Search Results - "RIDLEY, J"

Life at the Leading Edge by Ridley, Anne J.

“…Cell migration requires sustained forward movement of the plasma membrane at the cell's front or “leading edge.” To date, researchers have uncovered four…”
Get full text

Rho GTPase signaling complexes in cell migration and invasion by Lawson, Campbell D, Ridley, Anne J

“…Cell migration is dependent on the dynamic formation and disassembly of actin filament-based structures, including lamellipodia, filopodia, invadopodia, and…”
Get full text

Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking by Ridley, Anne J.

“…Rho GTPases are well known to regulate actin dynamics. They activate two types of actin nucleators, WASP/WAVE proteins and Diaphanous-related formins (DRFs),…”
Get full text

Crossing the endothelial barrier during metastasis by Reymond, Nicolas, d'Água, Bárbara Borda, Ridley, Anne J.

“…Key Points To form metastases, cancer cells twice cross the endothelial cells that line blood vessels (once during intravasation and once during…”
Get full text

Tight multimessenger constraints on the neutron star equation of state from GW170817 and a forward model for kilonova light-curve synthesis by Nicholl, Matt, Margalit, Ben, Schmidt, Patricia, Smith, Graham P, Ridley, Evan J, Nuttall, James

“…ABSTRACT We present a rapid analytic framework for predicting kilonova light curves following neutron star (NS) mergers, where the main input parameters are…”
Get full text

Rho GTPases in cancer cell biology by Vega, Francisco M., Ridley, Anne J.

“…Rho GTPases contribute to multiple cellular processes that could affect cancer progression, including cytoskeletal dynamics, cell cycle progression,…”
Get full text

The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease by Hartmann, Svenja, Ridley, Anne J, Lutz, Susanne

“…Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved…”
Get full text

Rho GTPases and cell migration by Ridley, A J

“…Cell migration involves dynamic and spatially regulated changes to the cytoskeleton and cell adhesion. The Rho GTPases play key roles in coordinating the…”
Get full text

Targeting Rho GTPase Signaling Networks in Cancer by Clayton, Natasha S, Ridley, Anne J

“…As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of cellular processes, including cell polarity, cell migration, and cell cycle…”
Get full text

Arctic Sea Ice Causes Seasonal Differences in the Response of Arctic Water Vapor to Climate Warming in the CMIP6 Model, HadGEM3‐GC3.1 by Ridley, J. K., Blockley, E. W., Ringer, M. A.

“…Water vapor in the Arctic can be attributed to local evaporation and transport from mid‐latitudes. Here we investigate the response of Arctic water vapor to…”
Get full text

RhoA and RhoC have distinct roles in migration and invasion by acting through different targets by Vega, Francisco M, Fruhwirth, Gilbert, Ng, Tony, Ridley, Anne J

“…Several studies suggest that RhoA and RhoC, despite their sequence similarity, have different roles in cell migration and invasion, but the molecular basis for…”
Get full text

Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2 by Lucotti, Serena, Cerutti, Camilla, Soyer, Magali, Gil-Bernabé, Ana M, Gomes, Ana L, Allen, Philip D, Smart, Sean, Markelc, Bostjan, Watson, Karla, Armstrong, Paul C, Mitchell, Jane A, Warner, Timothy D, Ridley, Anne J, Muschel, Ruth J

“…Because metastasis is associated with the majority of cancer-related deaths, its prevention is a clinical aspiration. Prostanoids are a large family of…”
Get full text

Proneural Transcription Factors Regulate Different Steps of Cortical Neuron Migration through Rnd-Mediated Inhibition of RhoA Signaling by Pacary, Emilie, Heng, Julian, Azzarelli, Roberta, Riou, Philippe, Castro, Diogo, Lebel-Potter, Mélanie, Parras, Carlos, Bell, Donald M., Ridley, Anne J., Parsons, Maddy, Guillemot, François

“…Little is known of the intracellular machinery that controls the motility of newborn neurons. We have previously shown that the proneural protein Neurog2…”
Get full text

Nutrition therapy in critical illness: a review of the literature for clinicians by Lambell, Kate J, Tatucu-Babet, Oana A, Chapple, Lee-Anne, Gantner, Dashiell, Ridley, Emma J

“…Nutrition therapy during critical illness has been a focus of recent research, with a rapid increase in publications accompanied by two updated international…”
Get full text

Western Disturbances: A review by Dimri, A. P., Niyogi, D., Barros, A. P., Ridley, J., Mohanty, U. C., Yasunari, T., Sikka, D. R.

“…Cyclonic storms associated with the midlatitude Subtropical Westerly Jet (SWJ), referred to as Western Disturbances (WDs), play a critical role in the…”
Get full text

Rho family proteins: coordinating cell responses by Ridley, Anne J.

“…Rho GTPases hit the headlines several times in 1990–1992: the proteins regulating their GTP–GDP cycle were identified and they were found to be key signal…”
Get full text

The RhoB small GTPase in physiology and disease by Vega, Francisco M., Ridley, Anne J.

“…RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific…”
Get full text

What Happens to Nutrition Intake in the Post–Intensive Care Unit Hospitalization Period? An Observational Cohort Study in Critically Ill Adults by Ridley, Emma J., Parke, Rachael L., Davies, Andrew R., Bailey, Michael, Hodgson, Carol, Deane, Adam M., McGuinness, Shay, Cooper, D. James

“…Background Little is currently known about nutrition intake and energy requirements in the post–intensive care unit (ICU) hospitalization period in critically…”
Get full text

MAGNETOSPHERIC STRUCTURE AND ATMOSPHERIC JOULE HEATING OF HABITABLE PLANETS ORBITING M-DWARF STARS by Cohen, O, Drake, J J, Glocer, A, GARRAFFO, C, POPPENHAEGER, K, Bell, J M, Ridley, A J, Gombosi, T I

“…We study the magnetospheric structure and the ionospheric Joule Heating of planets orbiting M-dwarf stars in the habitable zone using a set of…”
Get full text

A Change in Climate State During a Pre‐Industrial Simulation of the CMIP6 Model HadGEM3 Driven by Deep Ocean Drift by Ridley, J. K., Blockley, E. W., Jones, G. S.

“…The Pre‐Industrial climate model simulation is intended as an equilibrium control experiment that uses constant external forcing, yet in the Coupled Model…”
Get full text