Search Results - "REMUZON, P"

Fluoronaphthyridines as antibacterial agents. 4. Synthesis and structure-activity relationships of 5-substituted 6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids by Bouzard, D, Di Cesare, P, Essiz, M, Jacquet, J. P, Ledoussal, B, Remuzon, P, Kessler, R. E, Fung-Tomc, J

“…A series of 5-substituted-6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8- naphthyridine-3-carboxylic acids have been prepared and tested for their in vitro…”
Get full text

4-Hydroxy-2-methyl-3(2 H)-isothiazolone-1,1-dioxide as protecting group of 4-( N-methylaminosulfonyl)methylphenylhydrazine during Fischer indole synthesis by Remuzon, P., Dussy, C., Jacquet, J.P., Soumeillant, M., Bouzard, D.

“…Protection of the benzylic position of 4-methylaminosulfonylmethylphenyl hydrazine 6 with a 4-hydroxy-2-methyl-3(2 H)-isothiazolone-1,1-dioxide group allowed…”
Get full text

Trans-4-hydroxy-L-proline, a useful and versatile chiral starting block by Remuzon, Philippe

Get full text

Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted derivatives by Remuzon, P, Bouzard, D, Di Cesare, P, Essiz, M, Jacquet, J. P, Kiechel, J. R, Ledoussal, B, Kessler, R. E, Fung-Tomc, J

“…A series of novel N-1-(mono-,-(di- and -(trifluoro-tert-butyl)quinolones and -naphthyridines has been prepared. Structure-activity relationship (SAR) studies…”
Get full text

Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives by Bouzard, D, Di Cesare, P, Essiz, M, Jacquet, J. P, Kiechel, J. R, Remuzon, P, Weber, A, Oki, T, Masuyoshi, M

“…A number of 7-substituted-1-tert-butyl-6-fluoroquinolone-3-carboxylic acids and 7-substituted-1-tert-butyl-6-fluoro-1,8-naphthyridine-3-carboxylic acids have…”
Get full text

Fluoronaphthyridines and -quinolones as antibacterial agents. 5. Synthesis and antimicrobial activity of chiral 1-tert-butyl-6-fluoro-7-substituted-naphthyridones by Di Cesare, P, Bouzard, D, Essiz, M, Jacquet, J. P, Ledoussal, B, Kiechel, J. R, Remuzon, P, Kessler, R. E, Fung-Tomc, J, Desiderio, J

“…A series of novel 7-substituted-1-tert-butyl-6-fluoronaphthyridone-3- carboxylic acids has been prepared. These derivatives are characterized by chiral…”
Get full text

Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives by Bouzard, D, Di Cesare, P, Essiz, M, Jacquet, J P, Remuzon, P, Weber, A, Oki, T, Masuyoshi, M

“…A series of novel 7-piperazinyl-1-substituted-6-fluoroquinolones and naphthyridines have been prepared and their antibacterial activities evaluated. These…”
Get full text

Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationship of new 1-substituted derivatives by Bouzard, D, Di Cesare, P, Essiz, M, Jacquet, J. P, Remuzon, P, Weber, A, Oki, T, Masuyoshi, M

Get full text

Synthesis of chiral α-substituted N-[((2S)-2-hydroxy-2-phenyl)-ethyl]-2-phenylglycine derivatives by diastereocontrolled alkylation of (6 R)-2,3,5,6-tetrahydro-3,6-diaryl-N-[(2′R)-(2′-methyl)phenyl-methyl]-4H-1,4-oxazin-2-ones by Remuzon, Philippe, Soumeillant, Maxime, Dussy, Christian, Bouzard, Daniel

Get full text

Quality of life in patients with aggressive non-Hodgkin's lymphoma. Validation of the medical outcomes study short form 20 and the Rotterdam symptom checklist in older patients by Tchen, Nadine, Soubeyran, Pierre, Eghbali, Houchingue, Ceccaldi, Joël, Cany, Laurent, Balzon, Jean-Claude, Remuzon, Philippe, Malet, Maxime, Bonichon, Françoise, Picot, Véronique, Monnereau, Alain, Hœrni, Bernard

“…In the elderly population, cancer treatment aims to cure and/or maintain Quality of Life (QoL). However, there is little QoL data to provide evidence for QoL…”
Get full text

Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-,3-,4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-dimethylethyl)-6-fluoro-1,4-di-hydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. Influence of the configuration on blood pressure in dogs. A quinolone-class effect by REMUZON, P, BOUZARD, D, GUIOL, C, JACQUET, J.-P

Get full text

Synthesis and reactivity of a N-aryl-2-vinyltetrahydro-4-oxoquinoline by Clémencin-Le Guillou, Claire, Rémuzon, Philippe, Bouzard, Daniel, Quirion, Jean-Charles, Giorgi-Renault, Sylviane, Husson, Henri-Philippe

“…Ethyl 2-ethenyl-6,7-methylenedioxy-1,2,3,4,-tetrahydro-1-(3′,4′,5′-trimethoxyphenyl)-4-oxoquinoline-3-carboxylate 1 was prepared by the reaction of…”
Get full text

Enantioselective synthesis of 1,2-acetonide of (2 S,3 R)-3- N-boc-3-amino-4-phenyl-1,2-butanediol by Remuzon, Philippe, Dussy, Christian, Jacquet, Jean-Pierre, Roty, Pascale, Bouzard, Daniel

“…An efficient and stereocontrolled preparation of the (2 S,3 R)-1,2-acetonide 15, from hydrazone 10, leading to a (D)-phenylalaninol derivative, potentially…”
Get full text

Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-dimethylethyl)-6-fluoro-1,4-dihy dro-4-oxo-1,8-naphthyridine-3-carboxylic acid. Influence of the configuration on blood pressure in dogs. A quinolone-class effect by Remuzon, P, Bouzard, D, Guiol, C, Jacquet, J P

“…A series of novel chiral 7-(1-, 3-, 4-, and 6-methyl-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-substituted naphthyridines has been prepared with the aim of…”
Get full text

Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo(2.2.1)heptan-2-yl)naphthyridine analogues of 7-((1R,4R)-2,5-diazabicyclo(2.2.1)heptan-2-yl)-1-(1,1-dimethylethy l)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. Influence of the configuration on blood pressure in dogs. A quinolone-class effect by Remuzon, P, Bouzard, D, Guiol, C, Jacquet, J-P

“…A series of novel chiral 7-(1-, 3-, 4-, and 6-methyl-(1R,4R)-2,5-diazabicyclo(2.2.1)heptan-2-yl)-substituted naphthyridines has been prepared with the aim of…”
Get full text

Studies Toward the Stereocontrolled Synthesis of a Key Azetidinone-Acid Intermediate in the Preparation of a New Carbapenem by Remuzon, Philippe, Bouzard, Daniel, DiCesare, Pierre, Essiz, Munir, Jacquet, Jean-Pierre, Nicolau, Andrei, Martel, Alain, Menard, Marcel, Bachand, Carol

“…An efficient and stereocontrolled preparation of the key a/etidinone-acid 5a is described…”
Get full text

Preparation of (1R,4R)-1-Methyl-2-(p-toluenesulfonyl)-5-phenylmethyl-2,5-diazabicyclo[2.2.1]heptane, Intermediate in a Synthesis of New Naphthyridones by Remuzon, Philippe, Massoudi, Massoud, Bouzard, Daniel, Jacquet, Jean-Pierre

Get full text

Fluoronaphthyridines and -quinolones as antibacterial agents. V: Synthesis and antimicrobial activity of chiral 1-tert-butyl-6-fluoro-7-substituted-naphthyridones by DI CESARE, P, BOUZARD, D, ESSIZ, M, JACQUET, J. P, LEDOUSSAL, B, KIECHEL, J. R, REMUZON, P, KESSLER, R. E, FUNG-TOMC, J, DESIDERIO, J

Get full text

Fluoronaphthyridines as antibacterial agents. IV: Synthesis and structure-activity relationships of 5-substituted-6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids by BOUZARD, D, DI CESARE, P, ESSIZ, M, JACQUET, J. P, LEDOUSSAL, B, REMUZON, P, KESSLER, R. E, FUNG-TOMC, J

Get full text

Preparation of (1R,4R)-1-methyl-2-(p-toluenesulfonyl)-5-phenyl-methyl-2,5-diazabicyclo [2.2.1] heptane, intermediate in a synthesis of new naphthyridones by REMUZON, P, MASSOUDI, M, BUZARD, D, JACQUET, J.-P

Get full text