Search Results - "REIMANN, F"

SCFAs strongly stimulate PYY production in human enteroendocrine cells by Larraufie, P., Martin-Gallausiaux, C., Lapaque, N., Dore, J., Gribble, F. M., Reimann, F., Blottiere, H. M.

“…Peptide-YY (PYY) and Glucagon-Like Peptide-1 (GLP-1) play important roles in the regulation of food intake and insulin secretion, and are of translational…”
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Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity by Worthington, J J, Reimann, F, Gribble, F M

“…The intestinal epithelium must balance efficient absorption of nutrients with partitioning commensals and pathogens from the bodies’ largest immune system. If…”
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Glucagon-like peptide 1 (GLP-1) by Müller, T.D., Finan, B., Bloom, S.R., D'Alessio, D., Drucker, D.J., Flatt, P.R., Fritsche, A., Gribble, F., Grill, H.J., Habener, J.F., Holst, J.J., Langhans, W., Meier, J.J., Nauck, M.A., Perez-Tilve, D., Pocai, A., Reimann, F., Sandoval, D.A., Schwartz, T.W., Seeley, R.J., Stemmer, K., Tang-Christensen, M., Woods, S.C., DiMarchi, R.D., Tschöp, M.H.

“…The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the…”
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Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion by Parker, H. E., Adriaenssens, A., Rogers, G., Richards, P., Koepsell, H., Reimann, F., Gribble, F. M.

“…Aims/hypothesis Several glucose-sensing pathways have been implicated in glucose-triggered secretion of glucagon-like peptide-1 (GLP-1) from intestinal L…”
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The glucose-dependent insulinotropic polypeptide signaling axis in the central nervous system by Adriaenssens, A.E., Gribble, F.M., Reimann, F.

“…•Glucose-dependent insulinotropic polypeptide receptor (GIPR) is expressed in feeding centres.•GIPR+ cell activation inhibits food intake, yet inhibiting GIPR…”
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Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells by Habib, A. M., Richards, P., Rogers, G. J., Reimann, F., Gribble, F. M.

“…Aims/hypothesis Targeting the secretion of gut peptides such as glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) is a strategy under development for the…”
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Preproglucagon neurons project widely to autonomic control areas in the mouse brain by Llewellyn-Smith, I.J, Reimann, F, Gribble, F.M, Trapp, S

“…Abstract Glucagon-like peptide 1 (GLP-1) and its analogue exendin-4 inhibit food intake, reduce blood glucose levels and increase blood pressure and heart rate…”
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Molecular mechanisms underlying bile acid‐stimulated glucagon‐like peptide‐1 secretion by Parker, HE, Wallis, K, le Roux, CW, Wong, KY, Reimann, F, Gribble, FM

“…BACKGROUND AND PURPOSE The glucagon‐like peptides GLP‐1 and GLP‐2 are secreted from enteroendocrine L‐cells following nutrient ingestion. Drugs that increase…”
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Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity by Worthington, J.J., Reimann, F., Gribble, F.M.

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Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells by Parker, H. E, Habib, A. M, Rogers, G. J, Gribble, F. M, Reimann, F

“…Aims/hypothesis Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with anti-apoptotic effects on the pancreatic beta cell. The aim of…”
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Sulphonylurea action revisited: the post-cloning era by GRIBBLE, F. M, REIMANN, F

“…Hypoglycaemic agents such as sulphonylureas and the newer group of "glinides" stimulate insulin secretion by closing ATP-sensitive potassium (K(ATP)) channels…”
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Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4 by Casas, S, Novials, A, Reimann, F, Gomis, R, Gribble, F. M

“…Aims/hypothesis To investigate the mechanism by which human islet amyloid polypeptide (hIAPP) fibril formation results in calcium influx across the plasma…”
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Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents by Moss, C. E., Marsh, W. J., Parker, H. E., Ogunnowo-Bada, E., Riches, C. H., Habib, A. M., Evans, M. L., Gribble, F. M., Reimann, F.

“…Aims/hypothesis Glucose-dependent insulinotropic polypeptide (GIP) is an enteroendocrine hormone that promotes storage of glucose and fat. Its secretion from…”
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Liquid chromatography/mass spectrometry based detection and semi‐quantitative analysis of INSL5 in human and murine tissues by Kay, R.G., Galvin, S., Larraufie, P., Reimann, F., Gribble, F.M.

“…Rationale Insulin‐like peptide 5 (INSL5) is a hormone produced by enteroendocrine L‐cells in the colon that has recently been implicated in the control of…”
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Preproglucagon (PPG) neurons innervate neurochemicallyidentified autonomic neurons in the mouse brainstem by Llewellyn-Smith, I.J, Gnanamanickam, G.J.E, Reimann, F, Gribble, F.M, Trapp, S

“…Highlights ► GLP-1 neurons directly innervate brainstem cholinergic and monoaminergic neurons. ► GLP-1 may influence satiety via heavy GLP-1 innervation of…”
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Electrical activity‐triggered glucagon‐like peptide‐1 secretion from primary murine L‐cells by Rogers, G. J., Tolhurst, G., Ramzan, A., Habib, A. M., Parker, H. E., Gribble, F. M., Reimann, F.

“…Non‐technical summary  Glucagon like peptide 1 (GLP‐1) based therapies are now widely used for the treatment of diabetes. The physiological source of the…”
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PREPROGLUCAGON (PPG) NEURONS INNERVATE NEUROCHEMICALLY IDENTIFIED AUTONOMIC NEURONS IN THE MOUSE BRAINSTEM by LLEWELLYN-SMITH, I. J, GNANAMANICKAM, G. J. E, REIMANN, F, GRIBBLE, F. M, TRAPP, S

“…Preproglucagon (PPG) neurons produce glucagon-like peptide-1 (GLP-1) and occur primarily in the nucleus tractus solitarius (NTS). GLP-1 affects a variety of…”
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Spinally projecting preproglucagon axons preferentially innervate sympathetic preganglionic neurons by Llewellyn-Smith, I.J, Marina, N, Manton, R.N, Reimann, F, Gribble, F.M, Trapp, S

“…Highlights • Spinal GLP-1 axons target primarily sympathetic preganglionic neurons. • Spinal GLP-1 axons innervate interneurons that may regulate sympathetic…”
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Ablation of AMP-activated protein kinase α1 and α2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo by Sun, G., Tarasov, A. I., McGinty, J., McDonald, A., da Silva Xavier, G., Gorman, T., Marley, A., French, P. M., Parker, H., Gribble, F., Reimann, F., Prendiville, O., Carzaniga, R., Viollet, B., Leclerc, I., Rutter, G. A.

“…Aims/hypothesis AMP-activated protein kinase (AMPK) is an evolutionarily conserved enzyme and a target of glucose-lowering agents, including metformin…”
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Ablation of AMP-activated protein kinase alpha 1 and alpha 2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo by Sun, G, Tarasov, AI, McGinty, J, McDonald, A, Silva Xavier, G, Gorman, T, Marley, A, French, P M, Parker, H, Gribble, F, Reimann, F, Prendiville, O, Carzaniga, R, Viollet, B, Leclerc, I, Rutter, G A

“…Aims/hypothesis: AMP-activated protein kinase (AMPK) is an evolutionarily conserved enzyme and a target of glucose-lowering agents, including metformin…”
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