Search Results - "REYNOLDS, JOHN J."

Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum by Reynolds, John N. J., Avvisati, Riccardo, Dodson, Paul D., Fisher, Simon D., Oswald, Manfred J., Wickens, Jeffery R., Zhang, Yan-Feng

“…Dopamine-dependent long-term plasticity is believed to be a cellular mechanism underlying reinforcement learning. In response to reward and reward-predicting…”
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BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks by Higgs, Martin R., Reynolds, John J., Winczura, Alicja, Blackford, Andrew N., Borel, Valérie, Miller, Edward S., Zlatanou, Anastasia, Nieminuszczy, Jadwiga, Ryan, Ellis L., Davies, Nicholas J., Stankovic, Tatjana, Boulton, Simon J., Niedzwiedz, Wojciech, Stewart, Grant S.

“…Recognition and repair of damaged replication forks are essential to maintain genome stability and are coordinated by the combined action of the Fanconi anemia…”
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PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination by Clarke, Thomas L., Sanchez-Bailon, Maria Pilar, Chiang, Kelly, Reynolds, John J., Herrero-Ruiz, Joaquin, Bandeiras, Tiago M., Matias, Pedro M., Maslen, Sarah L., Skehel, J. Mark, Stewart, Grant S., Davies, Clare C.

“…Protein post-translation modification plays an important role in regulating DNA repair; however, the role of arginine methylation in this process is poorly…”
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DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain by Zhang, Jing, Bellani, Marina A., James, Ryan C., Pokharel, Durga, Zhang, Yongqing, Reynolds, John J., McNee, Gavin S., Jackson, Andrew P., Stewart, Grant S., Seidman, Michael M.

“…Duplication of mammalian genomes requires replisomes to overcome numerous impediments during passage through open (eu) and condensed (hetero) chromatin…”
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PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling by Yang, Yang, Jayaprakash, Deepika, Jhujh, Satpal S, Reynolds, John J, Chen, Steve, Gao, Yanzhe, Anand, Jay Ramanlal, Mutter-Rottmayer, Elizabeth, Ariel, Pablo, An, Jing, Cheng, Xing, Pearce, Kenneth H, Blanchet, Sophie-Anne, Nandakumar, Nandana, Zhou, Pei, Fradet-Turcotte, Amélie, Stewart, Grant S, Vaziri, Cyrus

“…RNF168 orchestrates a ubiquitin-dependent DNA damage response to regulate the recruitment of repair factors, such as 53BP1 to DNA double-strand breaks (DSBs)…”
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Ultrasound-Mediated Blood-Brain Barrier Disruption for Drug Delivery: A Systematic Review of Protocols, Efficacy, and Safety Outcomes from Preclinical and Clinical Studies by Gandhi, Kushan, Barzegar-Fallah, Anita, Banstola, Ashik, Rizwan, Shakila B, Reynolds, John N J

“…Ultrasound-mediated blood-brain barrier (BBB) disruption has garnered focus as a method of delivering normally impenetrable drugs into the brain. Numerous…”
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RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells by Krishnan, Rehna, Lapierre, Mariah, Gautreau, Brandon, Nixon, Kevin C J, El Ghamrasni, Samah, Patel, Parasvi S, Hao, Jun, Yerlici, V Talya, Guturi, Kiran Kumar Naidu, St-Germain, Jonathan, Mateo, Francesca, Saad, Amine, Algouneh, Arash, Earnshaw, Rebecca, Shili, Duan, Seitova, Alma, Miller, Joshua, Khosraviani, Negin, Penn, Adam, Ho, Brandon, Sanchez, Otto, Hande, M Prakash, Masson, Jean-Yves, Brown, Grant W, Alaoui-Jamali, Moulay, Reynolds, John J, Arrowsmith, Cheryl, Raught, Brian, Pujana, Miguel A, Mekhail, Karim, Stewart, Grant S, Hakem, Anne, Hakem, Razqallah

“…Abstract Breast cancer linked with BRCA1/2 mutations commonly recur and resist current therapies, including PARP inhibitors. Given the lack of effective…”
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Mutations in PNKP cause microcephaly, seizures and defects in DNA repair by Walsh, Christopher A, Shen, Jun, Gilmore, Edward C, Marshall, Christine A, Haddadin, Mary, Reynolds, John J, Eyaid, Wafaa, Bodell, Adria, Barry, Brenda, Gleason, Danielle, Allen, Kathryn, Ganesh, Vijay S, Chang, Bernard S, Grix, Arthur, Hill, R Sean, Topcu, Meral, Caldecott, Keith W, Barkovich, A James

