Search Results - "RISHI, Arun K"

Tumor hypoxia directed multimodal nanotherapy for overcoming drug resistance in renal cell carcinoma and reprogramming macrophages by Alsaab, Hashem O., Sau, Samaresh, Alzhrani, Rami M., Cheriyan, Vino T., Polin, Lisa A., Vaishampayan, Ulka, Rishi, Arun K., Iyer, Arun K.

“…Drug resistance is one of the significant clinical burden in renal cell carcinoma (RCC). The development of drug resistance is attributed to many factors,…”
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Polysaccharide hydrogel based 3D printed tumor models for chemotherapeutic drug screening by Gebeyehu, Aragaw, Surapaneni, Sunil Kumar, Huang, John, Mondal, Arindam, Wang, Vivian Ziwen, Haruna, Nana Fatima, Bagde, Arvind, Arthur, Peggy, Kutlehria, Shallu, Patel, Nil, Rishi, Arun K., Singh, Mandip

“…A series of stable and ready-to-use bioinks have been developed based on the xeno-free and tunable hydrogel (VitroGel) system. Cell laden scaffold fabrication…”
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Upregulation of miR-150 and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R by Farhana, Lulu, Dawson, Marcia I, Murshed, Farhan, Das, Jayanta K, Rishi, Arun K, Fontana, Joseph A

“…MicroRNAs have been implicated in many critical cellular processes including apoptosis. We have previously found that apoptosis in pancreatic cancer cells was…”
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Adaptor proteins mediate CXCR4 and PI4KA crosstalk in prostate cancer cells and the significance of PI4KA in bone tumor growth by Govindarajan, Barani, Sbrissa, Diego, Pressprich, Mark, Kim, Seongho, Rishi, Arun K., Vaishampayan, Ulka, Cher, Michael L., Chinni, Sreenivasa R.

“…The chemokine receptor, CXCR4 signaling regulates cell growth, invasion, and metastasis to the bone-marrow niche in prostate cancer (PCa). Previously, we…”
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Curcumin enhances the effects of 5‐fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF‐1R by Patel, Bhaumik B., Sengupta, Radha, Qazi, Sadia, Vachhani, Hetal, Yu, Yingjie, Rishi, Arun K., Majumdar, Adhip P.N.

“…Curcumin (diferuloylmethane), which has been shown to inhibit growth of transformed cells, has no discernible toxicity and achieves high levels in colonic…”
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Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis by Cheriyan, Vino T, Wang, Ying, Muthu, Magesh, Jamal, Shazia, Chen, Di, Yang, Huanjie, Polin, Lisa A, Tarca, Adi L, Pass, Harvey I, Dou, Q Ping, Sharma, Sunita, Wali, Anil, Rishi, Arun K

“…Dithiocarbamate compound Disulfiram (DSF) that binds with copper and functions as an inhibitor of aldehyde dehydrogenase is a Food and Drug Administration…”
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Withaferin A inhibits the proteasome activity in mesothelioma in vitro and in vivo by Yang, Huanjie, Wang, Ying, Cheryan, Vino T, Wu, Wenjuan, Cui, Cindy Qiuzhi, Polin, Lisa A, Pass, Harvey I, Dou, Q Ping, Rishi, Arun K, Wali, Anil

“…The medicinal plant Withania somnifera has been used for over centuries in Indian Ayurvedic Medicine to treat a wide spectrum of disorders. Withaferin A (WA),…”
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Phosphorylation of cell cycle and apoptosis regulatory protein-1 by stress activated protein kinase P38γ is a novel mechanism of apoptosis signaling by genotoxic chemotherapy by Venkatesh, Jaganathan, Muthu, Magesh, Singaravelu, Indulekha, Cheriyan, Vino T, Sekhar, Sreeja C, Acharige, Nuwan C P N, Levi, Edi, Assad, Hadeel, Pflum, Mary Kay H, Rishi, Arun K

“…CARP-1, a perinuclear phospho-protein, regulates cell survival and apoptosis signaling induced by genotoxic drugs. However, kinase(s) phosphorylating CARP-1…”
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Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis by Khan, Islauddin, Kaur, Sukhmandeep, Rishi, Arun K, Boire, Breana, Aare, Mounika, Singh, Mandip

“…In this study, we investigated in detail the role of cannabidiol (CBD), beta-caryophyllene (BC), or their combinations in diabetic peripheral neuropathy (DN)…”
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Myc mediates cancer stem-like cells and EMT changes in triple negative breast cancers cells by Yin, Shuping, Cheryan, Vino T, Xu, Liping, Rishi, Arun K, Reddy, Kaladhar B

“…Women with triple negative breast cancer (TNBC) have poor prognosis compared to other breast cancer subtypes. There were several reports indicating racial…”
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Combined Ubisol-Q10 and Ashwagandha Root Extract Target Multiple Biochemical Mechanisms and Reduces Neurodegeneration in a Paraquat-Induced Rat Model of Parkinson’s Disease by Vegh, Caleb, Wear, Darcy, Okaj, Iva, Huggard, Rachel, Culmone, Lauren, Eren, Sezen, Cohen, Jerome, Rishi, Arun K., Pandey, Siyaram

