Search Results - "RITCHIE, H"

Basic Mechanisms of Diabetic Heart Disease by Ritchie, Rebecca H., Abel, E. Dale

“…Diabetes mellitus predisposes affected individuals to a significant spectrum of cardiovascular complications, one of the most debilitating in terms of…”
Get full text

Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways by HUYNH, Karina, BERNARDO, Bianca C, MCMULLEN, Julie R, RITCHIE, Rebecca H

“…Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic population. Both experimental and clinical evidence suggest that…”
Get full text

Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments by Peng, Cheng, Stewart, Alastair G, Woodman, Owen L, Ritchie, Rebecca H, Qin, Cheng Xue

“…Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease (NAFLD). Currently, around 25% of the population is estimated to have…”
Get full text

Are targeted therapies for diabetic cardiomyopathy on the horizon? by Tate, Mitchel, Grieve, David J, Ritchie, Rebecca H

“…Diabetes increases the risk of heart failure approximately 2.5-fold, independent of coronary artery disease and other comorbidities. This process, termed…”
Get more information

Phylogenetic relationships among hadal amphipods of the Superfamily Lysianassoidea: Implications for taxonomy and biogeography by Ritchie, H., Jamieson, A.J., Piertney, S.B.

“…Amphipods of the superfamily Lysianassoidea are ubiquitous at hadal depths (>6000m) and therefore are an ideal model group for investigating levels of endemism…”
Get full text

Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications by Sharma, Arpeeta, Tate, Mitchel, Mathew, Geetha, Vince, James E, Ritchie, Rebecca H, de Haan, Judy B

“…It is now increasingly appreciated that inflammation is not limited to the control of pathogens by the host, but rather that sterile inflammation which occurs…”
Get full text

Targeting mitochondrial reactive oxygen species-mediated oxidative stress attenuates nicotine-induced cardiac remodeling and dysfunction by Ramalingam, Anand, Budin, Siti Balkis, Mohd Fauzi, Norsyahida, Ritchie, Rebecca H., Zainalabidin, Satirah

“…Long-term nicotine intake is associated with an increased risk of myocardial damage and dysfunction. However, it remains unclear whether targeting…”
Get full text

Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation by Senchenkova, Elena Y, Ansari, Junaid, Becker, Felix, Vital, Shantel A, Al-Yafeai, Zaki, Sparkenbaugh, Erica M, Pawlinski, Rafal, Stokes, Karen Y, Carroll, Jennifer L, Dragoi, Ana-Maria, Qin, Cheng Xue, Ritchie, Rebecca H, Sun, Hai, Cuellar-Saenz, Hugo H, Rubinstein, Mara R, Han, Yiping W, Orr, A Wayne, Perretti, Mauro, Granger, D Neil, Gavins, Felicity N.E

“…BACKGROUND:Ischemia reperfusion injury (I/RI) is a common complication of cardiovascular diseases. Resolution of detrimental I/RI-generated prothrombotic and…”
Get full text

Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart by Prakoso, Darnel, Lim, Shiang Y, Erickson, Jeffrey R, Wallace, Rachel S, Lees, Jarmon G, Tate, Mitchel, Kiriazis, Helen, Donner, Daniel G, Henstridge, Darren C, Davey, Jonathan R, Qian, Hongwei, Deo, Minh, Parry, Laura J, Davidoff, Amy J, Gregorevic, Paul, Chatham, John C, De Blasio, Miles J, Ritchie, Rebecca H

“…Abstract Aims  The glucose-driven enzymatic modification of myocardial proteins by the sugar moiety, β-N-acetylglucosamine (O-GlcNAc), is increased in…”
Get full text

Guidelines for in vivo mouse models of myocardial infarction by Lindsey, Merry L, Brunt, Keith R, Kirk, Jonathan A, Kleinbongard, Petra, Calvert, John W, de Castro Brás, Lisandra E, DeLeon-Pennell, Kristine Y, Del Re, Dominic P, Frangogiannis, Nikolaos G, Frantz, Stefan, Gumina, Richard J, Halade, Ganesh V, Jones, Steven P, Ritchie, Rebecca H, Spinale, Francis G, Thorp, Edward B, Ripplinger, Crystal M, Kassiri, Zamaneh

“…Despite significant improvements in reperfusion strategies, acute coronary syndromes all too often culminate in a myocardial infarction (MI). The consequent MI…”
Get more information

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice by Qin, Cheng Xue, May, Lauren T., Li, Renming, Cao, Nga, Rosli, Sarah, Deo, Minh, Alexander, Amy E., Horlock, Duncan, Bourke, Jane E., Yang, Yuan H., Stewart, Alastair G., Kaye, David M., Du, Xiao-Jun, Sexton, Patrick M., Christopoulos, Arthur, Gao, Xiao-Ming, Ritchie, Rebecca H.

