Search Results - "RITTENHOUSE, Stephen"

Efficacy of Cefiderocol against Carbapenem-Resistant Gram-Negative Bacilli in Immunocompetent-Rat Respiratory Tract Infection Models Recreating Human Plasma Pharmacokinetics by Matsumoto, Shuhei, Singley, Christine M, Hoover, Jennifer, Nakamura, Rio, Echols, Roger, Rittenhouse, Stephen, Tsuji, Masakatsu, Yamano, Yoshinori

“…Cefiderocol (S-649266), a novel siderophore cephalosporin, shows potent activity against carbapenem-resistant Gram-negative bacilli. In this study, we…”
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Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies by Clegg, Jonah, Soldaini, Elisabetta, McLoughlin, Rachel M, Rittenhouse, Stephen, Bagnoli, Fabio, Phogat, Sanjay

“…is one of the most important human pathogens worldwide. Its high antibiotic resistance profile reinforces the need for new interventions like vaccines in…”
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Challenges of antibacterial discovery revisited by Gwynn, Michael N., Portnoy, Alison, Rittenhouse, Stephen F., Payne, David J.

“…The discovery of novel antibiotic classes has not kept pace with the growing threat of bacterial resistance. Antibiotic candidates that act at new targets or…”
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Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections by O'Dwyer, Karen, Spivak, Aaron T, Ingraham, Karen, Min, Sharon, Holmes, David J, Jakielaszek, Charles, Rittenhouse, Stephen, Kwan, Alan L, Livi, George P, Sathe, Ganesh, Thomas, Elizabeth, Van Horn, Stephanie, Miller, Linda A, Twynholm, Monique, Tomayko, John, Dalessandro, Marybeth, Caltabiano, Madelyn, Scangarella-Oman, Nicole E, Brown, James R

“…GSK2251052, a novel leucyl-tRNA synthetase (LeuRS) inhibitor, was in development for the treatment of infections caused by multidrug-resistant Gram-negative…”
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Selection of Retapamulin, a Novel Pleuromutilin for Topical Use by RITTENHOUSE, Stephen, BISWAS, Sanjoy, BROSKEY, John, MCCLOSKEY, Lynn, MOORE, Terrance, VASEY, Sandra, WEST, Joshua, ZALACAIN, Magdalena, ZONIS, Rimma, PAYNE, David

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Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus by GENTRY, Daniel R, MCCLOSKEY, Lynn, GWYNN, Michael N, RITTENHOUSE, Stephen F, SCANGARELLA, Nicole, SHAWAR, Ribhi, HOLMES, David J

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Stepwise Exposure of Staphylococcus aureus to Pleuromutilins Is Associated with Stepwise Acquisition of Mutations in rplC and Minimally Affects Susceptibility to Retapamulin by GENTRY, Daniel R, RITTENHOUSE, Stephen F, MCCLOSKEY, Lynn, HOLMES, David J

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Use of the Surgical Wound Infection Model To Determine the Efficacious Dosing Regimen of Retapamulin, a Novel Topical Antibiotic by RITTENHOUSE, Stephen, SINGLEY, Christine, HOOVER, Jennifer, PAGE, Roni, PAYNE, David

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A rapid microtiter plate assay for measuring the effect of compounds on Staphylococcus aureus membrane potential by Gentry, Daniel R., Wilding, Imogen, Johnson, John M., Chen, Dongzhao, Remlinger, Katja, Richards, Cindy, Neill, Susan, Zalacain, Magdalena, Rittenhouse, Stephen F., Gwynn, Michael N.

“…We developed a homogenous microtiter based assay using the cationic dye 3, 3′-Diethyloxacarbocyanine iodide, DiOC 2(3), to measure the effect of compounds on…”
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Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK by Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, DeWolf, Walter E, Elkins, Patricia A, Head, Martha S, Jakas, Dalia R, Janson, Cheryl A, Keller, Paul M, Manley, Peter J, Moore, Terrance D, Payne, David J, Pearson, Stewart, Polizzi, Brian J, Qiu, Xiayang, Rittenhouse, Stephen F, Uzinskas, Irene N, Wallis, Nicola G, Huffman, William F

“…Bacterial enoyl-ACP reductase (FabI) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis and is an attractive target for the…”
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Discovery of Aminopyridine-Based Inhibitors of Bacterial Enoyl-ACP Reductase (FabI) by Miller, William H, Seefeld, Mark A, Newlander, Kenneth A, Uzinskas, Irene N, Burgess, Walter J, Heerding, Dirk A, Yuan, Catherine C. K, Head, Martha S, Payne, David J, Rittenhouse, Stephen F, Moore, Terrance D, Pearson, Stewart C, Berry, Valerie, DeWolf, Walter E, Keller, Paul M, Polizzi, Brian J, Qiu, Xiayang, Janson, Cheryl A, Huffman, William F

