Search Results - "RIZZO, Stacey"

Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder by Lanz, Thomas A., Reinhart, Veronica, Sheehan, Mark J., Rizzo, Stacey J. Sukoff, Bove, Susan E., James, Larry C., Volfson, Dmitri, Lewis, David A., Kleiman, Robin J.

“…Psychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) arise from complex interactions between genetic…”
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The essential role of animal models in the advancement of our understanding of human behaviors: A Commentary on the Special issue on the 30th Anniversary of the International Behavioral Neuroscience Society (IBNS) by Sukoff Rizzo, Stacey J.

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Toward more predictive genetic mouse models of Alzheimer's disease by Onos, Kristen D, Sukoff Rizzo, Stacey J, Howell, Gareth R, Sasner, Michael

“…Highlights • Mouse models have improved our understanding of early-onset Alzheimer's disease. • The field lacks useful models of the more common late-onset…”
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Enhancing face validity of mouse models of Alzheimer's disease with natural genetic variation by Onos, Kristen D, Uyar, Asli, Keezer, Kelly J, Jackson, Harriet M, Preuss, Christoph, Acklin, Casey J, O'Rourke, Rita, Buchanan, Rebecca, Cossette, Travis L, Sukoff Rizzo, Stacey J, Soto, Ileana, Carter, Gregory W, Howell, Gareth R

“…Classical laboratory strains show limited genetic diversity and do not harness natural genetic variation. Mouse models relevant to Alzheimer's disease (AD)…”
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Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease by Paumier, Katrina L, Sukoff Rizzo, Stacey J, Berger, Zdenek, Chen, Yi, Gonzales, Cathleen, Kaftan, Edward, Li, Li, Lotarski, Susan, Monaghan, Michael, Shen, Wei, Stolyar, Polina, Vasilyev, Dmytro, Zaleska, Margaret, D Hirst, Warren, Dunlop, John

“…Parkinson's disease (PD) pathology is characterized by the formation of intra-neuronal inclusions called Lewy bodies, which are comprised of alpha-synuclein…”
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Meeting report of the annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease research by Sasner, Michael, Territo, Paul R, Sukoff Rizzo, Stacey J

“…The second annual 5-day workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease Research was held…”
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Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism by Silverman, Jill L, Smith, Daniel G, Rizzo, Stacey J Sukoff, Karras, Michael N, Turner, Sarah M, Tolu, Seda S, Bryce, Dianne K, Smith, Deborah L, Fonseca, Kari, Ring, Robert H, Crawley, Jacqueline N

“…Neurodevelopmental disorders such as autism and fragile X syndrome were long thought to be medically untreatable, on the assumption that brain dysfunctions…”
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Meeting report of the fifth annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease Research by Sasner, Michael, Onos, Kristen D., Territo, Paul R., Sukoff Rizzo, Stacey J.

“…The fifth annual workshop on Principles and Techniques for Improving Preclinical Translation of Alzheimer's Disease Research was held in May 2023 at The…”
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Acarbose improves health and lifespan in aging HET3 mice by Harrison, David E., Strong, Randy, Alavez, Silvestre, Astle, Clinton Michael, DiGiovanni, John, Fernandez, Elizabeth, Flurkey, Kevin, Garratt, Michael, Gelfond, Jonathan A. L., Javors, Martin A., Levi, Moshe, Lithgow, Gordon J., Macchiarini, Francesca, Nelson, James F., Sukoff Rizzo, Stacey J., Slaga, Thomas J., Stearns, Tim, Wilkinson, John Erby, Miller, Richard A.

“…To follow‐up on our previous report that acarbose (ACA), a drug that blocks postprandial glucose spikes, increases mouse lifespan, we studied ACA at three…”
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Improving preclinical to clinical translation of cognitive function for aging-related disorders: the utility of comprehensive touchscreen testing batteries in common marmosets by Murai, Takeshi, Bailey, Lauren, Schultz, Laura, Mongeau, Lauren, DeSana, Andrew, Silva, Afonso C., Roberts, Angela C., Sukoff Rizzo, Stacey J.

“…Concerns about poor animal to human translation have come increasingly to the fore, in particular with regards to cognitive improvements in rodent models,…”
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Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy by Diggle, Christine P., Sukoff Rizzo, Stacey J., Popiolek, Michael, Hinttala, Reetta, Schülke, Jan-Philip, Kurian, Manju A., Carr, Ian M., Markham, Alexander F., Bonthron, David T., Watson, Christopher, Sharif, Saghira Malik, Reinhart, Veronica, James, Larry C., Vanase-Frawley, Michelle A., Charych, Erik, Allen, Melanie, Harms, John, Schmidt, Christopher J., Ng, Joanne, Pysden, Karen, Strick, Christine, Vieira, Päivi, Mankinen, Katariina, Kokkonen, Hannaleena, Kallioinen, Matti, Sormunen, Raija, Rinne, Juha O., Johansson, Jarkko, Alakurtti, Kati, Huilaja, Laura, Hurskainen, Tiina, Tasanen, Kaisa, Anttila, Eija, Marques, Tiago Reis, Howes, Oliver, Politis, Marius, Fahiminiya, Somayyeh, Nguyen, Khanh Q., Majewski, Jacek, Uusimaa, Johanna, Sheridan, Eamonn, Brandon, Nicholas J.

