Search Results - "RICE, Amy"

Hydrologic-Process-Based Soil Texture Classifications for Improved Visualization of Landscape Function by Groenendyk, Derek G, Ferré, Ty P A, Thorp, Kelly R, Rice, Amy K

“…Soils lie at the interface between the atmosphere and the subsurface and are a key component that control ecosystem services, food production, and many other…”
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Numerical Investigation of Wellbore Methane Leakage From a Dual‐Porosity Reservoir and Subsequent Transport in Groundwater by Rice, Amy K., McCray, John E., Singha, Kamini

“…Three‐dimensional, multiphase simulations are used to analyze migration of methane leakage from a hydrocarbon wellbore. The objective is to evaluate the…”
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Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus by Lee, Hyun, Ren, Jinhong, Nocadello, Salvatore, Rice, Amy J., Ojeda, Isabel, Light, Samuel, Minasov, George, Vargas, Jason, Nagarathnam, Dhanapalan, Anderson, Wayne F., Johnson, Michael E.

“…Zika flavivirus infection during pregnancy appears to produce higher risk of microcephaly, and also causes multiple neurological problems such as…”
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Methane Leakage From Hydrocarbon Wellbores into Overlying Groundwater: Numerical Investigation of the Multiphase Flow Processes Governing Migration by Rice, Amy K., McCray, John E., Singha, Kamini

“…Methane leakage due to compromised hydrocarbon well integrity can lead to impaired groundwater quality. Here we use a three‐dimensional, multiphase (vapor and…”
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Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M by Kim, Ho Shin, Hammill, Jared T., Scott, Daniel C., Chen, Yizhe, Rice, Amy L., Pistel, William, Singh, Bhuvanesh, Schulman, Brenda A., Guy, R. Kiplin

“…The cullin-RING ubiquitin ligases (CRLs) are ubiquitin E3 enzymes that play a key role in controlling proteasomal degradation and are activated by neddylation…”
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Identification and design of novel small molecule inhibitors against MERS-CoV papain-like protease via high-throughput screening and molecular modeling by Lee, Hyun, Ren, Jinhong, Pesavento, Russell P., Ojeda, Isabel, Rice, Amy J., Lv, Haining, Kwon, Youngjin, Johnson, Michael E.

“…[Display omitted] The development of new therapeutic agents against the coronavirus causing Middle East Respiratory Syndrome (MERS) is a continuing imperative…”
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Planar aggregation of the influenza viral fusion peptide alters membrane structure and hydration, promoting poration by Rice, Amy, Haldar, Sourav, Wang, Eric, Blank, Paul S., Akimov, Sergey A., Galimzyanov, Timur R., Pastor, Richard W., Zimmerberg, Joshua

“…To infect, enveloped viruses employ spike protein, spearheaded by its amphipathic fusion peptide (FP), that upon activation extends out from the viral surface…”
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Optimization of Orally Bioavailable Antileishmanial 2,4,5-Trisubstituted Benzamides by Kim, Ho Shin, Ortiz, Diana, Kadayat, Tara Man, Fargo, Corinne M., Hammill, Jared T., Chen, Yizhe, Rice, Amy L., Begley, Kristin L., Shoeran, Gaurav, Pistel, William, Yates, Phillip A., Sanchez, Marco A., Landfear, Scott M., Guy, R. Kiplin

“…Leishmaniasis, a neglected tropical disease caused by Leishmania species parasites, annually affects over 1 million individuals worldwide. Treatment options…”
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Usefulness of MRI detection of cervical spine and brain injuries in the evaluation of abusive head trauma by Kadom, Nadja, Khademian, Zarir, Vezina, Gilbert, Shalaby-Rana, Eglal, Rice, Amy, Hinds, Tanya

“…Background In the evaluation of children younger than 3 years with intracranial hemorrhage it can be difficult to determine whether the cause of hemorrhage was…”
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Identification of Small Molecule Inhibitors against Staphylococcus aureus Dihydroorotase via HTS by Rice, Amy J., Pesavento, Russell P., Ren, Jinhong, Youn, Isoo, Kwon, Youngjin, Ellepola, Kassapa, Che, Chun-Tao, Johnson, Michael E., Lee, Hyun

“…Drug-resistant Staphylococcus aureus is an imminent threat to public health, increasing the importance of drug discovery utilizing unexplored bacterial…”
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Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV by Lee, Hyun, Lei, Hao, Santarsiero, Bernard D, Gatuz, Joseph L, Cao, Shuyi, Rice, Amy J, Patel, Kavankumar, Szypulinski, Michael Z, Ojeda, Isabel, Ghosh, Arun K, Johnson, Michael E

