Search Results - "RIGOUTS, Leen"

GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions by Farhat, Maha R., Freschi, Luca, Calderon, Roger, Ioerger, Thomas, Snyder, Matthew, Meehan, Conor J., de Jong, Bouke, Rigouts, Leen, Sloutsky, Alex, Kaur, Devinder, Sunyaev, Shamil, van Soolingen, Dick, Shendure, Jay, Sacchettini, Jim, Murray, Megan

“…Drug resistance diagnostics that rely on the detection of resistance-related mutations could expedite patient care and TB eradication. We perform minimum…”
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A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region by Ngabonziza, Jean Claude Semuto, Loiseau, Chloé, Marceau, Michael, Jouet, Agathe, Menardo, Fabrizio, Tzfadia, Oren, Antoine, Rudy, Niyigena, Esdras Belamo, Mulders, Wim, Fissette, Kristina, Diels, Maren, Gaudin, Cyril, Duthoy, Stéphanie, Ssengooba, Willy, André, Emmanuel, Kaswa, Michel K., Habimana, Yves Mucyo, Brites, Daniela, Affolabi, Dissou, Mazarati, Jean Baptiste, de Jong, Bouke Catherine, Rigouts, Leen, Gagneux, Sebastien, Meehan, Conor Joseph, Supply, Philip

“…The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa…”
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Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs by Jouet, Agathe, Gaudin, Cyril, Badalato, Nelly, Allix-Béguec, Caroline, Duthoy, Stéphanie, Ferré, Alice, Diels, Maren, Laurent, Yannick, Contreras, Sandy, Feuerriegel, Silke, Niemann, Stefan, André, Emmanuel, Kaswa, Michel K, Tagliani, Elisa, Cabibbe, Andrea, Mathys, Vanessa, Cirillo, Daniela, de Jong, Bouke C, Rigouts, Leen, Supply, Philip

“…Conventional molecular tests for detecting complex (MTBC) drug resistance on clinical samples cover a limited set of mutations. Whole-genome sequencing (WGS)…”
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Reconstituting the genus Mycobacterium by Meehan, Conor J, Barco, Roman A, Loh, Yong-Hwee E, Cogneau, Sari, Rigouts, Leen

“…The definition of a genus has wide-ranging implications both in terms of binomial species names and also evolutionary relationships. In recent years, the…”
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Rifampin Drug Resistance Tests for Tuberculosis: Challenging the Gold Standard by Van Deun, Armand, Aung, Kya J M, Bola, Valentin, Lebeke, Rossin, Hossain, Mohamed Anwar, de Rijk, Willem Bram, Rigouts, Leen, Gumusboga, Aysel, Torrea, Gabriela, de Jong, Bouke C

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Rifampin Resistance Missed in Automated Liquid Culture System for Mycobacterium tuberculosis Isolates with Specific rpoB Mutations by Rigouts, Leen, Gumusboga, Mourad, de Rijk, Willem Bram, Nduwamahoro, Elie, Uwizeye, Cécile, de Jong, Bouke, Van Deun, Armand

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Reference set of Mycobacterium tuberculosis clinical strains: A tool for research and product development by Borrell, Sònia, Trauner, Andrej, Brites, Daniela, Rigouts, Leen, Loiseau, Chloe, Coscolla, Mireia, Niemann, Stefan, De Jong, Bouke, Yeboah-Manu, Dorothy, Kato-Maeda, Midori, Feldmann, Julia, Reinhard, Miriam, Beisel, Christian, Gagneux, Sebastien

“…The Mycobacterium tuberculosis complex (MTBC) causes tuberculosis (TB) in humans and various other mammals. The human-adapted members of the MTBC comprise…”
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Broad diversity of Mycobacterium tuberculosis complex strains isolated from humans and cattle in Northern Algeria suggests a zoonotic transmission cycle by Damene, Hanane, Tahir, Djamel, Diels, Maren, Berber, Ali, Sahraoui, Naima, Rigouts, Leen

“…Mycobacterium tuberculosis complex (MTBC) comprises closely related species responsible for human and animal tuberculosis (TB). Efficient species determination…”
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Newly Identified Mycobacterium africanum Lineage 10, Central Africa by Guyeux, Christophe, Senelle, Gaetan, Le Meur, Adrien, Supply, Philip, Gaudin, Cyril, Phelan, Jody E, Clark, Taane G, Rigouts, Leen, de Jong, Bouke, Sola, Christophe, Refrégier, Guislaine

“…Analysis of genome sequencing data from >100,000 genomes of Mycobacterium tuberculosis complex using TB-Annotator software revealed a previously unknown…”
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High Level of Cross-Resistance between Kanamycin, Amikacin, and Capreomycin among Mycobacterium tuberculosis Isolates from Georgia and a Close Relation with Mutations in the rrs Gene by JUGHELI, Levan, BZEKALAVA, Nino, DE RIJK, Pim, FISSETTE, Krista, PORTAELS, Françoise, RIGOUTS, Leen

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Community-based active tuberculosis case finding in poor urban settlements of Phnom Penh, Cambodia: a feasible and effective strategy by Lorent, Natalie, Choun, Kimcheng, Thai, Sopheak, Kim, Tharin, Huy, Sopheaktra, Pe, Reaksmey, van Griensven, Johan, Buyze, Jozefien, Colebunders, Robert, Rigouts, Leen, Lynen, Lutgarde

