Search Results - "RILEY, Graham J"

Epigenetic Regulator CoREST Controls Social Behavior in Ants by Glastad, Karl M., Graham, Riley J., Ju, Linyang, Roessler, Julian, Brady, Cristina M., Berger, Shelley L.

“…Ants acquire distinct morphological and behavioral phenotypes arising from a common genome, underscoring the importance of epigenetic regulation. In Camponotus…”
Get full text

Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus by Simola, Daniel F., Graham, Riley J., Brady, Cristina M., Enzmann, Brittany L., Desplan, Claude, Ray, Anandasankar, Zwiebel, Laurence J., Bonasio, Roberto, Reinberg, Danny, Liebig, Jürgen, Berger, Shelley L.

“…Eusocial insects organize themselves into behavioral castes whose regulation has been proposed to involve epigenetic processes, including histone modification…”
Get full text

Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist by Hagan, Jim J, Price, Gary W, Jeffrey, Phillip, Deeks, Nigel J, Stean, Tania, Piper, David, Smith, Martin I, Upton, Neil, Medhurst, Andrew D, Middlemiss, Derek N, Riley, Graham J, Lovell, Peter J, Bromidge, Steven M, Thomas, David R

“…The novel 5‐HT7 receptor antagonist, SB‐269970‐A, potently displaced [3H]‐5‐CT from human 5‐HT7(a) (pKi 8.9±0.1) and 5‐HT7 receptors in guinea‐pig cortex (pKi…”
Get full text

Design and Synthesis of trans-3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1H-3-benzazepine (SB-414796):  A Potent and Selective Dopamine D3 Receptor Antagonist by Macdonald, Gregor J, Branch, Clive L, Hadley, Michael S, Johnson, Christopher N, Nash, David J, Smith, Alexander B, Stemp, Geoffrey, Thewlis, Kevin M, Vong, Antonio K. K, Austin, Nigel E, Jeffrey, Phillip, Winborn, Kim Y, Boyfield, Izzy, Hagan, Jim J, Middlemiss, Derek N, Reavill, Charlie, Riley, Graham J, Watson, Jeannette M, Wood, Martyn, Parker, Steve G, Ashby, Charles R

“…At their clinical doses, current antipsychotic agents share the property of both dopamine D2 and D3 receptor blockade. However, a major disadvantage of many…”
Get full text

Biarylcarbamoylindolines Are Novel and Selective 5-HT2C Receptor Inverse Agonists:  Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent by Bromidge, Steven M, Dabbs, Steven, Davies, David T, Davies, Susannah, Duckworth, D. Malcolm, Forbes, Ian T, Gaster, Laramie M, Ham, Peter, Jones, Graham E, King, Frank D, Mulholland, Keith R, Saunders, Damian V, Wyman, Paul A, Blaney, Frank E, Clarke, Stephen E, Blackburn, Thomas P, Holland, Vicky, Kennett, Guy A, Lightowler, Sean, Middlemiss, Derek N, Trail, Brenda, Riley, Graham J, Wood, Martyn D

“…The evolution, synthesis, and biological activity of a novel series of 5-HT2C receptor inverse agonists are reported. Biarylcarbamoylindolines have been…”
Get full text

Identification of a novel series of selective 5-HT7 receptor antagonists by FORBES, Ian T, COOPER, David G, RILEY, Graham J, THOMAS, David R, DODDS, Emma K, DOUGLAS, Sara E, GRIBBLE, Andrew D, IFE, Robert J, LIGHTFOOT, Andrew P, MEESON, Malcolm, CAMPBELL, Lorraine P, COLEMAN, Tanya

“…Novel 5-HT(7) receptor antagonists containing the benzocycloheptanone core were identified from high throughput screening. Molecular modelling and SAR studies…”
Get full text

Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor by Orlek, Barry S, Blaney, Frank E, Brown, Frank, Clark, Michael S. G, Hadley, Michael S, Hatcher, John, Riley, Graham J, Rosenberg, Howard E, Wadsworth, Harry J, Wyman, Paul

“…The link between the cognitive deficit associated with Alzheimer type dementia and the loss of cholinergic function in the disease provides a basis for…”
Get full text

