Search Results - "RIFKIN, D. B"

Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms by Bellini, C., Bersi, M. R., Caulk, A. W., Ferruzzi, J., Milewicz, D. M., Ramirez, F., Rifkin, D. B., Tellides, G., Yanagisawa, H., Humphrey, J. D.

“…Thoracic aortic aneurysms are life-threatening lesions that afflict young and old individuals alike. They frequently associate with genetic mutations and are…”
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Differential ascending and descending aortic mechanics parallel aneurysmal propensity in a mouse model of Marfan syndrome by Bellini, C, Korneva, A, Zilberberg, L, Ramirez, F, Rifkin, D.B, Humphrey, J.D

“…Abstract Marfan syndrome (MFS) is a multi-system connective tissue disorder that results from mutations to the gene that codes the elastin-associated…”
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Biology and biochemistry of proteinases in tumor invasion by Mignatti, P, Rifkin, D B

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Latent transforming growth factor-β: Structural features and mechanisms of activation by Munger, John S., Harpel, John G., Gleizes, Pierre-Emmanuel, Mazzieri, Roberta, Nunes, Irene, Rifkin, Daniel B.

“…Latent transforming growth factor-β: Structural features and mechanisms of activation. Transforming growth factors-β are cytokines with a wide range of…”
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Extracellular microfibrils in development and disease by Ramirez, F, Sakai, L. Y, Rifkin, D. B, Dietz, H. C

“…Fibrillins are the structural components of extracellular microfibrils that impart physical properties to tissues, alone or together with elastin as elastic…”
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Osteopetrosis-like phenotype in latent TGF-β binding protein 3 deficient mice by Dabovic, B., Levasseur, R., Zambuto, L., Chen, Y., Karsenty, G., Rifkin, D.B.

“…LTBPs are extracellular matrix proteins resembling fibrillins. LTBP-1, 3, and 4 covalently bind latent TGF-β and modulate tissue levels of this potent cytokine…”
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An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct by Abe, M, Harpel, J G, Metz, C N, Nunes, I, Loskutoff, D J, Rifkin, D B

“…Transforming growth factor-beta (TGF-beta) is a potent regulator of cellular differentiation, proliferation, migration, and protein expression. These…”
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Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF-beta presentation by Dabovic, B, Chen, Y, Colarossi, C, Zambuto, L, Obata, H, Rifkin, DB

“…The latent transforming growth factor (TGF)-beta binding proteins (LTBP)-1, -3 and -4 bind the latent form of the multipotent cytokine TGF-beta. To examine the…”
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Requirement for Transglutaminase in the Activation of Latent Transforming Growth Factor-β in Bovine Endothelial Cells by Kojima, Soichi, Nara, Kiyomitsu, Rifkin, Daniel B.

“…A hitherto unknown function for transglutaminase (TGase; R-glutaminyl-peptide: amine γ-glutamyltransferase, EC 2.3.2.13) was found in the conversion of latent…”
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Latent TGF-β binding proteins by Todorovic, V., Jurukovski, V., Chen, Y., Fontana, L., Dabovic, B., Rifkin, D.B.

“…Latent TGF-β binding proteins are multidomain proteins with a common, highly repetitive structural organization and partially overlapping expression patterns…”
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Recent Developments in the Cell Biology of Basic Fibroblast Growth Factor by Rifkin, Daniel B., Moscatelli, David

“…In the past four years there has been an enormous increase in research involving basic fibroblast growth factor (FGF) as a result of the development of…”
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Autocrine Activities of Basic Fibroblast Growth Factor: Regulation of Endothelial Cell Movement, Plasminogen Activator Synthesis, and DNA Synthesis by Sato, Yasufumi, Rifkin, Daniel B.

“…We have found that the spontaneous migration of bovine aortic endothelial cells from the edge of a denuded area in a confluent monolayer is dependent upon the…”
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Release of Basic Fibroblast Growth Factor-Heparan Sulfate Complexes from Endothelial Cells by Plasminogen Activator-Mediated Proteolytic Activity by Saksela, Olli, Rifkin, Daniel B.

“…Cultured bovine capillary endothelial (BCE) cells synthesize heparan sulfate proteoglycans (HSPG), which are both secreted into the culture medium and…”
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Characterization of the Activation of Latent TGF-β by Co-Cultures of Endothelial Cells and Pericytes or Smooth Muscle Cells: A Self-Regulating System by Sato, Y., Tsuboi, R., Lyons, R., Moses, H., Rifkin, D. B.

“…The conversion of latent transforming growth factor beta (LTGF-β) to the active species, transforming growth factor beta (TGF-β), has been characterized in…”
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Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture by Sato, Y, Rifkin, D B

“…When a confluent monolayer of bovine aortic endothelial (BAE) cells is wounded with a razor blade, endothelial cells (ECs) spontaneously move into the denuded…”
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Absence of LTBP-3 attenuates the aneurysmal phenotype but not spinal effects on the aorta in Marfan syndrome by Korneva, A., Zilberberg, L., Rifkin, D. B., Humphrey, J. D., Bellini, C.

“…Fibrillin-1 is an elastin-associated glycoprotein that contributes to the long-term fatigue resistance of elastic fibers as well as to the bioavailability of…”
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Endothelial Cell-Derived Heparan Sulfate Binds Basic Fibroblast Growth Factor and Protects It from Proteolytic Degradation by Saksela, Olli, Moscatelli, David, Sommer, Andreas, Rifkin, Daniel B.

“…Cultured bovine capillary endothelial (BCE) cells were found to synthesize and secrete high molecular mass heparan sulfate proteoglycans and…”
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Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding by ROGHANI, M, MANSUKHANI, A, DELL'ERA, P, BELLOSTA, P, BASILICO, C, RIFKIN, D. B, MOSCATELLI, D

“…The role of heparin or heparan sulfates in the interaction of basic fibroblast growth factor (bFGF) with its high affinity receptor were investigated using…”
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High-Affinity RNA Ligands to Basic Fibroblast Growth Factor Inhibit Receptor Binding by Jellinek, D., Lynott, C. K., Rifkin, D. B., Janjic, N.

“…We have isolated RNA ligands with low-nanomolar affinity and high specificity to basic fibroblast growth factor from a pool of 1014molecules containing 30…”
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Basic Fibroblast Growth Factor-Induced Activation of Latent Transforming Growth Factor β in Endothelial Cells: Regulation of Plasminogen Activator Activity by Flaumenhaft, Robert, Abe, Mayumi, Mignatti, Paolo, Rifkin, Daniel B.

“…Exposure of bovine aortic or capillary endothelial cells to basic FGF (bFGF) for 1 h resulted in an approximately sixfold increase in plasminogen activator…”
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