Search Results - "REINARTZ, Silke"

Tumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C by Steitz, Anna Mary, Steffes, Alina, Finkernagel, Florian, Unger, Annika, Sommerfeld, Leah, Jansen, Julia M., Wagner, Uwe, Graumann, Johannes, Müller, Rolf, Reinartz, Silke

“…A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the extensive transcoelomic spreading of tumor cell via the peritoneal fluid or…”
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Mixed‐polarization phenotype of ascites‐associated macrophages in human ovarian carcinoma: Correlation of CD163 expression, cytokine levels and early relapse by Reinartz, Silke, Schumann, Tim, Finkernagel, Florian, Wortmann, Annika, Jansen, Julia M., Meissner, Wolfgang, Krause, Michael, Schwörer, Anne‐Marie, Wagner, Uwe, Müller‐Brüsselbach, Sabine, Müller, Rolf

“…Ovarian cancer is typically accompanied by the occurrence of malignant ascites containing large number of macrophages. It has been suggested that these…”
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Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment by Worzfeld, Thomas, Finkernagel, Florian, Reinartz, Silke, Konzer, Anne, Adhikary, Till, Nist, Andrea, Stiewe, Thorsten, Wagner, Uwe, Looso, Mario, Graumann, Johannes, Müller, Rolf

“…Ovarian cancer is characterized by early transcoelomic metastatic spread via the peritoneal fluid, where tumor cell spheroids (TU), tumor-associated T cells…”
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Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma by Graumann, Johannes, Finkernagel, Florian, Reinartz, Silke, Stief, Thomas, Brödje, Dörte, Renz, Harald, Jansen, Julia M., Wagner, Uwe, Worzfeld, Thomas, Pogge von Strandmann, Elke, Müller, Rolf

“…A central reason behind the poor clinical outcome of patients with high-grade serous carcinoma (HGSC) of the ovary is the difficulty in reliably detecting…”
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Prognosis of ovarian cancer is associated with effector memory CD8 + T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells by Lieber, Sonja, Reinartz, Silke, Raifer, Hartmann, Finkernagel, Florian, Dreyer, Tobias, Bronger, Holger, Jansen, Julia M, Wagner, Uwe, Worzfeld, Thomas, Müller, Rolf, Huber, Magdalena

“…The accumulation of intratumoral CD8 T cells is associated with the survival of high grade serous ovarian carcinoma patients, but it is unclear which CD8 T…”
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Cell type‐selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment by Reinartz, Silke, Lieber, Sonja, Pesek, Jelena, Brandt, Dominique T., Asafova, Alina, Finkernagel, Florian, Watzer, Bernard, Nockher, Wolfgang Andreas, Nist, Andrea, Stiewe, Thorsten, Jansen, Julia M., Wagner, Uwe, Konzer, Anne, Graumann, Johannes, Grosse, Robert, Worzfeld, Thomas, Müller‐Brüsselbach, Sabine, Müller, Rolf

“…The peritoneal fluid of ovarian carcinoma patients promotes cancer cell invasion and metastatic spread with lysophosphatidic acid (LPA) as a potentially…”
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Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures by Hammoud, Mohamad K., Dietze, Raimund, Pesek, Jelena, Finkernagel, Florian, Unger, Annika, Bieringer, Tim, Nist, Andrea, Stiewe, Thorsten, Bhagwat, Aditya M., Nockher, Wolfgang Andreas, Reinartz, Silke, Müller‐Brüsselbach, Sabine, Graumann, Johannes, Müller, Rolf

“…Survival of ovarian carcinoma is associated with the abundance of immunosuppressed CD163highCD206high tumor‐associated macrophages (TAMs) and high levels of…”
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Upregulation of mesothelial genes in ovarian carcinoma cells is associated with an unfavorable clinical outcome and the promotion of cancer cell adhesion by Ojasalu, Kaire, Brehm, Corinna, Hartung, Kristin, Nischak, Maximilian, Finkernagel, Florian, Rexin, Peter, Nist, Andrea, Pavlakis, Evangelos, Stiewe, Thorsten, Jansen, Julia M., Wagner, Uwe, Gattenlöhner, Stefan, Bräuninger, Andreas, Müller‐Brüsselbach, Sabine, Reinartz, Silke, Müller, Rolf

