Search Results - "REMPEL, S. A"

PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion by LIU, X, HU, Y, HAO, C, REMPEL, S. A, YE, K

“…PIKE-A (phosphoinositide 3-kinases (PI 3)-kinase enhancer) is a ubiquitously expressed GTPase, which binds to and enhances protein kinase B (Akt) kinase…”
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Identification and Localization of the Cytokine SDF1 and Its Receptor, CXC Chemokine Receptor 4, to Regions of Necrosis and Angiogenesis in Human Glioblastoma by REMPEL, S. A, DUDAS, S, SHUGANG GE, GUTIERREZ, J. A

“…Glioblastoma multiforme (GBM) tumors display extensive histomorphological heterogeneity, with great variability in the extent of invasiveness, angiogenesis,…”
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Splenic and immune alterations of the Sparc-null mouse accompany a lack of immune response by Rempel, S A, Hawley, R C, Gutiérrez, J A, Mouzon, E, Bobbitt, K R, Lemke, N, Schultz, C R, Schultz, L R, Golembieski, W, Koblinski, J, VanOsdol, S, Miller, C G

“…Sparc-null mice have been used as models to assess tumor-host immune cell interactions. However, it is not known if they have a competent immune system. In…”
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Loss of DAL-1, a protein 4.1-related tumor suppressor, is an important early event in the pathogenesis of meningiomas by GUTMANN, D. H, DONAHOE, J, PERRY, A, LEMKE, N, GORSE, K, KITTINIYOM, K, REMPEL, S. A, GUTIERREZ, J. A, NEWSHAM, I. F

“…Meningiomas are common nervous system tumors, whose molecular pathogenesis is poorly understood. To date, the most frequent genetic alteration detected in…”
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SPARC: A Potential Diagnostic Marker of Invasive Meningiomas by REMPEL, S. A, SHUGANG GE, GUTIERREZ, J. A

“…SPARC, a secreted, extracellular matrix-associated protein implicated in the modulation of cell adhesion and migration, was evaluated as a marker for invasive…”
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SPARC modulates cell growth, attachment and migration of U87 glioma cells on brain extracellular matrix proteins by Rempel, S A, Golembieski, W A, Fisher, J L, Maile, M, Nakeff, A

“…We have identified secreted protein acidic and rich in cysteine (SPARC) as a potential glioma invasion-promoting gene. To determine whether SPARC alters the…”
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SPARC: A Signal of Astrocytic Neoplastic Transformation and Reactive Response in Human Primary and Xenograft Gliomas by REMPEL, SANDRA A, GOLEMBIESKI, WILLIAM A, GE, SHUGANG, LEMKE, NANCY, ELISEVICH, KOST, MIKKELSEN, TOM, GUTIÉRREZ, JORGE A

“…In an attempt to identify genetic alterations occurring early in astrocytoma progression, we performed subtractive hybridization between astrocytoma and…”
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A study of SPARC and vitronectin localization and expression in pediatric and adult gliomas: high SPARC secretion correlates with decreased migration on vitronectin by Menon, P M, Gutierrez, J A, Rempel, S A

“…SPARC is a secreted glycoprotein that interacts with extracellular matrix (ECM) proteins to promote de-adhesion of cells from the matrix, thereby inducing a…”
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Cathepsin B expression and localization in glioma progression and invasion by REMPEL, S. A, ROSENBLUM, M. L, MIKKELSEN, T, PEI-SHA YAN, ELLIS, K. D, GOLEMBIESKI, W. A, SAMENI, M, ROZHIN, J, ZIEGLER, G, SLOANE, B. F

“…The poor prognosis of human malignant gliomas is due to their invasion and recurrence, the molecular mechanisms of which remain poorly characterized. We have…”
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Targeting angiogenesis inhibits tumor infiltration and expression of the pro‐invasive protein SPARC by Vajkoczy, Peter, Menger, Michael D., Goldbrunner, Roland, Ge, Shugang, Fong, T. Annie T., Vollmar, Brigitte, Schilling, Lothar, Ullrich, Axel, Hirth, K. Peter, Tonn, Jörg C., Schmiedek, Peter, Rempel, Sandra A.

“…The solid growth of high‐grade glioma appears to be cri‐tically dependent on tumor angiogenesis. It remains unknown, however, whether the diffuse infiltration…”
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Increased SPARC expression promotes U87 glioblastoma invasion in vitro by Golembieski, W.A., Ge, S., Nelson, K., Mikkelsen, T., Rempel, S.A.

“…Our recent studies have focused on identifying invasion‐promoting genes that are expressed early in brain tumor progression. We identified and characterized…”
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Carboxyamido-triazole Induces Apoptosis in Bovine Aortic Endothelial and Human Glioma Cells by SHUGANG GE, REMPEL, S. A, DIVINE, G, MIKKELSEN, T

“…Carboxyamido-triazole (CAI), an inhibitor of non-voltage-gated calcium channels, has been studied in Phase I/II clinical trials following the identification of…”
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Loss of heterozygosity for loci on chromosome 10 is associated with morphologically malignant meningioma progression by REMPEL, S. A, SCHWECHHEIMER, K, DAVIS, R. L, CAVENEE, W. K, ROSENBLUM, M. L

“…Meningioma is a common tumor of the central nervous system which displays morphological heterogeneity. In order to determine whether this phenotypic…”
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Hippocampal Connexin 43 Expression in Human Complex Partial Seizure Disorder by Elisevich, Kost, Rempel, Sandra A., Smith, Brien J., Edvardsen, Klaus

“…An increase in the cellular production of gap junction proteins and increased numbers of gap junctions in the neuronoglial syncytium of an epileptic focus have…”
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Single Cell Monitoring of Growth Arrest and Morphological Changes Induced by Transfer of Wild-Type p53 Alleles to Glioblastoma Cells by Van Meir, Erwin G., Roemer, Klaus, Diserens, Annie-Claire, Kikuchi, Tetsuro, Rempel, Sandra A., Haas, Martin, H.-J. Su Huang, Friedmann, Theodore, de Tribolet, Nicolas, Cavenee, Webster K.

“…Mutation of the p53 tumor suppressor gene is one of the earliest identified genetic lesions during malignant progression of human astrocytomas. To assess the…”
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Use of horizontal ultrathin gel electrophoresis to analyze allelic deletions in chromosome band 11p15.5 in gliomas by Newsham, I F, Gorse, K M, Rempel, S A, Luckey, J, Golden, J B, Bögler, O

“…The prognosis for most patients with astrocytic glioma is poor, and postoperative life expectancy has not significantly improved in the last decade despite…”
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International hermelin brain tumor symposium on matricellular proteins in normal and cancer cell-matrix interactions by Bos, T.J, Cohn, S.L, Koblinski, J, Kleinman, H.K, Murphy-Ullrich, J.E, Podhajcer, O.L, Rempel, S.A, Rich, J.N, Rutka, J.T, Sage, E.H, Thompson, E.W

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Molecular biology of nervous system tumors by Rempel, S A

“…Many genetic alterations that contribute to CNS tumorigenesis and progression have been identified. One goal of such studies is to identify loci that would…”
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Steroid-induced cell proliferation in vivo is associated with increased c-myc proto-oncogene transcript abundance by Rempel, S A, Johnston, R N

“…Enhanced c-myc transcript abundance has been observed in a variety of human malignancies, in normal liver tissue induced to proliferate in vivo by partial…”
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New innovations and developments for glioma treatment by Croteau, D, Mikkelsen, T, Rempel, S A, Bogler, O, Rosenblum, M

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