Search Results - "ROBERTS, A. I"

A three-dimensional finite element analysis of the temperature field during laser melting of metal powders in additive layer manufacturing by Roberts, I.A., Wang, C.J., Esterlein, R., Stanford, M., Mynors, D.J.

“…Simulating the transient temperature field in additive layer manufacturing (ALM) processes has presented a challenge to many researchers in the field. The…”
Get full text

Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity by Cao, K, Wang, G, Li, W, Zhang, L, Wang, R, Huang, Y, Du, L, Jiang, J, Wu, C, He, X, Roberts, A I, Li, F, Rabson, A B, Wang, Y, Shi, Y

“…The poor efficacy of the in vivo anti-tumor immune response has been partially attributed to ineffective T-cell responses mounted against the tumor…”
Get full text

The interaction between mesenchymal stem cells and steroids during inflammation by Chen, X, Gan, Y, Li, W, Su, J, Zhang, Y, Huang, Y, Roberts, A I, Han, Y, Li, J, Wang, Y, Shi, Y

“…Mesenchymal stem cells (MSCs) are believed to exert their regenerative effects through differentiation and modulation of inflammatory responses. However, the…”
Get full text

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity by Rieux-Laucat, F., Le Deist, F., Hivroz, C., Roberts, I. A. G., Debatin, K. M., Fischer, A., de Villartay, J. P.

“…Fas (also known as Apo1 and CD95) is a cell surface receptor involved in apoptotic cell death. Fas expression and function were analyzed in three children…”
Get full text

Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species by Su, J, Chen, X, Huang, Y, Li, W, Li, J, Cao, K, Cao, G, Zhang, L, Li, F, Roberts, A I, Kang, H, Yu, P, Ren, G, Ji, W, Wang, Y, Shi, Y

“…Mammalian mesenchymal stem cells (MSCs) have been shown to be strongly immunosuppressive in both animal disease models and human clinical trials. We have…”
Get full text

Mesenchymal stem cells: a double-edged sword in regulating immune responses by Li, W, Ren, G, Huang, Y, Su, J, Han, Y, Li, J, Chen, X, Cao, K, Chen, Q, Shou, P, Zhang, L, Yuan, Z-R, Roberts, A I, Shi, S, Le, A D, Shi, Y

“…Mesenchymal stem cells (MSCs) have been employed successfully to treat various immune disorders in animal models and clinical settings. Our previous studies…”
Get full text

Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia by Eggleston, B., Patience, M., Edwards, S., Adamkiewicz, T., Buchanan, G. R., Davies, S. C., Dickerhoff, R., Donfield, S., Feig, S. A., Giller, R. H., Haight, A., Horan, J., Hsu, L. L., Kamani, N., Lane, P., Levine, J. E., Margolis, D., Moore, T. B., Ohene‐Frempong, K., Redding‐Lallinger, R., Roberts, I. A. G., Rogers, Z. R., Sanders, J. E., Scott, J. P., Sleight, B., Thompson, A. A., Sullivan, K. M., Walters, M. C.

“…Summary Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short‐ and long‐term toxicities limit…”
Get full text

Selective expansion of intraepithelial lymphocytes expressing the HLA-E–specific natural killer receptor CD94 in celiac disease by Jabri , ‡, §, Bana, De Serre ∥, Natacha Patey–Mariaud, Cellier ¶, Christophe, Evans #, Kelly, Gache, Cécile, Carvalho, Carla, Mougenot ‡, Jean–François, Allez, Matthieu, Jian, Raymond, Desreumaux ‡‡, Pierre, Colombel ‡‡, Jean–Fréderic, Matuchansky §§, Claude, Cugnenc ¶, Henri, Lopez–Botet ∥∥, Miguel, Vivier ¶¶, Eric, Moretta ##, Alessandro, Roberts, Arthur I., Ebert, Ellen C., Guy–Grand ‡‡‡, Delphine, Brousse ∥, Nicole, Schmitz ‡, Jacques, Cerf–Bensussan, Nadine

“…Background & Aims: Celiac disease is a gluten-induced enteropathy characterized by the presence of gliadin-specific CD4 + T cells in the lamina propria and by…”
Get full text

Non-TBI stem cell transplantation protocol for Fanconi anaemia using HLA-compatible sibling and unrelated donors by DE LA FUENTE, J, REISS, S, MCCLOY, M, VULLIAMY, T, ROBERTS, I. A. G, RAHEMTULLA, A, DOKAL, I

“…Allogeneic haemopoietic stem cell transplantation (SCT) is the only curative option for severe bone marrow (BM) failure in patients with Fanconi anaemia (FA)…”
Get full text

Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation by Agace, W.W., Amara, A., Roberts, A.I., Pablos, J.L., Thelen, S., Uguccioni, M., Li, X.Y., Marsal, J., Arenzana-Seisdedos, F., Delaunay, T., Ebert, E.C., Moser, B., Parker, C.M.

