Search Results - "RIECKMANN, Karl H"

First Assessment in Humans of the Safety, Tolerability, Pharmacokinetics, and Ex Vivo Pharmacodynamic Antimalarial Activity of the New Artemisinin Derivative Artemisone by NAGELSCHMITZ, Johannes, VOITH, Barbara, WENSING, Georg, ROEMER, Axel, FUGMANN, Burkhard, HAYNES, Richard K, KOTECKA, Barbara M, RIECKMANN, Karl H, EDSTEIN, Michael D

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Evaluation of Artemisone Combinations in Aotus Monkeys Infected with Plasmodium falciparum by OBALDIA, Nicanor, KOTECKA, Barbara M, EDSTEIN, Michael D, HAYNES, Richard K, FUGMANN, Burkhard, KYLE, Dennis E, RIECKMANN, Karl H

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Efficacy of Monthly Tafenoquine for Prophylaxis of Plasmodium vivax and Multidrug-Resistant P. falciparum Malaria by Walsh, Douglas S., Eamsila, Chirapa, Sasiprapha, Theerayuth, Sangkharomy, Suebpong, Khaewsathien, Pradith, Supakalin, Panpaka, Tang, Douglas B., Jarasrumgsichol, Phongsak, Cherdchu, Chainarong, Edstein, Michael D., Rieckmann, Karl H., Brewer, Thomas G.

“…We assessed monthly doses of tafenoquine for preventing Plasmodium vivax and multidrug-resistant P. falciparum malaria. In a randomized, double-blind,…”
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Simple In Vitro Assay for Determining the Sensitivity of Plasmodium vivax Isolates from Fresh Human Blood to Antimalarials in Areas where P. vivax Is Endemic by RUSSELL, Bruce M, UDOMSANGPETCH, Rachanee, RIECKMANN, Karl H, KOTECKA, Barbara M, COLEMAN, Russell E, SATTABONGKOT, Jetsumon

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Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New Guinea by Reeder, J C, Rieckmann, K H, Genton, B, Lorry, K, Wines, B, Cowman, A F

“…Plasmodium falciparum isolates from 24 Papua New Guinean patients with symptomatic malaria were tested for susceptibility to pyrimethamine and cycloguanil…”
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Can primaquine therapy for vivax malaria be improved? by Baird, J.Kevin, Rieckmann, Karl H.

“…The incidence and range of endemic malaria caused by Plasmodium vivax has expanded during the past 30 years. This parasite forms hypnozoites in the liver,…”
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Does gender, food or grapefruit juice alter the pharmacokinetics of primaquine in healthy subjects? by Cuong, Bui Tri, Binh, Vu Quoc, Dai, Bui, Duy, Dinh Ngoc, Lovell, Claire M., Rieckmann, Karl H., Edstein, Michael D.

“…Aims To evaluate the effects of gender, food and grapefruit juice on the pharmacokinetics of primaquine in healthy subjects. Methods In a randomized, two‐phase…”
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Phenoxypropoxybiguanides, Prodrugs of DHFR−Inhibiting Diaminotriazine Antimalarials by Jensen, Norman P, Ager, Arba L, Bliss, Robert A, Canfield, Craig J, Kotecka, Barbara M, Rieckmann, Karl H, Terpinski, Jacek, Jacobus, David P

“…A total of 34 analogues of the biguanide PS-15 (5s), a prodrug of the diaminotriazine WR-99210 (8s), have been prepared. Several of them, such as 5b (PS-33)…”
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Vivax malaria: preliminary observations following a shorter course of treatment with artesunate plus primaquine by Dao, Nguyen Van Hoang, Cuong, Bui Tri, Ngoa, Nguyen Dang, Thuy, Le Thi Thanh, The, Nguyen Duy, Duy, Dinh Ngoc, Dai, Bui, Thanh, Nguyen Xuan, Chavchich, Marina, Rieckmann, Karl H., Edstein, Michael D.

