Search Results - "RENREN WEN"

CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance by Chen, Yuhong, Yu, Mei, Zheng, Yongwei, Fu, Guoping, Xin, Gang, Zhu, Wen, Luo, Lan, Burns, Robert, Li, Quan-Zhen, Dent, Alexander L., Zhu, Nan, Cui, Weiguo, Malherbe, Laurent, Wen, Renren, Wang, Demin

“…Many autoimmune diseases are characterized by the production of autoantibodies. The current view is that CD4 + T follicular helper (Tfh) cells are the main…”
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IVIg for Treatment of Severe Refractory Heparin-Induced Thrombocytopenia by Padmanabhan, Anand, Jones, Curtis G., Pechauer, Shannon M., Curtis, Brian R., Bougie, Daniel W., Irani, Mehraboon S., Bryant, Barbara J., Alperin, Jack B., Deloughery, Thomas G., Mulvey, Kevin P., Dhakal, Binod, Wen, Renren, Wang, Demin, Aster, Richard H.

“…Heparin-induced thrombocytopenia (HIT) complicated by severe thrombocytopenia and thrombosis can pose significant treatment challenges. Use of alternative…”
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A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control by Xin, Gang, Schauder, David M., Lainez, Begoña, Weinstein, Jason S., Dai, Zhengxi, Chen, Yuhong, Esplugues, Enric, Wen, Renren, Wang, Demin, Parish, Ian A., Zajac, Allan J., Craft, Joe, Cui, Weiguo

“…Control of chronic viral infections by CD8 T cells is critically dependent on CD4 help. In particular, helper-derived IL-21 plays a key role in sustaining the…”
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PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development by Yu, Mei, Chen, Yuhong, Zeng, Hu, Zheng, Yongwei, Fu, Guoping, Zhu, Wen, Broeckel, Ulrich, Aggarwal, Praful, Turner, Amy, Neale, Geoffrey, Guy, Cliff, Zhu, Nan, Chi, Hongbo, Wen, Renren, Wang, Demin

“…The precise molecular mechanism underlying the regulation of early B cell lymphopoiesis is unclear. The PLCγ signaling pathway is critical for antigen…”
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Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in NrasQ61R/+ mice by Wen, Zhi, Finn, Remington, Gao, Xin, Li, Lin, Hebert, Alexander, Ranheim, Erik A., Zhou, Yun, Yun, Grant, Roose, Jeroen P., Coon, Joshua J., Shiang, Rita, Wen, Renren, Yu, Menggang, Wang, Demin, Zhang, Jing

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Critical role for mouse marginal zone B cells in PF4/heparin antibody production by Zheng, Yongwei, Yu, Mei, Podd, Andrew, Yuan, Liudi, Newman, Debra K., Wen, Renren, Arepally, Gowthami, Wang, Demin

“…Heparin-induced thrombocytopenia (HIT) is an immune-mediated disorder that can cause fatal arterial or venous thrombosis/thromboembolism. Immune complexes…”
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B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia by Zheng, Yongwei, Wang, Alexander W., Yu, Mei, Padmanabhan, Anand, Tourdot, Benjamin E., Newman, Debra K., White, Gilbert C., Aster, Richard H., Wen, Renren, Wang, Demin

“…Immune complexes consisting of heparin, platelet factor 4 (PF4), and PF4/heparin-reactive antibodies are central to the pathogenesis of heparin-induced…”
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Kras Is Critical for B Cell Lymphopoiesis by Chen, Yuhong, Zheng, Yongwei, You, Xiaona, Yu, Mei, Fu, Guoping, Su, Xinlin, Zhou, Fen, Zhu, Wen, Wu, Zhihong, Zhang, Jing, Wen, Renren, Wang, Demin

“…The three major Ras members, Kras, Hras, and Nras, are highly homologous and individual Ras genes can have distinct biological functions. Embryonic lethality…”
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Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells by Chen, Yuhong, Yu, Mei, Dai, Xuezhi, Zogg, Mark, Wen, Renren, Weiler, Hartmut, Wang, Demin

