Search Results - "REINES, Scott"

Inhibition of phosphodiesterase-4D in adults with fragile X syndrome: a randomized, placebo-controlled, phase 2 clinical trial by Berry-Kravis, Elizabeth M., Harnett, Mark D., Reines, Scott A., Reese, Melody A., Ethridge, Lauren E., Outterson, Abigail H., Michalak, Claire, Furman, Jeremiah, Gurney, Mark E.

“…The goal of this study was to determine whether a phosphodiesterase-4D (PDE4D) allosteric inhibitor (BPN14770) would improve cognitive function and behavioral…”
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Misuse of Tramadol in the United States: An Analysis of the National Survey of Drug Use and Health 2002-2017 by Reines, Scott A, Goldmann, Bonnie, Harnett, Mark, Lu, Lucy

“…Objective: To analyze the rates of misuse - that is, use in any way not directed by a doctor - of products containing oral tramadol, a Schedule IV opioid, from…”
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Auditory N1 event-related potential amplitude is predictive of serum concentration of BPN14770 in fragile X syndrome by Norris, Jordan E, Berry-Kravis, Elizabeth M, Harnett, Mark D, Reines, Scott A, Reese, Melody A, Outterson, Abigail H, Michalak, Claire, Furman, Jeremiah, Gurney, Mark E, Ethridge, Lauren E

“…Abstract Fragile X syndrome (FXS) is a rare neurodevelopmental disorder caused by a CGG repeat expansion ≥ 200 repeats in 5’ untranslated region of the FMR1…”
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Lack of Efficacy of the Substance P (Neurokinin 1 Receptor) Antagonist Aprepitant in the Treatment of Major Depressive Disorder by Keller, Martin, Montgomery, Stuart, Ball, William, Morrison, Mary, Snavely, Duane, Liu, Guanghan, Hargreaves, Richard, Hietala, Jarmo, Lines, Christopher, Beebe, Katherine, Reines, Scott

“…An early clinical trial suggested that the substance P (neurokinin 1 receptor) antagonist, aprepitant, might provide a unique mechanism of antidepressant…”
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Intravenous Tramadol is Effective in the Management of Postoperative Pain Following Abdominoplasty: A Three-Arm Randomized Placebo- and Active-Controlled Trial by Minkowitz, Harold, Salazar, Hernan, Leiman, David, Solanki, Daneshvari, Lu, Lucy, Reines, Scott, Ryan, Michael, Harnett, Mark, Singla, Neil

“…Background and Objective Oral tramadol, an atypical opioid approved in the United States (US) since 1995 and a Schedule IV controlled substance, has less abuse…”
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Comparing the Pharmacokinetics of 2 Novel Intravenous Tramadol Dosing Regimens to Oral Tramadol: A Randomized 3‐Arm Crossover Study by Lu, Lucy, Ryan, Michael, Harnett, Mark, Atiee, George J., Reines, Scott A.

“…Tramadol is a dual‐mechanism (opiate and monoamine reuptake inhibition) analgesic. Intravenous (IV) tramadol has been widely prescribed outside the United…”
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A Randomized, Double-Blind, Study of Rofecoxib in Patients with Mild Cognitive Impairment by THAL, Leon J, FERRIS, Steven H, REINES, Scott A, KIRBY, Louis, BLOCK, Gilbert A, LINES, Christopher R, YUEN, Eric, ASSAID, Christopher, NESSLY, Michael L, NORMAN, Barbara A, BARANAK, Christine C

“…Inflammatory mechanisms have been implicated in Alzheimer's disease (AD) and might be mediated via the COX-2 enzyme. Previous studies with the selective COX-2…”
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The Oral Neurokinin-1 Antagonist Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial in Patients Receiving High-Dose Cisplatin—The Aprepitant Protocol 052 Study Group by HESKETH, Paul J, GRUNBERG, Steven M, EVANS, Judith K, BECK, Klaus, REINES, Scott, HORGAN, Kevin J, GRALLA, Richard J, WARR, David G, ROILA, Fausto, DE WIT, Ronald, CHAWLA, Sant P, CARIDES, Alexandra D, LANUS, Juliana, ELMER, Mary E

“…In early clinical trials with patients receiving highly emetogenic chemotherapy, the neurokinin antagonist aprepitant significantly enhanced the efficacy of a…”
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Demonstration of the Efficacy and Safety of a Novel Substance P (NK ) Receptor Antagonist in Major Depression by KRAMER, Mark S, WINOKUR, Andrew, APTER, Jeffrey T, CUNNINGHAM, Lynn, KLING, Mitchel, BARI, Mohammed, GETSON, Albert, YIH LEE, KELSEY, Jeffrey, PRESKORN, Sheldon H, ROTHSCHILD, Anthony J, SNAVELY, Duane, GHOSH, Kalyan, BALL, William A, REINES, Scott A, MUNJACK, Dennis