“…The Middle East Respiratory Syndrome coronavirus (MERS-CoV) papain-like protease (PLpro) blocking loop 2 (BL2) structure differs significantly from that of…”
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Patient characteristics affect the response to ketamine and opioids during the treatment of vaso-occlusive episode-related pain in sickle cell disease by Nobrega, Raissa, Sheehy, Kathy A, Lippold, Caroline, Rice, Amy L, Finkel, Julia C, Quezado, Zenaide M N

“…Background N-methyl-D-aspartate receptor activation has been implicated in the pathobiology of inflammatory, nociceptive and neuropathic pain, opioid…”
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Groundwater‐quality hazards of methane leakage from hydrocarbon wells: A review of observational and numerical studies and four testable hypotheses by Rice, Amy K., Lackey, Greg, Proctor, James, Singha, Kamini

“…Methane leakage from hydrocarbon wells plays an important role in the groundwater‐quality impacts of hydrocarbon development and presents a more likely hazard…”
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Identification of Plasmodium falciparum heat shock 90 inhibitors via molecular docking by Everson, Nikalet, Bach, Jordan, Hammill, Jared T., Falade, Mofolusho O., Rice, Amy L., Guy, R. Kiplin, Eagon, Scott

“…[Display omitted] A virtual screen was performed to identify anti-malarial compounds targeting Plasmodium falciparum heat shock 90 protein by applying a series…”
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Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents by Hammill, Jared T, Sviripa, Vitaliy M, Kril, Liliia M, Ortiz, Diana, Fargo, Corinne M, Kim, Ho Shin, Chen, Yizhe, Rector, Jonah, Rice, Amy L, Domagalska, Malgorzata A, Begley, Kristin L, Liu, Chunming, Rangnekar, Vivek M, Dujardin, Jean-Claude, Watt, David S, Landfear, Scott M, Guy, R Kiplin

“…Leishmaniasis, a disease caused by protozoa of the species, afflicts roughly 12 million individuals worldwide. Most existing drugs for leishmaniasis are toxic,…”
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Retrospective comparison of the Low Risk Ankle Rules and the Ottawa Ankle Rules in a pediatric population by Ellenbogen, Amy L., MD, Rice, Amy L., PhD, Vyas, Pranav, MD

“…Abstract Background A recent multicenter prospective Canadian study presented prospective evidence supporting the Low Risk Ankle Rules (LRAR) as a means of…”
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Ca-asp bound X-ray structure and inhibition of Bacillus anthracis dihydroorotase (DHOase) by Rice, Amy J., Lei, Hao, Santarsiero, Bernard D., Lee, Hyun, Johnson, Michael E.

“…[Display omitted] Dihydroorotase (DHOase) is the third enzyme in the de novo pyrimidine synthesis pathway and is responsible for the reversible cyclization of…”
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Antimalarial activity of tetrahydro-β-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein by Eagon, Scott, Hammill, Jared T., Bach, Jordan, Everson, Nikalet, Sisley, Tyler A., Walls, Michael J., Durham, Sierra, Pillai, Dylan R., Falade, Mofolusho O., Rice, Amy L., Kimball, Joshua J., Lazaro, Horacio, DiBernardo, Celine, Kiplin Guy, R.

“…[Display omitted] •The natural product harmine is known to have antimalarial activity.•We report a new series of harmine derivatives that show improved…”
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Gastric emptying of milk in infants and children up to 5 years of age: normative data and influencing factors by Kwatra, Neha S., Shalaby-Rana, Eglal, Andrich, Mary P., Tsai, Jason, Rice, Amy L., Ghelani, Sunil J., Spottswood, Stephanie E., Majd, Massoud

“…Background Gastric emptying scintigraphy is widely used in infants and children, but there is a lack of age-specific normative data. Objective The objectives…”
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Evaluation of 1,1-cyclopropylidene as a thioether isostere in the 4-thio-thienopyrimidine (TTP) series of antimalarials by Barrows, Robert D., Hammill, Jared T., Tran, Michael C., Falade, Mofolusho O., Rice, Amy L., Davis, Christopher W., Emge, Thomas J., Rablen, Paul R., Kiplin Guy, R., Knapp, Spencer

“…[Display omitted] The 4-(heteroarylthio)thieno[2,3-d]pyrimidine (TTP) series of antimalarials, represented by 1 and 17, potently inhibit proliferation of the…”
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