Search Results - "REMACLE, José"

Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes by GILLET, Jean-Pierre, EFFERTH, Thomas, STEINBACH, Daniel, HAMELS, Jacques, DE LONGUEVILLE, Francoise, BERTHOLET, Vincent, REMACLE, José

“…Different mechanisms of drug resistance, including ATP-binding cassette (ABC) transporters, are responsible for treatment failure of tumors. We developed a…”
Get full text

Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-β1 signaling pathway by Debacq-Chainiaux, Florence, Borlon, Céline, Pascal, Thierry, Royer, Véronique, Eliaers, François, Ninane, Noëlle, Carrard, Géraldine, Friguet, Bertrand, de Longueville, Françoise, Boffe, Sophie, Remacle, José, Toussaint, Olivier

“…Premature senescence of human diploid fibroblasts (HDFs) can be induced by exposures to a variety of oxidative stress and DNA damaging agents. In this study we…”
Get full text

Microarray-based Detection System for Genetically Modified (GM) Food Ingredients by Leimanis, S, Hernandez, M, Fernandez, S, Boyer, F, Burns, M, Bruderer, S, Glouden, T, Harris, N, Kaeppeli, O, Philipp, P

“…A multiplex DNA microarray chip was developed for simultaneous identification of nine genetically modified organisms (GMOs), five plant species and three GMO…”
Get full text

Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays by Pascal, Thierry, Debacq-Chainiaux, Florence, Chrétien, Aline, Bastin, Coralie, Dabée, Anne-France, Bertholet, Vincent, Remacle, José, Toussaint, Olivier

“…Human diploid fibroblasts (HDFs) exposed to subcytotoxic stress display many features of senescence. Using differential display RT-PCR, gene expression of HDFs…”
Get full text

Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress by Michiels, C, Raes, M, Toussaint, O, Remacle, J

“…Eukaryotic cells have to constantly cope with highly reactive oxygen-derived free radicals. Their defense against these free radicals is achieved by natural…”
Get more information

Comparison between Different Strategies of Covalent Attachment of DNA to Glass Surfaces to Build DNA Microarrays by Zammatteo, Nathalie, Jeanmart, Laurent, Hamels, Sandrine, Courtois, Stéphane, Louette, Pierre, Hevesi, Laszlo, Remacle, José

“…DNA microarray is a powerful tool allowing simultaneous detection of many different target molecules present in a sample. The efficiency of the array depends…”
Get full text

Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast by Dumont, Patrick, Burton, Maggi, Chen, Qin M, Gonos, Efstathios S, Frippiat, Christophe, Mazarati, Jean-Baptiste, Eliaers, François, Remacle, José, Toussaint, Olivier

“…We tested the long-term effects of sublethal oxidative stresses on replicative senescence. WI-38 human diploid fibroblasts (HDFs) at early cumulative…”
Get full text

Use of a Low-Density Microarray for Studying Gene Expression Patterns Induced by Hepatotoxicants on Primary Cultures of Rat Hepatocytes by de Longueville, Francoise, Atienzar, Franck A., Marcq, Laurence, Dufrane, Simon, Evrard, Stéphanie, Wouters, Lydia, Leroux, Florence, Bertholet, Vincent, Gerin, Brigitte, Whomsley, Rhys, Arnould, Thierry, Remacle, José, Canning, Mickael

“…In the field of gene expression analysis, DNA microarray technology is having a major impact on many different areas including toxicology. For instance, a…”
Get full text

Proteome analysis and identification of symbiosis-related proteins from Medicago truncatula Gaertn. by two-dimensional electrophoresis and mass spectrometry by Bestel-Corre, Gwénaëlle, Dumas-Gaudot, Eliane, Poinsot, Véréna, Dieu, Marc, Dierick, Jean-François, Tuinen, Diederik van, Remacle, José, Gianinazzi-Pearson, Vivienne, Gianinazzi, Silvio

“…Time‐course analysis of root protein profiles was studied by two‐dimensional gel electrophoresis and silver staining in the model plant Medicago truncatula,…”
Get full text

Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts by de Magalhães, João Pedro, Chainiaux, Florence, Remacle, José, Toussaint, Olivier

“…To test the involvement of the telomeres in the senescent phenotype, we used telomerase-immortalized human foreskin fibroblasts (hTERT-BJ1). We exposed…”
Get full text

Hypoxia-induced increase in intracellular calcium concentration in endothelial cells: Role of the Na+-glucose cotransporter by Berna, Nancy, Arnould, Thierry, Remacle, José, Michiels, Carine

“…Hypoxia is a common denominator of many vascular disorders, especially those associated with ischemia. To study the effect of oxygen depletion on endothelium,…”
Get full text

Chemotherapy-induced resistance by ATP-binding cassette transporter genes by Gillet, Jean-Pierre, Efferth, Thomas, Remacle, José

“…A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of…”
Get full text

Gene expression profiling of drug metabolism and toxicology markers using a low-density DNA microarray by de Longueville, Françoise, Surry, Dominic, Meneses-Lorente, Georgina, Bertholet, Vincent, Talbot, Valérie, Evrard, Stephanie, Chandelier, Nathalie, Pike, Andrew, Worboys, Phil, Rasson, Jean-Paul, Le Bourdellès, Béatrice, Remacle, José

