Search Results - "RICHEL, D. J"

Tumour–stroma interactions in pancreatic ductal adenocarcinoma: Rationale and current evidence for new therapeutic strategies by Heinemann, V, Reni, M, Ychou, M, Richel, D.J, Macarulla, T, Ducreux, M

“…Abstract Most patients with pancreatic cancer present with advanced/metastatic disease and have a dismal prognosis. Despite the proven albeit modest benefits…”
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Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity by Vermeulen, L, Todaro, M, de Sousa Mello, F, Sprick, M.R, Kemper, K, Perez Alea, M, Richel, D.J, Stassi, G, Medema, J.P

“…Colon carcinoma is one of the leading causes of death from cancer and is characterized by a heterogenic pool of cells with distinct differentiation patterns…”
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Final results of the European Advanced Renal Cell Carcinoma Sorafenib (EU-ARCCS) expanded-access study: a large open-label study in diverse community settings by Beck, J., Procopio, G., Bajetta, E., Keilholz, U., Negrier, S., Szczylik, C., Bokemeyer, C., Bracarda, S., Richel, D.J., Staehler, M., Strauss, U.P., Mersmann, S., Burock, K., Escudier, B.

“…The European Advanced Renal Cell Carcinoma Sorafenib (EU-ARCCS) expanded-access study provided sorafenib to advanced renal cell carcinoma (RCC) patients in…”
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Improved survival of colon cancer due to improved treatment and detection: a nationwide population-based study in The Netherlands 1989–2006 by van Steenbergen, L.N., Elferink, M.A.G., Krijnen, P., Lemmens, V.E.P.P., Siesling, S., Rutten, H.J.T., Richel, D.J., Karim-Kos, H.E., Coebergh, J.W.W.

“…We described changes in treatment of colon cancer over time and the impact on survival in The Netherlands in the period 1989–2006. All 103744 patients with…”
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Bevacizumab and dose-intense temozolomide in recurrent high-grade glioma by Verhoeff, J.J.C., Lavini, C., van Linde, M.E., Stalpers, L.J.A., Majoie, C.B.L.M., Reijneveld, J.C., van Furth, W.R., Richel, D.J.

“…Angiogenesis inhibition is a rational treatment strategy for high-grade glioma (HGG). Combined antiangiogenic therapy and chemotherapy could be beneficial,…”
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Mechanisms of heparin induced anti-cancer activity in experimental cancer models by Niers, T.M.H, Klerk, C.P.W, DiNisio, M, Van Noorden, C.J.F, Büller, H.R, Reitsma, P.H, Richel, D.J

“…Abstract Background Retrospective analyses of clinical trials and prospective clinical studies have suggested that heparins may have an effect on cancer…”
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Effect of aspirin on the Wnt/β-catenin pathway is mediated via protein phosphatase 2A by BOS, C. L, KODACH, L. L, VAN DEN BRINK, G. R, DIKS, S. H, VAN SANTEN, M. M, RICHEL, D. J, PEPPELENBOSCH, M. P, HARDWICK, J. C. H

“…Nonsteroidal anti-inflammatory drugs show chemopreventive efficacy in colon cancer, but the mechanism behind this remains unclear. Elucidating this mechanism…”
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Cardiac safety of adjuvant pegylated liposomal doxorubicin with concurrent trastuzumab: a randomized phase II trial by Rayson, D., Suter, T.M., Jackisch, C., van der Vegt, S., Bermejo, B., van den Bosch, J., Vivanco, G.L., van Gent, A.M., Wildiers, H., Torres, A., Provencher, L., Temizkan, M., Chirgwin, J., Canon, J.L., Ferrandina, G., Srinivasan, S., Zhang, L., Richel, D.J.

“…The cardiac safety of trastuzumab concurrent with pegylated liposomal doxorubicin (PLD) in an adjuvant breast cancer treatment regimen is unknown. Women with…”
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Prospective Randomized Trial of Docetaxel Versus Mitomycin Plus Vinblastine in Patients With Metastatic Breast Cancer Progressing Despite Previous Anthracycline-Containing Chemotherapy by NABHOLTZ, J.-M, SENN, H. J, DRBAL, J, MOLINO, A, NORTIER, J. W. R, RICHEL, D. J, NAGYKALNAI, T, SIEDLECKI, P, WILKING, N, GENOT, J. Y, HUPPERETS, P. S. G. J, PANNUTI, F, BEZWODA, W. R, SKARLOS, D, TOMIAK, E. M, MURAWSKY, M, ALAKL, M, RIVA, A, AOPRO, M, MELNYCHUK, D, DESCHENES, L, DOUMA, J, VANDENBERG, T. A, RAPOPORT, B, ROSSO, R, TRILLET-LENOIR, V

“…PURPOSE: This phase III study compared docetaxel with mitomycin plus vinblastine (MV) in patients with metastatic breast cancer (MBC) progressing despite…”
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Neoadjuvant chemoradiation followed by surgery versus surgery alone for patients with adenocarcinoma or squamous cell carcinoma of the esophagus (CROSS) by van Heijl, M, van Lanschot, J J B, Koppert, L B, van Berge Henegouwen, M I, Muller, K, Steyerberg, E W, van Dekken, H, Wijnhoven, B P L, Tilanus, H W, Richel, D J, Busch, O R C, Bartelsman, J F, Koning, C C E, Offerhaus, G J, van der Gaast, A

