberick, Frank, Kimber, Ian, Dearman, Rebecca J, Ryan, Cindy A, Basketter, David A, Aptula, Aynur O

“…The goal of eliminating animal testing in the predictive identification of chemicals with the intrinsic ability to cause skin sensitization is an important…”
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Interpretation of murine local lymph node assay (LLNA) data for skin sensitization: Overload effects, danger signals and chemistry-based read-across by Roberts, David W.

“…[Display omitted] •Irregular dose–response patterns occur quite frequently in LLNA datasets.•These involve an overload effect, giving a bell-shaped or inverse…”
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Validation and Error Minimization of Global Ecosystem Dynamics Investigation (GEDI) Relative Height Metrics in the Amazon by East, Alyson, Hansen, Andrew, Jantz, Patrick, Currey, Bryce, Roberts, David W., Armenteras, Dolors

“…Global Ecosystem Dynamics Investigation (GEDI) is a relatively new technology for global forest research, acquiring LiDAR measurements of vertical vegetation…”
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Review of clinical trials in intraoperative molecular imaging during cancer surgery by Lee, John Y. K, Cho, Steve S, Stummer, Walter, Tanyi, Janos L, Vahrmeijer, Alexander L, Rosenthal, Eben, Smith, Barbara, Henderson, Eric, Roberts, David W, Lee, Amy, Hadjipanayis, Constantinos G, Bruce, Jeffrey N, Newman, Jason G, Singhal, Sunil

“…Most solid cancers are treated by surgical resections to reduce the burden of disease. Surgeons often face the challenge of detecting small areas of residual…”
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Frameless robotically targeted stereotactic brain biopsy: feasibility, diagnostic yield, and safety by Bekelis, Kimon, Radwan, Tarek A, Desai, Atman, Roberts, David W

“…Frameless stereotactic brain biopsy has become an established procedure in many neurosurgical centers worldwide. Robotic modifications of image-guided…”
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A comparative study of hard clustering algorithms for vegetation data by Pakgohar, Naghmeh, Eshaghi Rad, Javad, Gholami, Gholamhossein, Alijanpour, Ahmad, Roberts, David W., Botta‐Dukát, Zoltán

“…Questions Which clustering algorithms are most effective according to different cluster validity evaluators? Which distance or dissimilarity measure is most…”
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Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection by Roberts, David W, Olson, Jonathan D, Evans, Linton T, Kolste, Kolbein K, Kanick, Stephen C, Fan, Xiaoyao, Bravo, Jaime J, Wilson, Brian C, Leblond, Frederic, Marois, Mikael, Paulsen, Keith D

“…OBJECTIVE The objective of this study was to detect 5-aminolevulinic acid (ALA)-induced tumor fluorescence from glioma below the surface of the surgical field…”
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Measurement and Estimation of Electrophilic Reactivity for Predictive Toxicology by Schwöbel, Johannes A. H, Koleva, Yana K, Enoch, Steven J, Bajot, Fania, Hewitt, Mark, Madden, Judith C, Roberts, David W, Schultz, Terry W, Cronin, Mark T. D

“…Schwobel et all examine the measurement and estimation of electrophilic reactivity for predictive toxicology…”
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Toxicity and Pharmacokinetic Profile for Single-Dose Injection of ABY-029: a Fluorescent Anti-EGFR Synthetic Affibody Molecule for Human Use by Samkoe, Kimberley S., Gunn, Jason R., Marra, Kayla, Hull, Sally M., Moodie, Karen L., Feldwisch, Joachim, Strong, Theresa V., Draney, Daniel R., Hoopes, P. Jack, Roberts, David W., Paulsen, Keith, Pogue, Brian W.

“…Purpose ABY-029, a synthetic Affibody peptide, Z03115-Cys, labeled with a near-infrared fluorophore, IRDye® 800CW, targeting epidermal growth factor receptor…”
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Interictal epileptiform discharges impair word recall in multiple brain areas by Horak, Peter C., Meisenhelter, Stephen, Song, Yinchen, Testorf, Markus E., Kahana, Michael J., Viles, Weston D., Bujarski, Krzysztof A., Connolly, Andrew C., Robbins, Ashlee A., Sperling, Michael R., Sharan, Ashwini D., Worrell, Gregory A., Miller, Laura R., Gross, Robert E., Davis, Kathryn A., Roberts, David W., Lega, Bradley, Sheth, Sameer A., Zaghloul, Kareem A., Stein, Joel M., Das, Sandhitsu R., Rizzuto, Daniel S., Jobst, Barbara C.

“…Summary Objectives Interictal epileptiform discharges (IEDs) have been linked to memory impairment, but the spatial and temporal dynamics of this relationship…”
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Tumor Bed Dynamics After Surgical Resection of Brain Metastases: Implications for Postoperative Radiosurgery by Jarvis, Lesley A., MD, PhD, Simmons, Nathan E., MD, Bellerive, Marc, MSc, DABR, Erkmen, Kadir, MD, Eskey, Clifford J., MD, PhD, Gladstone, David J., ScD, Hug, Eugen B., MD, Roberts, David W., MD, Hartford, Alan C., MD, PhD

“…Purpose To analyze 2 factors that influence timing of radiosurgery after surgical resection of brain metastases: target volume dynamics and intracranial tumor…”
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