“…Effective treatment for managing myocardial infarction (MI) remains an urgent, unmet clinical need. Formyl peptide receptors (FPR) regulate inflammation, a…”
Get full text

Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes by Ng, Hooi Hooi, Leo, Chen Huei, Prakoso, Darnel, Qin, Chengxue, Ritchie, Rebecca H., Parry, Laura J.

“…Serelaxin prevents endothelial dysfunction in the mouse aorta ex vivo and inhibits apoptosis in cardiomyocytes under acute hyperglycaemia. Less is known about…”
Get full text

DSPP dosage affects tooth development and dentin mineralization by Lim, Dandrich, Wu, Ko-Chien, Lee, Arthur, Saunders, Thomas L, Ritchie, Helena H

“…Dentin Sialoprotein (DSP) and phosphophoryn (PP) are two most dominant non-collagenous proteins in dentin, which are the cleavage products of the DSPP (dentin…”
Get full text

Distinct contributions of hyperglycemia and high-fat feeding in metabolic syndrome-induced neuroinflammation by Wanrooy, Brooke J, Kumar, Kathryn Prame, Wen, Shu Wen, Qin, Cheng Xue, Ritchie, Rebecca H, Wong, Connie H Y

“…High-fat feeding and hyperglycemia, key risk factors for the development of metabolic syndrome (MetS), are emerging to associate with increased risk of…”
Get full text

Myocardial oxidative stress contributes to transgenic β2‐adrenoceptor activation‐induced cardiomyopathy and heart failure by Xu, Q, Dalic, A, Fang, L, Kiriazis, H, Ritchie, RH, Sim, K, Gao, X‐M, Drummond, G, Sarwar, M, Zhang, Y‐Y, Dart, AM, Du, X‐J

“…BACKGROUND AND PURPOSE While maintaining cardiac performance, chronic β‐adrenoceptor activation eventually exacerbates the progression of cardiac remodelling…”
Get full text

The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction by Sharma, Arpeeta, Rizky, Luddwi, Stefanovic, Nada, Tate, Mitchel, Ritchie, Rebecca H, Ward, Keith W, de Haan, Judy B

“…Vascular dysfunction is a pivotal event in the development of diabetes-associated vascular disease. Increased inflammation and oxidative stress are major…”
Get full text

Relaxin elicits renoprotective actions accompanied by increasing bile acid levels in streptozotocin-induced diabetic mice by Leo, Chen Huei, Ou, Jamie Li Min, Ong, Eng Shi, Qin, Cheng Xue, Ritchie, Rebecca H., Parry, Laura J., Ng, Hooi Hooi

“…The peptide hormone relaxin has potent anti-fibrotic and anti-inflammatory properties in various organs, including the kidneys. However, the protective effects…”
Get full text

The Novel Small-molecule Annexin-A1 Mimetic, Compound 17b, Elicits Vasoprotective Actions in Streptozotocin-induced Diabetic Mice by Marshall, Sarah A, Qin, Cheng Xue, Jelinic, Maria, O'Sullivan, Kelly, Deo, Minh, Walsh, Jesse, Li, Mandy, Parry, Laura J, Ritchie, Rebecca H, Leo, Chen Huei

“…The formyl peptide receptor (FPR) family are a group of G-protein coupled receptors that play an important role in the regulation of inflammatory processes. It…”
Get full text

Nitroxyl (HNO): the Cinderella of the nitric oxide story by Irvine, Jennifer C, Ritchie, Rebecca H, Favaloro, Joanne L, Andrews, Karen L, Widdop, Robert E, Kemp-Harper, Barbara K

“…Until recently, most of the biological effects of nitric oxide (NO) have been attributed to its uncharged state (NO ), yet NO can also exist in the reduced…”
Get full text

Cardioprotective potential of annexin-A1 mimetics in myocardial infarction by Qin, Chengxue, Yang, Yuan H, May, Lauren, Gao, Xiaoming, Stewart, Alastair G, Tu, Yan, Woodman, Owen L, Ritchie, Rebecca H

“…Myocardial infarction (MI) and its resultant heart failure remains a major cause of death in the world. The current treatments for patients with MI are…”
Get full text