A Novel, Potent, and Selective 5-HT7 Antagonist:  (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970) by Lovell, Peter J, Bromidge, Steven M, Dabbs, Steven, Duckworth, D. Malcolm, Forbes, Ian T, Jennings, Andrew J, King, Frank D, Middlemiss, Derek N, Rahman, Shirley K, Saunders, Damian V, Collin, Lissa L, Hagan, Jim J, Riley, Graham J, Thomas, David R

Get full text

3,4-Dihydro-2H-benzoxazinones are 5-HT1A receptor antagonists with potent 5-HT reuptake inhibitory activity by ATKINSON, Peter J, BROMIDGE, Steven M, RAMI, Harshad K, RILEY, Graham J, SCOTT, Claire M, SHAW, Tracey E, STARR, Kathryn R, STEMP, Geoffrey, THEWLIS, Kevin M, THOMAS, David R, THOMPSON, Mervyn, VONG, Antonio K. K, DUXON, Mark S, WATSON, Jeannette M, GASTER, Laramie M, HADLEY, Michael S, HAMMOND, Beverley, JOHNSON, Christopher N, MIDDLEMISS, Derek N, NORTH, Stephanie E, PRICE, Gary W

Get full text

Design and Synthesis of trans-N-[4-[2-(6-Cyano-1,2,3,4-tetrahydroisoquinolin-2- yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011):  A Potent and Selective Dopamine D3 Receptor Antagonist with High Oral Bioavailability and CNS Penetration in the Rat by Stemp, Geoffrey, Ashmeade, Tracey, Branch, Clive L, Hadley, Michael S, Hunter, A. Jacqueline, Johnson, Christopher N, Nash, David J, Thewlis, Kevin M, Vong, Antonio K. K, Austin, Nigel E, Jeffrey, Phillip, Avenell, Kim Y, Boyfield, Izzy, Hagan, Jim J, Middlemiss, Derek N, Reavill, Charlie, Riley, Graham J, Routledge, Carole, Wood, Martyn

“…A selective dopamine D3 receptor antagonist offers the potential for an effective antipsychotic therapy, free of the serious side effects of currently…”
Get full text

SB-656104-A: A novel 5-HT7 receptor antagonist with improved in vivo properties by FORBES, Ian T, DOUGLAS, Sara, THOMAS, David R, GRIBBLE, Andrew D, IFE, Robert J, LIGHTFOOT, Andrew P, GARNER, Ashley E, RILEY, Graham J, JEFFREY, Phillip, STEVENS, Alexander J, STEAN, Tania O

Get full text

Evidence for antagonist activity of the dopamine D3 receptor partial agonist, BP 897, at human dopamine D3 receptor by Wood, Martyn D, Boyfield, Izzy, Nash, David J, Jewitt, Frances R, Avenell, Kim Y, Riley, Graham J

“…The dopaminergic system has long been implicated in the mechanisms of reward and addiction. 1-(4-(2-Naphthoylamino)butyl)-4-(2-methoxyphenyl)-1A-piperazine HCl…”
Get full text

A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists by GOODACRE, Caroline J, BROMIDGE, Steven M, TRAIL, Brenda K, WOOD, Martyn D, CLAPHAM, David, KING, Frank D, LOVELL, Peter J, ALLEN, Mike, CAMPBELL, Lorraine P, HOLLAND, Vicky, RILEY, Graham J, STARR, Kathryn R

“…Bisaryl cyclic ureas have been identified as high affinity 5-HT2C receptor antagonists with selectivity over 5-HT2A and 5-HT2B. Compounds such as 8 and 22 have…”
Get full text

(R)-3,N-Dimethyl-N-[1-methyl-3-(4-methylpiperidin-1-yl)propyl]benzenesulfonamide:  The First Selective 5-HT7 Receptor Antagonist by Forbes, Ian T, Dabbs, Steven, Duckworth, D. Malcolm, Jennings, Andrew J, King, Frank D, Lovell, Peter J, Brown, Anthony M, Collin, Lissa, Hagan, Jim J, Middlemiss, Derek N, Riley, Graham J, Thomas, David R, Upton, Neil

