Search Results - "RIAD, Alexander"

Reduced Degradation of the Chemokine MCP-3 by Matrix Metalloproteinase-2 Exacerbates Myocardial Inflammation in Experimental Viral Cardiomyopathy by WESTERMANN, Dirk, SAVVATIS, Kostantinos, RIAD, Alexander, PLENDL, Johanna, KLINGEL, Karin, POLLER, Wolfgang, SCHULTHEISS, Heinz-Peter, TSCHÖPE, Carsten, LINDNER, Diana, ZIETSCH, Christin, MORITZ BECHER, Peter, HAMMER, Elke, HEIMESAAT, Markus M, BERESWILL, Stefan, VÖLKER, Uwe, ESCHER, Felicitas

“…Myocarditis is an important cause for cardiac failure, especially in younger patients, followed by the development of cardiac dysfunction and death. The…”
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Gene Deletion of the Kinin Receptor B1 Attenuates Cardiac Inflammation and Fibrosis During the Development of Experimental Diabetic Cardiomyopathy by WESTERMANN, Dirk, WALTHER, Thomas, SAVVATIS, Konstantinos, ESCHER, Felcicitas, SOBIREY, Meike, RIAD, Alexander, BADER, Michael, SCHULTHEISS, Heinz-Peter, TSCHÖPE, Carsten

“…Gene Deletion of the Kinin Receptor B1 Attenuates Cardiac Inflammation and Fibrosis During the Development of Experimental Diabetic Cardiomyopathy Dirk…”
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Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy by Van Linthout, Sophie, Seeland, Ute, Riad, Alexander, Eckhardt, Oleg, Hohl, Mathias, Dhayat, Nasser, Richter, Utz, Fischer, Jens W., Böhm, Michael, Pauschinger, Matthias, Schultheiss, Heinz-Peter, Tschöpe, Carsten

“…Objective To evaluate the regulation of matrix metalloproteinase (MMP)-2 in diabetic cardiomyopathy. Methods Left ventricle (LV) function was determined by a…”
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Toll-Like Receptor-4 Modulates Survival by Induction of Left Ventricular Remodeling after Myocardial Infarction in Mice by Riad, Alexander, Jager, Sebastian, Sobirey, Meike, Escher, Felicitas, Yaulema-Riss, Aymaru, Westermann, Dirk, Karatas, Aysun, Heimesaat, Markus M, Bereswill, Stefan, Dragun, Duska, Pauschinger, Matthias, Schultheiss, Heinz P, Tschope, Carsten

“…Left ventricular (LV) remodeling is known to contribute to morbidity and mortality after myocardial infarction (MI). Because LV remodeling is strongly…”
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Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice by Riad, Alexander, Bien, Sandra, Gratz, Matthias, Escher, Felicitas, Heimesaat, Markus M., Bereswill, Stefan, Krieg, Thomas, Felix, Stephan B., Schultheiss, Heinz P., Kroemer, Heyo K., Tschöpe, Carsten

“…Background: Cardiac inflammation and generation of oxidative stress are known to contribute to doxorubicin (Dox)-induced cardiomyopathy. Toll-like receptors…”
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TRIF is a critical survival factor in viral cardiomyopathy by Riad, Alexander, Westermann, Dirk, Zietsch, Christin, Savvatis, Konstantinos, Becher, Peter M, Bereswill, Stefan, Heimesaat, Markus M, Lettau, Olga, Lassner, Dirk, Dörner, Andrea, Poller, Wolfgang, Busch, Matthias, Felix, Stephan B, Schultheiss, Heinz P, Tschöpe, Carsten

“…TRIF is a member of the innate immune system known to be involved in viral recognition and type I IFN activation. Because IFNs are thought to play an important…”
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Cardioprotective and Anti-Inflammatory Effects of Interleukin Converting Enzyme Inhibition in Experimental Diabetic Cardiomyopathy by WESTERMANN, Dirk, VAN LINTHOUT, Sophie, TSCHÖPE, Carsten, DHAYAT, Sameer, DHAYAT, Nasser, ESCHER, Felicitas, BÜCKER-GÄRTNER, Carola, SPILLMANN, Frank, NOUTSIAS, Michel, RIAD, Alexander, SCHULTHEISS, Heinz-Peter

