Search Results - "RIECKMANN, Karl"

First Assessment in Humans of the Safety, Tolerability, Pharmacokinetics, and Ex Vivo Pharmacodynamic Antimalarial Activity of the New Artemisinin Derivative Artemisone by NAGELSCHMITZ, Johannes, VOITH, Barbara, WENSING, Georg, ROEMER, Axel, FUGMANN, Burkhard, HAYNES, Richard K, KOTECKA, Barbara M, RIECKMANN, Karl H, EDSTEIN, Michael D

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Artemisone-A Highly Active Antimalarial Drug of the Artemisinin Class by Haynes, Richard K., Fugmann, Burkhard, Stetter, Jörg, Rieckmann, Karl, Heilmann, Hans-Dietrich, Chan, Ho-Wai, Cheung, Man-Ki, Lam, Wai-Lun, Wong, Ho-Ning, Croft, Simon L., Vivas, Livia, Rattray, Lauren, Stewart, Lindsay, Peters, Wallace, Robinson, Brian L., Edstein, Michael D., Kotecka, Barbara, Kyle, Dennis E., Beckermann, Bernhard, Gerisch, Michael, Radtke, Martin, Schmuck, Gabriele, Steinke, Wolfram, Wollborn, Ute, Schmeer, Karl, Römer, Axel

“…Artemisinin—the next generation: Efficacies of artemisone against the malaria parasite are substantially greater than those of the current artemisinin “gold…”
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Can primaquine therapy for vivax malaria be improved? by Baird, J.Kevin, Rieckmann, Karl H.

“…The incidence and range of endemic malaria caused by Plasmodium vivax has expanded during the past 30 years. This parasite forms hypnozoites in the liver,…”
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Evaluation of Artemisone Combinations in Aotus Monkeys Infected with Plasmodium falciparum by OBALDIA, Nicanor, KOTECKA, Barbara M, EDSTEIN, Michael D, HAYNES, Richard K, FUGMANN, Burkhard, KYLE, Dennis E, RIECKMANN, Karl H

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Efficacy of Monthly Tafenoquine for Prophylaxis of Plasmodium vivax and Multidrug-Resistant P. falciparum Malaria by Walsh, Douglas S., Eamsila, Chirapa, Sasiprapha, Theerayuth, Sangkharomy, Suebpong, Khaewsathien, Pradith, Supakalin, Panpaka, Tang, Douglas B., Jarasrumgsichol, Phongsak, Cherdchu, Chainarong, Edstein, Michael D., Rieckmann, Karl H., Brewer, Thomas G.

“…We assessed monthly doses of tafenoquine for preventing Plasmodium vivax and multidrug-resistant P. falciparum malaria. In a randomized, double-blind,…”
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Sulfadoxine Resistance in Plasmodium vivax Is Associated with a Specific Amino Acid in Dihydropteroate Synthase at the Putative Sulfadoxine-Binding Site by Korsinczky, Michael, Fischer, Katja, Chen, Nanhua, Baker, Joanne, Rieckmann, Karl, Cheng, Qin

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Simple In Vitro Assay for Determining the Sensitivity of Plasmodium vivax Isolates from Fresh Human Blood to Antimalarials in Areas where P. vivax Is Endemic by RUSSELL, Bruce M, UDOMSANGPETCH, Rachanee, RIECKMANN, Karl H, KOTECKA, Barbara M, COLEMAN, Russell E, SATTABONGKOT, Jetsumon

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Does gender, food or grapefruit juice alter the pharmacokinetics of primaquine in healthy subjects? by Cuong, Bui Tri, Binh, Vu Quoc, Dai, Bui, Duy, Dinh Ngoc, Lovell, Claire M., Rieckmann, Karl H., Edstein, Michael D.

“…Aims To evaluate the effects of gender, food and grapefruit juice on the pharmacokinetics of primaquine in healthy subjects. Methods In a randomized, two‐phase…”
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Phenoxypropoxybiguanides, Prodrugs of DHFR−Inhibiting Diaminotriazine Antimalarials by Jensen, Norman P, Ager, Arba L, Bliss, Robert A, Canfield, Craig J, Kotecka, Barbara M, Rieckmann, Karl H, Terpinski, Jacek, Jacobus, David P

“…A total of 34 analogues of the biguanide PS-15 (5s), a prodrug of the diaminotriazine WR-99210 (8s), have been prepared. Several of them, such as 5b (PS-33)…”
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Vivax malaria: preliminary observations following a shorter course of treatment with artesunate plus primaquine by Dao, Nguyen Van Hoang, Cuong, Bui Tri, Ngoa, Nguyen Dang, Thuy, Le Thi Thanh, The, Nguyen Duy, Duy, Dinh Ngoc, Dai, Bui, Thanh, Nguyen Xuan, Chavchich, Marina, Rieckmann, Karl H., Edstein, Michael D.