“…The efficacy and safety of a selective NK(1) antagonist, L-759274, was investigated in outpatients with diagnosis of major depressive disorder with melancholic…”
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Lack of efficacy of L-759274, a novel neurokinin 1 (substance P) receptor antagonist, for the treatment of generalized anxiety disorder by Michelson, David, Hargreaves, Richard, Alexander, Robert, Ceesay, Paulette, Hietala, Jarmo, Lines, Christopher, Reines, Scott

“…Preclinical studies suggest that substance P acting at neurokinin 1 (NK1) receptors may be involved in stress responses and NK1 receptor antagonists show…”
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Addition of an NK1 receptor antagonist to an SSRI did not enhance the antidepressant effects of SSRI monotherapy: results from a randomized clinical trial in patients with major depressive disorder by Ball, William A., Snavely, Duane B., Hargreaves, Richard J., Szegedi, Armin, Lines, Christopher, Reines, Scott A.

“…Objective Aprepitant is a neurokinin 1 receptor antagonist approved for prevention of chemotherapy‐induced and post‐operative nausea and vomiting. Early…”
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Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant by Bergström, Mats, Hargreaves, Richard J, Burns, H.Donald, Goldberg, Michael R, Sciberras, David, Reines, Scott A, Petty, Kevin J, Ögren, Mattias, Antoni, Gunnar, Långström, Bengt, Eskola, Olli, Scheinin, Mika, Solin, Olof, Majumdar, Anup K, Constanzer, Marvin L, Battisti, Wendy P, Bradstreet, Thomas E, Gargano, Cynthia, Hietala, Jarmo

“…Aprepitant is a highly selective substance P (neurokinin 1 [NK 1] receptor) antagonist that significantly improves the pharmacotherapy of acute and delayed…”
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Efficacy and Safety of Intravenously Administered Tramadol in Patients with Moderate to Severe Pain Following Bunionectomy: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study by Singla, Neil K., Pollak, Richard, Gottlieb, Ira, Leiman, David, Minkowitz, Harold, Zimmerman, John, Harnett, Mark, Ryan, Michael, Lu, Lucy, Reines, Scott

“…Introduction This study is part of the registrational program for intravenously administered (IV) tramadol in the USA and compared the analgesic benefit and…”
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Is bigger better for depression trials? by Liu, Kenneth S, Snavely, Duane B, Ball, William A, Lines, Christopher R, Reines, Scott A, Potter, William Z

“…Abstract Objective A key assumption underlying the principle that power increases with sample size is that the standardized effect size is fixed over time. In…”
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Rizatriptan (MAXALT) for the Acute Treatment of Migraine and Migraine Recurrence. A Placebo-Controlled, Outpatient Study by Teall, Judith, Tuchman, Michael, Cutler, Neal, Gross, Michael, Willoughby, Ernest, Smith, Betty, Jiang, Kai, Reines, Scott, Block, Gilbert

“…Rizatriptan is a novel 5‐HT1B/1D agonist which is rapidly absorbed after oral administration. The efficacy and tolerability of oral rizatriptan (5 mg and 10…”
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Look-alike, sound-alike drug errors with Reminyl and Amaryl by Reines, Scott A

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Montelukast for Migraine Prophylaxis: A Randomized, Double-Blind, Placebo-Controlled Study by Brandes, Jan L., Visser, W. Hester, Farmer, Mildred V., Schuhl, Amy L., Malbecq, William, Vrijens, France, Lines, Christopher R., Reines, Scott A.

“…Objective.—To evaluate the efficacy and tolerability of montelukast 20 mg in the prophylactic treatment of migraine. Background.—A previous small open‐label…”
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Efficacy and Safety of Rizatriptan Versus Standard Care During Long-term Treatment for Migraine by Block, Gilbert A., Goldstein, Jerome, Polis, Adam, Reines, Scott A., Smith, Mary E.

“…Rizatriptan is a novel, selective 5‐HT1B/1D receptor agonist with a rapid onset of action after oral dosing for the acute treatment of migraine. We conducted a…”
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Oral Rizatriptan Versus Oral Sumatriptan: A Direct Comparative Study in the Acute Treatment of Migraine by Tfelt-Hansen, Peer, Teall, Judith, Rodriguez, Francisco, Giacovazzo, Mario, Paz, Jose, Malbecq, William, Block, Gilbert A., Reines, Scott A., Visser, W. Hester

“…Rizatriptan is a potent, oral, 5‐HT1B/1D agonist with more rapid absorption and higher bioavailability than oral sumatriptan. It was postulated that this would…”
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IV Tramadol - A New Treatment Option for Management of Post-Operative Pain in the US: An Open-Label, Single-Arm, Safety Trial Including Various Types of Surgery by Minkowitz, Harold, Leiman, David, Lu, Lucy, Reines, Scott, Ryan, Michael, Harnett, Mark, Singla, Neil

“…There is a need to reduce exposure to Schedule II opioids in the United States (US) due to the ongoing opioid epidemic. Schedule II opioids have higher…”
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