Search Results - "REUVENY, SHAUL"

Application of human mesenchymal and pluripotent stem cell microcarrier cultures in cellular therapy: Achievements and future direction by Chen, Allen Kuan-Liang, Reuveny, Shaul, Oh, Steve Kah Weng

“…Mesenchymal stem cells (MSCs) have recently made significant progress with multiple clinical trials targeting modulation of immune responses, regeneration of…”
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Recent advances in serum-free microcarrier expansion of mesenchymal stromal cells: Parameters to be optimized by Tan, Kah Yong, Reuveny, Shaul, Oh, Steve Kah Weng

“…Mesenchymal stromal cells (MSCs) are being investigated for a variety of therapeutic indications. However, current 2D planar technology cannot meet the…”
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Human mesenchymal stem cell therapy for cartilage repair: Review on isolation, expansion, and constructs by Lam, Alan T.L., Reuveny, Shaul, Oh, Steve Kah-Weng

“…●Articular cartilage has a poor intrinsic capacity for self-repair.●Mesenchymal stem cell (MSC)-based therapy for cartilage regeneration.●Bioprocessing…”
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An intermittent rocking platform for integrated expansion and differentiation of human pluripotent stem cells to cardiomyocytes in suspended microcarrier cultures by Ting, Sherwin, Chen, Allen, Reuveny, Shaul, Oh, Steve

“…The development of novel platforms for large scale production of human embryonic stem cells (hESC) derived cardiomyocytes (CM) becomes more crucial as the…”
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Critical microcarrier properties affecting the expansion of undifferentiated human embryonic stem cells by Chen, Allen Kuan-Liang, Chen, Xiaoli, Choo, Andre Boon Hwa, Reuveny, Shaul, Oh, Steve Kah Weng

“…A variety of microcarriers may be used for the expansion of human embryonic stem cells (hESC) for cell therapy applications. This study investigated the…”
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Selection of human induced pluripotent stem cells lines optimization of cardiomyocytes differentiation in an integrated suspension microcarrier bioreactor by Laco, Filip, Lam, Alan Tin-Lun, Woo, Tsung-Liang, Tong, Gerine, Ho, Valerie, Soong, Poh-Loong, Grishina, Elina, Lin, Kun-Han, Reuveny, Shaul, Oh, Steve Kah-Weng

“…The production of large quantities of cardiomyocyte is essential for the needs of cellular therapies. This study describes the selection of a human-induced…”
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Integrated processes for expansion and differentiation of human pluripotent stem cells in suspended microcarriers cultures by Lam, Alan Tin-Lun, Chen, Allen Kuan-Liang, Ting, Sherwin Qi-Peng, Reuveny, Shaul, Oh, Steve Kah-Weng

“…Current methods for human pluripotent stem cells (hPSC) expansion and differentiation can be limited in scalability and costly (due to their labor intensive…”
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Multiomics analyses of cytokines, genes, miRNA, and regulatory networks in human mesenchymal stem cells expanded in stirred microcarrier-spinner cultures by Lam, Alan Tin-Lun, Lee, Alison P., Jayaraman, Premkumar, Tan, Kah Yong, Raghothaman, Deepak, Lim, Hsueh Lee, Cheng, He, Zhou, Lihan, Tan, Andy Hee-Meng, Reuveny, Shaul, Oh, Steve

“…•Multiomics depicting the differ between hMSCs cultured in MC-spinner and MNL-static.•Two distinct expression of secretomes, transcriptomes, and miRNomes were…”
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Microcarrier-Expanded Neural Progenitor Cells Can Survive, Differentiate, and Innervate Host Neurons Better When Transplanted as Aggregates by Qiu, Lifeng, Lim, Yu Ming, Chen, Allen K, Reuveny, Shaul, Oh, Steve K W, Tan, Eng King, Zeng, Li

“…Neuronal progenitor cells (NPCs) derived from human embryonic stem cells (hESCs) are an excellent cell source for transplantation therapy due to their…”
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Scalable platform for human embryonic stem cell differentiation to cardiomyocytes in suspended microcarrier cultures by Lecina, Marti, Ting, Sherwin, Choo, Andre, Reuveny, Shaul, Oh, Steve

“…A scalable platform for human embryonic stem cell (hESC)-derived cardiomyocyte (CM) production can provide a readily available source of CMs for cell therapy,…”
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Long-term microcarrier suspension cultures of human embryonic stem cells by Oh, Steve K W, Chen, Allen K, Mok, Yanglin, Chen, Xiaoli, Lim, U-Ming, Chin, Angela, Choo, Andre B H, Reuveny, Shaul

