Search Results - "RITTER, Mirko"

Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody by Geiger, Martina, Stubenrauch, Kay-Gunnar, Sam, Johannes, Richter, Wolfgang F., Jordan, Gregor, Eckmann, Jan, Hage, Carina, Nicolini, Valeria, Freimoser-Grundschober, Anne, Ritter, Mirko, Lauer, Matthias E., Stahlberg, Henning, Ringler, Philippe, Patel, Jigar, Sullivan, Eric, Grau-Richards, Sandra, Endres, Stefan, Kobold, Sebastian, Umaña, Pablo, Brünker, Peter, Klein, Christian

“…T-cell bispecific antibodies (TCBs) crosslink tumor and T-cells to induce tumor cell killing. While TCBs are very potent, on-target off-tumor toxicity remains…”
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Immunohistochemical Detection of Synuclein Pathology in Skin in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinsonism by Al‐Qassabi, Ahmed, Tsao, Tsu‐Shuen, Racolta, Adriana, Kremer, Thomas, Cañamero, Marta, Belousov, Anton, Santana, Madison A., Beck, Rachel C., Zhang, Hongjun, Meridew, Jeffrey, Pugh, Judith, Lian, Fangru, Robida, Mark D., Ritter, Mirko, Czech, Christian, Beach, Thomas G., Pestic‐Dragovich, Lidija, Taylor, Kirsten I., Zago, Wagner, Tang, Lei, Dziadek, Sebastian, Postuma, Ronald B.

“…ABSTRACT Background Recent studies reported abnormal alpha‐synuclein deposition in biopsy‐accessible sites of the peripheral nervous system in Parkinson's…”
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Characterization of anti-drug antibody responses to the T-cell engaging bispecific antibody cibisatamab to understand the impact on exposure by Lotz, Gregor P, Lutz, Achim, Martin-Facklam, Meret, Hansbauer, Andre, Schick, Eginhard, Moessner, Ekkehard, Antony, Michael, Stuchly, Thomas, Viert, Maria, Hosse, Ralf J, Freimoser-Grundschober, Anne, Klein, Christian, Schäfer, Martin, Ritter, Mirko, Stubenrauch, Kay-Gunnar

“…An appropriately designed pharmacokinetic (PK) assay that is sensitive for anti-drug antibody (ADA) impact on relevant exposure is an alternative strategy to…”
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Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response by Ritter, Mirko, Mennerich, Detlev, Weith, Andreas, Seither, Peter

“…Bacterial and viral exacerbations play a crucial role in a variety of lung diseases including COPD or asthma. Since the lung epithelium is a major source of…”
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Development of AAVLP(HPV16/31L2) particles as broadly protective HPV vaccine candidate by Nieto, Karen, Weghofer, Margit, Sehr, Peter, Ritter, Mirko, Sedlmeier, Sebastian, Karanam, Balasubramanyam, Seitz, Hanna, Müller, Martin, Kellner, Markus, Hörer, Markus, Michaelis, Uwe, Roden, Richard B S, Gissmann, Lutz, Kleinschmidt, Jürgen A

“…The human papillomavirus (HPV) minor capsid protein L2 is a promising candidate for a broadly protective HPV vaccine yet the titers obtained in most…”
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Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies by Moors, Tim E, Mona, Daniel, Luehe, Stefan, Duran-Pacheco, Gonzalo, Spycher, Liz, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N, Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Dernick, Gregor, van de Berg, Wilma D J, Britschgi, Markus

“…Based on immunostainings and biochemical analyses, certain post-translationally modified alpha-synuclein (aSyn) variants, including C-terminally truncated…”
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Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli by Buechler, Christa, Ritter, Mirko, Orsó, Evelyn, Langmann, Thomas, Klucken, Jochen, Schmitz, Gerd

“…CD163, also referred to as M130, a member of the scavenger receptor cysteine‐rich family (SRCR) is exclusively expressed on cells of the monocyte lineage. In…”
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Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation by Ritter, Mirko, Göggel, Rolf, Chaudhary, Nveed, Wiedenmann, Alexander, Jung, Birgit, Weith, Andreas, Seither, Peter

“…TARC (CCL17) and MDC (CCL22) are well-known chemoattractants for Th2 cells. Here, we evaluated the role of both chemokines for cigarette smoke-induced airway…”
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ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism by Drobnik, Wolfgang, Lindenthal, Bernhard, Lieser, Bernd, Ritter, Mirko, Weber, Trudy Christiansen, Liebisch, Gerhard, Giesa, Uwe, Igel, Michael, Borsukova, Hana, Büchler, Christa, Fung-Leung, Wai Ping, Bergmann, Klaus Von, Schmitz, Gerd

“…Background & Aims: Members of the family of ABC transporters are involved in different processes of sterol metabolism, and ABCA1 was recently identified as a…”
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Genomic Organization and Chromosomal Localization of the Human CD163 (M130) Gene: A Member of the Scavenger Receptor Cysteine-Rich Superfamily by Ritter, Mirko, Buechler, Christa, Langmann, Thomas, Schmitz, Gerd

