Search Results - "RICH, P."

Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study by Rich, P., Sigurgeirsson, B., Thaci, D., Ortonne, J.-P., Paul, C., Schopf, R.E., Morita, A., Roseau, K., Harfst, E., Guettner, A., Machacek, M., Papavassilis, C.

“…Summary Background  Interleukin (IL)‐17A has major proinflammatory activity in psoriatic lesional skin. Objectives  To assess the efficacy and safety of…”
Get full text

Large environments reveal the statistical structure governing hippocampal representations by Rich, P. Dylan, Liaw, Hua-Peng, Lee, Albert K.

“…The rules governing the formation of spatial maps in the hippocampus have not been determined. We investigated the large-scale structure of place field…”
Get full text

Fully integrated silicon probes for high-density recording of neural activity by Jun, James J., Steinmetz, Nicholas A., Siegle, Joshua H., Denman, Daniel J., Bauza, Marius, Barbarits, Brian, Lee, Albert K., Anastassiou, Costas A., Andrei, Alexandru, Aydın, Çağatay, Barbic, Mladen, Blanche, Timothy J., Bonin, Vincent, Couto, João, Dutta, Barundeb, Gratiy, Sergey L., Gutnisky, Diego A., Häusser, Michael, Karsh, Bill, Ledochowitsch, Peter, Lopez, Carolina Mora, Mitelut, Catalin, Musa, Silke, Okun, Michael, Pachitariu, Marius, Putzeys, Jan, Rich, P. Dylan, Rossant, Cyrille, Sun, Wei-lung, Svoboda, Karel, Carandini, Matteo, Harris, Kenneth D., Koch, Christof, O’Keefe, John, Harris, Timothy D.

“…New silicon probes known as Neuropixels are shown to record from hundreds of neurons simultaneously in awake and freely moving rodents. High-density neural…”
Get full text

Hippocampal spatial representations exhibit a hyperbolic geometry that expands with experience by Zhang, Huanqiu, Rich, P. Dylan, Lee, Albert K., Sharpee, Tatyana O.

“…Daily experience suggests that we perceive distances near us linearly. However, the actual geometry of spatial representation in the brain is unknown. Here we…”
Get full text

Oscillatory activity in the medial prefrontal cortex and nucleus accumbens correlates with impulsivity and reward outcome by Donnelly, Nicholas A, Holtzman, Tahl, Rich, P Dylan, Nevado-Holgado, Alejo J, Fernando, Anushka B P, Van Dijck, Gert, Holzhammer, Tobias, Paul, Oliver, Ruther, Patrick, Paulsen, Ole, Robbins, Trevor W, Dalley, Jeffrey W

“…Actions expressed prematurely without regard for their consequences are considered impulsive. Such behaviour is governed by a network of brain regions…”
Get full text

The molecular machinery of Keilin's respiratory chain by Rich, P R

“…Keilin's classic paper of 1925 [Keilin (1925) Proc. R. Soc. London Ser. B 100, 129-151], achieved with simple, but elegant, techniques, describes the…”
Get more information

Magnetic voluntary head-fixation in transgenic rats enables lifespan imaging of hippocampal neurons by Rich, P. Dylan, Thiberge, Stephan Yves, Scott, Benjamin B., Guo, Caiying, Tervo, D. Gowanlock R., Brody, Carlos D., Karpova, Alla Y., Daw, Nathaniel D., Tank, David W.

“…The precise neural mechanisms within the brain that contribute to the remarkable lifetime persistence of memory are not fully understood. Two-photon calcium…”
Get full text

Inflammation and tissue remodeling mediator expression during gingivitis: A comparison between experimental, naturally occurring gingivitis, and periodontal health by Hsu, Yung-Ting, Chang, Ana M, Daubert, Diane, Roberts, Frank, Chen, Dandan, Trivedi, Harsh M, Gomez, Juliana, Darveau, Rich P

“…The aim of this study is to evaluate the immune regulation and tissue remodeling responses during experimental gingivitis (EG) and naturally occurring…”
Get full text

Efficacy and safety of mirikizumab (LY3074828) in the treatment of moderate‐to‐severe plaque psoriasis: results from a randomized phase II study by Reich, K., Rich, P., Maari, C., Bissonnette, R., Leonardi, C., Menter, A., Igarashi, A., Klekotka, P., Patel, D., Li, J., Tuttle, J., Morgan‐Cox, M., Edson‐Heredia, E., Friedrich, S., Papp, K.

“…Summary Background Inhibiting interleukin (IL)‐23 in patients with psoriasis has demonstrated high levels of skin clearance. Objectives To investigate, in a…”
Get full text

Temporal responses of NDVI to precipitation and temperature in the central Great Plains, USA by Wang, J., Rich, P. M., Price, K. P.