“…The standard adult treatment regimen for Plasmodium vivax malaria is chloroquine (1500 mg over 3 d) plus primaquine (15 or 30 mg daily for 14 d), but patient…”
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New haplotypes of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene among chloroquine-resistant parasite isolates by Nagesha, Hadya S, Casey, Gerard J, Rieckmann, Karl H, Fryauff, David J, Laksana, Budi S, Reeder, John C, Maguire, Jason D, Baird, J Kevin

“…Mutations in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene were examined to assess their associations with chloroquine resistance…”
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Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate—JPC2056—in cynomolgus monkeys using an in vivo–in vitro model by Edstein, Michael D., Kotecka, Barbara M., Ager, Arba L., Smith, Kirsten S., DiTusa, Charles A., Diaz, Damaris S., Kyle, Dennis E., Schiehser, Guy A., Jacobus, David P., Rieckmann, Karl H., O'Neil, Michael T.

“…Objectives To assess the antimalarial pharmacodynamics and pharmacokinetics of the novel dihydrofolate reductase (DHFR) inhibitor, JPC2056 and its principal…”
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Short report: the activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains) by Sweeney, Anthony W, Blackburn, Charles R B, Rieckmann, Karl H

“…It was reported in 1946 that the administration of pamaquine during the incubation period delayed but did not prevent primary attacks of a New Guinea strain of…”
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Plasma Concentrations of Tafenoquine, a New Long-Acting Antimalarial Agent, in Thai Soldiers Receiving Monthly Prophylaxis by Edstein, Michael D., Kocisko, David A., Walsh, Douglas S., Eamsila, Chirapa, Charles, Bruce G., Rieckmann, Karl H.

“…We measured plasma tafenoquine concentrations in Thai soldiers given a monthly regimen of tafenoquine to determine whether these concentrations adequately…”
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Fatty food does not alter blood mefloquine concentrations in the treatment of falciparum malaria by Dao, Nguyen Van Hoang, Quoc, Nguyen Phuc, Ngoa, Nguyen Dang, Thuy, Le Thanh, The, Nguyen Duy, Dai, Bui, Binh, Vu Quoc, Rieckmann, Karl H., Edstein, Michael D.

“…Food has been reported to increase the bioavailability of mefloquine in healthy volunteers, but its role in increasing blood mefloquine concentrations in…”
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Cytotoxic Effects of Inhibitors of de Novo Pyrimidine Biosynthesis upon Plasmodium falciparum by Seymour, Kristen K, Lyons, Stephen D, Phillips, Leonidas, Rieckmann, Karl H, Christopherson, Richard I

“…The malarial parasite Plasmodium falciparum can only synthesize pyrimidine nucleotides via the de novo pathway which is therefore a suitable target for…”
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WR 238605, chloroquine, and their combinations as blood schizonticides against a chloroquine-resistant strain of Plasmodium vivax in Aotus monkeys by Obaldia, 3rd, N, Rossan, R N, Cooper, R D, Kyle, D E, Nuzum, E O, Rieckmann, K H, Shanks, G D

“…The compound WR 238605 is a primaquine analog being developed by the U.S. Army as an antimalarial drug. Currently, there is no established treatment for…”
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Activity of PS-15 and its metabolite, WR99210, against Plasmodium falciparum in an in vivo-in vitro model by Rieckmann, Karl H., Yeo, Anthony E.T., Edstein, Michael D.

“…An in vivo-in vitro model was used to assess the antimalarial activity of PS-15 and its metabolite, WR99210, against Plasmodium falciparum. WR99210, an…”
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Risk factors of chloroquine resistance in Plasmodium falciparum malaria by Hess, Folke I., Iannuzzi, Aniello, Leafasia, Judson, Cowdrey, David, Nothdurft, Hans D., Von Sonnenburg, Frank, Löscher, Thomas, Rieckmann, Karl H.

“…Objective: To identify patient-related risk factors of chloroquine resistance. Design: A case control study. Subjects: Plasmodium falciparum infected school…”
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Chloroquine bioassay using malaria microcultures by Kotecka, B M, Rieckmann, K H

“…The in vitro microculture technique was used to develop a relatively simple bioassay for estimating chloroquine (CQ) in plasma or serum. Chloroquine…”
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Plasma chloroquine concentrations in young and older malaria patients treated with chloroquine by Maitland, Kathryn, Williams, Thomas N, Kotecka, Barbara M, Edstein, Michael D, Rieckmann, Karl H

“…Plasma chloroquine (CQ) concentrations were measured by bioassay in young (0–4 years, n=9) and older (5–60 years, n=21) patients from Vanuatu infected with…”
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