Search Results - "ROBBERECHT, WIM"

The changing scene of amyotrophic lateral sclerosis by Robberecht, Wim, Philips, Thomas

“…Key Points Amyotrophic lateral sclerosis (ALS) is a clinical, genetic and pathogenic heterogenous condition. It lies at one end of a spectrum of a single…”
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The phenotypic variability of amyotrophic lateral sclerosis by Swinnen, Bart, Robberecht, Wim

“…Key Points Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous entity Cognitive impairment is a common feature of ALS: frontotemporal dementia and…”
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Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease by Philips, Thomas, MSc, Robberecht, Wim, Prof

“…Summary Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) are characterised by the…”
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RNA toxicity in non‐coding repeat expansion disorders by Swinnen, Bart, Robberecht, Wim, Van Den Bosch, Ludo

“…Several neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) and spinocerebellar ataxia (SCA) are caused by non‐coding nucleotide repeat…”
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A revision of the El Escorial criteria - 2015 by Ludolph, Albert, Drory, Vivian, Hardiman, Orla, Nakano, Imaharu, Ravits, John, Robberecht, Wim, Shefner, Jeremy

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Modelling amyotrophic lateral sclerosis: progress and possibilities by Van Damme, Philip, Robberecht, Wim, Van Den Bosch, Ludo

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects the motor system and presents with progressive muscle weakness. Most…”
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Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS by Jovičić, Ana, Mertens, Jerome, Boeynaems, Steven, Bogaert, Elke, Chai, Noori, Yamada, Shizuka B, Paul, Joseph W, Sun, Shuying, Herdy, Joseph R, Bieri, Gregor, Kramer, Nicholas J, Gage, Fred H, Van Den Bosch, Ludo, Robberecht, Wim, Gitler, Aaron D

“…C9orf72 mutations are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. With unbiased screens in Saccharomyces cerevisiae ,…”
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HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients by Guo, Wenting, Naujock, Maximilian, Fumagalli, Laura, Vandoorne, Tijs, Baatsen, Pieter, Boon, Ruben, Ordovás, Laura, Patel, Abdulsamie, Welters, Marc, Vanwelden, Thomas, Geens, Natasja, Tricot, Tine, Benoy, Veronick, Steyaert, Jolien, Lefebvre-Omar, Cynthia, Boesmans, Werend, Jarpe, Matthew, Sterneckert, Jared, Wegner, Florian, Petri, Susanne, Bohl, Delphine, Vanden Berghe, Pieter, Robberecht, Wim, Van Damme, Philip, Verfaillie, Catherine, Van Den Bosch, Ludo

“…Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in…”
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Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo by Beel, Sander, Moisse, Matthieu, Damme, Markus, De Muynck, Louis, Robberecht, Wim, Van Den Bosch, Ludo, Saftig, Paul, Van Damme, Philip

“…Loss of function mutations in progranulin (GRN) cause frontotemporal dementia, but how GRN haploinsufficiency causes neuronal dysfunction remains unclear. We…”
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Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics by Boeynaems, Steven, Bogaert, Elke, Kovacs, Denes, Konijnenberg, Albert, Timmerman, Evy, Volkov, Alex, Guharoy, Mainak, De Decker, Mathias, Jaspers, Tom, Ryan, Veronica H., Janke, Abigail M., Baatsen, Pieter, Vercruysse, Thomas, Kolaitis, Regina-Maria, Daelemans, Dirk, Taylor, J. Paul, Kedersha, Nancy, Anderson, Paul, Impens, Francis, Sobott, Frank, Schymkowitz, Joost, Rousseau, Frederic, Fawzi, Nicolas L., Robberecht, Wim, Van Damme, Philip, Tompa, Peter, Van Den Bosch, Ludo

“…Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA…”
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HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease by d'Ydewalle, Constantin, Krishnan, Jyothsna, Chiheb, Driss M, Van Damme, Philip, Irobi, Joy, Kozikowski, Alan P, Berghe, Pieter Vanden, Timmerman, Vincent, Robberecht, Wim, Van Den Bosch, Ludo

“…Charcot-Marie-Tooth type 2 disease is characterized by peripheral axon loss and motor and sensory dysfunction. Constantin d'Ydewalle et al . demonstrate that…”
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HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease by Benoy, Veronick, Van Helleputte, Lawrence, Prior, Robert, d'Ydewalle, Constantin, Haeck, Wanda, Geens, Natasja, Scheveneels, Wendy, Schevenels, Begga, Cader, M Zameel, Talbot, Kevin, Kozikowski, Alan P, Vanden Berghe, Pieter, Van Damme, Philip, Robberecht, Wim, Van Den Bosch, Ludo