“…Normalized Difference Vegetation Index (NDVI) is generally recognized as a good indicator of terrestrial vegetation productivity. Understanding climatic…”
Get full text

Long‐term safety and efficacy of trifarotene 50 μg/g cream, a first‐in‐class RAR‐γ selective topical retinoid, in patients with moderate facial and truncal acne by Blume‐Peytavi, U., Fowler, J., Kemény, L., Draelos, Z., Cook‐Bolden, F., Dirschka, T., Eichenfield, L., Graeber, M., Ahmad, F., Alió Saenz, A., Rich, P., Tanghetti, E.

“…Background Treatment for both facial and truncal acne has not sufficiently been studied. Objectives To evaluate the long‐term safety and efficacy of…”
Get full text

Counseling in fetal medicine: agenesis of the corpus callosum by Santo, S., D'Antonio, F., Homfray, T., Rich, P., Pilu, G., Bhide, A., Thilaganathan, B., Papageorghiou, A. T.

“…In this Review, we aim to provide up‐to‐date and evidence‐based answers to common questions regarding the diagnosis and prognosis of prenatally detected…”
Get full text

Development and validation of the Physician's Global Assessment of Fingernail Psoriasis by Hudgens, S., Rich, P., Geng, Z., Williams, D., Fleischer, A., Ganguli, A.

“…Background Several clinician‐rated scoring systems are available to assess nail psoriasis severity, but only one has been partially validated. Objective To…”
Get full text

Spatial patterns of NDVI in response to precipitation and temperature in the central Great Plains by Wang, Jue, Price, K. P., Rich, P. M.

“…The Normalized Difference Vegetation Index (NDVI ) has proven to be a robust indicator of terrestrial vegetation productivity. Among climatic factors,…”
Get full text

Ustekinumab improves nail disease in patients with moderate-to-severe psoriasis: results from PHOENIX 1 by Rich, P., Bourcier, M., Sofen, H., Fakharzadeh, S., Wasfi, Y., Wang, Y., Kerkmann, U., Ghislain, P.-D., Poulin, Y.

“…Summary Background Most patients with psoriasis have nail changes, and treating nail psoriasis is challenging. Objectives To assess improvement in fingernail…”
Get full text

Ixekizumab treatment improves fingernail psoriasis in patients with moderate‐to‐severe psoriasis: results from the randomized, controlled and open‐label phases of UNCOVER‐3 by Kerkhof, P., Guenther, L., Gottlieb, A.B., Sebastian, M., Wu, J.J., Foley, P., Morita, A., Goldblum, O., Zhang, L., Erickson, J., Ball, S., Rich, P.

“…Background Fingernail psoriasis is difficult to treat. Objective The objective was to evaluate the effect of ixekizumab, a monoclonal antibody selectively…”
Get full text

Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy by Wee, Yinshen, Wang, Junhua, Wilson, Emily C., Rich, Coulson P., Rogers, Aaron, Tong, Zongzhong, DeGroot, Evelyn, Gopal, Y. N. Vashisht, Davies, Michael A., Ekiz, H. Atakan, Tay, Joshua K. H., Stubben, Chris, Boucher, Kenneth M., Oviedo, Juan M., Fairfax, Keke C., Williams, Matthew A., Holmen, Sheri L., Wolff, Roger K., Grossmann, Allie H.

“…Tumour-host immune interactions lead to complex changes in the tumour microenvironment (TME), impacting progression, metastasis and response to therapy. While…”
Get full text

Adalimumab for nail psoriasis: efficacy and safety over 52 weeks from a phase‐3, randomized, placebo‐controlled trial by Elewski, B.E., Baker, C.S., Crowley, J.J., Poulin, Y., Okun, M.M., Calimlim, B., Geng, Z., Reyes Servin, O., Rich, P.A.

“…Background Few clinical trials have evaluated long‐term treatment of nail psoriasis with biologics. Objective Safety and efficacy of adalimumab [ADA; Humira…”
Get full text

Improvement of scalp and nail lesions with ixekizumab in a phase 2 trial in patients with chronic plaque psoriasis by Langley, R.G., Rich, P., Menter, A., Krueger, G., Goldblum, O., Dutronc, Y., Zhu, B., Wei, H., Cameron, G.S., Heffernan, M.P.

“…Background Scalp and nail psoriasis have a major impact on quality of life and are traditionally resistant to therapy. Ixekizumab is a monoclonal antibody that…”
Get full text

Relations between NDVI and tree productivity in the central Great Plains by Wang, J., Rich, P. M., Price, K. P., Kettle, W. D.

“…Remotely sensed Normalized Difference Vegetation Index (NDVI) is a good measure of photosynthetic activity at landscape scales, and can be used to estimate…”
Get full text