“…Parkinson’s disease (PD) is characterized by progressive neurodegeneration in the substantia nigra (SN) region resulting in loss of movement coordination…”
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SM22α suppresses cytokine-induced inflammation and the transcription of NF-κB inducing kinase (Nik) by modulating SRF transcriptional activity in vascular smooth muscle cells by Dai, Xiaohua, Thiagarajan, Devi, Fang, Jingye, Shen, Jianbin, Annam, Neeraja Priyanka, Yang, Zhao, Jiang, Hong, Ju, Donghong, Xie, Youming, Zhang, Kezhong, Tseng, Yan Yuan, Yang, Zhe, Rishi, Arun K, Li, Hui J, Yang, Maozhou, Li, Li

“…Vascular smooth muscle cell (VSMC) phenotypic modulation is characterized by the downregulation of SMC actin cytoskeleton proteins. Our published study shows…”
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Formulation, Pharmacokinetic, and Efficacy Studies of Mannosylated Self-Emulsifying Solid Dispersions of Noscapine by Andey, Terrick, Patel, Apurva, Marepally, Srujan, Chougule, Mahavir, Spencer, Shawn D, Rishi, Arun K, Singh, Mandip

“…To formulate hydroxypropyl methylcellulose-stabilized self-emulsifying solid dispersible carriers of noscapine to enhance oral bioavailability. Formulation of…”
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Akt, FoxO and regulation of apoptosis by Zhang, Xinbo, Tang, Naimei, Hadden, Timothy J., Rishi, Arun K.

“…Forkhead box O (FoxO) transcription factors are downstream targets of the serine/threonine protein kinase B (PKB)/Akt. The Akt kinase regulates processes of…”
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Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells by Nottingham, Ebony, Mazzio, Elizabeth, Surapaneni, Sunil Kumar, Kutlehria, Shallu, Mondal, Arindam, Badisa, Ramesh, Safe, Stephen, Rishi, Arun K., Singh, Mandip

“…Non-small cell lung cancer (NSCLC) is often characterized by an underlying mutation in the epidermal growth factor receptor (EGFR), contributing to aggressive…”
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Mechanisms of neuroblastoma cell growth inhibition by CARP-1 functional mimetics by Muthu, Magesh, Cheriyan, Vino T, Munie, Sara, Levi, Edi, Frank, John, Ashour, Abdelkader E, Singh, Mandip, Rishi, Arun K

“…Neuroblastomas (NBs) are a clinically heterogeneous group of extra cranial pediatric tumors. Patients with high-risk, metastatic NBs have a long-term survival…”
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CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth by Ashour, Abdelkader E, Jamal, Shazia, Cheryan, Vino T, Muthu, Magesh, Zoheir, Khairy M A, Alafeefy, Ahmed M, Abd-Allah, Adel R, Levi, Edi, Tarca, Adi L, Polin, Lisa A, Rishi, Arun K

“…Medulloblastomas (MBs) constitute an aggressive class of intracranial pediatric tumors. Current multimodality treatments for MBs include surgery, ionizing…”
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CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells by Jamal, Shazia, Cheriyan, Vino T, Muthu, Magesh, Munie, Sara, Levi, Edi, Ashour, Abdelkader E, Pass, Harvey I, Wali, Anil, Singh, Mandip, Rishi, Arun K

“…Malignant pleural mesothelioma (MPM) is an asbestos-related thoracic malignancy that is characterized by late metastases, and resistance to therapeutic…”
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Enhanced oral bioavailability and in vitro evaluation of cannabidiol camel milk-derived exosome formulation in resistant MDA-MB-231 and MDA-MB-468 breast cancer cells by Aare, Mounika, Bagde, Arvind, Nathani, Aakash, Rishi, Arun K., Singh, Mandip

“…[Display omitted] •In this study, the potential of Camel milk-derived exosomes (CMDE) to enhance the bioavailability of CBD was explored.•CBD loaded CMDE…”
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Identification and Testing of Novel CARP-1 Functional Mimetic Compounds as Inhibitors of Non-Small Cell Lung and Triple Negative Breast Cancers by Muthu, Magesh, Somagoni, Jaganmohan, Cheriyan, Vino T, Munie, Sara, Levi, Edi, Ashour, Abdelkader E, Yassin, Alaa Eldeen B, Alafeefy, Ahmed M, Sochacki, Paula, Polin, Lisa A, Reddy, Kaladhar B, Larsen, Scott D, Singh, Mandip, Rishi, Arun K

“…The triple negative breast cancer (TNBCs) and non-small cell lung cancers (NSCLCs) often acquire mutations that contribute to failure of drugs in clinic and…”
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