“…The standard adult treatment regimen for Plasmodium vivax malaria is chloroquine (1500 mg over 3 d) plus primaquine (15 or 30 mg daily for 14 d), but patient…”
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New haplotypes of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene among chloroquine-resistant parasite isolates by Nagesha, Hadya S, Casey, Gerard J, Rieckmann, Karl H, Fryauff, David J, Laksana, Budi S, Reeder, John C, Maguire, Jason D, Baird, J Kevin

“…Mutations in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene were examined to assess their associations with chloroquine resistance…”
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Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate—JPC2056—in cynomolgus monkeys using an in vivo–in vitro model by Edstein, Michael D., Kotecka, Barbara M., Ager, Arba L., Smith, Kirsten S., DiTusa, Charles A., Diaz, Damaris S., Kyle, Dennis E., Schiehser, Guy A., Jacobus, David P., Rieckmann, Karl H., O'Neil, Michael T.

“…Objectives To assess the antimalarial pharmacodynamics and pharmacokinetics of the novel dihydrofolate reductase (DHFR) inhibitor, JPC2056 and its principal…”
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Short report: the activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains) by Sweeney, Anthony W, Blackburn, Charles R B, Rieckmann, Karl H

“…It was reported in 1946 that the administration of pamaquine during the incubation period delayed but did not prevent primary attacks of a New Guinea strain of…”
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Plasma Concentrations of Tafenoquine, a New Long-Acting Antimalarial Agent, in Thai Soldiers Receiving Monthly Prophylaxis by Edstein, Michael D., Kocisko, David A., Walsh, Douglas S., Eamsila, Chirapa, Charles, Bruce G., Rieckmann, Karl H.

“…We measured plasma tafenoquine concentrations in Thai soldiers given a monthly regimen of tafenoquine to determine whether these concentrations adequately…”
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Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New Guinea by Reeder, J C, Rieckmann, K H, Genton, B, Lorry, K, Wines, B, Cowman, A F

“…Plasmodium falciparum isolates from 24 Papua New Guinean patients with symptomatic malaria were tested for susceptibility to pyrimethamine and cycloguanil…”
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Fatty food does not alter blood mefloquine concentrations in the treatment of falciparum malaria by Dao, Nguyen Van Hoang, Quoc, Nguyen Phuc, Ngoa, Nguyen Dang, Thuy, Le Thanh, The, Nguyen Duy, Dai, Bui, Binh, Vu Quoc, Rieckmann, Karl H., Edstein, Michael D.

“…Food has been reported to increase the bioavailability of mefloquine in healthy volunteers, but its role in increasing blood mefloquine concentrations in…”
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Cytotoxic Effects of Inhibitors of de Novo Pyrimidine Biosynthesis upon Plasmodium falciparum by Seymour, Kristen K, Lyons, Stephen D, Phillips, Leonidas, Rieckmann, Karl H, Christopherson, Richard I

“…The malarial parasite Plasmodium falciparum can only synthesize pyrimidine nucleotides via the de novo pathway which is therefore a suitable target for…”
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Relapses of Plasmodium vivax Infection Result from Clonal Hypnozoites Activated at Predetermined Intervals by Chen, Nanhua, Auliff, Alyson, Rieckmann, Karl, Cheng, Qin

“…Plasmodium vivax infections are characterized by varying numbers of relapses occurring at different intervals as a result of activation of liver-stage…”
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WR 238605, chloroquine, and their combinations as blood schizonticides against a chloroquine-resistant strain of Plasmodium vivax in Aotus monkeys by Obaldia, 3rd, N, Rossan, R N, Cooper, R D, Kyle, D E, Nuzum, E O, Rieckmann, K H, Shanks, G D

“…The compound WR 238605 is a primaquine analog being developed by the U.S. Army as an antimalarial drug. Currently, there is no established treatment for…”
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Mutations in Plasmodium falciparumCytochrome b That Are Associated with Atovaquone Resistance Are Located at a Putative Drug-Binding Site by Korsinczky, Michael, Chen, Nanhua, Kotecka, Barbara, Saul, Allan, Rieckmann, Karl, Cheng, Qin

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