Search Results - "REITER, Russel J"

Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection by Galano, Annia, Reiter, Russel J.

“…Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including lipids, proteins, and DNA. The associated molecular damage…”
Get full text

Melatonin: exceeding expectations by Reiter, Russel J, Tan, Dun Xian, Galano, Annia

“…Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian…”
Get full text

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK by Galano, Annia, Tan, Dun Xian, Reiter, Russel J.

“…The reactions of N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine (AFMK) and N1‐acetyl‐5‐methoxykynuramine (AMK) with •OH, •OOH, and •OOCCl3 radicals have been studied…”
Get full text

Melatonin feedback on clock genes: a theory involving the proteasome by Vriend, Jerry, Reiter, Russel J.

“…The expression of ‘clock’ genes occurs in all tissues, but especially in the suprachiasmatic nuclei (SCN) of the hypothalamus, groups of neurons in the brain…”
Get full text

Melatonin as a natural ally against oxidative stress: a physicochemical examination by Galano, Annia, Tan, Dun Xian, Reiter, Russel J.

“…:  Oxidative stress has been proven to be related to the onset of a large number of health disorders. This chemical stress is triggered by an excess of free…”
Get full text

Melatonin as a mitochondria-targeted antioxidant: one of evolution’s best ideas by Reiter, Russel J., Rosales-Corral, Sergio, Tan, Dun Xian, Jou, Mei Jie, Galano, Annia, Xu, Bing

“…Melatonin is an ancient antioxidant. After its initial development in bacteria, it has been retained throughout evolution such that it may be or may have been…”
Get full text

Melatonin: A Versatile Protector against Oxidative DNA Damage by Galano, Annia, Tan, Dun-Xian, Reiter, Russel J

“…Oxidative damage to DNA has important implications for human health and has been identified as a key factor in the onset and development of numerous diseases…”
Get full text

Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation by Ma, Ning, Zhang, Jie, Reiter, Russel J., Ma, Xi

“…Nowadays, melatonin, previously considered only as a pharmaceutical product for rhythm regulation and sleep aiding, has shown its potential as a co‐adjuvant…”
Get full text

Melatonin Synthesis and Function: Evolutionary History in Animals and Plants by Zhao, Dake, Yu, Yang, Shen, Yong, Liu, Qin, Zhao, Zhiwei, Sharma, Ramaswamy, Reiter, Russel J

“…Melatonin is an ancient molecule that can be traced back to the origin of life. Melatonin's initial function was likely that as a free radical scavenger…”
Get full text

Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress by Dehdashtian, Ehsan, Mehrzadi, Saeed, Yousefi, Bahman, Hosseinzadeh, Azam, Reiter, Russel J., Safa, Majid, Ghaznavi, Habib, Naseripour, Masood

“…Diabetic retinopathy (DR), a microvascular complication of diabetes mellitus (DM), remains as one of the major causes of vision loss worldwide. The release of…”
Get full text

Melatonin as an antioxidant: under promises but over delivers by Reiter, Russel J., Mayo, Juan C., Tan, Dun-Xian, Sainz, Rosa M., Alatorre-Jimenez, Moises, Qin, Lilan

“…Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large number of circumstances. It achieves this action via a variety of…”
Get full text

Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells by Anderson, George, Rodriguez, Moses, Reiter, Russel J

“…Recent data highlight the important roles of the gut microbiome, gut permeability, and alterations in mitochondria functioning in the pathophysiology of…”
Get full text

Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics by Tan, Dun-Xian, Manchester, Lucien C, Qin, Lilan, Reiter, Russel J

“…Melatonin has been speculated to be mainly synthesized by mitochondria. This speculation is supported by the recent discovery that aralkylamine…”
Get full text

Melatonin: Current Status and Future Perspectives in Plant Science by Nawaz, Muhammad A, Huang, Yuan, Bie, Zhilong, Ahmed, Waqar, Reiter, Russel J, Niu, Mengliang, Hameed, Saba

“…Melatonin (N-acetyl-5-methoxytryptamine) is a ubiquitous molecule with pleiotropic actions in different organisms. It performs many important functions in…”
Get full text

Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 by Banerjee, Aditi, Czinn, Steven J., Reiter, Russel J., Blanchard, Thomas G.

“…The outbreak of COVID-19 caused by 2019–nCov/SARS-CoV-2 has become a pandemic with an urgent need for understanding the mechanisms and identifying a treatment…”
Get full text

Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions by Slominski, Andrzej T., Hardeland, Ruediger, Zmijewski, Michal A., Slominski, Radomir M., Reiter, Russel J., Paus, Ralf

“…Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the main neuroendocrine secretory product of the pineal gland…”
Get full text

Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases by Reiter, Russel J, Sharma, Ramaswamy, Rosales-Corral, Sergio

“…Glucose is an essential nutrient for every cell but its metabolic fate depends on cellular phenotype. Normally, the product of cytosolic glycolysis, pyruvate,…”
Get full text

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice by Yin, Jie, Li, Yuying, Han, Hui, Chen, Shuai, Gao, Jing, Liu, Gang, Wu, Xin, Deng, Jinping, Yu, Qifang, Huang, Xingguo, Fang, Rejun, Li, Tiejun, Reiter, Russel J., Zhang, Dong, Zhu, Congrui, Zhu, Guoqiang, Ren, Wenkai, Yin, Yulong

“…Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin…”
Get full text

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis by Reiter, Russel J, Rosales-Corral, Sergio A, Tan, Dun-Xian, Acuna-Castroviejo, Dario, Qin, Lilan, Yang, Shun-Fa, Xu, Kexin

“…There is highly credible evidence that melatonin mitigates cancer at the initiation, progression and metastasis phases. In many cases, the molecular mechanisms…”
Get full text

Melatonin protects against maternal obesity‐associated oxidative stress and meiotic defects in oocytes via the SIRT3‐SOD2‐dependent pathway by Han, Longsen, Wang, Haichao, Li, Ling, Li, Xiaoyan, Ge, Juan, Reiter, Russel J., Wang, Qiang

“…Maternal obesity in humans is associated with poor outcomes across the reproductive spectrum. Emerging evidence indicates that these defects are likely…”
Get full text