Search Results - "RIGO, Benoit"

From Conventional Lewis Acids to Heterogeneous Montmorillonite K10: Eco‐Friendly Plant‐Based Catalysts Used as Green Lewis Acids by Hechelski, Marie, Ghinet, Alina, Louvel, Brice, Dufrénoy, Pierrick, Rigo, Benoît, Daïch, Adam, Waterlot, Christophe

“…The concept of green chemistry began in the USA in the 1990s. Since the publication of the 12 principles of this concept, many reactions in organic chemistry…”
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Pyroglutamide-Based P2X7 Receptor Antagonists Targeting Inflammatory Bowel Disease by Homerin, Germain, Jawhara, Samir, Dezitter, Xavier, Baudelet, Davy, Dufrénoy, Pierrick, Rigo, Benoît, Millet, Régis, Furman, Christophe, Ragé, Guillaume, Lipka, Emmanuelle, Farce, Amaury, Renault, Nicolas, Sendid, Boualem, Charlet, Rogatien, Leroy, Jordan, Phanithavong, Mélodie, Richeval, Camille, Wiart, Jean-François, Allorge, Delphine, Adriouch, Sahil, Vouret-Craviari, Valérie, Ghinet, Alina

“…This report deals with the design, the synthesis, and the pharmacological evaluation of pyroglutamide-based P2X7 antagonists. A dozen were shown to possess…”
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Site‐Selective Pd‐Catalysed Fujiwara‐Moritani type Reaction of N,S‐Heterocyclic Systems with Olefins by Danton, Fanny, Najjar, Riham, Othman, Mohamed, Lawson, Ata Martin, Moncol, Ján, Ghinet, Alina, Rigo, Benoît, Oulyadi, Hassan, Daïch, Adam

“…Dihydro‐1,4‐thiazine skeletons bearing olefin fragment at their α‐position were prepared through a Pd(OAc)2‐catalysed Fujiwara‐Moritani type reaction via C−H…”
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Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands by Ghinet, Alina, Thuru, Xavier, Floquet, Emilie, Dubois, Joëlle, Farce, Amaury, Rigo, Benoît

“…[Display omitted] •34 synthesized benzo(thio)phenones.•Unprecedented dual tubulin/PDHK1 inhibitors identified.•Molecular docking on studied targets.•Cell cycle…”
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New plant immunity elicitors from a sugar beet byproduct protect wheat against Zymoseptoria tritici by Mejri, Samara, Ghinet, Alina, Magnin-Robert, Maryline, Randoux, Béatrice, Abuhaie, Cristina-Maria, Tisserant, Benoit, Gautret, Philippe, Rigo, Benoit, Halama, Patrice, Reignault, Philippe, Siah, Ali

“…The current worldwide context promoting agroecology and green agriculture require the discovery of new ecofriendly and sustainable plant protection tools…”
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The Reactivity of Enantiopure (S)‐6‐Oxopipecolic Acid and Corresponding Pyridoisoquinolines Under Acidic Conditions by Šafář, Peter, Marchalín, Štefan, Balónová, Barbora, Šoral, Michal, Moncol, Ján, Ghinet, Alina, Rigo, Benoît, Daïch, Adam

“…Enantiopure N‐benzyl 6‐oxopipecolic acid, obtained from (S)‐2‐aminoadipic acid, was evaluated under π‐cationic cyclization conditions. If the combination of…”
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New salicylic acid and pyroglutamic acid conjugated derivatives confer protection to bread wheat against Zymoseptoria tritici by Mejri, Samara, Siah, Ali, Abuhaie, Cristina‐Maria, Halama, Patrice, Magnin‐Robert, Maryline, Randoux, Béatrice, Reignault, Philippe, Rigo, Benoît, Ghinet, Alina

“…BACKGROUND To promote sustainable agriculture and healthy food, research that contributes towards a new generation of eco‐friendly phytosanitary compounds is…”
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Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents by Ghinet, Alina, Moise, Iuliana-Monica, Rigo, Benoît, Homerin, Germain, Farce, Amaury, Dubois, Joëlle, Bîcu, Elena

“…[Display omitted] New phenothiazine derivatives 6–20 have been designed, synthesized and evaluated in vitro for their ability to inhibit tubulin polymerization…”
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Exploring isoxazoles and pyrrolidinones decorated with the 4,6‐dimethoxy‐1,3,5‐triazine unit as human farnesyltransferase inhibitors by Lucescu, Liliana, Ghinet, Alina, Shova, Sergiu, Magnez, Romain, Thuru, Xavier, Farce, Amaury, Rigo, Benoît, Belei, Dalila, Dubois, Joëlle, Bîcu, Elena

“…Unprecedented triazinyl‐isoxazoles were afforded via an effective cycloaddition reaction between nitrile oxides and the scarcely described…”
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Synthesis and biological evaluation of a new series of N-ylides as protein farnesyltransferase inhibitors by Abuhaie, Cristina-Maria, Ghinet, Alina, Farce, Amaury, Dubois, Joëlle, Rigo, Benoît, Bîcu, Elena

“…A new family of 30 benzoylated N-ylides 4 and 5 was synthesized and evaluated for the inhibitory activity on human protein farnesyltransferase. Most of these…”
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Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors by Abuhaie, Cristina-Maria, Ghinet, Alina, Farce, Amaury, Dubois, Joëlle, Gautret, Philippe, Rigo, Benoît, Belei, Dalila, Bîcu, Elena

