Search Results - "RENNIE, KATHERINE J."

Inhibition of Ionic Currents by Fluoxetine in Vestibular Calyces in Different Epithelial Loci by Mohamed, Nesrien M M, Meredith, Frances L, Rennie, Katherine J

“…Previous studies have suggested a role for selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac ) in the treatment of dizziness and inner…”
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Dopaminergic Inhibition of Na + Currents in Vestibular Inner Ear Afferents by Meredith, Frances L, Rennie, Katherine J

“…Inner ear hair cells form synapses with afferent terminals and afferent neurons carry signals as action potentials to the central nervous system. Efferent…”
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Regional and Developmental Differences in Na + Currents in Vestibular Primary Afferent Neurons by Meredith, Frances L, Rennie, Katherine J

“…The vestibular system relays information about head position afferent nerve fibers to the brain in the form of action potentials. Voltage-gated Na channels in…”
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MET-PREVENT: metformin to improve physical performance in older people with sarcopenia and physical prefrailty/frailty – protocol for a double-blind, randomised controlled proof-of-concept trial by Rennie, Katherine J, Witham, Miles, Bradley, Penny, Clegg, Andrew, Connolly, Stephen, Hancock, Helen C, Hiu, Shaun, Marsay, Leanne, McDonald, Claire, Robertson, Laura, Simms, Laura, Steel, Alison J, Steves, Claire J, Storey, Bryony, Wason, James, Wilson, Nina, von Zglinicki, Thomas, Sayer, Avan A P

“…IntroductionSkeletal muscle dysfunction is central to both sarcopenia and physical frailty, which are associated with a wide range of adverse outcomes…”
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Nasal Airway Obstruction Study (NAIROS): a phase III, open-label, mixed-methods, multicentre randomised controlled trial of septoplasty versus medical management of a septal deviation with nasal obstruction by Rennie, Katherine J, O'Hara, James, Rousseau, Nikki, Stocken, Deborah, Howel, Denise, Ternent, Laura, Drinnan, Mike, Bray, Alison, Rooshenas, Leila, Hamilton, David W, Steel, Alison, Fouweather, Tony, Hynes, Ann-Marie, Holstein, Eva-Maria, Oluboyede, Yemi, Abouhajar, Alaa, Wilson, Janet A, Carrie, Sean

“…Septoplasty (surgery to straighten a deviation in the nasal septum) is a frequently performed operation worldwide, with approximately 250,000 performed…”
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Kv1 channels and neural processing in vestibular calyx afferents by Meredith, Frances L, Kirk, Matthew E, Rennie, Katherine J

“…Potassium-selective ion channels are important for accurate transmission of signals from auditory and vestibular sensory end organs to their targets in the…”
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Persistent and resurgent Na + currents in vestibular calyx afferents by Meredith, Frances L., Rennie, Katherine J.

“…Action potential firing patterns differ between groups of afferent neurons innervating vestibular epithelia. We investigated the biophysical properties of Na +…”
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Expression of hyperpolarization-activated current ( I h ) in zonally defined vestibular calyx terminals of the crista by Meredith, Frances L, Vu, Tiffany A, Gehrke, Brandon, Benke, Timothy A, Dondzillo, Anna, Rennie, Katherine J

“…Calyx terminals make afferent synapses with type I hair cells in vestibular epithelia and express diverse ionic conductances that influence action potential…”
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Channeling your inner ear potassium: K+ channels in vestibular hair cells by Meredith, Frances L., Rennie, Katherine J.

“…During development of vestibular hair cells, K+ conductances are acquired in a specific pattern. Functionally mature vestibular hair cells express different…”
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Zonal variations in K+ currents in vestibular crista calyx terminals by Meredith, Frances L, Rennie, Katherine J

“…We developed a rodent crista slice to investigate regional variations in electrophysiological properties of vestibular afferent terminals. Thin transverse…”
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AMPA receptor-mediated rapid EPSCs in vestibular calyx afferents by Kirk, Matthew E, Meredith, Frances L, Benke, Timothy A, Rennie, Katherine J

“…In the vestibular periphery neurotransmission between hair cells and primary afferent nerves occurs via specialized ribbon synapses. Type I vestibular hair…”
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Hyperpolarization-Activated Current (Ih) in Vestibular Calyx Terminals: Characterization and Role in Shaping Postsynaptic Events by Meredith, Frances L., Benke, Tim A., Rennie, Katherine J.

“…Calyx afferent terminals engulf the basolateral region of type I vestibular hair cells, and synaptic transmission across the vestibular type I hair cell/calyx…”
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Sporadic intragenic inversion of the mitochondrial DNA MTND1 gene causing fatal infantile lactic acidosis by BLAKELY, Emma L, RENNIE, Katherine J, TAYLOR, Robert W, JONES, Linda, ELSTNER, Mattias, HRZANOWSKA-LIGHTOWLERS, Zofia M. A. C, WHITE, Christopher B, SHIELD, Julian P. H, PILZ, Daniela T, TURNBULL, Douglass M, POULTON, Joanna

“…Mutations of mitochondrial DNA (mtDNA) are an important cause of genetic disease, yet rarely present in the neonatal period. Here we report the clinical,…”
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Effects of KCNQ channel blockers on K(+) currents in vestibular hair cells by Rennie, K J, Weng, T, Correia, M J

“…Linopirdine and XE991, selective blockers of K(+) channels belonging to the KCNQ family, were applied to hair cells isolated from gerbil vestibular system and…”
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Co-localisation of intra-nuclear membrane type-1 matrix metalloproteinase and hypoxia inducible factor-2α in osteosarcoma and prostate carcinoma cells by Chan, Corey D, Haagensen, Emma J, Tensaout, Hayeit A, Rennie, Katherine J, Gamie, Zakareya, Barry, James, Birch, Mark A, Gerrand, Craig H, Nisar, Sohail, Robson, Craig N, Lunec, John, Rankin, Kenneth S

“…Increased membrane type-1 matrix metalloproteinase (MT1-MMP) expression in osteosarcoma is predictive of poor prognosis and directs bone metastasis in prostate…”
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Postnatal Expression of an Apamin-Sensitive K(Ca) Current in Vestibular Calyx Terminals by Meredith, Frances L., Li, Gang Q., Rennie, Katherine J.

“…Afferent innervation patterns in the vestibular periphery are complex, and vestibular afferents show a large variation in their regularity of firing. Calyx…”
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Voltage-Dependent Currents in Isolated Vestibular Afferent Calyx Terminals by Rennie, Katherine J, Streeter, Michele A

“…1 Departments of Otolaryngology and 2 Physiology and Biophysics, University of Colorado at Denver and Health Sciences Center, Denver, Colorado Submitted 18…”
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Development of K(+) and Na(+) conductances in rodent postnatal semicircular canal type I hair cells by Li, Gang Q, Meredith, Frances L, Rennie, Katherine J

“…The rodent vestibular system is immature at birth. During the first postnatal week, vestibular type I and type II hair cells start to acquire their…”
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Inhibition of K+ currents in type I vestibular hair cells by gentamicin and neomycin by Mann, Scott E, Johnson, Matthew, Meredith, Frances L, Rennie, Katherine J

“…Significant ototoxicity limits the use of aminoglycoside (AG) antibiotics. Several mechanisms may contribute to the death of both auditory and vestibular hair…”
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K+ Currents in Isolated Vestibular Afferent Calyx Terminals by Dhawan, Ritu, Mann, Scott E., Meredith, Frances L., Rennie, Katherine J.

“…Vestibular hair cells transduce mechanical displacements of their hair bundles into an electrical receptor potential which modulates transmitter release and…”
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