Search Results - "REMICK, Daniel G"

Pathophysiology of Sepsis by Remick, Daniel G., M.D

“…Sepsis remains a critical problem with significant morbidity and mortality even in the modern era of critical care management. Multiple derangements exist in…”
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Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding by Iskander, Kendra N, Osuchowski, Marcin F, Stearns-Kurosawa, Deborah J, Kurosawa, Shinichiro, Stepien, David, Valentine, Catherine, Remick, Daniel G

“…Sepsis represents the host's systemic inflammatory response to a severe infection. It causes substantial human morbidity resulting in hundreds of thousands of…”
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Circulating Cytokine/Inhibitor Profiles Reshape the Understanding of the SIRS/CARS Continuum in Sepsis and Predict Mortality by Osuchowski, Marcin F, Welch, Kathy, Siddiqui, Javed, Remick, Daniel G

“…Mortality in sepsis remains unacceptably high and attempts to modulate the inflammatory response failed to improve survival. Previous reports postulated that…”
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The pathogenesis of sepsis by Stearns-Kurosawa, Deborah J, Osuchowski, Marcin F, Valentine, Catherine, Kurosawa, Shinichiro, Remick, Daniel G

“…Sepsis is a serious clinical condition that represents a patient's response to a severe infection and has a very high mortality rate. Normal immune and…”
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Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis by Osuchowski, Marcin F, Ayala, Alfred, Bahrami, Soheyl, Bauer, Michael, Boros, Mihaly, Cavaillon, Jean-Marc, Chaudry, Irshad H, Coopersmith, Craig M, Deutschman, Clifford, Drechsler, Susanne, Efron, Philip, Frostell, Claes, Fritsch, Gerhard, Gozdzik, Waldemar, Hellman, Judith, Huber-Lang, Markus, Inoue, Shigeaki, Knapp, Sylvia, Kozlov, Andrey V, Libert, Claude, Marshall, John C, Moldawer, Lyle L, Radermacher, Peter, Redl, Heinz, Remick, Daniel G, Singer, Mervyn, Thiemermann, Christoph, Wang, Ping, Wiersinga, W Joost, Xiao, Xianzhong, Zingarelli, Basilia

“…ABSTRACTPre-clinical animal studies precede the majority of clinical trials. While the clinical definitions of sepsis and recommended treatments are regularly…”
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Pathophysiologic mechanisms in septic shock by King, Elizabeth G, Bauzá, Gustavo J, Mella, Juan R, Remick, Daniel G

“…The systemic inflammatory response that occurs in the septic patient as a result of an infectious insult affects multiple organs and systems, causing numerous…”
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Early enhanced local neutrophil recruitment in peritonitis-induced sepsis improves bacterial clearance and survival by Craciun, Florin L, Schuller, Elizabeth R, Remick, Daniel G

“…Neutrophils are critical for the rapid eradication of bacterial pathogens, but they also contribute to the development of multiple organ failure in sepsis. We…”
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Acute-Phase Deaths from Murine Polymicrobial Sepsis Are Characterized by Innate Immune Suppression Rather Than Exhaustion by Chiswick, Evan L, Mella, Juan R, Bernardo, John, Remick, Daniel G

“…Sepsis, a leading cause of death in the United States, has poorly understood mechanisms of mortality. To address this, our model of cecal ligation and puncture…”
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Part II: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Types of Infections and Organ Dysfunction Endpoints by Libert, Claude, Ayala, Alfred, Bauer, Michael, Cavaillon, Jean-Marc, Deutschman, Clifford, Frostell, Claes, Knapp, Sylvia, Kozlov, Andrey V, Wang, Ping, Osuchowski, Marcin F, Remick, Daniel G

“…ABSTRACTAlthough the clinical definitions of sepsis and recommended treatments are regularly updated, a systematic review has not been done for preclinical…”
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Mechanisms of Mortality in Early and Late Sepsis by Xiao, Hongyan, Siddiqui, Javed, Remick, Daniel G

“…A recent hypothesis postulates that sepsis moves through different phases, with periods of enhanced inflammation alternating with periods of immune…”
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Disruption of immune regulation by microbial pathogens and resulting chronic inflammation by Barth, Kenneth, Remick, Daniel G., Genco, Caroline A.

