Search Results - "RIGOBELLO, MARIA PIA"

Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase by Gandin, Valentina, Fernandes, Aristi Potamitou, Rigobello, Maria Pia, Dani, Barbara, Sorrentino, Francesca, Tisato, Francesco, Björnstedt, Mikael, Bindoli, Alberto, Sturaro, Alberto, Rella, Rocco, Marzano, Cristina

“…The thioredoxin system, composed of thioredoxin reductase (TrxR), thioredoxin (Trx), and NADPH (nicotinamide adenine dinucleotide phosphate), plays a central…”
Get full text

Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functions by Pia Rigobello, Maria, Messori, Luigi, Marcon, Giordana, Agostina Cinellu, Maria, Bragadin, Marcantonio, Folda, Alessandra, Scutari, Guido, Bindoli, Alberto

“…The effects of gold(I) complexes (auranofin, triethylphosphine gold and aurothiomalate), gold(III) complexes ([Au(2,2 ′-diethylendiamine)Cl]Cl 2,…”
Get full text

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs by Bindoli, Alberto, Rigobello, Maria Pia, Scutari, Guido, Gabbiani, Chiara, Casini, Angela, Messori, Luigi

“…The thioredoxin system plays a key role in regulating the overall intracellular redox balance. It basically comprises the small redox protein thioredoxin…”
Get full text

Milk-derived bioactive peptides exhibit antioxidant activity through the Keap1-Nrf2 signaling pathway by Tonolo, Federica, Folda, Alessandra, Cesaro, Luca, Scalcon, Valeria, Marin, Oriano, Ferro, Stefania, Bindoli, Alberto, Rigobello, Maria Pia

“…[Display omitted] •Milk-derived bioactive peptides inhibit lipid peroxidation in Caco-2 cells.•Antioxidant effect of bioactive peptides is exerted activating…”
Get full text

The Role of Antioxidant Foods and Nutraceuticals in Ageing by Giorgio, Marco, Rigobello, Maria Pia

“…The free radical theory of aging proposed by Denham Harman in the 1950s identified the accumulation of oxidative damage over time as a cause of aging [...]…”
Get full text

Nrf2-Activating Bioactive Peptides Exert Anti-Inflammatory Activity through Inhibition of the NF-κB Pathway by Tonolo, Federica, Folda, Alessandra, Scalcon, Valeria, Marin, Oriano, Bindoli, Alberto, Rigobello, Maria Pia

“…Redox status and inflammation are related to the pathogenesis of the majority of diseases. Therefore, understanding the role of specific food-derived molecules…”
Get full text

Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells by Marzano, Christine, Gandin, Valentina, Folda, Alessandra, Scutari, Guido, Bindoli, Alberto, Rigobello, Maria Pia

“…Cisplatin is an effective antitumor agent for the treatment of several carcinomas. However, the development of resistance to cisplatin represents a serious…”
Get full text

The mitochondrial antioxidant defence system and its response to oxidative stress by Rabilloud, Thierry, Heller, Manfred, Rigobello, Maria-Pia, Bindoli, Alberto, Aebersold, Ruedi, Lunardi, Joël

“…The antioxidant systems of mitochondria are not well known. Using a proteomics‐based approach, we defined these mitochondrial antioxidant systems and analyzed…”
Get full text

Gold(I) NHC-based homo- and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents by Bertrand, Benoît, Citta, Anna, Franken, Inge L., Picquet, Michel, Folda, Alessandra, Scalcon, Valeria, Rigobello, Maria Pia, Le Gendre, Pierre, Casini, Angela, Bodio, Ewen

“…While N -heterocyclic carbenes (NHC) are ubiquitous ligands in catalysis for organic or industrial syntheses, their potential to form transition metal…”
Get full text

From In Silico to a Cellular Model: Molecular Docking Approach to Evaluate Antioxidant Bioactive Peptides by Tonolo, Federica, Grinzato, Alessandro, Bindoli, Alberto, Rigobello, Maria Pia

“…The increasing need to counteract the redox imbalance in chronic diseases leads to focusing research on compounds with antioxidant activity. Among natural…”
Get full text

Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds by Casini, Angela, Gabbiani, Chiara, Sorrentino, Francesca, Rigobello, Maria Pia, Bindoli, Alberto, Geldbach, Tilmann J, Marrone, Alessandro, Re, Nazzareno, Hartinger, Christian G, Dyson, Paul J, Messori, Luigi

“…A series of ruthenium(II)−arene (RAPTA) compounds were evaluated for their ability to inhibit thioredoxin reductase (either cytosolic or mitochondrial) and…”
Get full text

