Search Results - "RICHARDSON, Bruce C"

The Epigenetic Face of Systemic Lupus Erythematosus by Ballestar, Esteban, Esteller, Manel, Richardson, Bruce C

“…Systemic lupus erythematosus (SLE) is an archetypical systemic, autoimmune inflammatory disease characterized by the production of autoantibodies to multiple…”
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Hypermethylation of PTGER2 Confers Prostaglandin E2 Resistance in Fibrotic Fibroblasts from Humans and Mice by Huang, Steven K, Fisher, Aaron S, Scruggs, Anne M, White, Eric S, Hogaboam, Cory M, Richardson, Bruce C, Peters-Golden, Marc

“…Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease that is characterized by excessive proliferation of fibroblasts. The lipid mediator…”
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Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer by Richardson, Bruce C

“…DNA methylation plays an essential role in maintaining cellular function, and changes in methylation patterns may contribute to the development of…”
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Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity by Rajagopalan, Sanjay, Somers, Emily C., Brook, Robert D., Kehrer, Christine, Pfenninger, Dana, Lewis, Emily, Chakrabarti, Anjan, Richardson, Bruce C., Shelden, Eric, McCune, W. Joseph, Kaplan, Mariana J.

“…Women with systemic lupus erythematosus (SLE) are at risk for premature atherothrombosis independent of Framingham risk factors. We investigated whether…”
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Decreased ERK and JNK signaling contribute to gene overexpression in “senescent” CD4+CD28– T cells through epigenetic mechanisms by Chen, Yingxuan, Gorelik, Gabriela J., Strickland, Faith M., Richardson, Bruce C.

“…Decreased ERK and JNK signaling in CD4+CD28− T cells decreases DNA methyltransferase levels causes demethylation and overexpression of genes normally…”
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Accelerated Macrophage Apoptosis Induces Autoantibody Formation and Organ Damage in Systemic Lupus Erythematosus by Denny, Michael F, Chandaroy, Parthapratim, Killen, Paul D, Caricchio, Roberto, Lewis, Emily E, Richardson, Bruce C, Lee, Kyung-Dall, Gavalchin, Jerrie, Kaplan, Mariana J

“…Increased monocyte/macrophage (Mphi) apoptosis occurs in patients with systemic lupus erythematosus (SLE) and is mediated, at least in part, by an autoreactive…”
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Oxidative Stress, T Cell DNA Methylation, and Lupus by Li, YePeng, Gorelik, Gabriela, Strickland, Faith M., Richardson, Bruce C.

“…Objective Lupus develops when genetically predisposed people encounter environmental agents, such as ultraviolet light, silica, infections, and cigarette…”
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The MAPK signalling pathways and colorectal cancer by Fang, Jing Yuan, Richardson, Bruce C

“…There are three major subfamilies of mitogen-activated protein kinases (MAPK): the extracellular-signal-regulated kinases (ERK MAPK); the c-jun N-terminal…”
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Oxidative stress and dietary micronutrient deficiencies contribute to overexpression of epigenetically regulated genes by lupus T cells by Ray, Donna, Strickland, Faith M., Richardson, Bruce C.

“…Patients with active lupus have altered T cells characterized by low DNA methyltransferase levels. We hypothesized that low DNA methyltransferase levels…”
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CD4+ T cells epigenetically modified by oxidative stress cause lupus-like autoimmunity in mice by Strickland, Faith M, Li, YePeng, Johnson, Kent, Sun, Zhichao, Richardson, Bruce C

“…Abstract Lupus develops when genetically predisposed people encounter environmental agents such as UV light, silica, infections and cigarette smoke that cause…”
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Epigenetics in 2013. DNA methylation and miRNA: key roles in systemic autoimmunity by Richardson, Bruce C, Patel, Dipak R

“…Several advances in 2013 have improved our understanding of how epigenetic mechanisms affect autoimmune disorders. Many new insights were made into the…”
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Diet Influences Expression of Autoimmune‐Associated Genes and Disease Severity by Epigenetic Mechanisms in a Transgenic Mouse Model of Lupus by Strickland, Faith M., Hewagama, Anura, Wu, Ailing, Sawalha, Amr H., Delaney, Colin, Hoeltzel, Mark F., Yung, Raymond, Johnson, Kent, Mickelson, Barbara, Richardson, Bruce C.

