Search Results - "REN, Songrong"

Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis by Xu, Pengfei, Xi, Yue, Zhu, Junjie, Zhang, Min, Luka, Zigmund, Stolz, Donna B., Cai, Xinran, Xie, Yang, Xu, Meishu, Ren, Songrong, Huang, Zhiying, Yang, Da, York, John D., Ma, Xiaochao, Xie, Wen

“…Sulfation is a conjugation reaction essential for numerous biochemical and cellular functions in mammals. The 3’-phosphoadenosine 5’-phosphosulfate (PAPS)…”
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PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice by He, Jinhan, Gao, Jie, Xu, Meishu, Ren, Songrong, Stefanovic-Racic, Maja, O'Doherty, Robert Martin, Xie, Wen

“…The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that…”
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A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway by Zhou, Jie, Zhai, Yonggong, Mu, Ying, Gong, Haibiao, Uppal, Hirdesh, Toma, David, Ren, Songrong, Evans, Ronald M., Xie, Wen

“…The pregnane X receptor (PXR) was isolated as a xenosensor regulating xenobiotic responses. In this study, we show that PXR plays an endobiotic role by…”
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Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance by Garbacz, Wojciech G., Lu, Peipei, Miller, Tricia M., Poloyac, Samuel M., Eyre, Nicholas S., Mayrhofer, Graham, Xu, Meishu, Ren, Songrong, Xie, Wen

“…The common complications in obesity and type 2 diabetes include hepatic steatosis and disruption of glucose-glycogen homeostasis, leading to hyperglycemia…”
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Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis by Xu, Pengfei, Xi, Yue, Kim, Jong-Won, Zhu, Junjie, Zhang, Min, Xu, Meishu, Ren, Songrong, Yang, Da, Ma, Xiaochao, Xie, Wen

“…Sulfation is a crucial and prevalent conjugation reaction involved in cellular processes and mammalian physiology. 3′-Phosphoadenosine 5′-phosphosulfate (PAPS)…”
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Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats by Mu, Ying, Zhang, Jinnan, Zhang, Shimin, Zhou, Hong-Hao, Toma, David, Ren, Songrong, Huang, Leaf, Yaramus, Maria, Baum, Andrew, Venkataramanan, Raman, Xie, Wen

“…The traditional Chinese medicines (TCMs) are essential components of alternative medicines. Many TCMs are known to alter the expression of hepatic…”
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Chronic Activation of LXRα Sensitizes Mice to Hepatocellular Carcinoma by Xie, Yang, Sun, Runzi, Gao, Li, Guan, Jibin, Wang, Jingyuan, Bell, Aaron, Zhu, Junjie, Zhang, Min, Xu, Meishu, Lu, Peipei, Cai, Xinran, Ren, Songrong, Xu, Pengfei, Monga, Satdarshan P., Ma, Xiaochao, Yang, Da, Liu, Yulan, Lu, Binfeng, Xie, Wen

“…The oxysterol receptor liver X receptor (LXR) is a nuclear receptor best known for its function in the regulation of lipid and cholesterol metabolism. LXRs,…”
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Activation of LXRs prevents bile acid toxicity and cholestasis in female mice by Uppal, Hirdesh, Saini, Simrat P.S., Moschetta, Antonio, Mu, Ying, Zhou, Jie, Gong, Haibiao, Zhai, Yonggong, Ren, Songrong, Michalopoulos, George K., Mangelsdorf, David J., Xie, Wen

“…Liver X receptors (LXRs) have been identified as sterol sensors that regulate cholesterol and lipid homeostasis and macrophage functions. In this study, we…”
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Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization by Uppal, Hirdesh, Zhai, Yonggong, Gangopadhyay, Archana, Khadem, Shaheen, Ren, Songrong, Moser, James A., Xie, Wen

“…Gallstone disease is a hepatobiliary disorder due to biochemical imbalances in the gallbladder bile. In this report, we show that activation of nuclear…”
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Pregnane X Receptor as a Therapeutic Target to Inhibit Androgen Activity by Zhang, Bin, Cheng, Qiuqiong, Ou, Zhimin, Lee, Jung Hoon, Xu, Meishu, Kochhar, Upasana, Ren, Songrong, Huang, Min, Pflug, Beth R, Xie, Wen

