Search Results - "RIDDELL, J. G"

Pharmacokinetics of candesartan after single and repeated doses of candesartan cilexetil in young and elderly healthy volunteers by Hübner, R, Högemann, A M, Sunzel, M, Riddell, J G

“…Candesartan cilexetil is rapidly and completely hydrolysed to the active compound candesartan during absorption from the gastrointestinal tract. Candesartan is…”
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Evaluation of the effect on heart rate variability of a β2‐adrenoceptor agonist and antagonist using non‐linear scatterplot and sequence methods by HANRATTY, C. G, SILKE, B, RIDDELL, J. G

“…Aims To examine the impact on heart rate variability (HRV), of agonism or antagonism at the cardiac β2‐adrenoceptor in healthy volunteers, using standard…”
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Bioavailability of candesartan is unaffected by food in healthy volunteers administered candesartan cilexetil by Riddell, J G

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Heart-Rate Variability Effects of β-Adrenoceptor Agonists (Xamoterol, Prenalterol, and Salbutamol) Assessed Nonlinearly with Scatterplots and Sequence Methods by Silke, B, Hanratty, C G, Riddell, J G

“…Full antagonists of the cardiac β-adrenoceptor improve heart-rate variability (HRV) in humans; however, partial agonism at the β2-adrenoceptor has been…”
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Effects of β-Adrenoceptor Agonists and Antagonists on Heart-Rate Variability in Normal Subjects Assessed Using Summary Statistics and Nonlinear Procedures by Silke, B, Guy, S, Riddell, J G

“…The influence of celiprolol (β1- and β2-adrenoceptor partial agonist), propranolol (β1- and β2-adrenoceptor antagonist), and atenolol (β1-adrenoceptor…”
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Evaluation of the effect on heart rate variability of some agents acting at the β-adrenoceptor using nonlinear scatterplot and sequence methods by SILKE, B, RIDDELL, J. G

“…There is evidence that the processes regulating heart rate variability (HRV) reflect nonlinear complexity and show "chaotic" determinism. Data analyses using…”
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Clinical pharmacokinetics of β-adrenoceptor antagonists: an update by RIDDELL, J. G, HARRON, D. W. G, SHANKS, R. G

“…The beta-adrenoceptor antagonists have been widely used clinically for over 20 years and their pharmacokinetics have been more thoroughly investigated than any…”
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Contrasting actions of celiprolol and metoprolol on cardiac performance in normal volunteers by SILKE, B, THOMPSON, A, RIDDELL, J. G

“…A double-blind, randomized, placebo-controlled comparison of metoprolol (50 mg) and celiprolol (200 mg) was undertaken in nine normal volunteers. Rest and…”
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β-adrenoceptor modulation and heart rate variability. The value of scatterplot measures of compactness by SILKE, B, HANRATTY, C. G, VERES, S. M, RIDDELL, J. G

“…This article compares different methods of scatterplot analysis to assess the optimal methodology. The scatterplot (Poincaré plot) is a nonlinear heart rate…”
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Heart rate variability effects of an agonist or antagonists of the beta-adrenoceptor assessed with scatterplot and sequence analysis by Silke, B, Riddell, J G

“…There is evidence that the processes regulating heart rate variations reflect non-linear complexity and show 'chaotic' determinism. Data analyses using…”
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Celiprolol! A preliminary review of its pharmacodynamic and pharmacokinetic properties and its therapeutic use in hypertension and angina pectoris by RIDDELL, J. G, SHANKS, R. G, BROGDEN, R. N

“…Celiprolol is a new 'cardioselective' beta-adrenoceptor blocking drug with intrinsic sympathomimetic (partial agonist) activity and a weak vasodilating effect…”
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Intra-articular ultrasonic stimulation and intracutaneous electrical stimulation: evoked potential and visual analogue scale data by Wright, A, Davies, I Ab I, Riddell, J G

“…The reproducibility of focussed ultrasound-induced intra-articular pain was compared with that of electrically induced cutaneous pain over a period of time by…”
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A placebo controlled comparison of the effects of metoprolol and celiprolol on echo‐Doppler measurements of cardiovascular function in normal volunteers by Silke, B, Thompson, A, Leitch, A, Riddell, JG

“…1. This study used a continuous‐wave echo‐Doppler method (Exerdrop) to investigate the effects of beta‐adrenoceptor antagonism and partial agonism on…”
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The dose dependency of the alpha‐ and beta‐adrenoceptor antagonist activity of carvedilol in man by Tham, TC, Guy, S, McDermott, BJ, Shanks, RG, Riddell, JG

“…1. The alpha‐ and beta‐adrenoceptor antagonist activity of carvedilol, a beta‐adrenoceptor antagonist with vasodilating properties, and labetalol were…”
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The selectivity of xamoterol, prenalterol, and salbutamol as assessed by their effects in the presence and absence of ICI 118,551 by McCaffrey, P M, Riddell, J G, Shanks, R G

“…The selectivity of single oral doses of xamoterol, 200 mg, prenalterol, 50 mg, and salbutamol, 8 mg, was compared in eight healthy male volunteers by measuring…”
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Possible association between toxic epidermal necrolysis and ciprofloxacin by Tham, T C, Allen, G, Hayes, D, McGrady, B, Riddell, J G

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The cardioselectivity of beta adrenoceptor antagonists by Pringle, T H, Riddell, J G

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The pharmacodynamics of dilevalol by Riddell, J G

“…Dilevalol, the R-R1 isomer of labetalol, has been shown in animal studies to be a non-selective beta-adrenoceptor antagonist with beta 2-agonist activity and…”
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Characterization of the beta-adrenoreceptors which mediate the isoprenaline-induced changes in finger tremor and cardiovascular function in man by PRINGLE, T. H, RIDDELL, J. G, SHANKS, R. G

“…We have studied the contribution of beta 1- and beta 2-adrenoceptors to the isoprenaline-induced changes in heart rate, blood pressure, forearm blood flow,…”
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A comparison of the cardioselectivity of five beta-adrenoceptor blocking drugs by Pringle, T H, Riddell, J G, Shanks, R G

“…The cardioselectivities of five beta-adrenoceptor antagonists were compared. Six normal subjects received, in a double-blind random order, 200 mg acebutolol,…”
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