“…Maintenance of DNA integrity is crucial for all cell types, but neurons are particularly sensitive to mutations in DNA repair genes, which lead to both…”
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Information on early medical abortion for women using an audiovisual animation vs face-to-face consultation: A consortium randomized and quasi-randomized trial by Reynolds-Wright, John J, Belleuvre, Florence, Daberius, Anette, Faucher, Philippe, Gemzell-Danielsson, Kristina, Cameron, Sharon T

“…There is some evidence that audiovisual formats can be an effective way of providing information about early medical abortion (EMA). A short animation (3…”
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Harnessing Ultrasound for Targeting Drug Delivery to the Brain and Breaching the Blood–Brain Tumour Barrier by Barzegar-Fallah, Anita, Gandhi, Kushan, Rizwan, Shakila B, Slatter, Tania L, Reynolds, John N. J

“…Despite significant advances in developing drugs to treat brain tumours, achieving therapeutic concentrations of the drug at the tumour site remains a major…”
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Pause and rebound: sensory control of cholinergic signaling in the striatum by Schulz, Jan M, Reynolds, John N.J

“…Cholinergic interneurons have emerged as one of the key players controlling network functions in the striatum. Extracellularly recorded cholinergic…”
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A cellular mechanism of reward-related learning by Wickens, Jeffery R, Reynolds, John N. J, Hyland, Brian I

“…Positive reinforcement helps to control the acquisition of learned behaviours. Here we report a cellular mechanism in the brain that may underlie the…”
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Analysis of novel missense ATR mutations reveals new splicing defects underlying Seckel syndrome by Llorens‐Agost, Marta, Luessing, Janna, Beneden, Amandine, Eykelenboom, John, O'Reilly, Dawn, Bicknell, Louise S, Reynolds, John J, Koegelenberg, Marianne, Hurles, Matthew E, Brady, Angela F, Jackson, Andrew P, Stewart, Grant S, Lowndes, Noel F

“…Ataxia Telangiectasia and Rad3 related (ATR) is one of the main regulators of the DNA damage response. It coordinates cell cycle checkpoint activation,…”
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Differential short-term plasticity at convergent inhibitory synapses to the substantia nigra pars reticulata by Connelly, William M, Schulz, Jan M, Lees, George, Reynolds, John N J

“…Inhibitory projections from the striatum and globus pallidus converge onto GABAergic projection neurons of the substantia nigra pars reticulata (SNr). Based on…”
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Short-Latency Activation of Striatal Spiny Neurons via Subcortical Visual Pathways by Schulz, Jan M, Redgrave, Peter, Mehring, Carsten, Aertsen, Ad, Clements, Koreen M, Wickens, Jeff R, Reynolds, John N. J

“…The striatum is a site of integration of neural pathways involved in reinforcement learning. Traditionally, inputs from cerebral cortex are thought to be…”
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The Sheep as a Large Animal Model for the Investigation and Treatment of Human Disorders by Banstola, Ashik, Reynolds, John N. J.

“…An essential aim of biomedical research is to translate basic science information obtained from preclinical research using small and large animal models into…”
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Therapeutic ultrasound: an innovative approach for targeting neurological disorders affecting the basal ganglia by Singh, Anurag, Reynolds, John N J

“…The basal ganglia are involved in motor control and action selection, and their impairment manifests in movement disorders such as Parkinson's disease (PD) and…”
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Defective DNA Ligation during Short-Patch Single-Strand Break Repair in Ataxia Oculomotor Apraxia 1 by Reynolds, John J., El-Khamisy, Sherif F., Katyal, Sachin, Clements, Paula, McKinnon, Peter J., Caldecott, Keith W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1 by Abu-Libdeh, Bassam, Jhujh, Satpal S, Dhar, Srijita, Sommers, Joshua A, Datta, Arindam, Longo, Gabriel Mc, Grange, Laura J, Reynolds, John J, Cooke, Sophie L, McNee, Gavin S, Hollingworth, Robert, Woodward, Beth L, Ganesh, Anil N, Smerdon, Stephen J, Nicolae, Claudia M, Durlacher-Betzer, Karina, Molho-Pessach, Vered, Abu-Libdeh, Abdulsalam, Meiner, Vardiella, Moldovan, George-Lucian, Roukos, Vassilis, Harel, Tamar, Brosh, Jr, Robert M, Stewart, Grant S

“…Despite being the first homolog of the bacterial RecQ helicase to be identified in humans, the function of RECQL1 remains poorly characterized. Furthermore,…”
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Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ by Kalasova, Ilona, Hanzlikova, Hana, Gupta, Neerja, Li, Yun, Altmüller, Janine, Reynolds, John J, Stewart, Grant S, Wollnik, Bernd, Yigit, Gökhan, Caldecott, Keith W

“…To address the relationship between novel mutations in polynucleotide 5'-kinase 3'-phosphatase (PNKP), DNA strand break repair, and neurologic disease. We have…”
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