“…Objective Lupus flares occur when genetically predisposed individuals encounter appropriate environmental agents. Current evidence indicates that the…”
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Demethylation of the Same Promoter Sequence Increases CD70 Expression in Lupus T Cells and T Cells Treated with Lupus-Inducing Drugs by Lu, Qianjin, Wu, Ailing, Richardson, Bruce C

“…Exposing genetically predisposed individuals to certain environmental agents is believed to cause human lupus. How environmental agents interact with the host…”
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Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients by Webb, Ryan, Kelly, Jennifer A, Somers, Emily C, Hughes, Travis, Kaufman, Kenneth M, Sanchez, Elena, Nath, Swapan K, Bruner, Gail, Alarcón-Riquelme, Marta E, Gilkeson, Gary S, Kamen, Diane L, Richardson, Bruce C, Harley, John B, Sawalha, Amr H

“…Systemic lupus erythematosus (SLE) is a chronic, multiorgan, autoimmune disease that affects people of all ages and ethnicities. To explore the relationship…”
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Dissecting complex epigenetic alterations in human lupus by Patel, Dipak R, Richardson, Bruce C

“…Systemic lupus erythematosus is a chronic relapsing autoimmune disease that primarily afflicts women, and both a genetic predisposition and appropriate…”
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Epigenetic mechanisms in lupus by Patel, Dipak R, Richardson, Bruce C

“…PURPOSE OF REVIEWEpigenetic mechanisms regulate gene expression, and epigenetic gene dysregulation is implicated in the pathogenesis of a growing number of…”
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Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus by Strickland, Faith M, Hewagama, Anura, Lu, Qianjian, Wu, Ailing, Hinderer, Robert, Webb, Ryan, Johnson, Kent, Sawalha, Amr H, Delaney, Colin, Yung, Raymond, Richardson, Bruce C

“…Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease primarily afflicting women. The reason for the gender bias is unclear, but genetic…”
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Prostaglandin E2 increases fibroblast gene‐specific and global DNA methylation via increased DNA methyltransferase expression by Huang, Steven K., Scruggs, Anne M., Donaghy, Jake, McEachin, Richard C., Fisher, Aaron S., Richardson, Bruce C., Peters‐Golden, Marc

“…Although alterations in DNA methylation patterns have been associated with specific diseases and environmental exposures, the mediators and signaling pathways…”
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Association of the interferon signature metric with serological disease manifestations but not global activity scores in multiple cohorts of patients with SLE by Kennedy, William P, Maciuca, Romeo, Wolslegel, Kristen, Tew, Wei, Abbas, Alexander R, Chaivorapol, Christina, Morimoto, Alyssa, McBride, Jacqueline M, Brunetta, Paul, Richardson, Bruce C, Davis, John C, Behrens, Timothy W, Townsend, Michael J

“…Objectives The interferon (IFN) signature (IS) in patients with systemic lupus erythematosus (SLE) includes over 100 genes induced by type I IFN pathway…”
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Stimulatory and Inhibitory Killer Ig-Like Receptor Molecules Are Expressed and Functional on Lupus T Cells by Basu, Dhiman, Liu, Ying, Wu, Ailing, Yarlagadda, Sushma, Gorelik, Gabriela J, Kaplan, Mariana J, Hewagama, Anura, Hinderer, Robert C, Strickland, Faith M, Richardson, Bruce C

“…T cells from lupus patients have hypomethylated DNA and overexpress genes normally suppressed by DNA methylation that contribute to disease pathogenesis. We…”
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