“…Two new families of human farnesyltransferase inhibitors 13a–m and 14a–d, based on a phenothiazine scaffold, were synthesized. Compounds 14a and 14b were the…”
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Synthesis and biological evaluation of phenstatin metabolites by Ghinet, Alina, Rigo, Benoît, Hénichart, Jean-Pierre, Le Broc-Ryckewaert, Delphine, Pommery, Jean, Pommery, Nicole, Thuru, Xavier, Quesnel, Bruno, Gautret, Philippe

“…Previous investigations on the incubation of phenstatin with rat and human microsomal fractions revealed the formation of nine main metabolites. The structures…”
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3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis by Tourteau, Aurélien, Andrzejak, Virginie, Body-Malapel, Mathilde, Lemaire, Lucas, Lemoine, Amélie, Mansouri, Roxane, Djouina, Madjid, Renault, Nicolas, El Bakali, Jamal, Desreumaux, Pierre, Muccioli, Giulio G., Lambert, Didier M., Chavatte, Philippe, Rigo, Benoît, Leleu-Chavain, Natascha, Millet, Régis

“…Recent investigations showed that anandamide, the main endogenous ligand of CB1 and CB2 cannabinoid receptors, possesses analgesic, antidepressant and…”
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Evaluation and comparison of three different separation techniques for analysis of retroamide enantiomers and their biological evaluation against h-P2X7 receptor by Baudelet, Davy, Furman, Christophe, Ghinet, Alina, Dezitter, Xavier, Adriouch, Sahil, Capet, Frédéric, Rogez-Florent, Tiphaine, Gautret, Philippe, Rigo, Benoit, Millet, Régis, Vaccher, Claude, Lipka, Emmanuelle

“…The P2X receptors are seven-transmembrane domain G protein-coupled receptors and the 7 subtypes of P2X receptors identified in humans, and named P2X1 to P2X7,…”
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Eaton's Reagent-Mediated Domino π-Cationic Arylations of Aromatic Carboxylic Acids to Iasi-Red Polymethoxylated Polycyclic Aromatic Hydrocarbons: Products with Unprecedented Biological Activities as Tubulin Polymerization Inhibitors by Ghinet, Alina, Gautret, Philippe, Hijfte, Nathalie Van, Ledé, Bertrand, Hénichart, Jean-Pierre, Bîcu, Elena, Darbost, Ulrich, Rigo, Benoît, Daïch, Adam

“…A rapid domino π‐cationic arylation of aromatic carboxylic acids, mediated by Eaton’s reagent, has been developed for the synthesis of Iasi‐red…”
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Toward new camptothecins. Part 7: Synthesis of thioluotonin and its 5-methoxycarbonyl derivative by Boisse, Thomas, Gavara, Laurent, Gautret, Philippe, Baldeyrou, Brigitte, Lansiaux, Amélie, Goossens, Jean-François, Hénichart, Jean-Pierre, Rigo, Benoît

“…The syntheses of thiodeoxyvasicinone (10) and thioluotonin (7, 8) derivatives are described. The results obtained indicate that in these series, oxygen to…”
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Design, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents by Dascalu, Anca-Elena, Ghinet, Alina, Lipka, Emmanuelle, Furman, Christophe, Rigo, Benoît, Fayeulle, Antoine, Billamboz, Muriel

“…[Display omitted] Twenty-eight 5-pyrrolidine-2-ones decorated by hydrazine or acyl hydrazones groups have been designed, synthesized and evaluated as…”
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1,3,5‐Oxadiazine Framework by Oxygen vs. Nitrogen Trapping of an N‐Acyliminium Ion Derived from N,O‐bis‐TMS Pyroglutamic Acid by Ghinet, Alina, Abuhaie, Cristina‐Maria, Homerin, Germain, Marzag, Hamid, Dubois, Joëlle, Lipka, Emmanuelle, Rigo, Benoît, Daïch, Adam

“…We report that the reaction of N,O‐bis‐TMS pyroglutamic acid with aldehydes, under basic or acid catalysis leads to O‐bis‐TMS adducts. Treatment of these…”
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Phenyliodine(III) Diacetate/I 2 ‐Mediated Domino Approach for Pyrrolo[1,4]Thiazines and 1,4‐Thiazines by a One‐Pot Morin Rearrangement of N,S ‐ Acetals by Danton, Fanny, Othman, Mohamed, Lawson, Ata Martin, Moncol, Ján, Ghinet, Alina, Rigo, Benoît, Daïch, Adam

“…Abstract An efficient domino transformation using a phenyliodine(III) diacetate (PIDA)/I 2 combination towards Morin 1,4‐thiazine compounds has been developed…”
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Discovery of indolizines containing triazine moiety as new leads for the development of antitumoral agents targeting mitotic events by Lucescu, Liliana, Ghinet, Alina, Belei, Dalila, Rigo, Benoît, Dubois, Joëlle, Bîcu, Elena

“…[Display omitted] A new family of 3-aroylindolizines bearing a dimethoxytriazine unit in their position 1 was designed, synthesized and evaluated for their…”
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