“…Bacterial enoyl-ACP reductase (FabI) catalyzes the final step in each cycle of bacterial fatty acid biosynthesis and is an attractive target for the…”
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Defining and Combating the Mechanisms of Triclosan Resistance in Clinical Isolates of Staphylococcus aureus by FAN, Frank, KANG YAN, SEEFELD, Mark A, NEWLANDER, Kenneth A, JAKAS, Dalia R, HEAD, Martha S, PAYNE, David J, WALLIS, Nicola G, REED, Shannon, MOORE, Terrance D, RITTENHOUSE, Stephen F, DEWOLF, Walter E, JIANZHONG HUANG, MCDEVITT, Damien, MILLER, William H

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Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases by PAYNE, David J, HUESO-RODRIGUEZ, Juan Antonio, RITTENHOUSE, Stephen, TEW, David, DIEZ, Emilio, PEREZ, Paloma, DE LA FUENTE, Jesus, REES, Michael, RIVERA-SAGREDO, Alfonso, BODY, Helen, CONCHA, Néstor O, JANSON, Cheryl A, GILPIN, Martin, BATESON, John H, CHEEVER, Christy, NICONOVICH, Nancy L, PEARSON, Stewart

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1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI) by Heerding, Dirk A, Chan, George, DeWolf, Walter E, Fosberry, Andrew P, Janson, Cheryl A, Jaworski, Deborah D, McManus, Edward, Miller, William H, Moore, Terrance D, Payne, David J, Qiu, Xiayang, Rittenhouse, Stephen F, Slater-Radosti, Courtney, Smith, Ward, Takata, Dennis T, Vaidya, Kalindi S, Yuan, Catherine C.K, Huffman, William F

“…1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal…”
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Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes by GENTRY, Daniel R, INGRAHAM, Karen A, STANHOPE, Michael J, RITTENHOUSE, Stephen, JARVEST, Richard L, O'HANLON, Peter J, BROWN, James R, HOLMES, David J

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New benzylidenethiazolidinediones as antibacterial agents by HEERDING, Dirk A, CHRISTMANN, Lisa T, CLARK, Tammy J, HOLMES, David J, RITTENHOUSE, Stephen F, TAKATA, Dennis T, VENSLAVSKY, Joseph W

“…A novel benzylidenethiazolidinedione has been discovered with antimicrobial activity. Here, we present the results of a structure-activity study on this…”
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In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains by Kohira, Naoki, West, Joshua, Ito, Akinobu, Ito-Horiyama, Tsukasa, Nakamura, Rio, Sato, Takafumi, Rittenhouse, Stephen, Tsuji, Masakatsu, Yamano, Yoshinori

“…S-649266 is a novel siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. Two sets of clinical isolate collections were…”
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Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents by PAYNE, David J, MILLER, William H, HEERDING, Dirk A, JANSON, Cheryl A, JAWORSKI, Deborah D, KELLER, Paul M, MANLEY, Peter J, MOORE, Terrance D, NEWLANDER, Kenneth A, PEARSON, Stewart, POLIZZI, Brian J, XIAYANG QIU, BERRY, Valerie, RITTENHOUSE, Stephen F, SLATER-RADOSTI, Courtney, SALYERS, Kevin L, SEEFELD, Mark A, SMYTH, Martin G, TAKATA, Dennis T, UZINSKAS, Irene N, VAIDYA, Kalindi, WALLIS, Nicola G, WINRAM, Scott B, BROSKY, John, YUAN, Catherine C. K, HUFFMAN, William F, BURGESS, Walter J, CHEN, Emile, DEWOLF, Walter E, FOSBERRY, Andrew P, GREENWOOD, Rebecca, HEAD, Martha S

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Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4- b]indoles as potential antibacterial agents by Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, Payne, David J, Rittenhouse, Stephen F, Moore, Terrance D, DeWolf, Walter E, Keller, Paul M, Qiu, Xiayang, Janson, Cheryl A, Vaidya, Kalindi, Fosberry, Andrew P, Smyth, Martin G, Jaworski, Deborah D, Slater-Radosti, Courtney, Huffman, William F

“…An SAR study of a screening lead has led to the identification of 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4- b]indoles as inhibitors of Staphylococcus…”
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In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria by Ito, Akinobu, Kohira, Naoki, Bouchillon, Samuel K, West, Joshua, Rittenhouse, Stephen, Sader, Helio S, Rhomberg, Paul R, Jones, Ronald N, Yoshizawa, Hidenori, Nakamura, Rio, Tsuji, Masakatsu, Yamano, Yoshinori

“…S-649266 is a parenteral siderophore cephalosporin antibiotic with a catechol moiety on its side chain. The in vitro antimicrobial activity of S-649266 against…”
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