Search Results - "RISINGER, John"

Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis by Reske, Jake J, Wilson, Mike R, Holladay, Jeanne, Siwicki, Rebecca A, Skalski, Hilary, Harkins, Shannon, Adams, Marie, Risinger, John I, Hostetter, Galen, Lin, Ken, Chandler, Ronald L

“…TP53 and ARID1A are frequently mutated across cancer but rarely in the same primary tumor. Endometrial cancer has the highest TP53-ARID1A mutual exclusivity…”
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MIG-6 Is Critical for Progesterone Responsiveness in Human Complex Atypical Hyperplasia and Early-Stage Endometrial Cancer by Jeong, Olivia, Broaddus, Russell R, Lessey, Bruce A, Risinger, John I, Hunter, Mark I, Kim, Tae Hoon

“…Women with complex atypical hyperplasia (CAH) or early-stage endometrioid endometrial cancer (EEC) are candidates for fertility preservation. The most common…”
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Pharmacological targeting of polyamine and hypusine biosynthesis reduces tumour activity of endometrial cancer by Kim, Hong Im, Schultz, Chad R., Chandramouli, Gadisetti V. R., Geerts, Dirk, Risinger, John I., Bachmann, André S.

“…Endometrial cancer (EC) is a common and deadly cancer in women and novel therapeutic approaches are urgently needed. Polyamines (putrescine, spermidine,…”
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Ornithine decarboxylase as a therapeutic target for endometrial cancer by Kim, Hong Im, Schultz, Chad R, Buras, Andrea L, Friedman, Elizabeth, Fedorko, Alyssa, Seamon, Leigh, Chandramouli, Gadisetti V R, Maxwell, G Larry, Bachmann, André S, Risinger, John I

“…Ornithine Decarboxylase (ODC) a key enzyme in polyamine biosynthesis is often overexpressed in cancers and contributes to polyamine-induced cell proliferation…”
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The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts by Aprelikova, Olga, Yu, Xiang, Palla, John, Wei, Bih-Rong, John, Simone, Yi, Ming, Stephens, Robert, Simpson, R. Mark, Risinger, John I., Jazaeri, Amir, Niederhuber, John

“…It is well established that there is a dynamic relationship between the expanding tumor and the host surrounding tissue. Cancer-associated fibroblasts (CAFs),…”
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Gene expression in uterine leiomyoma from tumors likely to be growing (from black women over 35) and tumors likely to be non-growing (from white women over 35) by Davis, Barbara J, Risinger, John I, Chandramouli, Gadisetti V R, Bushel, Pierre R, Baird, Donna Day, Peddada, Shyamal D

“…The study of uterine leiomyomata (fibroids) provides a unique opportunity to investigate the physiological and molecular determinants of hormone dependent…”
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MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT by Yoo, Jung-Yoon, Kang, Hee-Bum, Broaddus, Russell R, Risinger, John I, Choi, Kyung-Chul, Kim, Tae Hoon

“…Aberrant hyperactivation of epithelial proliferation, AKT signaling, and association with unopposed estrogen (E2) exposure is the most common endometrial…”
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MicroRNAs in endometrial cancers from black and white patients by Maxwell, G. Larry, MD, Shoji, Yutaka, PhD, Darcy, Kathleen, PhD, Litzi, Tracy, MS, Berchuck, Andrew, MD, Hamilton, Chad A., MD, Conrads, Thomas P., PhD, Risinger, John I., PhD

“…Objective Previous studies have identified differences in gene mutations among endometrial cancers from whites and blacks suggesting that differences in tumor…”
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Nuclear PTEN Localization Contributes to DNA Damage Response in Endometrial Adenocarcinoma and Could Have a Diagnostic Benefit for Therapeutic Management of the Disease by Mukherjee, Ananda, Patterson, Amanda L, George, Jitu W, Carpenter, Tyler J, Madaj, Zachary B, Hostetter, Galen, Risinger, John I, Teixeira, Jose M

“…Endometrial adenocarcinoma (EndoCA) is the most common gynecologic cancer type in the United States, and its incidence is increasing. The majority of patients…”
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Metronomic dosing of ovarian cancer cells with the ATR inhibitor AZD6738 leads to loss of CDC25A expression and resistance to ATRi treatment by Ao, Wei, Kim, Hong Im, Tommarello, Domenic, Conrads, Kelly A., Hood, Brian L., Litzi, Tracy, Abulez, Tamara, Teng, Pang-Ning, Dalgard, Clifton L., Zhang, Xijun, Wilkerson, Matthew D., Darcy, Kathleen M., Tarney, Christopher M., Phippen, Neil T., Bakkenist, Christopher J., Maxwell, G. Larry, Conrads, Thomas P., Risinger, John I., Bateman, Nicholas W.