“…The androgen-androgen receptor signaling pathway plays an important role in the pathogenesis of prostate cancer. Accordingly, androgen deprivation has been the…”
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A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification by Saini, Simrat P S, Sonoda, Junichiro, Xu, Li, Toma, David, Uppal, Hirdesh, Mu, Ying, Ren, Songrong, Moore, David D, Evans, Ronald M, Xie, Wen

“…Cytosolic sulfotransferase (SULT)-mediated sulfation plays an essential role in the detoxification of bile acids and is necessary to avoid pathological…”
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Activation of Liver X Receptor α Sensitizes Mice to T‐Cell Mediated Hepatitis by Gao, Li, Li, Bin, Wang, Jingyuan, Shen, Danhua, Yang, Min, Sun, Runzi, Tung, Hung‐Chun, Xu, Meishu, Ren, Songrong, Zhang, Min, Yang, Da, Lu, Binfeng, Wang, Hui, Liu, Yulan, Xie, Wen

“…Autoimmune hepatitis (AIH) is an inflammatory disease of the liver. Liver X receptors (LXRs), including the α and β isoforms, are previously known for their…”
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Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice by UPPAL, Hirdesh, TOMA, David, SAINI, Simrat P. S, SONGRONG REN, JONES, Thomas J, WEN XIE

“…Efficient detoxification of bile acids is necessary to avoid pathological conditions such as cholestatic liver damage and colon cancer. The orphan nuclear…”
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Transgenic overexpression of steroid sulfatase alleviates cholestasis by Jiang, Mengxi, Xu, Meishu, Ren, Songrong, Selcer, Kyle W., Xie, Wen

“…Sulfotransferase (SULT)-mediated sulfation and steroid sulfatase (STS)-mediated desulfation represent two critical mechanisms that regulate the chemical and…”
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Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice by SAINI, Simrat P. S, YING MU, HAIBIAO GONG, TOMA, David, UPPAL, Hirdesh, SONGRONG REN, SONG LI, POLOYAC, Samuel M, WEN XIE

“…The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are implicated in xenobiotic and endobiotic detoxification, including the…”
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ERINA Is an Estrogen-Responsive LncRNA That Drives Breast Cancer through the E2F1/RB1 Pathway by Fang, Zihui, Wang, Yue, Wang, Zehua, Xu, Meishu, Ren, Songrong, Yang, Da, Hong, Mei, Xie, Wen

“…Resistance to therapeutic drugs is a major challenge in the treatment of cancers, including breast cancer. Long noncoding RNAs (lncRNA) are known to have…”
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A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development by Mu, Ying, Stephenson, Corey R J, Kendall, Christopher, Saini, Simrat P S, Toma, David, Ren, Songrong, Cai, Hongbo, Strom, Stephen C, Day, Billy W, Wipf, Peter, Xie, Wen

“…Pregnane X receptor (PXR) is an orphan nuclear receptor that regulates the expression of genes encoding drug-metabolizing enzymes and transporters. In addition…”
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CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1α by Gao, Jie, Yan, Jiong, Xu, Meishu, Ren, Songrong, Xie, Wen

“…The constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor gamma coactivator-1α (PGC1α) are master regulators of drug metabolism…”
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Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice by Yan, Jiong, Tung, Hung-Chun, Li, Sihan, Niu, Yongdong, Garbacz, Wojciech G., Lu, Peipei, Bi, Yuhan, Li, Yanping, He, Jinhan, Xu, Meishu, Ren, Songrong, Monga, Satdarshan P., Schwabe, Robert F., Yang, Da, Xie, Wen

“…The role of aryl hydrocarbon receptor (AhR) in liver fibrosis is controversial because loss and gain of AhR activity both lead to liver fibrosis. The goal of…”
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Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock–Induced Liver Injury by Xie, Yang, Xu, Meishu, Deng, Meihong, Li, Zhigang, Wang, Pengcheng, Ren, Songrong, Guo, Yan, Ma, Xiaochao, Fan, Jie, Billiar, Timothy R., Xie, Wen

“…Hemorrhagic shock (HS) is a life‐threatening condition associated with tissue hypoperfusion and often leads to injury of multiple organs including the liver…”
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