“…The human protein CD163 (M130) is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, which is exclusively expressed by monocytes and…”
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Cloning and Characterization of a Novel Apolipoprotein A-I Binding Protein, AI-BP, Secreted by Cells of the Kidney Proximal Tubules in Response to HDL or ApoA-I by Ritter, Mirko, Buechler, Christa, Boettcher, Alfred, Barlage, Stefan, Schmitz-Madry, Anna, Orsó, Evelyn, Bared, Salim Maa, Schmiedeknecht, Gerno, Baehr, Carsten H, Fricker, Gert, Schmitz, Gerd

“…Apolipoprotein A-I (apoA-I) is the major apolipoprotein of high-density lipoproteins (HDL) and has an important role in the regulation of the stability, lipid…”
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Molecular and Functional Interaction of the ATP-binding Cassette Transporter A1 with Fas-associated Death Domain Protein by Buechler, Christa, Bared, Salim Maa, Aslanidis, Charalampos, Ritter, Mirko, Drobnik, Wolfgang, Schmitz, Gerd

“…ATP-binding cassette transporter A1 (ABCA1) is a major regulator of cellular cholesterol and phospholipid homeostasis. Its function has not been fully…”
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The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy by Moors, Tim E., Maat, Christina A., Niedieker, Daniel, Mona, Daniel, Petersen, Dennis, Timmermans-Huisman, Evelien, Kole, Jeroen, El-Mashtoly, Samir F., Spycher, Liz, Zago, Wagner, Barbour, Robin, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N., Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Geurts, Jeroen J. G., Gerwert, Klaus, Britschgi, Markus, van de Berg, Wilma D. J.

“…Various post-translationally modified (PTM) proteoforms of alpha-synuclein (aSyn)—including C-terminally truncated (CTT) and Serine 129 phosphorylated…”
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Immunogenicity testing of therapeutic antibodies in ocular fluids after intravitreal injection by Wessels, Uwe, Zadak, Markus, Reiser, Astrid, Brockhaus, Janis, Ritter, Mirko, Abdolzade-Bavil, Afsaneh, Heinrich, Julia, Stubenrauch, Kay

“…High drug concentrations in ocular fluids after intravitreal administration preclude the use of drug-sensitive immunoassays. A drug-tolerant immunoassay is…”
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Novel drug and soluble target tolerant antidrug antibody assay for therapeutic antibodies bearing the P329G mutation by Wessels, Uwe, Schick, Eginhard, Ritter, Mirko, Kowalewsky, Frank, Heinrich, Julia, Stubenrauch, Kay

“…Bridging immunoassays for detection of antidrug antibodies (ADAs) are typically susceptible to high concentrations of residual drug. Sensitive drug-tolerant…”
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Proof of concept study with an HER-2 mimotope anticancer vaccine deduced from a novel AAV-mimotope library platform by Singer, Josef, Manzano-Szalai, Krisztina, Fazekas, Judit, Thell, Kathrin, Bentley-Lukschal, Anna, Stremnitzer, Caroline, Roth-Walter, Franziska, Weghofer, Margit, Ritter, Mirko, Pino Tossi, Kerstin, Hörer, Markus, Michaelis, Uwe, Jensen-Jarolim, Erika

“…Background: Anticancer vaccines could represent a valuable complementary strategy to established therapies, especially in settings of early stage and minimal…”
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Adeno-associated virus-like particles as new carriers for B-cell vaccines: testing immunogenicity and safety in BALB/c mice by Manzano-Szalai, Krisztina, Thell, Kathrin, Willensdorfer, Anna, Weghofer, Margit, Pfanzagl, Beatrix, Singer, Josef, Ritter, Mirko, Stremnitzer, Caroline, Flaschberger, Ingo, Michaelis, Uwe, Jensen-Jarolim, Erika

“…Adeno-associated viruses (AAVs) are established vectors for gene therapy of different human diseases. AAVs are assembled of 60 capsomers, which can be…”
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Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: Gender-specific genetic predisposition to sepsis by Hubacek, Jaroslav A, Stüber, Frank, Fröhlich, Dieter, Book, Malte, Wetegrove, Silke, Ritter, Mirko, Rothe, Gregor, Schmitz, Gerd

“…OBJECTIVESTo determine whether the genotype frequencies of the five bi-allelic polymorphisms in the bactericidal/permeability increasing protein (BPI) (Lys216…”
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Development of AAVLP by Nieto, Karen, Weghofer, Margit, Sehr, Peter, Ritter, Mirko, Sedlmeier, Sebastian, Karanam, Balasubramanyam, Seitz, Hanna, Müller, Martin, Kellner, Markus, Hörer, Markus, Michaelis, Uwe, Roden, Richard B. S, Gissmann, Lutz, Kleinschmidt, Jürgen A

“…The human papillomavirus (HPV) minor capsid protein L2 is a promising candidate for a broadly protective HPV vaccine yet the titers obtained in most…”
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Soluble CD163 is not increased in visceral fat and steatotic liver and is even suppressed by free fatty acids in vitro by Bauer, Sabrina, Weiss, Thomas S., Wiest, Reiner, Schacherer, Doris, Hellerbrand, Claus, Farkas, Stefan, Scherer, Marcus N., Ritter, Mirko, Schmitz, Gerd, Schäffler, Andreas, Buechler, Christa

“…Visceral fat differs from subcutaneous fat by higher local inflammation and increased release of IL-6 and free fatty acids (FFA) which contribute to hepatic…”
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