“…In light of the limitations of the current case finding strategies and the global urgency to improve tuberculosis (TB) case-detection, a renewed interest in…”
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Challenges and knowledge gaps in the management of non-tuberculous mycobacterial pulmonary disease in sub-Saharan African countries with a high tuberculosis burden: a scoping review by Abbew, Elizabeth Tabitha, Lorent, Natalie, Mesic, Anita, Wachinou, Ablo Prudence, Obiri-Yeboah, Dorcas, Decroo, Tom, Rigouts, Leen, Lynen, Lutgarde

“…IntroductionIn sub-Saharan African (SSA) countries endemic for tuberculosis (TB), previous TB is a significant risk factor for non-tuberculous mycobacterial…”
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GeneXpert MTB/RIF Ultra performance to detect uncommon rpoB mutations in Mycobacterium tuberculosis by Rigouts, Leen, Keysers, Jelle, Rabab, Reenaers, Fissette, Kristina, van Deun, Armand, de Jong, Bouke Catherine

“…To investigate the performance of GeneXpert MTB/RIF Ultra to accurately detect rifampicin resistance for less common rpoB mutations that potentially confer…”
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GeneXpert MTB/RIF Assay for the Diagnosis of Tuberculous Lymphadenitis on Concentrated Fine Needle Aspirates in High Tuberculosis Burden Settings by Tadesse, Mulualem, Abebe, Gemeda, Abdissa, Ketema, Aragaw, Dossegnaw, Abdella, Kedir, Bekele, Alemayehu, Bezabih, Mesele, Apers, Ludwig, de Jong, Bouke C, Rigouts, Leen

“…The diagnosis of tuberculous lymphadenitis (TBL) remains challenging. The routinely used methods (cytology and smear microscopy) have sub-optimal sensitivity…”
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Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase by Ezewudo, Matthew, Borens, Amanda, Chiner-Oms, Álvaro, Miotto, Paolo, Chindelevitch, Leonid, Starks, Angela M., Hanna, Debra, Liwski, Richard, Zignol, Matteo, Gilpin, Christopher, Niemann, Stefan, Kohl, Thomas Andreas, Warren, Robin M., Crook, Derrick, Gagneux, Sebastien, Hoffner, Sven, Rodrigues, Camilla, Comas, Iñaki, Engelthaler, David M., Alland, David, Rigouts, Leen, Lange, Christoph, Dheda, Keertan, Hasan, Rumina, McNerney, Ruth, Cirillo, Daniela M., Schito, Marco, Rodwell, Timothy C., Posey, James

“…Drug-resistant tuberculosis poses a persistent public health threat. The ReSeqTB platform is a collaborative, curated knowledgebase, designed to standardize…”
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Targeted next-generation sequencing of sputum for diagnosis of drug-resistant TB: results of a national survey in Democratic Republic of the Congo by Kayomo, Michel Kaswa, Mbula, Vital Nkake, Aloni, Muriel, André, Emmanuel, Rigouts, Leen, Boutachkourt, Fairouz, de Jong, Bouke C., Nkiere, Nicolas M., Dean, Anna S.

“…The surveillance of drug resistance among tuberculosis (TB) patients is central to preventing the spread of antimicrobial resistance. The Democratic Republic…”
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Rifampin Heteroresistance in Mycobacterium tuberculosis Cultures as Detected by Phenotypic and Genotypic Drug Susceptibility Test Methods by Folkvardsen, Dorte Bek, Thomsen, Vibeke Ø, Rigouts, Leen, Rasmussen, Erik Michael, Bang, Didi, Bernaerts, Gertjan, Werngren, Jim, Toro, Juan Carlos, Hoffner, Sven, Hillemann, Doris, Svensson, Erik

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Genotypic characterization directly applied to sputum improves the detection of Mycobacterium africanum West African 1, under-represented in positive cultures by Sanoussi, C N'Dira, Affolabi, Dissou, Rigouts, Leen, Anagonou, Séverin, de Jong, Bouke

“…This study aimed to compare the prevalence of Mycobacterium tuberculosis complex (MTBc) lineages between direct genotyping (on sputum) and indirect genotyping…”
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Initial resistance to companion drugs should not be considered an exclusion criterion for the shorter multidrug-resistant tuberculosis treatment regimen by Lempens, Pauline, Decroo, Tom, Aung, Kya J.M., Hossain, Mohammad A., Rigouts, Leen, Meehan, Conor J., Van Deun, Armand, de Jong, Bouke C.

“…•Shorter treatment regimen for multidrug-resistant tuberculosis.•Effect of companion drug resistance on adverse outcomes.•Gatifloxacin and isoniazid minimum…”
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Genetic diversity of the Mycobacterium tuberculosis complex strains from newly diagnosed tuberculosis patients in Northwest Ethiopia reveals a predominance of East-African-Indian and Euro-American lineages by Ejo, Mebrat, Torrea, Gabriela, Uwizeye, Cecile, Kassa, Meseret, Girma, Yilak, Bekele, Tiruzer, Ademe, Yilkal, Diro, Ermias, Gehre, Florian, Rigouts, Leen, de Jong, Bouke C.

“…•Northern Ethiopia hosts a wide diversity of Mycobacterium tuberculosis complex (MTBc) lineages: L1–L4 and L7.•East-African-Indian (L3) is the most frequent…”
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