“…OBJECTIVEATR kinase inhibitors promote cell killing by inducing replication stress and through potentiation of genotoxic agents in gynecologic cancer cells. To…”
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Human Ovarian Cancer Tumor Formation in Severe Combined Immunodeficient (SCID) Pigs by Boettcher, Adeline N, Kiupel, Matti, Adur, Malavika K, Cocco, Emiliano, Santin, Alessandro D, Bellone, Stefania, Charley, Sara E, Blanco-Fernandez, Barbara, Risinger, John I, Ross, Jason W, Tuggle, Christopher K, Shapiro, Erik M

“…Ovarian cancer (OvCa) is the most lethal gynecologic malignancy, with two-thirds of patients having late-stage disease (II-IV) at diagnosis. Improved diagnosis…”
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An immune competent orthotopic model of endometrial cancer with metastasis by Fedorko, Alyssa M., Kim, Tae Hoon, Broaddus, Russell, Schmandt, Rosemarie, Chandramouli, Gadisetti V.R., Kim, Hong Im, Jeong, Jae-Wook, Risinger, John I.

“…Endometrial cancer is the most common gynecologic malignancy in the U.S. with metastatic disease remaining the major cause of patient death. Therapeutic…”
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Improving Risk Assessment for Metastatic Disease in Endometrioid Endometrial Cancer Patients Using Molecular and Clinical Features: An NRG Oncology/Gynecologic Oncology Group Study by Casablanca, Yovanni, Wang, Guisong, Lankes, Heather A, Tian, Chunqiao, Bateman, Nicholas W, Miller, Caela R, Chappell, Nicole P, Havrilesky, Laura J, Wallace, Amy Hooks, Ramirez, Nilsa C, Miller, David S, Oliver, Julie, Mitchell, Dave, Litzi, Tracy, Blanton, Brian E, Lowery, William J, Risinger, John I, Hamilton, Chad A, Phippen, Neil T, Conrads, Thomas P, Mutch, David, Moxley, Katherine, Lee, Roger B, Backes, Floor, Birrer, Michael J, Darcy, Kathleen M, Maxwell, George Larry

“…A risk assessment model for metastasis in endometrioid endometrial cancer (EEC) was developed using molecular and clinical features, and prognostic association…”
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PPP2R1A mutations are common in the serous type of endometrial cancer by Nagendra, Deepak C., Burke III, James, Maxwell, G. Larry, Risinger, John I.

“…Recently unbiased sequencing efforts identified PPP2R1A mutations in clear cell ovarian cancers (OCC). Similar mutations were also noted with high frequency in…”
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Proteomics of the human endometrial glandular epithelium and stroma from the proliferative and secretory phases of the menstrual cycle by Hood, Brian L, Liu, Baoquan, Alkhas, Addie, Shoji, Yutaka, Challa, Rusheeswar, Wang, Guisong, Ferguson, Susan, Oliver, Julie, Mitchell, Dave, Bateman, Nicholas W, Zahn, Christopher M, Hamilton, Chad A, Payson, Mark, Lessey, Bruce, Fazleabas, Asgerally T, Maxwell, G Larry, Conrads, Thomas P, Risinger, John I

“…Despite its importance in reproductive biology and women's health, a detailed molecular-level understanding of the human endometrium is lacking. Indeed, no…”
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Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Promotes Uterine Serous Cancer Cell Proliferation and Cell Cycle Progression by Kwan, Suet-Ying, Au-Yeung, Chi-Lam, Yeung, Tsz-Lun, Rynne-Vidal, Angela, Wong, Kwong-Kwok, Risinger, John I, Lin, Hui-Kuan, Schmandt, Rosemarie E, Yates, Melinda S, Mok, Samuel C, Lu, Karen H

“…Uterine serous carcinoma (USC) is the most aggressive form of endometrial cancer, with poor survival rates and high recurrence risk. Therefore, the purpose of…”
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Evaluation of a Patient With Non-Myoinvasive Uterine Serous Carcinoma Confined to a Polyp and Positive Peritoneal Washings With Somatic ARHGAP35 and KRAS Mutations by Silverwood, Sierra M, Lagstein, Amir, Risinger, John I, Gressel, Gregory

“…Currently, the application of peritoneal washings as a diagnostic tool for endometrial cancer staging is not well defined. The case described aims to highlight…”
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Human Ovarian Cancer Stroma Contains Luteinized Theca Cells Harboring Tumor Suppressor Gene GT198 Mutations by Peng, Min, Zhang, Hao, Jaafar, Lahcen, Risinger, John I., Huang, Shuang, Mivechi, Nahid F., Ko, Lan

“…Ovarian cancer is a highly lethal gynecological cancer, and its causes remain to be understood. Using a recently identified tumor suppressor gene, GT198…”
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Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes by VATOLIN, Sergei, ABDULLAEV, Ziedulla, RISINGER, John I, BARRETT, J. Carl, LOBANENKOV, Victor V, PACK, Svetlana D, FLANAGAN, Patrick T, CUSTER, Mary, LOUKINOV, Dmitri I, PUGACHEVA, Elena, HONG, Julie A, MORSE, Herbert III, SCHRUMP, David S

“…Brother of the Regulator of Imprinted Sites (BORIS) is a mammalian CTCF paralog with the same central 11Zn fingers (11ZF) that mediate specific interactions…”
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Racial disparities in blacks with gynecologic cancers by Farley, John, Risinger, John I., Rose, G. Scott, Maxwell, G. Larry

“…Black women have a lower incidence of gynecologic cancers but they have a higher mortality associated with their disease. The etiology of the racial disparity…”
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