“…HIV particles that use the chemokine receptor CXCR4 as a coreceptor for entry into cells (X4-HIV) inefficiently transmit infection across mucosal surfaces [1],…”
Get full text

p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation by Huang, Y, Yu, P, Li, W, Ren, G, Roberts, A I, Cao, W, Zhang, X, Su, J, Chen, X, Chen, Q, Shou, P, Xu, C, Du, L, Lin, L, Xie, N, Zhang, L, Wang, Y, Shi, Y

“…p53 is one of the most studied genes in cancer biology, and mutations in this gene may be predictive for the development of many types of cancer in humans and…”
Get full text

A novel subset of helper T cells promotes immune responses by secreting GM-CSF by Zhang, J, Roberts, A I, Liu, C, Ren, G, Xu, G, Zhang, L, Devadas, S, Shi, Yufang

“…Helper T cells are crucial for maintaining proper immune responses. Yet, they have an undefined relationship with one of the most potent immune stimulatory…”
Get full text

Evidence for a continuous decline in haemopoietic cell function from birth: application to evaluating bone marrow failure in children by MARLEY, S. B, LEWIS, J. L, DAVIDSON, R. J, ROBERTS, I. A. G, DOKAL, I, GOLDMAN, J. M, GORDON, M. Y

“…There are considerable differences in haemopoietic activity between young children and adults on the one hand, and between adults and the elderly on the other…”
Get full text

Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients by Murray, N. A., Howarth, L. J., McCloy, M. P., Letsky, E. A., Roberts, I. A. G.

“…Summary Platelet transfusions are frequently given to neonatal intensive care unit (NICU) patients with severe thrombocytopenia (platelets less than 50 × 109…”
Get full text

The Effect of a Dominant Phytophthora infestans Genotype (13_A2) in Great Britain on Host Resistance to Foliar Late Blight in Commercial Potato Cultivars by Lees, A. K., Stewart, J. A., Lynott, J. S., Carnegie, S. F., Campbell, H., Roberts, A. M. I.

“…As a result of recent changes in the Phytophthora infestans population in Great Britain, in particular the dominance of one genotype (13_A2) and the possible…”
Get full text

Caspofungin for invasive fungal infections: Combination treatment with liposomal amphotericin B in children undergoing hemopoietic stem cell transplantation by Pancham, S., Hemmaway, C., New, H., Albert, E., Dokal, I., Roberts, I. A. G., McCloy, M.

“…:  Invasive fungal infections often prove difficult to eradicate especially in the stem cell transplant setting. Amphotericin has been the mainstay of…”
Get full text

Fludarabine‐based stem cell transplantation protocol for Fanconi's anaemia in myelodysplastic transformation by McCloy, M., Almeida, A., Daly, P., Vulliamy, T., Roberts, I. A. G., Dokal, I.

“…Allogeneic stem cell transplantation (SCT) represents the treatment of choice for severe bone marrow (BM) failure in patients with Fanconi's anaemia (FA)…”
Get full text

The impact of antenatal and perinatal variables on cord blood haemopoietic stem/progenitor cell yield available for transplantation by SHLEBAK, A. A, ROBERTS, I. A. G, STEVENS, T. A, SYZDLO, R. M, GOLDMAN, J. M, GORDON, M. Y

“…We investigated the impact of maternal and fetal variables on cord blood (CB) haemopoietic stem/progenitor cell content. These included maternal age, ethnic…”
Get full text

Mesenchymal cells stimulate human intestinal intraepithelial lymphocytes by Roberts, AI, Nadler, SC, Ebert, EC

“…BACKGROUND & AIMS: Intraepithelial lymphocytes (IELs) from human intestinal mucosa proliferate minimally to T-cell stimuli. Optimal growth may depend on…”
Get full text

Analysis of chimaerism in thalassaemic children undergoing stem cell transplantation by Amrolia, P. J., Vulliamy, T., Vassiliou, G ., Lawson, S., Bryon, J., Kaeda, J., Dokal, I., Johnston, R., Veys, P., Darbyshire, P., Roberts, I. A. G.

“…We have prospectively assessed the relative contribution of host and donor to haemopoiesis following stem cell transplantation (SCT) in children with…”
Get full text