Search Results - "RIBEIRO DOS SANTOS, Ricardo"
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Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease
Published in International journal of molecular sciences (24-03-2021)“…Chagas disease, caused by the parasite ( ), remains a serious public health problem for which there is no effective treatment in the chronic stage. Intense…”
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Conditioned Medium of Bone Marrow-Derived Mesenchymal Stromal Cells as a Therapeutic Approach to Neuropathic Pain: A Preclinical Evaluation
Published in Stem cells international (01-01-2018)“…Neuropathic pain is a type of chronic pain caused by injury or dysfunction of the nervous system, without effective therapeutic approaches. Mesenchymal stromal…”
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Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy
Published in Stem cells international (01-01-2017)“…Therapies based on transplantation of mesenchymal stromal cells (MSC) hold promise for the management of inflammatory disorders. In chronic Chagas disease…”
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Clinical Trials with Mesenchymal Stem Cell Therapies for Osteoarthritis: Challenges in the Regeneration of Articular Cartilage
Published in International journal of molecular sciences (01-06-2023)“…Osteoarthritis (OA) is a whole-joint disease primarily characterized by the deterioration of hyaline cartilage. Current treatments include microfracture and…”
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Performance predictors for graphics processing units applied to dark‐silicon‐aware design space exploration
Published in Concurrency and computation (01-08-2023)“…The limitations on the scalability of computer systems imposed by the dark‐silicon effects are so severe that they support the extensive use of heterogeneity…”
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Circulating miRNAs as Potential Biomarkers Associated with Cardiac Remodeling and Fibrosis in Chagas Disease Cardiomyopathy
Published in International journal of molecular sciences (20-08-2019)“…Chagas disease (CD) affects approximately 6-7 million people worldwide, from which 30% develop chronic Chagas cardiomyopathy (CCC), usually after being…”
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The effects of inflammation on connexin 43 in chronic Chagas disease cardiomyopathy
Published in Frontiers in immunology (29-07-2024)“…Cardiac arrhythmias are the main cause of sudden death due to Chronic Chagasic Cardiomyopathy (CCC). Here we investigated alterations in connexin 43 (Cx43)…”
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The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases - A Review
Published in Memórias do Instituto Oswaldo Cruz (01-10-2005)“…The modern approach to the development of new chemical entities against complex diseases, especially the neglected endemic diseases such as tuberculosis and…”
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Antimalarial Activity of Physalins B, D, F, and G
Published in Journal of natural products (Washington, D.C.) (28-10-2011)“…The antimalarial activities of physalins B, D, F, and G (1–4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity…”
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Cell Therapy in Chagas Cardiomyopathy (Chagas Arm of the Multicenter Randomized Trial of Cell Therapy in Cardiopathies Study): A Multicenter Randomized Trial
Published in Circulation (New York, N.Y.) (22-05-2012)“…Previous studies suggested that transplantation of autologous bone marrow-derived mononuclear cells (BMNCs) improves heart function in chronic chagasic…”
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Transplantation of stem cells obtained from murine dental pulp improves pancreatic damage, renal function, and painful diabetic neuropathy in diabetic type 1 mouse model
Published in Cell transplantation (01-12-2013)“…Diabetes mellitus (DM) is one of the most common and serious chronic diseases in the world. Here, we investigated the effects of mouse dental pulp stem cell…”
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Gene Expression Changes Associated with Myocarditis and Fibrosis in Hearts of Mice with Chronic Chagasic Cardiomyopathy
Published in The Journal of infectious diseases (15-08-2010)“…Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi–infected individuals develop…”
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Lack of association between serum syndecan-4, myocardial fibrosis and ventricular dysfunction in subjects with chronic Chagas disease
Published in PloS one (12-12-2017)“…Syndecan-4 is a transmembrane glycoprotein associated with inflammation and fibrosis. Increased syndecan-4 levels were previously detected after acute…”
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Generation of three control iPS cell lines for sickle cell disease studies by reprogramming erythroblasts from individuals without hemoglobinopathies
Published in Stem cell research (01-07-2019)“…Sickle cell disease (SCD) is one of the most prevalent and severe monogenetic disorders. Previously, we generated iPS cell lines from SCD patients. Here, we…”
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Reversion of gene expression alterations in hearts of mice with chronic chagasic cardiomyopathy after transplantation of bone marrow cells
Published in Cell cycle (Georgetown, Tex.) (01-05-2011)“…Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries, being associated with intense inflammatory response and…”
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Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract
Published in Journal of ethnopharmacology (17-08-2009)“…Blechnum occidentale L. is a terrestrial fern that ranges from the United States to South America, and is employed in Brazilian folk medicine. In the present…”
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Activity of physalins purified from Physalis angulata in in vitro and in vivo models of cutaneous leishmaniasis
Published in Journal of antimicrobial chemotherapy (01-07-2009)“…Objectives We have previously demonstrated the immunomodulatory effects of physalins, secosteroids purified from Physalis angulata. Here we investigate the…”
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Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease
Published in World journal of gastroenterology : WJG (21-02-2007)“…AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver…”
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Mechanisms of the anti‐inflammatory effects of the natural secosteroids physalins in a model of intestinal ischaemia and reperfusion injury
Published in British journal of pharmacology (01-09-2005)“…Reperfusion of an ischaemic tissue is associated with an intense inflammatory response and inflammation‐mediated tissue injury. Physalins, a group of…”
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Distribution and proliferation of bone marrow cells in the brain after pilocarpine‐induced status epilepticus in mice
Published in Epilepsia (Copenhagen) (01-08-2010)“…Summary The distribution of bone marrow cells in brain areas during the acute period after pilocarpine‐induced status epilepticus (SE) was investigated here…”
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