“…Patients with Charcot-Marie-Tooth disease with predominant axonal loss (CMT2) show extensive genetic heterogeneity. Benoy et al. demonstrate a link between…”
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Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD by Boeynaems, Steven, Bogaert, Elke, Michiels, Emiel, Gijselinck, Ilse, Sieben, Anne, Jovičić, Ana, De Baets, Greet, Scheveneels, Wendy, Steyaert, Jolien, Cuijt, Ivy, Verstrepen, Kevin J., Callaerts, Patrick, Rousseau, Frederic, Schymkowitz, Joost, Cruts, Marc, Van Broeckhoven, Christine, Van Damme, Philip, Gitler, Aaron D., Robberecht, Wim, Van Den Bosch, Ludo

“…Hexanucleotide repeat expansions in C9orf72 are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) (c9ALS/FTD)…”
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Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity by Bogaert, Elke, Boeynaems, Steven, Kato, Masato, Guo, Lin, Caulfield, Thomas R., Steyaert, Jolien, Scheveneels, Wendy, Wilmans, Nathalie, Haeck, Wanda, Hersmus, Nicole, Schymkowitz, Joost, Rousseau, Frederic, Shorter, James, Callaerts, Patrick, Robberecht, Wim, Van Damme, Philip, Van Den Bosch, Ludo

“…RNA-binding protein aggregation is a pathological hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and…”
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EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans by Van Hoecke, Annelies, Schoonaert, Lies, Lemmens, Robin, Timmers, Mieke, Staats, Kim A, Laird, Angela S, Peeters, Elke, Philips, Thomas, Goris, An, Dubois, Bénédicte, Andersen, Peter M, Al-Chalabi, Ammar, Thijs, Vincent, Turnley, Ann M, van Vught, Paul W, Veldink, Jan H, Hardiman, Orla, Van Den Bosch, Ludo, Gonzalez-Perez, Paloma, Van Damme, Philip, Brown, Robert H, van den Berg, Leonard H, Robberecht, Wim

“…Epha4 is a receptor involved in axonal repulsion. Wim Robberecht and his colleagues report that genetic or pharmacological inhibition of Epha4 is protective in…”
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Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival by Van Damme, Philip, Van Hoecke, Annelies, Lambrechts, Diether, Vanacker, Peter, Bogaert, Elke, van Swieten, John, Carmeliet, Peter, Van Den Bosch, Ludo, Robberecht, Wim

“…Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense…”
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Benefit of the Awaji diagnostic algorithm for amyotrophic lateral sclerosis: A prospective study by Schrooten, Maarten, Smetcoren, Charlotte, Robberecht, Wim, Van Damme, Philip

“…Objective: Early and accurate diagnosis of amyotrophic lateral sclerosis (ALS) is important for patient care and for entry in clinical trials. Retrospective…”
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Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine-induced peripheral neuropathies and inhibits tumor growth by Van Helleputte, Lawrence, Kater, Mandy, Cook, Dana P., Eykens, Caroline, Rossaert, Elisabeth, Haeck, Wanda, Jaspers, Tom, Geens, Natasja, Vanden Berghe, Pieter, Gysemans, Conny, Mathieu, Chantal, Robberecht, Wim, Van Damme, Philip, Cavaletti, Guido, Jarpe, Matthew, Van Den Bosch, Ludo

“…As cancer is becoming more and more a chronic disease, a large proportion of patients is confronted with devastating side effects of certain anti-cancer drugs…”
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Astrocyte-derived Jagged-1 mitigates deleterious Notch signaling in amyotrophic lateral sclerosis by Nonneman, Annelies, Criem, Nathan, Lewandowski, Sebastian A., Nuyts, Rik, Thal, Dietmar R., Pfrieger, Frank W., Ravits, John, Van Damme, Philip, Zwijsen, An, Van Den Bosch, Ludo, Robberecht, Wim

“…Amyotrophic lateral sclerosis (ALS) is a late-onset devastating degenerative disease mainly affecting motor neurons. Motor neuron degeneration is accompanied…”
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Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice by Beel, Sander, Herdewyn, Sarah, Fazal, Raheem, De Decker, Mathias, Moisse, Matthieu, Robberecht, Wim, Van Den Bosch, Ludo, Van Damme, Philip

“…TAR DNA binding protein 43 (TDP-43) is the main disease protein in most patients with amyotrophic lateral sclerosis (ALS) and about 50% of patients with…”
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