Get full text

The design of 8,8-Dimethyl[1,6]naphthyridines as potential anticonvulsant agents by Austin, Nigel E, Hadley, Michael S, Harling, John D, Harrington, Frank P, Macdonald, Gregor J, Mitchell, Darren J, Riley, Graham J, Stean, Tania O, Stemp, Geoffrey, Stratton, Sharon C, Thompson, Mervyn, Upton, Neil

“…Starting from a series of 7-linked tetrahydroisoquinoline derivatives, as exemplified by SB-270664, a new series of 8,8-dimethylnaphthyridine compounds has…”
Get full text

8-piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines : Potent, selective, orally bioavailable 5-HT1 receptor ligands by HEIGHTMAN, Tom D, GASTER, Laramie M, GORDON, Laurie J, HOLLAND, Vicky A, POWLES, Jenifer, RILEY, Graham J, STEAN, Tania O, TRAIL, Brenda K, UPTON, Neil, AUSTIN, Nigel E, AYRTON, Andrew D, COLEMAN, Tanya, PARDOE, Sarah L, CUTLER, Leanne, PILLEUX, Jean-Pierre, HADLEY, Michael S, MIDDLEMISS, Derek N, PRICE, Gary W, ROBERTS, Claire, SCOTT, Claire M, WATSON, Jeannette M

“…The novel 8-piperazinyl-2,3-dihydropyrroloisoquinoline template was synthesized in nine steps. The template was N-substituted to give a series of compounds…”
Get full text

Novel and Selective 5-HT2C/2B Receptor Antagonists as Potential Anxiolytic Agents:  Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines by Bromidge, Steven M, Dabbs, Steven, Davies, David T, Duckworth, D. Malcolm, Forbes, Ian T, Ham, Peter, Jones, Graham E, King, Frank D, Saunders, Damian V, Starr, Susannah, Thewlis, Kevin M, Wyman, Paul A, Blaney, Frank E, Naylor, Christopher B, Bailey, Fiona, Blackburn, Thomas P, Holland, Vicky, Kennett, Guy A, Riley, Graham J, Wood, Martyn D

“…The synthesis, biological activity, and molecular modeling of a novel series of substituted 1-(3-pyridylcarbamoyl)indolines are reported. These compounds are…”
Get full text

Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor by AUSTIN, Nigel E, AVENELL, Kim Y, SMITH, Alexander B, STEMP, Geoffrey, THEWLIS, Kevin M, VONG, Antonio K. K, WOOD, Martyn D, BOYFIELD, Izzy, BRANCH, Clive L, HADLEY, Michael S, JEFFREY, Phillip, JOHNSON, Christopher N, MACDONALD, Gregor J, NASH, David J, RILEY, Graham J

“…Starting from the tetrahydroisoquinoline SB-277011 1, a novel series of 5-substituted-2,3-dihydro-1H-isoindoles has been designed. Subsequent optimisation…”
Get full text

Design and Synthesis of 2-Naphthoate Esters as Selective Dopamine D4 Antagonists by Boyfield, Izzy, Brown, Thomas H, Coldwell, Martyn C, Cooper, David G, Hadley, Michael S, Hagan, Jim J, Healy, Maureen A, Johns, Amanda, King, Ron J, Middlemiss, Derek N, Nash, David J, Riley, Graham J, Scott, Emma E, Smith, Stephen A, Stemp, Geoffrey

Get full text

Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor by AUSTIN, Nigel E, AVENELL, Kim Y, SMITH, Alexander B, STEMP, Geoffrey, THEWLIS, Kevin M, VONG, Antonio K. K, WOOD, Martyn, BOYFIELD, Izzy, BRANCH, Clive L, HADLEY, Michael S, JEFFREY, Phillip, JOHNSON, Christopher N, MACDONALD, Gregor J, NASH, David J, RILEY, Graham J

“…Starting from the dopamine D3 receptor antagonist SB-277011 1, a series of 2,3,4,5-tetrahydro-1H-3-benzazepines has been identified with high affinity for the…”
Get full text