“…DNA microarrays are useful tools to study changes of gene expression in response to a treatment with drugs. Here, we describe the optimization of conditions…”
Get full text

Genetics of Healthy Aging in Europe by FRANCESCHI, CLAUDIO, BEZRUKOV, VLADYSLAV, BLANCHÉ, HÉLÈNE, BOLUND, LARS, CHRISTENSEN, KAARE, BENEDICTIS, GIOVANNA DE, DEIANA, LUCA, GONOS, EFSTHATIOS, HERVONEN, ANTTI, YANG, HUANNING, JEUNE, BERNARD, KIRKWOOD, TOM B. L., KRISTENSEN, PETER, LEON, ALBERTA, PELICCI, PIER GIUSEPPE, PELTONEN, LEENA, POULAIN, MICHEL, REA, IRENE MAEVE, REMACLE, JOSÉ, ROBINE, JEAN MARIE, SCHREIBER, STEFAN, SIKORA, EWA, SLAGBOOM, PIETERNELLA ELINE, SPAZZAFUMO, LIANA, STAZI, MARIA ANTONIETTA, TOUSSAINT, OLIVIER, VAUPEL, JAMES W.

“…:  The aim of the 5‐year European Union (EU)‐Integrated Project GEnetics of Healthy Aging (GEHA), constituted by 25 partners (24 from Europe plus the Beijing…”
Get full text

The co‐occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific by Raule, Nicola, Sevini, Federica, Li, Shengting, Barbieri, Annalaura, Tallaro, Federica, Lomartire, Laura, Vianello, Dario, Montesanto, Alberto, Moilanen, Jukka S., Bezrukov, Vladyslav, Blanché, Hélène, Hervonen, Antti, Christensen, Kaare, Deiana, Luca, Gonos, Efstathios S., Kirkwood, Tom B. L., Kristensen, Peter, Leon, Alberta, Pelicci, Pier Giuseppe, Poulain, Michel, Rea, Irene M., Remacle, Josè, Robine, Jean Marie, Schreiber, Stefan, Sikora, Ewa, Eline Slagboom, Peternella, Spazzafumo, Liana, Antonietta Stazi, Maria, Toussaint, Olivier, Vaupel, James W., Rose, Giuseppina, Majamaa, Kari, Perola, Markus, Johnson, Thomas E., Bolund, Lars, Yang, Huanming, Passarino, Giuseppe, Franceschi, Claudio

“…Summary To re‐examine the correlation between mtDNA variability and longevity, we examined mtDNAs from samples obtained from over 2200 ultranonagenarians (and…”
Get full text

Role of the PLA2‐independent peroxiredoxin VI activity in the survival of immortalized fibroblasts exposed to cytotoxic oxidative stress by Salmon, Michel, Dedessus Le Moutier, Jérémie, Wenders, Frédéric, Chiarizia, Sophie, Eliaers, François, Remacle, José, Royer, Véronique, Pascal, Thierry, Toussaint, Olivier

“…Peroxiredoxin VI (PrxVI) is a bifunctional enzyme with non‐selenium glutathione peroxidase and Ca2+‐independent acidic phospholipase A2 activities. We…”
Get full text

ABCChips as New Diagnostic Tool to Monitoring Multidrug Resistance in Human Tumor Cells to Chemotherapeutics Agents by Expression Profiling of ATP-Binding Cassette Transporter Genes by Gillet, Jean-Pierre, Efferth, Thomas, Steinbach, Damiel, de Longueville, Françoise, Bertholet, Vincent, Remacle, José, Sayer, Herbert G.

“…A major problem in the treatment of tumors represents the development of resistance to chemotherapy. Many mechanisms are responsible for the failure of…”
Get full text

An Evaluation of a Low-Density DNA Microarray Using Cytochrome P450 Inducers by Meneses-Lorente, Georgina, de Longueville, Françoise, Dos Santos-Mendes, Sofia, Bonnert, Timothy P, Jack, Andrew, Evrard, Stéphanie, Bertholet, Vincent, Pike, Andrew, Scott-Stevens, Paul, Remacle, José, Sohal, Bindi

“…The aim of this study was to validate a low-density DNA microarray “Rat HepatoChip”, which contains 59 genes from a range of potential toxic markers and drug…”
Get full text

Identification of p38-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts by Zdanov, Stephanie, Debacq-Chainiaux, Florence, Remacle, Jose, Toussaint, Olivier

“…Premature senescence of IMR-90 human diploid fibroblasts expressing telomerase (hTERT) establishes after exposure to an acute sublethal concentration of H2O2…”
Get full text

Identification of BRCA1 Deficiency Using Multi-Analyte Estimation of BRCA1 and Its Repressors in FFPE Tumor Samples from Patients with Triple Negative Breast Cancer by Korlimarla, Aruna, Prabhu, Jyothi S, Remacle, Jose, Rajarajan, Savitha, Raja, Uma, C E, Anupama, Srinath, B S, Manjunath, Suraj, K S, Gopinath, Correa, Marjorrie, M S N, Prasad, Sridhar, T S

“…Apart from germ-line BRCA1-mutated breast cancers, a significant proportion of women with sporadic triple negative breast cancer (TNBC) sub-type are known to…”
Get full text