“…Deficits in the basal ganglia pathways modulating cortical motor activity underlie both Parkinson disease (PD) and Huntington disease (HD). Phosphodiesterase…”
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Integrated analysis of the molecular pathogenesis of FDXR-associated disease by Slone, Jesse D., Yang, Li, Peng, Yanyan, Queme, Luis F., Harris, Belinda, Rizzo, Stacey J. Sukoff, Green, Torrian, Ryan, Jennifer L., Jankowski, Michael P., Reinholdt, Laura G., Huang, Taosheng

“…The mitochondrial flavoprotein ferredoxin reductase (FDXR) is required for biogenesis of iron–sulfur clusters and for steroidogenesis. Iron–sulfur (Fe–S)…”
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Exercise prevents obesity-induced cognitive decline and white matter damage in mice by Graham, Leah C., Grabowska, Weronika A., Chun, Yoona, Risacher, Shannon L., Philip, Vivek M., Saykin, Andrew J., Sukoff Rizzo, Stacey J., Howell, Gareth R.

“…Obesity in the western world has reached epidemic proportions, and yet the long-term effects on brain health are not well understood. To address this, we…”
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Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank by Vitek, Michael P., Araujo, Joseph A., Fossel, Michael, Greenberg, Barry D., Howell, Gareth R., Rizzo, Stacey J. Sukoff, Seyfried, Nicholas T., Tenner, Andrea J., Territo, Paul R., Windisch, Manfred, Bain, Lisa J., Ross, April, Carrillo, Maria C., Lamb, Bruce T., Edelmayer, Rebecca M.

“…Over 5 million Americans and 50 million individuals worldwide are living with Alzheimer's disease (AD). The progressive dementia associated with AD currently…”
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The Importance of Complementary Collaboration of Researchers, Veterinarians, and Husbandry Staff in the Successful Training of Marmoset Behavioral Assays by Murai, Takeshi, Sukoff Rizzo, Stacey J

“…Abstract Interest in marmosets as research models has seen exponential growth over the last decade, especially given that the research community is eager to…”
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Continuous Glucose Monitoring in Female NOD Mice Reveals Daily Rhythms and a Negative Correlation With Body Temperature by Korstanje, Ron, Ryan, Jennifer L, Savage, Holly S, Lyons, Bonnie L, Kane, Kevin G, Sukoff Rizzo, Stacey J

“…Previous studies with continuous glucose monitoring in mice have been limited to several days or weeks, with the mouse's physical attachment to the equipment…”
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Repetitive Behavioral Assessments for Compound Screening in Mouse Models of Autism Spectrum Disorders by Rizzo, Stacey J Sukoff

“…Treatments for repetitive behaviors in Autism Spectrum Disorders (ASD) and other neurodevelopmental disorders remain an unmet medical need. Mouse models are…”
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Behavioral Phenotyping Assays for Genetic Mouse Models of Neurodevelopmental, Neurodegenerative, and Psychiatric Disorders by Sukoff Rizzo, Stacey J, Crawley, Jacqueline N

“…Animal models offer heuristic research tools to understand the causes of human diseases and to identify potential treatments. With rapidly evolving genetic…”
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STOP-AD portal: Selecting the optimal pharmaceutical for preclinical drug testing in Alzheimer's disease by Quinney, Sara K, Murugesh, Kandasamy, Oblak, Adrian, Onos, Kristen D, Sasner, Mike, Greenwood, Anna K, Woo, Kara H, Rizzo, Stacey J Sukoff, Territo, Paul R

“…We propose an unbiased methodology to rank compounds for advancement into comprehensive preclinical testing for Alzheimer's disease (AD). Translation of…”
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Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study by Oblak, Adrian L, Lin, Peter B, Kotredes, Kevin P, Pandey, Ravi S, Garceau, Dylan, Williams, Harriet M, Uyar, Asli, O'Rourke, Rita, O'Rourke, Sarah, Ingraham, Cynthia, Bednarczyk, Daria, Belanger, Melisa, Cope, Zackary A, Little, Gabriela J, Williams, Sean-Paul G, Ash, Carl, Bleckert, Adam, Ragan, Tim, Logsdon, Benjamin A, Mangravite, Lara M, Sukoff Rizzo, Stacey J, Territo, Paul R, Carter, Gregory W, Howell, Gareth R, Sasner, Michael, Lamb, Bruce T

“…The ability to investigate therapeutic interventions in animal models of neurodegenerative diseases depends on extensive characterization of the model(s) being…”
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