“…Cardioprotective and Anti-Inflammatory Effects of Interleukin Converting Enzyme Inhibition in Experimental Diabetic Cardiomyopathy Dirk Westermann , Sophie Van…”
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Renin Inhibition Improves Cardiac Function and Remodeling After Myocardial Infarction Independent of Blood Pressure by Westermann, Dirk, Riad, Alexander, Lettau, Olga, Roks, Anton, Savvatis, Konstantinos, Becher, Peter Moritz, Escher, Felicitas, Danser, A H. Jan, Schultheiss, Heinz-Peter, Tschöpe, Carsten

“…Pharmacological renin inhibition with aliskiren is an effective antihypertensive drug treatment, but it is currently unknown whether aliskiren is able to…”
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Multicenter Long-Term Validation of a Minicourse in Radiation-Reducing Techniques in the Catheterization Laboratory by Kuon, Eberhard, MD, Weitmann, Kerstin, MSc, Hoffmann, Wolfgang, MD, Dörr, Marcus, MD, Hummel, Astrid, MD, Riad, Alexander, MD, Busch, Mathias C., MD, Felix, Stephan B., MD, Empen, Klaus, MD

“…Patient radiation exposure in invasive cardiology is considerable. We aimed to investigate, in a multicenter field study, the long-term efficacy of an…”
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Myeloid differentiation factor-88 contributes to TLR9-mediated modulation of acute coxsackievirus B3-induced myocarditis in vivo by Riad, Alexander, Westermann, Dirk, Escher, Felicitas, Becher, Peter M, Savvatis, Konstantinos, Lettau, Olga, Heimesaat, Markus M, Bereswill, Stefan, Volk, Hans D, Schultheiss, Heinz P, Tschöpe, Carsten

“…Toll-like receptor 9 (TLR9) is a member of the innate immune system and has been shown to influence myocardial function, but its role in myocarditis is…”
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The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy by Bien, Sandra, Riad, Alexander, Ritter, Christoph A, Gratz, Matthias, Olshausen, Florian, Westermann, Dirk, Grube, Markus, Krieg, Thomas, Ciecholewski, Sabine, Felix, Stephan B, Staudt, Alexander, Schultheiss, Heinz-Peter, Ewert, Ralf, Völker, Uwe, Tschöpe, Carsten, Kroemer, Heyo K

“…Doxorubicin is a frequently used anticancer drug, but its therapeutic benefit is limited by acute and chronic cardiotoxicity, often leading to heart failure…”
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Stiffness of Left Ventricular Cardiac Fibroblasts Is Associated With Ventricular Dilation in Patients With Recent-Onset Nonischemic and Nonvalvular Cardiomyopathy by Glaubitz, Michael, Block, Stephan, Witte, Jeannine, Empen, Klaus, Gross, Stefan, Schlicht, Robert, Weitmann, Kerstin, Klingel, Karin, Kandolf, Reinhard, Hoffmann, Wolfgang, Gottschalk, Kay E., Busch, Mathias, Dörr, Marcus, Helm, Christiane A., Felix, Stephan B., Riad, Alexander

“…Background:Ventricular dilation is known as a pivotal predictor in recent-onset cardiomyopathy (ROCM), but its pathophysiology is not fully understood. In the…”
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Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease by WALTHER, Thomas, TSCHÖPE, Carsten, BADER, Michael, SHAKIBAEI, Mehdi, SCHULTHEISS, Heinz-Peter, DÖRNER, Andrea, STERNER-KOCK, Anja, WESTERMANN, Dirk, HERINGER-WALTHER, Silvia, RIAD, Alexander, NIKOLIC, Alen, YONG WANG, EBERMANN, Linda, SIEMS, Wolf-Eberhard

