Search Results - "ROBBERECHT, P."

Molecular mechanisms involved in vasoactive intestinal peptide receptor activation and regulation: current knowledge, similarities to and differences from the A family of G-protein-coupled receptors by Langer, I, Robberecht, P

“…An actual paradigm for activation and regulation of the GPCR (G-protein-coupled receptors)/seven-transmembrane helix family of receptors essentially emerges…”
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Multisystemic production of interleukin 10 limits the severity of acute pancreatitis in mice by Van Laethem, J-L, Eskinazi, R, Louis, H, Rickaert, F, Robberecht, P, Devière, J

“…Background—Interleukin 10 (IL-10) decreases the severity of experimental acute pancreatitis. The role of endogenous IL-10 in modulating the course of…”
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Activation of p38 and p42/44 MAP kinase in neuropathic pain: involvement of VPAC2 and NK2 receptors and mediation by spinal glia by Garry, E M, Delaney, A, Blackburn-Munro, G, Dickinson, T, Moss, A, Nakalembe, I, Robertson, D C, Rosie, R, Robberecht, P, Mitchell, R, Fleetwood-Walker, S M

“…Activation of intracellular signaling pathways involving p38 and p42/44 MAP kinases may contribute importantly to synaptic plasticity underlying spinal…”
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Two Basic Residues of the h-VPAC1 Receptor Second Transmembrane Helix Are Essential for Ligand Binding and Signal Transduction by Solano, Rosa Maria, Langer, Ingrid, Perret, Jason, Vertongen, Pascale, Juarranz, Maria Guillerma, Robberecht, Patrick, Waelbroeck, Magali

“…We mutated the vasoactive intestinal peptide (VIP) Asp3 residue and two VPAC1receptor second transmembrane helix basic residues (Arg188and Lys195). VIP had a…”
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Transforming growth factor beta promotes development of fibrosis after repeated courses of acute pancreatitis in mice by Van Laethem, JL, Robberecht, P, Resibois, A, Deviere, J

“…BACKGROUND & AIMS: Transforming growth factor beta (TGF-beta) is a putative mediator of fibrosis in several chronic diseases. Recently, chronic pancreatitis…”
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Stimulation of Tyrosine Phosphatase and Inhibition of Cell Proliferation by Somatostatin Analogues: Mediation by Human Somatostatin Receptor Subtypes SSTR1 and SSTR2 by Buscail, Louis, Delesque, Nathalie, Esteve, Jean-Pierre, Saint-Laurent, Nathalie, Prats, Herve, Clerc, Pascal, Robberecht, Patrick, Bell, Graeme I., Liebow, Charles, Schally, Andrew V., Vaysse, Nicole, Susini, Christiane

“…The effects of somatostatin analogues RC-160 and SMS-201-995 on tyrosine phosphatase and cell proliferation were investigated in COS-7 and NIH 3T3 cells…”
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Development of selective agonists and antagonists for the human vasoactive intestinal polypeptide VPAC2 receptor by Moreno, D., Gourlet, P., De Neef, P., Cnudde, J., Waelbroeck, M., Robberecht, P.

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Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts by Svoboda, M, Tastenoy, M, Van Rampelbergh, J, Goossens, J F, De Neef, P, Waelbroeck, M, Robberecht, P

“…We have cloned and sequenced a cDNA isolated from a human SUP-T1 lymphoblast cell line library. It encoded a 457 amino acids protein having 87% identity with…”
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The long-acting vasoactive intestinal polypeptide agonist RO 25-1553 is highly selective of the VIP2 receptor subclass by Gourlet, P, Vertongen, P, Vandermeers, A, Vandermeers-Piret, M C, Rathe, J, De Neef, P, Waelbroeck, M, Robberecht, P

“…RO 25-1553 is a synthetic VIP analogue that induced a long-lasting relaxation of tracheal and bronchial smooth muscles as well as a reduction of edema and…”
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Relative quantitative analysis of glucagon receptor mRNA in rat tissues by Svoboda, M, Tastenoy, M, Vertongen, P, Robberecht, P