“…Activation of the immune response is a tightly regulated, coordinated effort that functions to control and eradicate exogenous microorganisms, while also…”
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Stratification is the key: Inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis by Osuchowski, Marcin F, Connett, Judith, Welch, Kathleen, Granger, Jill, Remick, Daniel G

“…OBJECTIVE:This study examined the effectiveness of prospective stratification to identify and target high-dose glucocorticoid therapy for subjects developing…”
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Shorter Duration of Post-Operative Antibiotics for Cecal Ligation and Puncture Does Not Increase Inflammation or Mortality by Iskander, Kendra N, Vaickus, Max, Duffy, Elizabeth R, Remick, Daniel G

“…Antimicrobial therapy for sepsis has beneficial effects, but prolonged use fosters emergence of resistant microorganisms, increases cost, and secondary…”
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Cytokines and the Brain: Implications for Clinical Psychiatry by Kronfol, Ziad, Remick, Daniel G.

“…OBJECTIVE: This article reviews recent developments in cytokine biology that are relevant to clinical psychiatry.METHOD: The authors reviewed English-language…”
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Mild Traumatic Brain Injury in Mice Beneficially Alters Lung NK1R and Structural Protein Expression to Enhance Survival after Pseudomonas aeruginosa Infection by Vaickus, Max, Hsieh, Terry, Kintsurashvili, Ekaterina, Kim, Jiyoun, Kirsch, Daniel, Kasotakis, George, Remick, Daniel G.

“…Mild traumatic brain injury (mTBI) in a murine model increases survival to a bacterial pulmonary challenge compared with blunt tail trauma (TT). We hypothesize…”
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A murine model of mild traumatic brain injury exhibiting cognitive and motor deficits by Yang, Sung H., MD, Gustafson, Josh, MD, Gangidine, Matt, BS, Stepien, David, PhD, Schuster, Rebecca, MA, Pritts, Timothy A., MD, PhD, Goodman, Michael D., MD, Remick, Daniel G., MD, Lentsch, Alex B., PhD

“…Abstract Background Mild traumatic brain injury (TBI) is a serious public health concern affecting more than 1.7 million people in the United States annually…”
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Altered Desmosomal Proteins in Granulomatous Myocarditis and Potential Pathogenic Links to Arrhythmogenic Right Ventricular Cardiomyopathy by Asimaki, Angeliki, Tandri, Harikrishna, Duffy, Elizabeth R, Winterfield, Jeffrey R, Mackey-Bojack, Shannon, Picken, Maria M, Cooper, Leslie T, Wilber, David J, Marcus, Frank I, Basso, Cristina, Thiene, Gaetano, Tsatsopoulou, Adalena, Protonotarios, Nikos, Stevenson, William G, McKenna, William J, Gautam, Shiva, Remick, Daniel G, Calkins, Hugh, Saffitz, Jeffrey E

“…BACKGROUND—Immunoreactive signal for the desmosomal protein plakoglobin (γ-catenin) is reduced at cardiac intercalated disks in patients with arrhythmogenic…”
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Role of Interleukin-6 in Mortality from and Physiologic Response to Sepsis by Remick, Daniel G, Bolgos, Gerald, Copeland, Shannon, Siddiqui, Javed

“…Previous studies have suggested that interleukin-6 (IL-6) serves as both a marker and a mediator for the severity of sepsis. We tested whether interleukin 6…”
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Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis by Osuchowski, Marcin F., Ayala, Alfred, Bahrami, Soheyl, Bauer, Michael, Boros, Mihaly, Cavaillon, Jean-Marc, Chaudry, Irshad H., Coopersmith, Craig M., Deutschman, Clifford, Drechsler, Susanne, Efron, Philip, Frostell, Claes, Fritsch, Gerhard, Gozdzik, Waldemar, Hellman, Judith, Huber-Lang, Markus, Inoue, Shigeaki, Knapp, Sylvia, Kozlov, Andrey V., Libert, Claude, Marshall, John C., Moldawer, Lyle L., Radermacher, Peter, Redl, Heinz, Remick, Daniel G., Singer, Mervyn, Thiemermann, Christoph, Wang, Ping, Wiersinga, Willem Joost, Xiao, Xianzhong, Zingarelli, Basilia

“…Background Pre-clinical animal studies precede the majority of clinical trials. While the clinical definitions of sepsis and recommended treatments are…”
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New Model of Murine Allergic Rhinosinusitis Induced Cockroach Allergens by Lussier, Bethany L., MD, Remick, Daniel G., MD

“…Methods Six week old female ICR mice were sensitized according to our asthma protocol via intratracheal instillation of (2)25 μL aliquots of 1:10 dilution…”
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