Search Results - "ROATTI, Angela"
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Apelin is expressed in intimal smooth muscle cells and promotes their phenotypic transition
Published in Scientific reports (31-10-2023)“…During atherosclerotic plaque formation, smooth muscle cells (SMCs) switch from a contractile/differentiated to a synthetic/dedifferentiated phenotype. We…”
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Forkhead Transcription Factors Coordinate Expression of Myocardial KATP Channel Subunits and Energy Metabolism
Published in Circulation research (01-02-2008)“…Coordinate adaptation of myocyte metabolism and function is fundamental to survival of the stressed heart, but the mechanisms for this coordination remain…”
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Increased Expression of Adenosine Triphosphate-Sensitive K+ Channels in Mitral Dysfunction
Published in Journal of the American College of Cardiology (01-01-2012)“…Objectives The aim of this study was to test whether adenosine triphosphate-sensitive K+ (KATP) channel expression relates to mechanical and hypoxic stress…”
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Unexpected role for the human Cx37 C1019T polymorphism in tumour cell proliferation
Published in Carcinogenesis (New York) (01-11-2010)“…Connexins are a large family of proteins that form gap junction channels allowing exchange of ions and small metabolites between neighboring cells. They have…”
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Abstract 550: Nuclear Targeting of Apelin in Vascular Smooth Muscle Cells: Implications in Cell Proliferation and Atherosclerotic Plaque Formation?
Published in Arteriosclerosis, thrombosis, and vascular biology (01-05-2012)“…Abstract only Background: The main circulatory form of Apelin is a highly conserved 13 amino acid hypotensive peptide derived from a 77 amino acid…”
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Central Venous Hypoxemia Is a Determinant of Human Atrial ATP-Sensitive Potassium Channel Expression: Evidence for a Novel Hypoxia-Inducible Factor 1α-Forkhead Box Class O Signaling Pathway
Published in Hypertension (Dallas, Tex. 1979) (01-05-2010)“…ATP-sensitive potassium channels couple cell excitability to energy metabolism, thereby providing life-saving protection of stressed cardiomyocytes. The…”
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Increased expression of adenosine triphosphate-sensitive K+ channels in mitral dysfunction: mechanically stimulated transcription and hypoxia-induced protein stability?
Published in Journal of the American College of Cardiology (24-01-2012)“…The aim of this study was to test whether adenosine triphosphate-sensitive K(+) (KATP) channel expression relates to mechanical and hypoxic stress within the…”
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TNF‐alpha modulates cardiac KATP channel subunits expression. Potential role for Forkhead and NFKB transcription factors
Published in The FASEB journal (01-04-2008)“…KATP channels coordinate metabolic sensing and cardiomyocyte contraction, and thus adapt metabolic expenditure to metabolic reserve. Paradoxically, KATP…”
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Pore loop-mutated rat KIR6.1 and KIR6.2 suppress KATP current in rat cardiomyocytes
Published in American journal of physiology. Heart and circulatory physiology (01-08-2004)“…Cardiomyocytes express mRNA for all major subunits of ATP-sensitive potassium (K(ATP)) channels: KIR6.1, KIR6.2, SUR1A, SUR2A, and SUR2B. It has remained…”
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Differential sensitivity of atrial and ventricular KATP channels to metabolic inhibition
Published in Cardiovascular research (01-02-2003)Get full text
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Intracellular targeting of truncated secretory peptides in the mammalian heart and brain
Published in The FASEB journal (01-04-2006)“…ABSTRACT Secretory polypeptides are vital for nervous system function, sleep, reproduction, growth, and metabolism. Ribosomes scanning the 5′‐end of mRNA…”
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Peptidyl-Glycine α-Amidating Monooxygenase Targeting and Shaping of Atrial Secretory Vesicles: Inhibition by Mutated N-Terminal ProANP and PBA
Published in Circulation research (10-12-2004)“…ANP (atrial natriuretic peptide) is widely recognized as an important vasorelaxant, diuretic, and cardioprotective hormone. Little is known, however, about how…”
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Plasmalemmal KATP channels shape triggered calcium transients in metabolically impaired rat atrial myocytes
Published in American journal of physiology. Heart and circulatory physiology (01-12-2002)“…The relative role of plasmalemmal and mitochondrial ATP-sensitive K(+) (K(ATP)) channels in calcium homeostasis of the atrium is little understood…”
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Acid Prohormone Sequence Determines Size, Shape, and Docking of Secretory Vesicles in Atrial Myocytes
Published in Circulation research (03-08-2001)“…ABSTRACT—How vesicles are born in the trans-Golgi network and reach their docking sites at the plasma membrane is still largely unknown and is investigated in…”
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A novel K(ATP) current in cultured neonatal rat atrial appendage cardiomyocytes
Published in Circulation research (15-10-1999)“…The functional and pharmacological properties of ATP-sensitive K(+) (K(ATP)) channels were studied in primary cultured neonatal rat atrial appendage…”
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A Novel K ATP Current in Cultured Neonatal Rat Atrial Appendage Cardiomyocytes
Published in Circulation research (15-10-1999)“…Abstract —The functional and pharmacological properties of ATP-sensitive K + (K ATP ) channels were studied in primary cultured neonatal rat atrial appendage…”
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Central venous hypoxemia is a determinant of human atrial ATP-sensitive potassium channel expression: evidence for a novel hypoxia-inducible factor 1alpha-Forkhead box class O signaling pathway
Published in Hypertension (Dallas, Tex. 1979) (01-05-2010)“…ATP-sensitive potassium channels couple cell excitability to energy metabolism, thereby providing life-saving protection of stressed cardiomyocytes. The…”
Get full text
Journal Article -
19
Differential sensitivity of atrial and ventricular K(ATP) channels to metabolic inhibition
Published in Cardiovascular research (01-02-2003)“…The aim is to compare the activation of ATP-sensitive potassium channels (K(ATP) channels) in intact and metabolically impaired atrial and ventricular…”
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Sulfonylurea receptor ligands modulate stretch-induced ANF secretion in rat atrial myocyte culture
Published in American journal of physiology. Heart and circulatory physiology (01-06-2000)“…Stretch-induced atrial natriuretic factor (ANF) secretion was studied in cultures of neonate atrial appendage myocytes. Stretch, applied for 40 min by…”
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