Search Results - "RING, B. J"

Three- and Four-Dimensional-Quantitative Structure Activity Relationship (3D/4D-QSAR) Analyses of CYP2C9 Inhibitors by EKINS, S, BRAVI, G, BINKLEY, S, GILLESPIE, J. S, RING, B. J, WIKEL, J. H, WRIGHTON, S. A

“…The interaction of competitive type inhibitors with the active site of cytochrome P450 (CYP) 2C9 has been predicted using three- and four-dimensional…”
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Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine by WRIGHTON, S. A, RING, B. J

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Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine by Ring, B J, Catlow, J, Lindsay, T J, Gillespie, T, Roskos, L K, Cerimele, B J, Swanson, S P, Hamman, M A, Wrighton, S A

“…The formation kinetics of 2-hydroxymethyl olanzapine (2-OH olanzapine), 4'-N-oxide olanzapine (N-O olanzapine) and 4'-N-desmethyl olanzapine (NdM olanzapine)…”
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Identification of a polymorphically expressed member of the human cytochrome P-450III family by Wrighton, S A, Ring, B J, Watkins, P B, VandenBranden, M

“…The human liver cytochrome P-450III family contains two highly related forms of cytochrome P-450 (P450), HLp and P450NF, that are expressed in the adult and a…”
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Autoactivation and activation of the cytochrome P450s by Ekins, S, Ring, B J, Binkley, S N, Hall, S D, Wrighton, S A

“…In order to reliably predict in vivo pharmacokinetic parameters from in vitro data, we must thoroughly understand the systems we currently use to determine…”
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Effect of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline on human CYP3A catalyzed 1'-hydroxy midazolam formation in vitro by Ring, B J, Binkley, S N, Roskos, L, Wrighton, S A

“…The ability of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline to inhibit the CYP3A subfamily of cytochromes P450 was examined in vitro, using…”
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Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine by Ring, B J, Eckstein, J A, Gillespie, J S, Binkley, S N, VandenBranden, M, Wrighton, S A

“…The formation of R- and S-norfluoxetine was analyzed in vitro in human liver microsomes. Low apparent K(m) values for R-norfluoxetine formation of < or =8…”
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In vitro interaction of the antipsychotic agent olanzapine with human cytochromes P450 CYP2C9, CYP2C19, CYP2D6 and CYP3A by RING, BARBARA J., BINKLEY, SHELLY N., VANDENBRANDEN, MARK, WRIGHTON, STEVEN A.

“…1 The ability of olanzapine to inhibit the metabolism of marker catalytic activities for the cytochromes P450 CYP3A, CYP2D6, CYP2C9, and CYP2C19 was examined…”
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The use of in vitro metabolism techniques in the planning and interpretation of drug safety studies by Wrighton, S A, Ring, B J, VandenBranden, M

“…An important issue in toxicology is the suitability of the data obtained with experimental animals for human risk assessment. Because it is not possible to use…”
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Alterations of the Catalytic Activities of Drug-Metabolizing Enzymes in Cultures of Human Liver Slices by VANDENBRANDEN, M, WRIGHTON, S. A, EKINS, S, GILLESPIE, J. S, BINKLEY, S. N, RING, B. J, GADBERRY, M. G, MULLINS, D. C, STROM, S. C, JENSEN, C. B

“…Precision-cut human liver slices are an important tool for defining the metabolism and hepatotoxicity of drug candidates early in development. Because of the…”
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PREDICTING DRUG INTERACTIONS AND PHARMACOKINETIC VARIABILITY WITH IN VITRO METHODS: THE OLANZAPINE EXPERIENCE by WRIGHTON, STEVEN A., RING, BARBARA J.

“…It is currently possible to gain an understanding of the ability of a new compound to interact with the various human P450s. Further, it is also possible to…”
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In vitro methods for assessing human hepatic drug metabolism: their use in drug development by Wrighton, S A, Vandenbranden, M, Stevens, J C, Shipley, L A, Ring, B J, Rettie, A E, Cashman, J R

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In vitro metabolism of zatosetron. Interspecies comparison and role of CYP 3A by Ring, B J, Parli, C J, George, M C, Wrighton, S A

“…The major in vivo human metabolite of zatosetron is 8-alpha-methyl,8-beta-oxo zatosetron [N-O (1) zatosetron]. N-Desmethyl zatosetron (NdM zatosetron) and…”
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A population approach to enzyme characterization and identification : Application to phenacetin O-deethylation by BELLE, Donna J, RING, Barbara J, ALLERHEILIGEN, Sandra R. B, HEATHMAN, Michael A, O'BRIEN, Lisa M, SINHA, Vikram, ROSKOS, Lorin K, WRIGHTON, Steven A

“…To determine the enzyme kinetics (EK) and identify the human cytochrome(s) P450 (CYP) involved in the deethylation of phenacetin to acetaminophen using a…”
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Inversion of real time spot prices in the direction of real power flow in a transmission line by Ward, A.G., Watson, N.R., Arnold, C.P., Turner, A.J., Ring, B.J.

“…An increasing number of electricity markets employing some form of spot pricing. However, limited experience of the behavior of spot prices exists. This paper…”
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Present and future in vitro approaches for drug metabolism by Ekins, Sean, Ring, Barbara J., Grace, James, McRobie-Belle, Donna J., Wrighton, Steven A.

“…The 1980s through 1990s witnessed the widespread incorporation of in vitro absorption, distribution, metabolism, and excretion (ADME) approaches into drug…”
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Three- and four-dimensional quantitative structure activity relationship analyses of cytochrome P-450 3A4 inhibitors by Ekins, S, Bravi, G, Binkley, S, Gillespie, J S, Ring, B J, Wikel, J H, Wrighton, S A

“…The program Catalyst was used to build three-dimensional quantitative structure activity relationship (3D-QSAR) pharmacophore models of the structural features…”
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Further characterization of the expression in liver and catalytic activity of CYP2B6 by Ekins, S, Vandenbranden, M, Ring, B J, Gillespie, J S, Yang, T J, Gelboin, H V, Wrighton, S A

“…Previous studies in this laboratory have determined the lack of specificity of several antibody and substrate probes of CYP2B6. The goals of the current study…”
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Computed temperature distributions around ectatic capillaries exposed to yellow (578 nm) laser light by Pickering, J W, Butler, P H, Ring, B J, Walker, E P

“…We have numerically modelled the thermal effects of yellow (577 or 578 nm) light illumination on the ectatic blood vessels of port wine stains. We investigated…”
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Three-dimensional quantitative structure activity relationship analyses of substrates for CYP2B6 by Ekins, S, Bravi, G, Ring, B J, Gillespie, T A, Gillespie, J S, Vandenbranden, M, Wrighton, S A, Wikel, J H

“…To begin to build an understanding of the interactions of CYP2B6 with substrates, two different 3-dimensional quantitative structure activity relationship…”
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