“…Strong evidence suggests that mitochondrial malfunction, which leads to disturbed energy metabolism and stimulated apoptosis, is a linchpin in the induction…”
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Viral myocarditis and coagulopathy: Increased tissue factor expression and plasma thrombogenicity by Antoniak, Silvio, Boltzen, Ulrike, Riad, Alexander, Kallwellis-Opara, Angela, Rohde, Maria, Dörner, Andrea, Tschöpe, Carsten, Noutsias, Michel, Pauschinger, Matthias, Schultheiss, Heinz-Peter, Rauch, Ursula

“…Abstract We investigated the effects of viral infection on Tissue Factor (TF) expression and activity in mice within the myocardium to understand increased…”
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Innate immune receptors in heart failure: Side effect or potential therapeutic target? by Wagner, Katharina B, Felix, Stephan B, Riad, Alexander

“…Heart failure(HF) is a leading cause of mortality and morbidity in western countries and occasions major expenses for public health systems. Although optimal…”
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Efficacy of a Minicourse in Radiation-Reducing Techniques in Invasive Cardiology by Kuon, Eberhard, MD, Weitmann, Kerstin, MSc, Hoffmann, Wolfgang, MD, Dörr, Marcus, MD, Reffelmann, Thorsten, MD, Hummel, Astrid, MD, Riad, Alexander, MD, Busch, Mathias C., MD, Empen, Klaus, MD, Felix, Stephan B., MD

“…Objectives Our goal was to validate an educational 90-min minicourse in lower-irradiating cardiac invasive techniques. Background Despite comprehensive…”
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Contributions of Inflammation and Cardiac Matrix Metalloproteinase Activity to Cardiac Failure in Diabetic Cardiomyopathy by Westermann, Dirk, Rutschow, Susanne, Jäger, Sebastian, Linderer, Anne, Anker, Stefan, Riad, Alexander, Unger, Thomas, Schultheiss, Heinz-Peter, Pauschinger, Matthias, Tschöpe, Carsten

“…Contributions of Inflammation and Cardiac Matrix Metalloproteinase Activity to Cardiac Failure in Diabetic Cardiomyopathy The Role of Angiotensin Type 1…”
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Role of Left Ventricular Stiffness in Heart Failure With Normal Ejection Fraction by WESTERMANN, Dirk, KASNER, Mario, TSCHÖPE, Carsten, STEENDIJK, Paul, SPILLMANN, Frank, RIAD, Alexander, WEITMANN, Kerstin, HOFFMANN, Wolfgang, POLLER, Wolfgang, PAUSCHINGER, Matthias, SCHULTHEISS, Heinz-Peter

“…Increased left ventricular stiffness is a distinct finding in patients who have heart failure with normal ejection fraction (HFNEF). To elucidate how diastolic…”
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Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction by Westermann, Dirk, Lindner, Diana, Kasner, Mario, Zietsch, Christine, Savvatis, K, Escher, F, von Schlippenbach, J, Skurk, C, Steendijk, Paul, Riad, Alexander, Poller, Wolfgang, Schultheiss, Heinz-Peter, Tschöpe, Carsten

“…The pathophysiology of heart failure with normal ejection fraction (HFNEF) is still under discussion. Here we report the influence of cardiac inflammation on…”
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High-Mobility Group Box Protein 1 Is an Independent Prognostic Marker for All-Cause Mortality in Patients With Dilated Cardiomyopathy by Kümmel, Andreas, Gross, Stefan, Feldtmann, Rico, Chamling, Bishwas, Strohbach, Anne, Lehnert, Kristin, Bahls, Martin, Loerzer, Lisa, Moormann, Katharina, Witte, Jeannine, Riad, Alexander, Dörr, Marcus, Fielitz, Jens, Felix, Stephan B.

“…High-mobility group box protein 1 (HMGB1) is released during tissue damage and activates the innate immune system through toll-like receptor 4. Because…”
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