“…A hallmark of ovarian high‐grade serous carcinoma (HGSC) is its early and massive peritoneal dissemination via the peritoneal fluid. It is generally believed…”
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The Unique Molecular and Cellular Microenvironment of Ovarian Cancer by Worzfeld, Thomas, Pogge von Strandmann, Elke, Huber, Magdalena, Adhikary, Till, Wagner, Uwe, Reinartz, Silke, Müller, Rolf

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Basal cell adhesion molecule promotes metastasis‐associated processes in ovarian cancer by Sivakumar, Suresh, Lieber, Sonja, Librizzi, Damiano, Keber, Corinna, Sommerfeld, Leah, Finkernagel, Florian, Roth, Katrin, Reinartz, Silke, Bartsch, Jörg W., Graumann, Johannes, Müller‐Brüsselbach, Sabine, Müller, Rolf

“…Background Basal cell adhesion molecule (BCAM) is a laminin α5 (LAMA5) binding membrane‐bound protein with a putative role in cancer. Besides full‐length…”
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Soluble NKG2D ligands in the ovarian cancer microenvironment are associated with an adverse clinical outcome and decreased memory effector T cells independent of NKG2D downregulation by Vyas, Maulik, Reinartz, Silke, Hoffmann, Nathalie, Reiners, Katrin S, Lieber, Sonja, Jansen, Julia M, Wagner, Uwe, Müller, Rolf, von Strandmann, Elke Pogge

“…The immune receptor NKG2D is predominantly expressed on NK cells and T cell subsets and confers anti-tumor activity. According to the current paradigm, immune…”
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The multicellular signalling network of ovarian cancer metastases by Sommerfeld, Leah, Finkernagel, Florian, Jansen, Julia M., Wagner, Uwe, Nist, Andrea, Stiewe, Thorsten, Müller‐Brüsselbach, Sabine, Sokol, Anna M., Graumann, Johannes, Reinartz, Silke, Müller, Rolf

“…Background Transcoelomic spread is the major route of metastasis of ovarian high‐grade serous carcinoma (HGSC) with the omentum as the major metastatic site…”
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TRAIL-dependent apoptosis of peritoneal mesothelial cells by NK cells promotes ovarian cancer invasion by Steitz, Anna Mary, Schröder, Clarissa, Knuth, Isabel, Keber, Corinna U., Sommerfeld, Leah, Finkernagel, Florian, Jansen, Julia M., Wagner, Uwe, Müller-Brüsselbach, Sabine, Worzfeld, Thomas, Huber, Magdalena, Beutgen, Vanessa M., Graumann, Johannes, Pogge von Strandmann, Elke, Müller, Rolf, Reinartz, Silke

“…A crucial requirement for metastasis formation in ovarian high-grade serous carcinoma (HGSC) is the disruption of the protective peritoneal mesothelium. Using…”
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Chromatin Binding of c -REL and p65 Is Not Limiting for Macrophage IL12B Transcription During Immediate Suppression by Ovarian Carcinoma Ascites by Unger, Annika, Finkernagel, Florian, Hoffmann, Nathalie, Neuhaus, Felix, Joos, Barbara, Nist, Andrea, Stiewe, Thorsten, Visekruna, Alexander, Wagner, Uwe, Reinartz, Silke, Müller-Brüsselbach, Sabine, Müller, Rolf, Adhikary, Till