“…A surgical resection is currently the preferred treatment for esophageal cancer if the tumor is considered to be resectable without evidence of distant…”
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Met expression is an independent prognostic risk factor in patients with oesophageal adenocarcinoma by Tuynman, J B, Lagarde, S M, ten Kate, F J W, Richel, D J, van Lanschot, J J B

“…Oesophageal adenocarcinoma is an aggressive malignancy with propensity for early lymphatic and haematogenous dissemination. Since conventional TNM staging does…”
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Could recombinant insulin compounds contribute to adenocarcinoma progression by stimulating local angiogenesis by Rensing, K. L, Houttuijn Bloemendaal, F. M, Weijers, E. M, Richel, D. J, Büller, H. R, Koolwijk, P, van der Loos, C. M, Twickler, Th. B, von der Thüsen, J. H

“…Aims/hypothesis Negative effects on the progression of adenocarcinomas by hyperinsulinaemia and the insulin analogue glargine (A21Gly,B31Arg,B32Arg human…”
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A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer by Rea, D. W., Nortier, J. W. R., Ten Bokkel Huinink, W. W., Falk, S., Richel, D. J., Maughan, T., Groenewegen, G., Smit, J. M., Steven, N., Bakker, J. M., Semiond, D., Kerr, D. J., Punt, C. J. A.

“…Purpose:: The aim of this study was to determine in patients with previously untreated advanced colorectal cancer the maximum tolerated dose (MTD) and safety…”
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Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer by van Hagen, P, Hulshof, M.C.C.M, van Lanschot, J.J.B, Steyerberg, E.W, Henegouwen, M.I. van Berge, Wijnhoven, B.P.L, Richel, D.J, Nieuwenhuijzen, G.A.P, Hospers, G.A.P, Bonenkamp, J.J, Cuesta, M.A, Blaisse, R.J.B, Busch, O.R.C, ten Kate, F.J.W, Creemers, G.-J, Punt, C.J.A, Plukker, J.T.M, Verheul, H.M.W, Bilgen, E.J. Spillenaar, van Dekken, H, van der Sangen, M.J.C, Rozema, T, Biermann, K, Beukema, J.C, Piet, A.H.M, van Rij, C.M, Reinders, J.G, Tilanus, H.W, van der Gaast, A

“…Weekly chemotherapy and concurrent radiotherapy for 5 weeks before curative resection in patients with esophageal or esophagogastric-junction cancer resulted…”
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Limited regression of central giant cell granuloma by interferon alpha after failed calcitonin therapy: a report of 2 cases by de Lange, J., van den Akker, H.P., van den Berg, H., Richel, D.J., Gortzak, R.A.Th

“…Central giant cell granuloma (CGCG) is a benign lesion of the jaws with a sometimes locally aggressive behaviour. The most common therapy is surgical curettage…”
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Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach by Bleuming, SA, Kodach, LL, Garcia Leon, MJ, Richel, DJ, Peppelenbosch, MP, Reitsma, PH, Hardwick, JC, van den Brink, GR

“…Morphogens regulate epithelial cell fate decisions in the adult gastrointestinal tract. The authors hypothesized that influx of inflammatory cells into the…”
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Coadministration of Cyclosporine Strongly Enhances the Oral Bioavailability of Docetaxel by MALINGRE, Mirte M, RICHEL, Dick J, BEIJNEN, Jos H, ROSING, Hilde, KOOPMAN, Franciska J, TEN BOKKEL HUININK, Wim W, SCHOT, Margaret E, SCHELLENS, Jan H. M

“…Oral bioavailability of docetaxel is very low, which is, at least in part, due to its affinity for the intestinal drug efflux pump P-glycoprotein (P-gp). In…”
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Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation by van Sluis, G.L, Brüggemann, L.W, Esmon, C.T, Kamphuisen, P.W, Richel, D.J, Büller, H.R, van Noorden, C.J.F, Spek, C.A

“…Abstract Fibrinogen and platelets play an important role in cancer cell survival in the circulation by protecting cancer cells from the immune system…”
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Preoperative chemoradiation combined with regional hyperthermia for patients with resectable esophageal cancer by Hulshof, M C C M, Van Haaren, P M A, Van Lanschot, J J B, Richel, D J, Fockens, P, Oldenborg, S, Geijsen, E D, Van Berge Henegouwen, M I, Crezee, J

“…To analyse the treatment results of neo-adjuvant chemoradiation combined with regional hyperthermia in patients with resectable esophageal cancer. Between…”
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Randomised trial of high-dose chemotherapy and haemopoietic progenitor-cell support in operable breast cancer with extensive axillary lymph-node involvement by Rodenhuis, Sjoerd, Richel, Dick J, van der Wall, Elsken, Schornagel, Jan H, Baars, Joke W, Koning, Caro CE, Peterse, Johannes L, Borger, Jacques H, Nooijen, Willem J, Bakx, Roel, Dalesio, Otilia, Rutgers, Emiel

“…Uncontrolled studies suggest that high-dose chemotherapy is beneficial in patients with breast cancer and multiple metastases to the axillary lymph nodes. Many…”
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