“…The conventional method of culturing human embryonic stem cells (hESC) is on two-dimensional (2D) surfaces, which is not amenable for scale up to therapeutic…”
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Improved erythroid differentiation of multiple human pluripotent stem cell lines in microcarrier culture by modulation of Wnt/β-Catenin signaling by Sivalingam, Jaichandran, Chen, Hong Yu, Yang, Bin-Xia, Lim, Zhong Ri, Lam, Alan Tin Lun, Woo, Tsung Liang, Chen, Allen Kuan-Liang, Reuveny, Shaul, Loh, Yuin-Han, Oh, Steve Kah-Weng

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Microcarrier suspension cultures for high-density expansion and differentiation of human pluripotent stem cells to neural progenitor cells by Bardy, Jo'an, Chen, Allen K, Lim, Yu Ming, Wu, Selena, Wei, Shunhui, Weiping, Han, Chan, Ken, Reuveny, Shaul, Oh, Steve K W

“…Neural progenitor cells (NPCs) derived from human induced pluripotent stem cells (hiPSCs) can be differentiated to neural cells that model neurodegenerative…”
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Rapid Detection of Senescent Mesenchymal Stromal Cells by a Fluorescent Probe by Ang, Joshur, Lee, Yong‐An, Raghothaman, Deepak, Jayaraman, Premkumar, Teo, Kim L., Khan, Fahima J., Reuveny, Shaul, Chang, Young‐Tae, Kang, Nam‐Young, Oh, Steve

“…Despite intense interest in human mesenchymal stromal cells (MSCs), monitoring of the progressive occurrence of senescence has been hindered by the lack of…”
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Unified microcarrier process for human pluripotent stem cell expansion, and cardiomyocyte differentiation and purification in a 500 mL bioreactor by Oh, Steve, Chen, Allen, Ting, Sherwin, Wei, Heming, Reuveny, Shaul

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Meticulous optimization of cardiomyocyte yields in a 3-stage continuous integrated agitation bioprocess by Ting, Sherwin, Lam, Alan, Tong, Gerine, Chen, Allen, Wei, Heming, Wu, JianJun, Lam, Yue Ning, Reuveny, Shaul, Oh, Steve

“…Human pluripotent stem cells (hPSCs) can be a renewable source for generating cardiomyocyte (CM) for treating myocardial infraction. In our previous…”
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Translating human embryonic stem cells from 2-dimensional to 3-dimensional cultures in a defined medium on laminin- and vitronectin-coated surfaces by Heng, Boon Chin, Li, Jian, Chen, Allen Kuan-Liang, Reuveny, Shaul, Cool, Simon M, Birch, William R, Oh, Steve Kah-Weng

“…While defining the environment for human embryonic stem cell (hESC) culture on 2-dimensional (2D) surfaces has made rapid progress, the industrial-scale…”
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Agitation can induce differentiation of human pluripotent stem cells in microcarrier cultures by Leung, Hau Wan, Chen, Allen, Choo, Andre B H, Reuveny, Shaul, Oh, Steve K W

“…One of the factors that can impact human embryonic stem cell expansion in stirred microcarrier culture reactors is mechanical stress caused by agitation…”
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Defined Serum‐Free Medium for Bioreactor Culture of an Immortalized Human Erythroblast Cell Line by Lee, Esmond, Lim, Zhong Ri, Chen, Hong‐Yu, Yang, Bin Xia, Lam, Alan Tin‐Lun, Chen, Allen Kuan‐Liang, Sivalingam, Jaichandran, Reuveny, Shaul, Loh, Yuin‐Han, Oh, Steve Kah‐Weng

“…Anticipated shortages in donated blood supply have prompted investigation of alternative approaches for in vitro production of red blood cells (RBCs), such as…”
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Critical attributes of human early mesenchymal stromal cell-laden microcarrier constructs for improved chondrogenic differentiation by Lin, Youshan Melissa, Lee, Jialing, Lim, Jessica Fang Yan, Choolani, Mahesh, Chan, Jerry Kok Yen, Reuveny, Shaul, Oh, Steve Kah Weng

“…Microcarrier cultures which are useful for producing large cell numbers can act as scaffolds to create stem cell-laden microcarrier constructs for cartilage…”
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