Search Results - "REYLAND, M. E"

Tyrosine phosphorylation regulates nuclear translocation of PKCδ by Humphries, M J, Ohm, A M, Schaack, J, Adwan, T S, Reyland, M E

“…PKCδ is essential for apoptosis, but regulation of the proapoptotic function of this ubiquitous kinase is not well understood. Nuclear translocation of PKCδ is…”
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Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus by Irani, B.G, Donato, J, Olson, D.P, Lowell, B.B, Sacktor, T.C, Reyland, M.E, Tolson, K.P, Zinn, A.R, Ueta, Y, Sakata, I, Zigman, J.M, Elias, C.F, Clegg, D.J

“…Abstract PKC-theta (PKC-θ), a member of the novel protein kinase C family (nPKC), regulates a wide variety of functions in the periphery. However, its presence…”
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Activation of PKC is sufficient to induce an apoptotic program in salivary gland acinar cells by Reyland, M E, Barzen, K A, Anderson, S M, Quissell, D O, Matassa, A A

“…Accumulating evidence suggests that specific isoforms of PKC may function to promote apoptosis. We show here that activation of the conventional and novel…”
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Co-dependency of PKCδ and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer by Ohm, A M, Tan, A-C, Heasley, L E, Reyland, M E

“…Recent studies suggest that the presence of a KRAS mutation may be insufficient for defining a clinically homogenous molecular group, as many KRAS mutant…”
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Protein kinase Cδ is required for ErbB2-driven mammary gland tumorigenesis and negatively correlates with prognosis in human breast cancer by Allen-Petersen, B L, Carter, C J, Ohm, A M, Reyland, M E

“…Protein kinase C δ (PKCδ) regulates apoptosis in the mammary gland, however, the functional contribution of PKCδ to the development or progression of breast…”
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Loss of PKCδ results in characteristics of Sjögren's syndrome including salivary gland dysfunction by Banninger, GP, Cha, S, Said, MS, Pauley, KM, Carter, CJ, Onate, M, Pauley, BA, Anderson, SM, Reyland, ME

“…Oral Diseases (2011) 17, 601–609 Objectives:  Chronic infiltration of lymphocytes into the salivary and lacrimal glands of patients with Sjögren’s Syndrome…”
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Role of protein kinase C δ in ER stress and apoptosis induced by oxidized LDL in human vascular smooth muscle cells by Larroque-Cardoso, P, Swiader, A, Ingueneau, C, Nègre-Salvayre, A, Elbaz, M, Reyland, M E, Salvayre, R, Vindis, C

“…During atherogenesis, excess amounts of low-density lipoproteins (LDL) accumulate in the subendothelial space where they undergo oxidative modifications…”
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Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma by Murakami, A, Wang, L, Kalhorn, S, Schraml, P, Rathmell, W K, Tan, A C, Nemenoff, R, Stenmark, K, Jiang, B-H, Reyland, M E, Heasley, L, Hu, C-J

“…A subset of clear cell renal cell carcinoma (ccRCC) tumors exhibit a HIF1A gene mutation, yielding two ccRCC tumor types, H1H2 type expressing both HIF1α and…”
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Oxysterols regulate expression of the steroidogenic acute regulatory protein by King, SR, Matassa, AA, White, EK, Walsh, LP, Jo, Y, Rao, RM, Stocco, DM, Reyland, ME

“…The steroidogenic acute regulatory (StAR) protein promotes intramitochondrial delivery of cholesterol to the cholesterol side-chain cleavage system, which…”
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Protein kinase C is a tonic negative regulator of steroidogenesis and steroid hydroxylase gene expression in Y1 adrenal cells and functions independently of protein kinase A by Reyland, M E

“…The role of protein kinase C (PKC) in the regulation of basal steroidogenesis and steroid hydroxylase gene expression in Y1 adrenocortical cells was…”
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Protein kinase C isozymes and the regulation of diverse cell responses by Dempsey, E C, Newton, A C, Mochly-Rosen, D, Fields, A P, Reyland, M E, Insel, P A, Messing, R O

“…Individual protein kinase C (PKC) isozymes have been implicated in many cellular responses important in lung health and disease, including permeability,…”
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Etoposide-induced activation of c-jun N-terminal kinase (JNK) correlates with drug-induced apoptosis in salivary gland acinar cells by Anderson, S M, Reyland, M E, Hunter, S, Deisher, L M, Barzen, K A, Quissell, D O

“…We have examined the ability of etoposide to induce apoptosis in two recently established rat salivary acinar cell lines. Etoposide induced apoptosis in the…”
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A cryptic proofreading 3' to 5' exonuclease associated with the polymerase subunit of the DNA polymerase-primase from Drosophila melanogaster by Cotterill, S.M, Reyland, M.E, Loeb, L.A, Lehman, I.R

“…The DNA polymerase-primase from Drosophila lacks 3′→ 5′ exonuclease activity. However, a potent exonuclease can be detected after separating the 182-kDa…”
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Loss of protein kinase C delta alters mammary gland development and apoptosis by Allen-Petersen, B L, Miller, M R, Neville, M C, Anderson, S M, Nakayama, K I, Reyland, M E

“…As apoptotic pathways are commonly deregulated in breast cancer, exploring how mammary gland cell death is regulated is critical for understanding human…”
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Suppression of cAMP-mediated signal transduction in mouse adrenocortical cells which express apolipoprotein E by Reyland, M.E., Williams, D.L.

“…We have reported previously that expression of the human apolipoprotein E (apoE) gene in mouse Y1 adrenocortical cells suppresses basal and adrenocorticotropin…”
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Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells by Reyland, M E, Anderson, S M, Matassa, A A, Barzen, K A, Quissell, D O

“…We have previously shown that parotid C5 salivary acinar cells undergo apoptosis in response to etoposide treatment as indicated by alterations in cell…”
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Expression of the Human Apolipoprotein E Gene Suppresses Steroidogenesis in Mouse Y1 Adrenal Cells by Reyland, Mary E., Gwynne, John T., Forgez, Patricia, Prack, Margaret M., Williams, David L.

“…The lipid transport protein, apolipoprotein E (apoE), is expressed in many peripheral tissues in vivo including the adrenal gland and testes. To investigate…”
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On the fidelity of DNA replication. Isolation of high fidelity DNA polymerase-primase complexes by immunoaffinity chromatography by Reyland, M E, Loeb, L A

“…Error rates for conventionally purified DNA polymerase-alpha from calf thymus, chicken, and human sources have been reported to be one in 10,000 to one in…”
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Specificity of proofreading by the 3‘—-5‘ exonuclease of the DNA polymerase-primase of Drosophila melanogaster by Reyland, M E, Lehman, I R, Loeb, L A

“…The DNA polymerase-primase from Drosophila melanogaster contains a cryptic 3'—-5' exonuclease that can be detected after separation of the 182-kDa polymerase…”
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Elevated levels of protein kinase C in Y1 cells which express apolipoprotein E decrease basal steroidogenesis by inhibiting expression of P450-cholesterol side chain cleavage mRNA by REYLAND, M. E, PRACK, M. M, WILLIAMS, D. L

“…We have previously reported that steroidogenesis is dramatically reduced in mouse Y1 adrenocortical cells which express the human apolipoprotein E gene (Y1-E…”
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