“…Tumors frequently exploit homeostatic mechanisms that suppress expression of IL-12, a central mediator of inflammatory and anti-tumor responses. The p40…”
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Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis‐associated adhesion of ovarian cancer cells by Neuhaus, Felix, Lieber, Sonja, Shinkevich, Veronika, Steitz, Anna Mary, Raifer, Hartmann, Roth, Kathrin, Finkernagel, Florian, Worzfeld, Thomas, Burchert, Andreas, Keber, Corinna, Nist, Andrea, Stiewe, Thorsten, Reinartz, Silke, Beutgen, Vanessa M., Graumann, Johannes, Pauck, Kim, Garn, Holger, Gaida, Matthias, Müller, Rolf, Huber, Magdalena

“…Background IL‐17A and TNF synergistically promote inflammation and tumorigenesis. Their interplay and impact on ovarian carcinoma (OC) progression are,…”
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Isolation of native EVs from primary biofluids—Free‐flow electrophoresis as a novel approach to purify ascites‐derived EVs by Preußer, Christian, Stelter, Kathrin, Tertel, Tobias, Linder, Manuel, Helmprobst, Frederik, Szymanski, Witold, Graumann, Johannes, Giebel, Bernd, Reinartz, Silke, Müller, Rolf, Weber, Gerhard, Strandmann, Elke Pogge

“…Although extracellular vesicles (EVs) have been extensively characterized, efficient purification methods, especially from primary biofluids, remain…”
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The Combination of MiRNA-196b, LCN2, and TIMP1 is a Potential Set of Circulating Biomarkers for Screening Individuals at Risk for Familial Pancreatic Cancer by Bartsch, Detlef K, Gercke, Norman, Strauch, Konstantin, Wieboldt, Ronja, Matthäi, Elvira, Wagner, Vinona, Rospleszcz, Susanne, Schäfer, Agnes, Franke, Frederike S, Mintziras, Ioannis, Bauer, Christian, Grote, Tobias, Figiel, Jens, Di Fazio, Pietro, Burchert, Andreas, Reinartz, Silke, Pogge von Strandmann, Elke, Klöppel, Günter, Slater, Emily P

“…Individuals at risk (IAR) of familial pancreatic cancer (FPC) are good candidates for screening. Unfortunately, neither reliable imaging modalities nor…”
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Phase I Study of Abagovomab in Patients with Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer by SABBATINI, Paul, DUPONT, Jakob, MCGUIRE, William, REINARTZ, Silke, SCHNEIDER, Sally, GRANDE, Cathy, LELE, Shashikant, RODABAUGH, Kerry, KEPNER, James, FERRONE, Soldano, ODUNSI, Kunle, AGHAJANIAN, Carol, DEROSA, Felicia, POYNOR, Elizabeth, ANDERSON, Sybil, HENSLEY, Martee, LIVINGSTON, Phillip, IASONOS, Alexia, SPRIGGS, David

“…Purpose: This open-label study assessed the safety and immunogenicity of two doses and two routes of the anti-idiotypic monoclonal antibody abagovomab…”
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Immunological Consolidation of Ovarian Carcinoma Recurrences with Monoclonal Anti-Idiotype Antibody ACA125: Immune Responses and Survival in Palliative Treatment by Uwe Wagner, Siegmund Köhler, Silke Reinartz, Patrick Giffels, Jens Huober, Kirsten Renke, Harald Schlebusch, Hans-Jürgen Biersack, Volker Möbus, Rolf Kreienberg, Thomas Bauknecht, Dieter Krebs, Diethelm Wallwiener

“…The aim of the present study was to assess whether the induction of specific immune responses by vaccination with the murine monoclonal anti-idiotypic antibody…”
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The Unique Molecular and Cellular Microenvironment of Ovarian Cancer by Worzfeld, Thomas, Pogge von Strandmann, Elke, Huber, Magdalena, Adhikary, Till, Wagner, Uwe, Reinartz, Silke, Müller, Rolf

“…The reciprocal interplay of cancer cells and host cells is an indispensable prerequisite for tumor growth and progression. Cells of both the innate and…”
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