Search Results - "RIVARD, N"
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Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer
Published in Oncogene (17-09-2015)“…Aberrant regulation of the Wnt/β-catenin signaling pathway is one of the major causes of colorectal cancer (CRC). Loss-of-function mutations in APC are…”
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Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition
Published in Oncogene (31-01-2013)“…Gain-of-function mutations in KRAS and BRAF genes are found in up to 50% of colorectal cancers. These mutations result in the activation of the BRAF/MEK…”
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Abstract # 1850 Early life stress predisposes to increased sensitivity to inflammatory stimuli through intestinal dysbiosis
Published in Brain, behavior, and immunity (01-10-2016)“…Stress, anxiety and depression are considered risk factors for Inflammatory Bowel Disease. We have previously shown in mice that early life stress induced by…”
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4-Phenylbutyrate reverses endoplasmic reticulum stress and lipotoxicity in human adipose tissue stem cells
Published in Canadian journal of diabetes (2011)Get full text
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A54 SHP2 FUNCTION IN NORMAL AND APC -MUTANT INTESTINAL EPITHELIAL CELLS
Published in Journal of the Canadian Association of Gastroenterology (14-02-2024)“…Abstract Background Somatic SHP2 gain-of-function mutations were found in some colorectal tumours. However, its function in colorectal epithelium remains to be…”
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A53 MOLECULAR MECHANISMS FOR A ROLE OF SHP-2 IN TLR4 SIGNALING IN INTESTINAL EPITHELIAL CELLS
Published in Journal of the Canadian Association of Gastroenterology (14-02-2024)“…Abstract Background Shp-2 gene polymorphisms are associated with greater susceptibility to ulcerative colitis. How Shp-2 contributes to disease susceptibility…”
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Oncogenic KRAS signalling promotes the Wnt/[beta]-catenin pathway through LRP6 in colorectal cancer
Published in Oncogene (17-09-2015)“…Aberrant regulation of the Wnt/β-catenin signaling pathway is one of the major causes of colorectal cancer (CRC). Loss-of-function mutations in APC are…”
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Pancreas growth, tyrosine kinase, PtdIns 3-kinase, and PLD involve high-affinity CCK-receptor occupation
Published in The American journal of physiology (01-01-1994)“…Cholecystokinin (CCK), CCK octapeptide (CCK-8), and caerulein (Cae) are the most potent trophic factors in the pancreas when given exogenously or released from…”
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Epidermal growth factor and transforming growth factor α down-regulate human gastric lipase gene expression
Published in Gastroenterology (New York, N.Y. 1943) (01-04-1999)“…Background & Aims: It was recently reported that human gastric lipase (HGL) activity is modulated by epidermal growth factor (EGF). The aims of this study were…”
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A249 ROLE OF LRP6 IN KRAS AND BRAF MUTATED COLORECTAL CANCER
Published in Journal of the Canadian Association of Gastroenterology (01-03-2018)Get full text
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Novel model of integration of signaling pathways in rat pancreatic acinar cells
Published in The American journal of physiology (01-09-1995)“…Cholecystokinin (CCK) is the major pancreatic secretagogue and acinar cell mitogen. This study was performed to determine by which effector systems CCK…”
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Dynamics of pancreatic tyrosine kinase and phospholipase D activities in the course of cerulein-induced acute pancreatitis and during regeneration
Published in Pancreas (01-05-1995)“…Acute pancreatitis can be induced in the rat by high doses of cerulein, a cholecystokinin analogue. Regeneration of the pancreatic gland after this aggression…”
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IncA/C Conjugative Plasmids Mobilize a New Family of Multidrug Resistance Islands in Clinical Vibrio cholerae Non-01/Non-0139 Isolates from Haiti
Published in mBio (2016)“…Mobile genetic elements play a pivotal role in the adaptation of bacterial populations, allowing them to rapidly cope with hostile conditions, including the…”
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Regulation of pancreatic tyrosine kinase and phosphatase activities by cholecystokinin and somatostatin
Published in The American journal of physiology (01-06-1994)“…Phosphorylation and dephosphorylation of proteins on tyrosyl residues are important reactions involved in cellular activities, namely, those associated with…”
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A208 SHP-2 PHOSPHATASE PREVENTS SENESCENCE IN NORMAL AND TUMOR INTESTINAL EPITHELIAL CELLS
Published in Journal of the Canadian Association of Gastroenterology (01-03-2018)“…Abstract Background The protein tyrosine phosphatase SHP-2 is known to regulate many cellular functions including growth, differentiation and survival…”
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A265 INVOLVEMENT OF LRP6 IN INTESTINAL HOMEOSTASIS AND INFLAMMATION
Published in Journal of the Canadian Association of Gastroenterology (01-03-2018)“…Abstract Background Self-renewal of the intestinal epithelium is tightly regulated by interacting intracellular signaling pathways, which control stem cell…”
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Endogenous cholecystokinin release responsible for pancreatic growth observed after pancreatic juice diversion
Published in Endocrinology (Philadelphia) (01-12-1991)“…This study was undertaken to determine whether intermittent pancreatic juice diversion (PJD) from the intestine can induce pancreatic and duodenal growth…”
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Human Homolog of Disc-large Is Required for Adherens Junction Assembly and Differentiation of Human Intestinal Epithelial Cells
Published in The Journal of biological chemistry (12-03-2004)“…We and others have shown that phosphatidylinositol 3-kinase (PI3K) is recruited to and activated by E-cadherin engagement. This PI3K activation is essential…”
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