“…Total RNA prepared from nine rat tissues were analyzed for their content in glucagon receptor mRNA by two independent hybridization approaches: (1) simple dot…”
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Lysine 195 and aspartate 196 in the first extracellular loop of the VPAC1 receptor are essential for high affinity binding of agonists but not of antagonists by LANGER, I, VERTONGEN, P, PERRET, J, WAELBROECK, M, ROBBERECHT, P

“…The role in ligand recognition and receptor activation of two adjacent charged residues (lysine 195 and aspartate 196) in the first extracellular loop of the…”
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Detection of c-Ki-ras gene codon 12 mutations from pancreatic duct brushings in the diagnosis of pancreatic tumours by Van Laethem, J L, Vertongen, P, Deviere, J, Van Rampelbergh, J, Rickaert, F, Cremer, M, Robberecht, P

“…Differential diagnosis of pancreatic cancer and chronic pancreatitis is sometimes difficult and cytological examination of brushings or aspirated material…”
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Mutational analysis of the human vasoactive intestinal peptide receptor subtype VPAC2: role of basic residues in the second transmembrane helix by Vertongen, P, Solano, R M, Perret, J, Langer, I, Robberecht, P, Waelbroeck, M

“…We investigated the role of two conserved basic residues in the second transmembrane helix arginine 172 (R172) and lysine 179 (K179) of the VPAC2 receptor…”
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Identification of secretin, vasoactive intestinal peptide and glucagon binding sites: from chimaeric receptors to point mutations by Waelbroeck, M, Perret, J, Vertongen, P, Van Craenenbroeck, M, Robberecht, P

“…We have identified two basic residues that are important for the recognition of secretin and vasoactive intestinal peptide (VIP) by their respective receptors…”
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Two tyrosine residues in the first transmembrane helix of the human vasoactive intestinal peptide receptors play a role in supporting the active conformation by Perret, J, Vertongen, P, Solano, R M, Langer, I, Cnudde, J, Robberecht, P, Waelbroeck, M

“…We investigated the human vasoactive intestinal polypeptide (VIP) receptors VPAC1 and VPAC2 mutated at conserved tyrosine residues in the first transmembrane…”
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Role of charged amino acids conserved in the vasoactive intestinal polypeptide/secretin family of receptors on the secretin receptor functionality by Di Paolo, E, Vilardaga, J.P, Petry, H, Moguilevsky, N, Bollen, A, Robberecht, P, Waelbroeck, M

“…The secretin receptor is a member of a large family of G-protein-coupled receptors that recognize polypeptide hormone and/or neuropeptides. Charged, conserved…”
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Properties of Chimeric Secretin and VIP Receptor Proteins Indicate the Importance of the N-Terminal Domain for Ligand Discrimination by Vilardaga, J.P., Deneef, P., Dipaolo, E., Bollen, A., Waelbroeck, M., Robberecht, P.

“…Two chimeras were obtained by substituting the DNA sequence encoding the N-terminal extracellular domain of the VIP and secretin receptors by the homologous…”
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Pharmacological, molecular and functional characterization of vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating polypeptide receptors in the rat pineal gland by Simonneaux, V, Kienlen-Campard, P, Loeffler, J.-P, Basille, M, Gonzalez, B.J, Vaudry, H, Robberecht, P, Pévet, P

“…Melatonin secretion from the mammalian pineal gland is strongly stimulated by noradrenaline and also by vasoactive intestinal polypeptide (VIP) and pituitary…”
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Analogues of VIP, Helodermin, and PACAP Discriminate between Rat and Human VIP1 and VIP2 Receptors by GOURLET, P., VANDERMEERS, A., VAN RAMPELBERGH, J., DE NEEF, P., CNUDDE, J., WAELBROECK, M., ROBBERECHT, P.

“…Vasoactive intestinal polypeptide (VIP) acts through interaction with two subclasses of seven transmembrane G protein-coupled receptors named VIP1 and VIP2…”
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Proline residue 280 in the second extracellular loop (EC2) of the VPAC2 receptor is essential for the receptor structure by Vertongen, P, Solano, R M, Juarranz, M G, Perret, J, Waelbroeck, M, Robberecht, P

“…Inspection of the amino acid sequence of the human VPAC1 and the VPAC2 receptors after alignment of the conserved residues indicates that the second…”
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