Identification of New Peptides from Fermented Milk Showing Antioxidant Properties: Mechanism of Action by Tonolo, Federica, Fiorese, Federico, Moretto, Laura, Folda, Alessandra, Scalcon, Valeria, Grinzato, Alessandro, Ferro, Stefania, Arrigoni, Giorgio, Bindoli, Alberto, Feller, Emiliano, Bellamio, Marco, Marin, Oriano, Rigobello, Maria Pia

“…Due to their beneficial properties, fermented foods are considered important constituents of the human diet. They also contain bioactive peptides,…”
Get full text

SOD1 in ALS: Taking Stock in Pathogenic Mechanisms and the Role of Glial and Muscle Cells by Peggion, Caterina, Scalcon, Valeria, Massimino, Maria Lina, Nies, Kelly, Lopreiato, Raffaele, Rigobello, Maria Pia, Bertoli, Alessandro

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons in the brain and spinal cord. While the…”
Get full text

Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State by Folda, Alessandra, Citta, Anna, Scalcon, Valeria, Calì, Tito, Zonta, Francesco, Scutari, Guido, Bindoli, Alberto, Rigobello, Maria Pia

“…The mitochondrial thioredoxin system (NADPH, thioredoxin reductase, thioredoxin) is a major redox regulator. Here we have investigated the redox correlation…”
Get full text

Exploring the C^N^C theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes by Jürgens, Sophie, Scalcon, Valeria, Estrada-Ortiz, Natalia, Folda, Alessandra, Tonolo, Federica, Jandl, Christian, Browne, Duncan L., Rigobello, Maria Pia, Kühn, Fritz E., Casini, Angela

“…[Display omitted] A family of cyclometalated Au(III) complexes featuring a tridentate C^N^C scaffold has been synthesized and characterized. Microwave assisted…”
Get full text

Fermented Soy-Derived Bioactive Peptides Selected by a Molecular Docking Approach Show Antioxidant Properties Involving the Keap1/Nrf2 Pathway by Tonolo, Federica, Moretto, Laura, Grinzato, Alessandro, Fiorese, Federico, Folda, Alessandra, Scalcon, Valeria, Ferro, Stefania, Arrigoni, Giorgio, Bellamio, Marco, Feller, Emiliano, Bindoli, Alberto, Marin, Oriano, Rigobello, Maria Pia

“…Bioactive peptides are a group of molecules with health beneficial properties, deriving from food matrices. They are protein fragments consisting of 2-20 amino…”
Get full text

Mitochondrial depletion of glutaredoxin 2 induces metabolic dysfunction-associated fatty liver disease in mice by Scalcon, Valeria, Folda, Alessandra, Lupo, Maria Giovanna, Tonolo, Federica, Pei, Naixuan, Battisti, Ilaria, Ferri, Nicola, Arrigoni, Giorgio, Bindoli, Alberto, Holmgren, Arne, Coppo, Lucia, Rigobello, Maria Pia

“…Glutaredoxin 2 (Grx2) is a glutathione-dependent oxidoreductase that facilitates glutathionylation/de-glutathionylation of target proteins. The main variants…”
Get full text

Dimers of glutaredoxin 2 as mitochondrial redox sensors in selenite-induced oxidative stress by Scalcon, Valeria, Tonolo, Federica, Folda, Alessandra, Bindoli, Alberto, Rigobello, Maria Pia

“…Glutaredoxin 2 (Grx2) has been previously shown to link thioredoxin and glutathione systems receiving reducing equivalents by both thioredoxin reductase and…”
Get full text

Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, in vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands by Vergara, Elena, Casini, Angela, Sorrentino, Francesca, Zava, Olivier, Cerrada, Elena, Rigobello, Maria Pia, Bindoli, Alberto, Laguna, Mariano, Dyson, Paul J.

“…Gold(I) complexes bearing water‐soluble phosphine ligands, including 1,3,5‐triaza‐7‐phosphaadamantane (PTA),…”
Get full text

By-Products Valorization: Peptide Fractions from Milk Permeate Exert Antioxidant Activity in Cellular and In Vivo Models by Scalcon, Valeria, Fiorese, Federico, Albanesi, Marica, Folda, Alessandra, Betti, Gianfranco, Bellamio, Marco, Feller, Emiliano, Lodovichi, Claudia, Arrigoni, Giorgio, Marin, Oriano, Rigobello, Maria Pia

“…The discarding of agri-food by-products is a stringent problem due to their high environmental impact. Recovery strategies can lead to a reduction of waste and…”
Get full text