Search Results - "RICHARD, I"

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction by Labbadia, Johnathan, Morimoto, Richard I.

“…The heat shock response (HSR) is essential for proteostasis and cellular health. In metazoans, aging is associated with a decline in quality control,…”
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The Biology of Proteostasis in Aging and Disease by Labbadia, Johnathan, Morimoto, Richard I

“…Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is characterized by the appearance of nonnative protein aggregates in…”
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COVID-19 and Depression by Shader, Richard I.

“…The COVID-19 pandemic embodies overwhelming stresses—unemployment, death, and isolation, among others. When called upon, clinicians must try to sort out…”
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MicroRNA biogenesis pathways in cancer by Lin, Shuibin, Gregory, Richard I.

“…Key Points MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate target gene expression through mRNA degradation or translational inhibition…”
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Perovskite Oxides Prepared by Hydrothermal and Solvothermal Synthesis: A Review of Crystallisation, Chemistry, and Compositions by Walton, Richard I.

“…Perovskite oxides with general composition ABO3 are a large group of inorganic materials that can contain a variety of cations from all parts of the Periodic…”
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Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging by Morimoto, Richard I

“…The long-term health of the cell is inextricably linked to protein quality control. Under optimal conditions this is accomplished by protein homeostasis, a…”
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RNAmod: an integrated system for the annotation of mRNA modifications by Liu, Qi, Gregory, Richard I

“…Dynamic and reversible RNA modifications such as N6-methyladenosine (m6A) can play important roles in regulating messenger RNA (mRNA) splicing, export,…”
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Rethinking HSF1 in Stress, Development, and Organismal Health by Li, Jian, Labbadia, Johnathan, Morimoto, Richard I.

“…The heat shock response (HSR) was originally discovered as a transcriptional response to elevated temperature shock and led to the identification of heat shock…”
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Cell-Nonautonomous Regulation of Proteostasis in Aging and Disease by Morimoto, Richard I

“…The functional health of the proteome is determined by properties of the proteostasis network (PN) that regulates protein synthesis, folding, macromolecular…”
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The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells by Lin, Shuibin, Choe, Junho, Du, Peng, Triboulet, Robinson, Gregory, Richard I

“…METTL3 is an RNA methyltransferase implicated in mRNA biogenesis, decay, and translation control through N(6)-methyladenosine (m(6)A) modification. Here we…”
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Huntington's disease: underlying molecular mechanisms and emerging concepts by Labbadia, John, Morimoto, Richard I.

“…•Spotlight on key advances in our understanding of molecular dysfunction and HD.•Description of novel pathways influencing intracellular levels of mutant…”
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Development of the hypothalamus: conservation, modification and innovation by Xie, Yuanyuan, Dorsky, Richard I

“…The hypothalamus, which regulates fundamental aspects of physiological homeostasis and behavior, is a brain region that exhibits highly conserved anatomy…”
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Status of vaccine research and development for Shigella by Mani, Sachin, Wierzba, Thomas, Walker, Richard I

“…Highlights • Shigella infections cause substantial mortality and morbidity in children and adults. • Results from animal studies and challenge models spur…”
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The span of space by Anderson, Richard I.

“…Twinkle, twinkle little star, tell me just how far you are. Richard I. Anderson discusses standard candles and their applications…”
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Discovery of cycle-to-cycle modulated spectral line variability and velocity gradients in long-period Cepheids by Anderson, Richard I

“…This work reports the discovery of cycle-to-cycle modulated spectral line and atmospheric velocity gradient variability in long-period Cepheids based on 925…”
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Magnetized interstellar molecular clouds – II. The large-scale structure and dynamics of filamentary molecular clouds by Li, Pak Shing, Klein, Richard I

“…Abstract We perform ideal magnetohydrodynamics high-resolution adaptive mesh refinement simulations with driven turbulence and self-gravity and find that long…”
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Heat shock factors: integrators of cell stress, development and lifespan by Sistonen, Lea, Åkerfelt, Malin, Morimoto, Richard I

“…Key Points Heat shock factors (HSFs) are essential for all organisms to survive exposures to stress, as they bind heat shock elements to induce transcription…”
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Association Between Antipsychotic Medication Use and Diabetes by Holt, Richard I. G.

“…Purpose of Review The prevalence of diabetes is 2–3-fold higher in people with severe mental illness than the general population. There are concerns that…”
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Passport officers' errors in face matching by White, David, Kemp, Richard I, Jenkins, Rob, Matheson, Michael, Burton, A Mike

“…Photo-ID is widely used in security settings, despite research showing that viewers find it very difficult to match unfamiliar faces. Here we test participants…”
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Large-scale investigation of the reasons why potentially important genes are ignored by Stoeger, Thomas, Gerlach, Martin, Morimoto, Richard I, Nunes Amaral, Luís A

“…Biomedical research has been previously reported to primarily focus on a minority of all known genes. Here, we demonstrate that these differences in attention…”
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