“…Mice and rats lacking the guanosine nucleotide-binding protein Gimap5 exhibit peripheral T cell lymphopenia, and Gimap5 can bind to Bcl-2. We show that…”
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A critical role of TAK1 in B-cell receptor–mediated nuclear factor κB activation by Schuman, James, Chen, Yuhong, Podd, Andrew, Yu, Mei, Liu, Hong-Hsing, Wen, Renren, Chen, Zhijian J., Wang, Demin

“…The kinase TAK1 is essential for T-cell receptor (TCR)–mediated nuclear factor κB (NF-κB) activation and T-cell development. However, the role of TAK1 in…”
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Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8 + T-Cell Activation by Wang, Zhengqi, Vaughan, Tamisha Y, Zhu, Wandi, Chen, Yuhong, Fu, Guoping, Medrzycki, Magdalena, Nishio, Hikaru, Bunting, Silvia T, Hankey-Giblin, Pamela A, Nusrat, Asma, Parkos, Charles A, Wang, Demin, Wen, Renren, Bunting, Kevin D

“…Inflammatory Bowel Disease (IBD) is a multi-factorial chronic inflammation of the gastrointestinal tract prognostically linked to CD8 T-cells, but little is…”
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Bcl10 plays a critical role in NF-κB activation induced by G protein-coupled receptors by Wang, Donghai, You, Yun, Lin, Pei-Chun, Xue, Liquan, Morris, Stephan W, Zeng, Hu, Wen, Renren, Lin, Xin

“…G protein-coupled receptors (GPCRs) play pivotal roles in cell proliferation, differentiation, and survival. Although many studies indicate that the…”
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Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors by Wang, Demin, Feng, Jian, Wen, Renren, Marine, Jean-Christophe, Sangster, Mark Y., Parganas, Evan, Hoffmeyer, Angelika, Jackson, Carl W., Cleveland, John L., Murray, Peter J., Ihle, James N.

“…Many receptors activate phospholipase Cγ1 or -γ2. To assess the role of PLCγ2, we derived enzyme-deficient mice. The mice are viable but have decreased mature…”
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Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1 by Zheng, Yongwei, Adams, Tamara, Zhi, Huiying, Yu, Mei, Wen, Renren, Newman, Peter J, Wang, Demin, Newman, Debra K

“…Receptor-mediated platelet activation requires phospholipase C (PLC) activity to elevate intracellular calcium and induce actin cytoskeleton reorganization…”
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A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development by Chen, Yuhong, Yu, Mei, Podd, Andrew, Wen, Renren, Chrzanowska-Wodnicka, Magdalena, White, Gilbert C., Wang, Demin

“…B-cell development is orchestrated by complex signaling networks. Rap1 is a member of the Ras superfamily of small GTP-binding proteins and has 2 isoforms,…”
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Differential and Nonredundant Roles of Phospholipase Cγ2 and Phospholipase Cγ1 in the Terminal Maturation of NK Cells by Regunathan, Jeyarani, Chen, Yuhong, Kutlesa, Snjezana, Dai, Xuezhi, Bai, Li, Wen, Renren, Wang, Demin, Malarkannan, Subramaniam

“…Abstract NK cells play a central role in mediating innate immune responses. Activation of NK cells results in cytotoxicity, cytokine, and chemokine secretions…”
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Phosphorylation of Bcl10 Negatively Regulates T-Cell Receptor-Mediated NF-κB Activation by Zeng, Hu, Di, Lie, Fu, Guoping, Chen, Yuhong, Gao, Xiang, Xu, Langlai, Lin, Xin, Wen, Renren

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MCD-DLBCL arises from germinal center B cells by Wen, Renren, Wang, Demin

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Identification of Shp-2 as a Stat5A Phosphatase by Chen, Yuhong, Wen, Renren, Yang, Shoua, Schuman, James, Zhang, Eric E., Yi, Taolin, Feng, Gen-Sheng, Wang, Demin

“…Stat5A, a member of the signal transducers and activators of transcription (Stat) family, is activated upon a single tyrosine phosphorylation. Although much is…”
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Phospholipase Cγ2 Contributes to Light-Chain Gene Activation and Receptor Editing by Bai, Li, Chen, Yuhong, He, Yinghong, Dai, Xuezhi, Lin, Xueyan, Wen, Renren, Wang, Demin

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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