Search Results - "RISCOE, M. K"

Structure of E. coli 5′-methylthioadenosine/S-adenosylhomocysteine Nucleosidase Reveals Similarity to the Purine Nucleoside Phosphorylases by Lee, Jeffrey E., Cornell, Kenneth A., Riscoe, Michael K., Howell, P.Lynne

“…Background: 5′-methylthioadenosine/S-adenosyl-homocysteine (MTA/AdoHcy) nucleosidase catalyzes the irreversible cleavage of 5′-methylthioadenosine and…”
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Potentiation of an antimalarial oxidant drug by WINTER, R. W, IGNATUSHCHENKO, M, OGUNDAHUNSI, O. A. T, CORNELL, K. A, ODUOLA, A. M. J, HINRICHS, D. J, RISCOE, M. K

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Potentiation of the antimalarial agent rufigallol by WINTER, R. W, CORNELL, K. A, JOHNSON, L. L, IGNATUSHCHENKO, M, HINRICHS, D. J, RISCOE, M. K

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Expression, purification, crystallization and preliminary X-ray analysis of Escherichia coli 5′-­methylthioadenosine/S-adenosylhomocysteine nucleosidase by Lee, Jeffrey E., Cornell, Kenneth A., Riscoe, Michael K., Howell, P. Lynne

“…A recombinant form of Escherichia coli 5′‐methylthioadenosine/S‐­adenosylhomocysteine nucleosidase (E.C. 3.2.2.9) has been purified to homogeneity and…”
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Analogs of 5-methylthioribose, a novel class of antiprotozoal agents by RISCOE, M. K, FERRO, A. J, FITCHEN, J. H

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Structural Snapshots of MTA/AdoHcy Nucleosidase Along the Reaction Coordinate Provide Insights into Enzyme and Nucleoside Flexibility During Catalysis by Lee, Jeffrey E., Smith, G.David, Horvatin, Cathy, Huang, David J.T., Cornell, Kenneth A., Riscoe, Michael K., Howell, P.Lynne

“…MTA/AdoHcy nucleosidase (MTAN) irreversibly hydrolyzes the N9-C1′ bond in the nucleosides, 5′-methylthioadenosine (MTA) and S-adenosylhomocysteine (AdoHcy) to…”
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Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis by Lee, Jeffrey E, Cornell, Kenneth A, Riscoe, Michael K, Howell, P Lynne

“…5'-Methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase is a key enzyme in a number of critical biological processes in many microbes. This…”
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Synergistic activity of 5-trifluoromethylthioribose and inhibitors of methionine synthesis against Klebsiella pneumoniae by TOWER, P. A, JOHNSON, L. L, FERRO, A. J, FITCHEN, J. H, RISCOE, M. K

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Selective killing of Klebsiella pneumoniae by 5-trifluoromethylthioribose. Chemotherapeutic exploitation of the enzyme 5-methylthioribose kinase by GIANOTTI, A J, TOWER, P. A, SHELEY, J. H, CONTE, P. A, SPIRO, C, FERRO, A. J, FITCHEN, J. H, RISCOE, M. K

“…5'-Deoxy-5'-methylthioadenosine (MTA), an important intermediate in methionine recycling, can be metabolized by one of two mechanisms that appear to be…”
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Methylthioadenosine Phosphorylase Deficiency in Acute Leukemia: Pathologic, Cytogenetic, and Clinical Features by Traweek, S. Thomas, Riscoe, Michael K., Ferro, Adolph J., Braziel, Rita M., Magenis, R. Ellen, Fitchen, John H.

“…Blast cells from 100 cases of acute leukemia were evaluated for the presence of methylthioadenosine phosphorylase (MTAase), an enzyme important in polyamine…”
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5-Methylthioribose. Its effects and function in mammalian cells by Riscoe, M K, Ferro, A J

“…The growth responses of 5-deoxy-5-methylthioribose on a 5'-deoxy-5'-methylthioadenosine phosphorylase containing cell line (BW5147) and the methylthioadenosine…”
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Xanthones as antimalarial agents; studies of a possible mode of action by Ignatushchenko, Marina V., Winter, R.W., Bächinger, Hans Peter, Hinrichs, David J., Riscoe, Michael K.

“…We recently demonstrated that 2,3,4,5,6-pentahydroxyxanthone (X5) inhibits the in vitro growth of both chloroquine-sensitive and multidrug-resistant strains of…”
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Methylthioadenosine phosphorylase deficiency in human leukemias and solid tumors by FITCHEN, J. H, RISCOE, M. K, DANA, B. W, LAWRENCE, H. J, FERRO, A. J

“…5'-Methylthioadenosine (MTA) is a naturally occurring nucleoside which is degraded by MTA phosphorylase (MTAase) to adenine and methylthioribose-1-phosphate in…”
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Purine metabolism as a target for leukemia chemotherapy by Riscoe, M K, Brouns, M C, Fitchen, J H

“…This article focuses on the chemotherapeutic agents which alter purine metabolism as a means to achieve selective killing of leukemic cells. We present an…”
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Mechanism of action of 5'-methylthioadenosine in S49 cells by Riscoe, M K, Tower, P A, Ferro, A J

“…5'-Deoxy-5'-methylthioadenosine, a naturally occurring co-product of polyamine biosynthesis, has been shown to inhibit a variety of biological processes. To…”
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Effect of 5'-methylthioadenosine (a naturally occurring nucleoside) on murine hematopoiesis by Wolford, R W, Riscoe, M K, Johnson, L, Ferro, A J, Fitchen, J H

“…5'-Methylthioadenosine (MTA), a naturally occurring nucleoside, inhibited in vitro colony formation by murine erythroid (CFU-E) and granulocyte-macrophage…”
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Inhibition of growth but not differentiation of normal and leukemic myeloid cells by methylthioadenosine by RISCOE, M. K, SCHWAMBORN, J, FERRO, A. J, OLSON, K. D, FITCHEN, J. H

“…Methylthioadenosine (MTA), a coproduct of polyamine biosynthesis, is known to inhibit proliferation in a variety of cell culture systems. In this paper, we…”
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Antimalarial quinolones: Synthesis, potency, and mechanistic studies by Winter, Rolf W., Kelly, Jane X., Smilkstein, Martin J., Dodean, Rozalia, Hinrichs, David, Riscoe, Michael K.

“…In the present article we examine the antiplasmodial activities of novel quinolone derivatives bearing extended alkyl or alkoxy side chains terminated by a…”
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Cloning and expression of Escherichia coli 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase: Identification of the pfs gene product by Cornell, Kenneth A, Riscoe, Michael K

“…The enzyme 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase (EC 3.2.2.9) is responsible for cleavage of the glycosidic bond in both…”
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Evaluation and lead optimization of anti-malarial acridones by Winter, Rolf W., Kelly, Jane X., Smilkstein, Martin J., Dodean, Rozalia, Bagby, Grover C., Rathbun, R. Keaney, Levin, Joshua I., Hinrichs, David, Riscoe, Michael K.

“…With 2-methoxy-6-chloroacridone as a lead compound, we synthesized and tested acridone derivatives to develop a better understanding of the anti-malarial…”
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